{"id":"https://openalex.org/W2397930477","doi":"https://doi.org/","title":"The efficacy of N-acetylcysteine in the treatment of methamphetamine dependence: a double-blind controlled, crossover study.","display_name":"The efficacy of N-acetylcysteine in the treatment of methamphetamine dependence: a double-blind controlled, crossover study.","publication_year":2015,"publication_date":"2015-01-01","ids":{"openalex":"https://openalex.org/W2397930477","doi":"https://doi.org/","mag":"2397930477","pmid":"https://pubmed.ncbi.nlm.nih.gov/25556383"},"language":"en","primary_location":{"id":"pmid:25556383","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25556383","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of Iranian medicine","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5004440635","display_name":"Seyed Ghafur Mousavi","orcid":"https://orcid.org/0000-0001-8769-6001","observed_orcids":["https://orcid.org/0000-0001-8769-6001"]},"institutions":[{"id":"https://openalex.org/I114982161","display_name":"Isfahan University of Medical Sciences","ror":"https://ror.org/04waqzz56","country_code":"IR","type":"education","lineage":["https://openalex.org/I114982161"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Seyed Ghafur Mousavi","raw_affiliation_strings":["Department of Psychiatry, Behavioral Sciences Research Center, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran. me_salehi@med.mui.ac.ir"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, Behavioral Sciences Research Center, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran. me_salehi@med.mui.ac.ir","institution_ids":["https://openalex.org/I114982161"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065162360","display_name":"Mohammad Reza Sharbafchi","orcid":"https://orcid.org/0000-0002-8038-9508","observed_orcids":["https://orcid.org/0000-0002-8038-9508"]},"institutions":[{"id":"https://openalex.org/I114982161","display_name":"Isfahan University of Medical Sciences","ror":"https://ror.org/04waqzz56","country_code":"IR","type":"education","lineage":["https://openalex.org/I114982161"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Mohammad Reza Sharbafchi","raw_affiliation_strings":["Department of Psychiatry, Behavioral Sciences Research Center, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, Behavioral Sciences Research Center, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran","institution_ids":["https://openalex.org/I114982161"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103230565","display_name":"Mehrdad Salehi","orcid":"https://orcid.org/0000-0003-3615-6149","observed_orcids":["https://orcid.org/0000-0003-3615-6149"]},"institutions":[{"id":"https://openalex.org/I114982161","display_name":"Isfahan University of Medical Sciences","ror":"https://ror.org/04waqzz56","country_code":"IR","type":"education","lineage":["https://openalex.org/I114982161"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Mehrdad Salehi","raw_affiliation_strings":["Department of Psychiatry, Behavioral Sciences Research Center, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, Behavioral Sciences Research Center, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran","institution_ids":["https://openalex.org/I114982161"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033609060","display_name":"Mohammad Peykanpour","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114982161","display_name":"Isfahan University of Medical Sciences","ror":"https://ror.org/04waqzz56","country_code":"IR","type":"education","lineage":["https://openalex.org/I114982161"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Mohammad Peykanpour","raw_affiliation_strings":["Department of Pharmaceutics, Psychosomatic Research Center, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutics, Psychosomatic Research Center, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran","institution_ids":["https://openalex.org/I114982161"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085010386","display_name":"Naeemeh Karimian Sichani","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I39268498","display_name":"University of Isfahan","ror":"https://ror.org/05h9t7759","country_code":"IR","type":"education","lineage":["https://openalex.org/I39268498"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Naeemeh Karimian Sichani","raw_affiliation_strings":["Department of Psychology, School of Psychology and Education Sciences, Isfahan University, Isfahan, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychology, School of Psychology and Education Sciences, Isfahan University, Isfahan, Iran","institution_ids":["https://openalex.org/I39268498"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5065055618","display_name":"Mohammad Reza Maracy","orcid":"https://orcid.org/0000-0002-3695-0863","observed_orcids":["https://orcid.org/0000-0002-3695-0863"]},"institutions":[{"id":"https://openalex.org/I114982161","display_name":"Isfahan University of Medical Sciences","ror":"https://ror.org/04waqzz56","country_code":"IR","type":"education","lineage":["https://openalex.org/I114982161"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Mohammad Maracy","raw_affiliation_strings":["Department of Biostatistics and Epidemiology, School of Public Health, Isfahan University of Medical Sciences, Isfahan, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics and Epidemiology, School of Public Health, Isfahan University of Medical Sciences, Isfahan, Iran","institution_ids":["https://openalex.org/I114982161"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":8.0332,"has_fulltext":false,"cited_by_count":67,"citation_normalized_percentile":{"value":0.98306977,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"18","issue":"1","first_page":"28","last_page":"33"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10043","display_name":"Substance Abuse Treatment and Outcomes","score":0.9702000021934509,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10043","display_name":"Substance Abuse Treatment and Outcomes","score":0.9702000021934509,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10576","display_name":"Opioid Use Disorder Treatment","score":0.013799999840557575,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.007499999832361937,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/n-acetylcysteine","display_name":"N-acetylcysteine","score":0.9990000128746033},{"id":"https://openalex.org/keywords/methamphetamine-dependence","display_name":"methamphetamine dependence","score":1.0},{"id":"https://openalex.org/keywords/cocaine-craving","display_name":"cocaine craving","score":0.7319999933242798},{"id":"https://openalex.org/keywords/pharmacological-treatment-of-addiction","display_name":"pharmacological treatment of addiction","score":0.7919999957084656},{"id":"https://openalex.org/keywords/placebo-controlled-crossover-trial","display_name":"placebo-controlled crossover trial","score":0.48100000619888306}],"concepts":[{"id":"https://openalex.org/C87813604","wikidata":"https://www.wikidata.org/wiki/Q1242899","display_name":"Crossover study","level":4,"score":0.7597678303718567},{"id":"https://openalex.org/C2779541405","wikidata":"https://www.wikidata.org/wiki/Q498902","display_name":"Craving","level":3,"score":0.7429840564727783},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6696304678916931},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.627676248550415},{"id":"https://openalex.org/C2781413609","wikidata":"https://www.wikidata.org/wiki/Q7308373","display_name":"Regimen","level":2,"score":0.49654656648635864},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.4122389853000641},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.35683727264404297},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2757578492164612},{"id":"https://openalex.org/C48856860","wikidata":"https://www.wikidata.org/wiki/Q12029","display_name":"Addiction","level":2,"score":0.1672910451889038},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.151035875082016},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000111","descriptor_name":"Acetylcysteine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000697","descriptor_name":"Central Nervous System Stimulants","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008694","descriptor_name":"Methamphetamine","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D011795","descriptor_name":"Surveys and Questionnaires","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013375","descriptor_name":"Substance Withdrawal Syndrome","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D013375","descriptor_name":"Substance Withdrawal Syndrome","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D016166","descriptor_name":"Free Radical Scavengers","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018592","descriptor_name":"Cross-Over Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019969","descriptor_name":"Amphetamine-Related Disorders","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066249","descriptor_name":"Craving","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:25556383","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25556383","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of Iranian medicine","raw_type":"Journal Article"},{"id":"mag:2397930477","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25556383","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[{"display_name":"Randomized Controlled Trial","id":"https://openalex.org/study-designs/randomized-controlled-trial"},{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3045919442","https://openalex.org/W3181877665","https://openalex.org/W1969236260","https://openalex.org/W2948546252","https://openalex.org/W2651436058","https://openalex.org/W2409249452","https://openalex.org/W3155780432","https://openalex.org/W1951949051","https://openalex.org/W4402323547","https://openalex.org/W2756375477"],"abstract_inverted_index":{"OBJECTIVE:":[0],"Preclinical":[1],"studies":[2],"and":[3,104,161,166,175,178,205,214,236],"early":[4],"pilot":[5],"clinical":[6,40],"investigations":[7],"have":[8],"suggested":[9],"that":[10,192],"N-acetylcysteine":[11],"(NAC)":[12],"may":[13,237],"be":[14,238],"useful":[15,240],"in":[16,59,145,158,232],"treatment":[17,242],"of":[18,71,82,92,107,142,156,172,184,217],"methamphetamine":[19],"(METH)":[20],"dependence.":[21],"The":[22,118,152,227],"present":[23],"study":[24],"evaluated":[25],"whether":[26],"NAC":[27,50,72,150,199,206,228],"would":[28],"suppress":[29],"craving":[30],"to":[31,47],"the":[32,89,93,113,137,139,170,182,185,193,215],"METH.":[33],"METHODS:":[34],"In":[35,132],"a":[36,239],"double-blind,":[37],"controlled":[38],"crossover":[39,90],"trial,":[41],"32":[42],"METH-dependent":[43],"volunteers":[44],"were":[45,57,120,163,212],"chosen":[46],"receive":[48],"either":[49,68],"(1200":[51],"mg/day)":[52],"or":[53,75],"placebo,":[54],"randomly.":[55],"They":[56],"intervened":[58],"two":[60],"four-week":[61],"sessions.":[62],"During":[63,96],"first":[64,173],"session":[65,86],"they":[66],"received":[67,102],"1200":[69],"mg/day":[70],"(group":[73,77],"A)":[74],"placebo":[76,204],"B).":[78],"After":[79],"three":[80],"days":[81],"washout":[83],"period,":[84],"next":[85],"started":[87],"with":[88,149],"intervention":[91],"previous":[94],"regimen.":[95],"these":[97],"eight":[98],"weeks,":[99],"all":[100],"participants":[101],"standardized,":[103],"Matrix":[105],"Model":[106],"treatment.":[108,151],"Craving":[109,115],"was":[110,196],"assessed":[111],"using":[112,122],"Cocaine":[114],"Questionnaire-Brief":[116],"(CCQ-Brief).":[117],"data":[119],"analyzed":[121],"SPSS":[123],"version":[124],"20.0":[125],"(SPSS":[126],"Inc.":[127],"Chicago,":[128],"Illinois,":[129],"USA).":[130],"RESULTS:":[131],"23":[133],"subjects":[134,218],"who":[135,219],"completed":[136],"study,":[138],"mean":[140,153],"score":[141],"CCQ-Brief":[143],"reduced":[144],"four":[146],"consecutive":[147],"weeks":[148],"(SD)":[154],"scores":[155],"carving":[157],"group":[159],"A":[160],"B":[162],"3.38":[164],"(1.16)":[165],"5.96":[167],"(1.03),":[168],"at":[169,181],"end":[171,183],"session;":[174],"4.57":[176],"(1.88)":[177],"3.2":[179],"(0.86),":[180],"second":[186],"session,":[187],"respectively.":[188],"Our":[189],"findings":[190],"indicate":[191],"main":[194],"effect":[195],"significant":[197],"for":[198,243],"(P":[200],"<":[201],"0.001).":[202],"Across":[203],"conditions,":[207],"only":[208],"mild":[209],"side":[210,221],"effects":[211,222],"noted,":[213],"number":[216],"reported":[220],"did":[223],"not":[224],"differ.":[225],"CONCLUSION:":[226],"showed":[229],"good":[230],"efficacy":[231],"suppressing":[233],"METH":[234,244],"craving,":[235],"pharmacological":[241],"dependency.":[245]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":12},{"year":2017,"cited_by_count":11},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}