{"id":"https://openalex.org/W2397917330","doi":"https://doi.org/10.1128/aem.01213-16","title":"Evidence for a Role for the Plasma Membrane in the Nanomechanical Properties of the Cell Wall as Revealed by an Atomic Force Microscopy Study of the Response of Saccharomyces cerevisiae to Ethanol Stress","display_name":"Evidence for a Role for the Plasma Membrane in the Nanomechanical Properties of the Cell Wall as Revealed by an Atomic Force Microscopy Study of the Response of Saccharomyces cerevisiae to Ethanol Stress","publication_year":2016,"publication_date":"2016-05-28","ids":{"openalex":"https://openalex.org/W2397917330","doi":"https://doi.org/10.1128/aem.01213-16","mag":"2397917330","pmid":"https://pubmed.ncbi.nlm.nih.gov/27235439","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4984286"},"language":"en","primary_location":{"id":"doi:10.1128/aem.01213-16","doi":"https://doi.org/10.1128/aem.01213-16","is_oa":true,"landing_page_url":"https://doi.org/10.1128/aem.01213-16","pdf_url":"https://aem.asm.org/content/aem/82/15/4789.full.pdf","source":{"id":"https://openalex.org/S158228368","display_name":"Applied and Environmental Microbiology","issn_l":"0099-2240","issn":["0099-2240","1070-6291","1098-5336"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Applied and Environmental Microbiology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://aem.asm.org/content/aem/82/15/4789.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5065030641","display_name":"Marion Schiavone","orcid":"https://orcid.org/0000-0002-8231-2053","observed_orcids":["https://orcid.org/0000-0002-8231-2053"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I196454796","display_name":"Institut National des Sciences Appliqu\u00e9es de Toulouse","ror":"https://ror.org/01h8pf755","country_code":"FR","type":"education","lineage":["https://openalex.org/I196454796"]},{"id":"https://openalex.org/I4210110888","display_name":"Toulouse Biotechnology Institute, Bio & Chemical Engineering","ror":"https://ror.org/01yypjb30","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I196454796","https://openalex.org/I4210088668","https://openalex.org/I4210110888"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Marion Schiavone","raw_affiliation_strings":["LISBP, Universit\u00e9 F\u00e9d\u00e9rale de Toulouse, CNRS, INRA, INSA, Toulouse, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"LISBP, Universit\u00e9 F\u00e9d\u00e9rale de Toulouse, CNRS, INRA, INSA, Toulouse, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I196454796","https://openalex.org/I4210110888"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041477025","display_name":"C\u00e9cile Formosa\u2010Dague","orcid":"https://orcid.org/0000-0002-8627-3784","observed_orcids":["https://orcid.org/0000-0002-8627-3784"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I190497903","display_name":"Laboratoire d'Analyse et d'Architecture des Syst\u00e8mes","ror":"https://ror.org/03vcm6439","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I190497903","https://openalex.org/I193033237","https://openalex.org/I196454796","https://openalex.org/I205747304","https://openalex.org/I4210095849","https://openalex.org/I4210152422","https://openalex.org/I4210159245","https://openalex.org/I4405258862","https://openalex.org/I4405259414"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"C\u00e9cile Formosa-Dague","raw_affiliation_strings":["CNRS, LAAS, Toulouse, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CNRS, LAAS, Toulouse, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I190497903"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033323975","display_name":"Carolina Elsztein","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I25112270","display_name":"Universidade Federal de Pernambuco","ror":"https://ror.org/047908t24","country_code":"BR","type":"education","lineage":["https://openalex.org/I25112270"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Carolina Elsztein","raw_affiliation_strings":["Departamento de Gen\u00e9tica, Universidade Federal de Pernambuco, Recife, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Gen\u00e9tica, Universidade Federal de Pernambuco, Recife, Brazil","institution_ids":["https://openalex.org/I25112270"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043242293","display_name":"Marie-Ange Teste","orcid":"https://orcid.org/0000-0001-9173-9190","observed_orcids":["https://orcid.org/0000-0001-9173-9190"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I196454796","display_name":"Institut National des Sciences Appliqu\u00e9es de Toulouse","ror":"https://ror.org/01h8pf755","country_code":"FR","type":"education","lineage":["https://openalex.org/I196454796"]},{"id":"https://openalex.org/I4210110888","display_name":"Toulouse Biotechnology Institute, Bio & Chemical Engineering","ror":"https://ror.org/01yypjb30","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I196454796","https://openalex.org/I4210088668","https://openalex.org/I4210110888"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Marie-Ange Teste","raw_affiliation_strings":["LISBP, Universit\u00e9 F\u00e9d\u00e9rale de Toulouse, CNRS, INRA, INSA, Toulouse, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"LISBP, Universit\u00e9 F\u00e9d\u00e9rale de Toulouse, CNRS, INRA, INSA, Toulouse, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I196454796","https://openalex.org/I4210110888"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049717514","display_name":"H\u00e9l\u00e8ne Martin\u2010Yken","orcid":"https://orcid.org/0000-0002-2024-3232","observed_orcids":["https://orcid.org/0000-0002-2024-3232"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I196454796","display_name":"Institut National des Sciences Appliqu\u00e9es de Toulouse","ror":"https://ror.org/01h8pf755","country_code":"FR","type":"education","lineage":["https://openalex.org/I196454796"]},{"id":"https://openalex.org/I4210110888","display_name":"Toulouse Biotechnology Institute, Bio & Chemical Engineering","ror":"https://ror.org/01yypjb30","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I196454796","https://openalex.org/I4210088668","https://openalex.org/I4210110888"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Helene Martin-Yken","raw_affiliation_strings":["LISBP, Universit\u00e9 F\u00e9d\u00e9rale de Toulouse, CNRS, INRA, INSA, Toulouse, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"LISBP, Universit\u00e9 F\u00e9d\u00e9rale de Toulouse, CNRS, INRA, INSA, Toulouse, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I196454796","https://openalex.org/I4210110888"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090874093","display_name":"Marcos Ant\u00f4nio de Morais","orcid":"https://orcid.org/0000-0002-9727-0300","observed_orcids":["https://orcid.org/0000-0002-9727-0300"]},"institutions":[{"id":"https://openalex.org/I25112270","display_name":"Universidade Federal de Pernambuco","ror":"https://ror.org/047908t24","country_code":"BR","type":"education","lineage":["https://openalex.org/I25112270"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Marcos A. De Morais","raw_affiliation_strings":["Departamento de Gen\u00e9tica, Universidade Federal de Pernambuco, Recife, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Gen\u00e9tica, Universidade Federal de Pernambuco, Recife, Brazil","institution_ids":["https://openalex.org/I25112270"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011427560","display_name":"\u00c9tienne Dague","orcid":"https://orcid.org/0000-0003-3290-9166","observed_orcids":["https://orcid.org/0000-0003-3290-9166"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I190497903","display_name":"Laboratoire d'Analyse et d'Architecture des Syst\u00e8mes","ror":"https://ror.org/03vcm6439","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I190497903","https://openalex.org/I193033237","https://openalex.org/I196454796","https://openalex.org/I205747304","https://openalex.org/I4210095849","https://openalex.org/I4210152422","https://openalex.org/I4210159245","https://openalex.org/I4405258862","https://openalex.org/I4405259414"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Etienne Dague","raw_affiliation_strings":["CNRS, LAAS, Toulouse, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CNRS, LAAS, Toulouse, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I190497903"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5037156035","display_name":"Jean Fran\u00e7ois","orcid":"https://orcid.org/0000-0001-9884-5535","observed_orcids":["https://orcid.org/0000-0001-9884-5535"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I196454796","display_name":"Institut National des Sciences Appliqu\u00e9es de Toulouse","ror":"https://ror.org/01h8pf755","country_code":"FR","type":"education","lineage":["https://openalex.org/I196454796"]},{"id":"https://openalex.org/I4210110888","display_name":"Toulouse Biotechnology Institute, Bio & Chemical Engineering","ror":"https://ror.org/01yypjb30","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I196454796","https://openalex.org/I4210088668","https://openalex.org/I4210110888"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Jean M. Fran\u00e7ois","raw_affiliation_strings":["LISBP, Universit\u00e9 F\u00e9d\u00e9rale de Toulouse, CNRS, INRA, INSA, Toulouse, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"LISBP, Universit\u00e9 F\u00e9d\u00e9rale de Toulouse, CNRS, INRA, INSA, Toulouse, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I196454796","https://openalex.org/I4210110888"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.7964,"has_fulltext":true,"cited_by_count":54,"citation_normalized_percentile":{"value":0.84566694,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"82","issue":"15","first_page":"4789","last_page":"4801"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10497","display_name":"Fungal and yeast genetics research","score":0.4839000105857849,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10497","display_name":"Fungal and yeast genetics research","score":0.4839000105857849,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.319599986076355,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10923","display_name":"Force Microscopy Techniques and Applications","score":0.16869999468326569,"subfield":{"id":"https://openalex.org/subfields/3107","display_name":"Atomic and Molecular Physics, and Optics"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ethanol-stress","display_name":"ethanol stress","score":0.8809999823570251},{"id":"https://openalex.org/keywords/saccharomyces-cerevisiae","display_name":"Saccharomyces cerevisiae","score":0.9390000104904175},{"id":"https://openalex.org/keywords/cell-wall-stiffness","display_name":"cell wall stiffness","score":0.9649999737739563},{"id":"https://openalex.org/keywords/plasma-membrane-integrity","display_name":"plasma membrane integrity","score":0.5559999942779541},{"id":"https://openalex.org/keywords/plasma-membrane","display_name":"plasma membrane","score":0.8199999928474426},{"id":"https://openalex.org/keywords/amphotericin-b","display_name":"amphotericin B","score":0.9419999718666077},{"id":"https://openalex.org/keywords/young-s-modulus","display_name":"Young's modulus","score":0.7940000295639038},{"id":"https://openalex.org/keywords/nanomechanical-properties","display_name":"nanomechanical properties","score":0.7730000019073486},{"id":"https://openalex.org/keywords/alcohol-toxicity","display_name":"ethanol toxicity","score":0.8650000095367432},{"id":"https://openalex.org/keywords/yeast-fermentation","display_name":"yeast fermentation","score":0.5180000066757202}],"concepts":[{"id":"https://openalex.org/C2777576037","wikidata":"https://www.wikidata.org/wiki/Q719725","display_name":"Saccharomyces cerevisiae","level":3,"score":0.8464651107788086},{"id":"https://openalex.org/C2779222958","wikidata":"https://www.wikidata.org/wiki/Q45422","display_name":"Yeast","level":2,"score":0.8221424221992493},{"id":"https://openalex.org/C125235067","wikidata":"https://www.wikidata.org/wiki/Q128700","display_name":"Cell wall","level":2,"score":0.632928729057312},{"id":"https://openalex.org/C2780161600","wikidata":"https://www.wikidata.org/wiki/Q153","display_name":"Ethanol","level":2,"score":0.6223284006118774},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.56409752368927},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.5500919222831726},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.5144569873809814},{"id":"https://openalex.org/C2778106830","wikidata":"https://www.wikidata.org/wiki/Q29548","display_name":"Cell membrane","level":3,"score":0.5092757940292358},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.49165159463882446},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4668470323085785},{"id":"https://openalex.org/C2779372316","wikidata":"https://www.wikidata.org/wiki/Q569057","display_name":"Stiffness","level":2,"score":0.44076237082481384},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.43412837386131287},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.32013821601867676},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.18356674909591675},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000431","descriptor_name":"Ethanol","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D002473","descriptor_name":"Cell Wall","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002473","descriptor_name":"Cell Wall","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002473","descriptor_name":"Cell Wall","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D018625","descriptor_name":"Microscopy, Atomic Force","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1128/aem.01213-16","doi":"https://doi.org/10.1128/aem.01213-16","is_oa":true,"landing_page_url":"https://doi.org/10.1128/aem.01213-16","pdf_url":"https://aem.asm.org/content/aem/82/15/4789.full.pdf","source":{"id":"https://openalex.org/S158228368","display_name":"Applied and Environmental Microbiology","issn_l":"0099-2240","issn":["0099-2240","1070-6291","1098-5336"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Applied and Environmental Microbiology","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:4127969","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4984286","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:27235439","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27235439","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Applied and environmental microbiology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4984286","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4984286/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Appl Environ Microbiol","raw_type":"Text"},{"id":"pmh:oai:HAL:hal-01552795v1","doi":null,"is_oa":true,"landing_page_url":"https://hal.science/hal-01552795","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Applied and Environmental Microbiology, 2016, 82 (15), pp.4789 - 4801. ⟨10.1128/AEM.01213-16⟩","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1128/aem.01213-16","doi":"https://doi.org/10.1128/aem.01213-16","is_oa":true,"landing_page_url":"https://doi.org/10.1128/aem.01213-16","pdf_url":"https://aem.asm.org/content/aem/82/15/4789.full.pdf","source":{"id":"https://openalex.org/S158228368","display_name":"Applied and Environmental Microbiology","issn_l":"0099-2240","issn":["0099-2240","1070-6291","1098-5336"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Applied and Environmental Microbiology","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G7510971296","display_name":"Exploring the yeast cell wall organization at the nanoscale by combining biomolecular, biochemical and biophysical approaches","funder_award_id":"ANR-11-JSV5-0001","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"}],"funders":[{"id":"https://openalex.org/F4320320883","display_name":"Agence Nationale de la Recherche","ror":"https://ror.org/00rbzpz17"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2397917330.pdf","grobid_xml":"https://content.openalex.org/works/W2397917330.grobid-xml"},"referenced_works_count":98,"referenced_works":["https://openalex.org/W98704950","https://openalex.org/W180762096","https://openalex.org/W629315643","https://openalex.org/W1187739204","https://openalex.org/W1501511167","https://openalex.org/W1539988911","https://openalex.org/W1740871519","https://openalex.org/W1951012306","https://openalex.org/W1966560765","https://openalex.org/W1967390330","https://openalex.org/W1969955354","https://openalex.org/W1972254777","https://openalex.org/W1972665652","https://openalex.org/W1975035065","https://openalex.org/W1978945721","https://openalex.org/W1981755158","https://openalex.org/W1987640473","https://openalex.org/W1988857801","https://openalex.org/W1995054170","https://openalex.org/W1995186750","https://openalex.org/W1995267722","https://openalex.org/W1998177015","https://openalex.org/W2001649514","https://openalex.org/W2004832477","https://openalex.org/W2005628267","https://openalex.org/W2008814411","https://openalex.org/W2009940316","https://openalex.org/W2010227280","https://openalex.org/W2011949091","https://openalex.org/W2013904302","https://openalex.org/W2015530645","https://openalex.org/W2016037572","https://openalex.org/W2018259963","https://openalex.org/W2019630613","https://openalex.org/W2020807365","https://openalex.org/W2024868442","https://openalex.org/W2028828246","https://openalex.org/W2028905621","https://openalex.org/W2030298107","https://openalex.org/W2030948786","https://openalex.org/W2031094779","https://openalex.org/W2031189086","https://openalex.org/W2031315147","https://openalex.org/W2031661929","https://openalex.org/W2031987597","https://openalex.org/W2033904822","https://openalex.org/W2034332162","https://openalex.org/W2034651317","https://openalex.org/W2041601195","https://openalex.org/W2050408363","https://openalex.org/W2051165804","https://openalex.org/W2058167342","https://openalex.org/W2064059521","https://openalex.org/W2064858085","https://openalex.org/W2066993231","https://openalex.org/W2067692758","https://openalex.org/W2069350458","https://openalex.org/W2070209802","https://openalex.org/W2070846083","https://openalex.org/W2073414410","https://openalex.org/W2074743540","https://openalex.org/W2075255571","https://openalex.org/W2079122560","https://openalex.org/W2080106668","https://openalex.org/W2083010093","https://openalex.org/W2083397995","https://openalex.org/W2083905285","https://openalex.org/W2085088747","https://openalex.org/W2086731610","https://openalex.org/W2088246177","https://openalex.org/W2090550483","https://openalex.org/W2091968634","https://openalex.org/W2094962583","https://openalex.org/W2099102671","https://openalex.org/W2100057937","https://openalex.org/W2107208315","https://openalex.org/W2109619915","https://openalex.org/W2110180483","https://openalex.org/W2126241360","https://openalex.org/W2128635872","https://openalex.org/W2129162289","https://openalex.org/W2129371499","https://openalex.org/W2129770809","https://openalex.org/W2131862769","https://openalex.org/W2133576858","https://openalex.org/W2136656652","https://openalex.org/W2136876669","https://openalex.org/W2139357034","https://openalex.org/W2139522960","https://openalex.org/W2145265114","https://openalex.org/W2149668695","https://openalex.org/W2152162730","https://openalex.org/W2156780012","https://openalex.org/W2157163471","https://openalex.org/W2165130891","https://openalex.org/W2167889111","https://openalex.org/W2168420558","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W3015837018","https://openalex.org/W2513582084","https://openalex.org/W2083905285","https://openalex.org/W1966560765","https://openalex.org/W1998177015","https://openalex.org/W2080972204","https://openalex.org/W2143624637","https://openalex.org/W4298049379","https://openalex.org/W2065731195","https://openalex.org/W2980082861"],"abstract_inverted_index":{"UNLABELLED:":[0],"A":[1],"wealth":[2],"of":[3,26,37,58,79,105,110,117,128,156,181,197,208,230,249,258,273,277,291,298,312,326],"biochemical":[4],"and":[5,146,216,228,304,333],"molecular":[6],"data":[7,22,148,235],"have":[8],"been":[9],"reported":[10],"regarding":[11],"ethanol":[12,27,66,98,157,217,292,299,307,327],"toxicity":[13,275],"in":[14,87,177],"the":[15,24,56,88,97,115,129,154,178,182,186,195,200,226,231,238,241,246,255,271,296,301,313,324,329,337,342],"yeast":[16,30,60,118,198,250,259],"Saccharomyces":[17],"cerevisiae":[18],"However,":[19],"direct":[20],"physical":[21],"on":[23,29,144,158,288],"effects":[25,297],"stress":[28,99],"cells":[31,61,119],"are":[32,218],"almost":[33],"nonexistent.":[34],"This":[35],"lack":[36],"information":[38],"can":[39],"now":[40],"be":[41,163,174],"addressed":[42],"by":[43,75,223],"using":[44],"atomic":[45],"force":[46],"microscopy":[47],"(AFM)":[48],"technology.":[49],"In":[50],"this":[51,169,214,268,274,321],"report,":[52],"we":[53,151,189,294],"show":[54],"that":[55,109,127,153,191,240,306,336],"stiffness":[57,106,116,160],"glucose-grown":[59],"challenged":[62],"with":[63,193,199],"9%":[64],"(vol/vol)":[65],"for":[67,267,280],"5":[68],"h":[69],"was":[70,122,133],"dramatically":[71],"reduced,":[72],"as":[73,192],"shown":[74],"a":[76,84,102,175,205,264,309],"5-fold":[77],"drop":[78],"Young's":[80],"modulus.":[81],"Quite":[82],"unexpectedly,":[83],"mutant":[85],"deficient":[86],"Msn2/Msn4":[89],"transcription":[90,170],"factor,":[91],"which":[92],"is":[93,254,262,276],"known":[94,219],"to":[95,108,137,141,173,220,237,245,323,341],"mediate":[96],"response,":[100],"exhibited":[101],"low":[103],"level":[104,303],"similar":[107],"ethanol-treated":[111],"wild-type":[112],"cells.":[113,251],"Reciprocally,":[114],"overexpressing":[120],"MSN2":[121],"about":[123],"35%":[124],"higher":[125],"than":[126],"wild":[130],"type":[131],"but":[132,261],"nevertheless":[134],"reduced":[135],"3-":[136],"4-fold":[138],"upon":[139],"exposure":[140],"ethanol.":[142],"Based":[143],"these":[145,234],"other":[147,187],"presented":[149],"herein,":[150],"postulated":[152],"effect":[155,322],"cell":[159,183,209,242,314,330,338,343],"may":[161],"not":[162],"mediated":[164],"through":[165],"Msn2/Msn4,":[166],"even":[167],"though":[168],"factor":[171],"appears":[172],"determinant":[176],"nanomechanical":[179,345],"properties":[180,248],"wall.":[184],"On":[185],"hand,":[188],"found":[190,305],"ethanol,":[194],"treatment":[196],"antifungal":[201],"amphotericin":[202],"B":[203],"caused":[204],"significant":[206],"reduction":[207,311],"wall":[210,315,344],"stiffness.":[211],"Since":[212],"both":[213],"drug":[215],"alter,":[221],"albeit":[222],"different":[224],"means,":[225],"fluidity":[227],"structure":[229],"plasma":[232],"membrane,":[233],"led":[236],"proposition":[239],"membrane":[243,331,339],"contributes":[244,340],"biophysical":[247,302],"IMPORTANCE:":[252],"Ethanol":[253],"main":[256],"product":[257],"fermentation":[260],"also":[263],"toxic":[265],"compound":[266],"process.":[269],"Understanding":[270],"mechanism":[272],"great":[278],"importance":[279],"industrial":[281],"applications.":[282],"While":[283],"most":[284],"research":[285],"has":[286],"focused":[287],"genomic":[289],"studies":[290],"tolerance,":[293],"investigated":[295],"at":[300],"causes":[308],"strong":[310],"rigidity":[316],"(or":[317],"stiffness).":[318],"We":[319],"ascribed":[320],"action":[325],"perturbing":[328],"integrity":[332],"hence":[334],"proposed":[335],"properties.":[346]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":9},{"year":2019,"cited_by_count":11},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":3}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}