{"id":"https://openalex.org/W2397914779","doi":null,"title":"[Transgenic bioinsecticides inimical to parasites, but imical to environment].","display_name":"[Transgenic bioinsecticides inimical to parasites, but imical to environment].","publication_year":2003,"publication_date":"2003-01-01","ids":{"openalex":"https://openalex.org/W2397914779","mag":"2397914779","pmid":"https://pubmed.ncbi.nlm.nih.gov/16889013"},"language":"pl","primary_location":{"id":"pmid:16889013","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16889013","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Wiadomosci parazytologiczne","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5016576493","display_name":"Jolanta Kuci\u0144ska","orcid":"https://orcid.org/0000-0002-5725-5907","observed_orcids":["https://orcid.org/0000-0002-5725-5907"]},"institutions":[{"id":"https://openalex.org/I219388962","display_name":"University of Wroc\u0142aw","ror":"https://ror.org/00yae6e25","country_code":"PL","type":"education","lineage":["https://openalex.org/I219388962"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Jolanta Kuci\u0144ska","raw_affiliation_strings":["Zak\u0142ad Parazytologii Og\u00f3lnej, Instytut Mikrobiologii, Uniwersytet Wroc\u0142awski"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Zak\u0142ad Parazytologii Og\u00f3lnej, Instytut Mikrobiologii, Uniwersytet Wroc\u0142awski","institution_ids":["https://openalex.org/I219388962"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008232654","display_name":"El\u017cbieta Lonc","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Elzbieta Lonc","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5047741408","display_name":"Katarzyna Rydzanicz","orcid":"https://orcid.org/0000-0002-0516-0973","observed_orcids":["https://orcid.org/0000-0002-0516-0973"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Katarzyna Rydzanicz","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.19553755,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"49","issue":"1","first_page":"11","last_page":"20"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11075","display_name":"Insect Resistance and Genetics","score":0.8422999978065491,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11075","display_name":"Insect Resistance and Genetics","score":0.8422999978065491,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11436","display_name":"Entomopathogenic Microorganisms in Pest Control","score":0.15080000460147858,"subfield":{"id":"https://openalex.org/subfields/1109","display_name":"Insect Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11065","display_name":"Insect Pest Control Strategies","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bacillus-thuringiensis","display_name":"Bacillus thuringiensis","score":0.8840000033378601},{"id":"https://openalex.org/keywords/delta-endotoxin","display_name":"delta-endotoxin","score":0.8880000114440918},{"id":"https://openalex.org/keywords/cry-proteins","display_name":"Cry proteins","score":0.9129999876022339},{"id":"https://openalex.org/keywords/transgenic-bacteria","display_name":"transgenic bacteria","score":0.6259999871253967},{"id":"https://openalex.org/keywords/bioinsecticides","display_name":"bioinsecticides","score":0.7940000295639038},{"id":"https://openalex.org/keywords/mosquito-control","display_name":"mosquito control","score":0.6110000014305115},{"id":"https://openalex.org/keywords/simuliidae","display_name":"Simuliidae","score":0.5929999947547913},{"id":"https://openalex.org/keywords/bacillus-thuringiensis-israelensis","display_name":"Bacillus thuringiensis var. israelensis","score":0.8119999766349792},{"id":"https://openalex.org/keywords/lysinibacillus-sphaericus","display_name":"Bacillus sphaericus","score":0.9919999837875366},{"id":"https://openalex.org/keywords/tetrahymena-pyriformis","display_name":"Tetrahymena pyriformis","score":0.8740000128746033},{"id":"https://openalex.org/keywords/cyanobacteria","display_name":"cyanobacteria","score":0.6320000290870667},{"id":"https://openalex.org/keywords/caulobacter-crescentus","display_name":"Caulobacter crescentus","score":0.8759999871253967},{"id":"https://openalex.org/keywords/ancylobacter-aquaticus","display_name":"Ancylobacter aquaticus","score":0.968999981880188},{"id":"https://openalex.org/keywords/exosporium","display_name":"exosporium","score":0.5659999847412109},{"id":"https://openalex.org/keywords/biological-control","display_name":"biological control","score":0.3499999940395355}],"concepts":[{"id":"https://openalex.org/C2779035793","wikidata":"https://www.wikidata.org/wiki/Q310467","display_name":"Bacillus thuringiensis","level":3,"score":0.8438184857368469},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8332338333129883},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.573066234588623},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.4974413216114044},{"id":"https://openalex.org/C92087593","wikidata":"https://www.wikidata.org/wiki/Q427389","display_name":"Vector (molecular biology)","level":4,"score":0.48461493849754333},{"id":"https://openalex.org/C2777367657","wikidata":"https://www.wikidata.org/wiki/Q184651","display_name":"Toxin","level":2,"score":0.47127029299736023},{"id":"https://openalex.org/C22744801","wikidata":"https://www.wikidata.org/wiki/Q172778","display_name":"Plasmid","level":3,"score":0.42755264043807983},{"id":"https://openalex.org/C10147152","wikidata":"https://www.wikidata.org/wiki/Q5413339","display_name":"Gene cassette","level":5,"score":0.4228236973285675},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.3911413252353668},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.3599279522895813},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.28264111280441284},{"id":"https://openalex.org/C2776650774","wikidata":"https://www.wikidata.org/wiki/Q420197","display_name":"Integron","level":4,"score":0.0}],"mesh":[{"descriptor_ui":"D000083722","descriptor_name":"Bacillus thuringiensis Toxins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001413","descriptor_name":"Bacillus thuringiensis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001427","descriptor_name":"Bacterial Toxins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D001427","descriptor_name":"Bacterial Toxins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004199","descriptor_name":"Disease Vectors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004731","descriptor_name":"Endotoxins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D004731","descriptor_name":"Endotoxins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004787","descriptor_name":"Environmental Pollution","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D006460","descriptor_name":"Hemolysin Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009032","descriptor_name":"Mosquito Control","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D009033","descriptor_name":"Culicidae","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D010572","descriptor_name":"Pest Control, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012843","descriptor_name":"Simuliidae","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D014169","descriptor_name":"Transformation, Bacterial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030801","descriptor_name":"Animals, Genetically Modified","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:16889013","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16889013","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Wiadomosci parazytologiczne","raw_type":"Journal Article"},{"id":"mag:2397914779","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16889013","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Zero hunger","id":"https://metadata.un.org/sdg/2","score":0.40450000762939453}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2045820212","https://openalex.org/W2316354075","https://openalex.org/W2006458895","https://openalex.org/W1978304986","https://openalex.org/W3022703606","https://openalex.org/W3192918850","https://openalex.org/W4381616126","https://openalex.org/W7133056812","https://openalex.org/W2065725349","https://openalex.org/W2471732413"],"abstract_inverted_index":{"Identification":[0],"of":[1,9,16,22,44,68,73,79,153,160,183,223,248,268,333,359,376,383,399],"Bacillus":[2],"thuringiensis":[3],"(Bt)":[4],"parasporal":[5],"crystalline":[6],"inclusions":[7],"composed":[8],"Cry":[10,319],"proteins":[11],"(=delta-endotoxins)":[12],"resulted":[13,196],"in":[14,53,115,119,125,175,190,198,201,212,350,356],"introduction":[15,78],"microbial":[17],"pesticides":[18],"for":[19,167],"biological":[20,357],"control":[21,358],"some":[23,287,322],"parasites.":[24],"Delta-endotoxins":[25],"are":[26,32,345,403],"encoded":[27],"by":[28,238],"cry":[29,80,143],"genes":[30,81,122,144,211],"and":[31,36,41,64,100,164,279,281,286,295,311,367,378],"active":[33],"against":[34],"pest":[35],"nuisance":[37],"insects":[38],"(mostly":[39],"mosquitoes":[40],"black":[42],"flies--vectors":[43],"still":[45,346,372,404],"important":[46,400],"infectious":[47],"diseases).":[48],"The":[49,361],"recent":[50],"significant":[51],"progress":[52],"DNA":[54],"recombination":[55],"technique":[56],"may":[57],"overcome":[58,157],"limitations":[59],"(a":[60],"short":[61],"residual":[62,228],"persistence":[63,203],"a":[65,131,265,331,374],"narrow":[66],"spectrum":[67,267],"activity)":[69],"associated":[70,396],"with":[71,145,397],"application":[72],"Bt":[74,226],"conventional":[75],"products.":[76],"An":[77],"from":[82,204],"mosquitocidal":[83,218],"subspecies":[84],"B.":[85,213,239,259,272],"th.":[86],"israelensis":[87],"(Bti)":[88],"to":[89,111,141,149,186,206,277,283,301,336,406],"the":[90,94,107,116,151,158,176,233,257,351,387],"aquatic":[91,177],"microorganisms":[92,338],"inhabiting":[93],"same":[95],"water":[96,253],"bodies":[97],"as":[98,330],"mosquito":[99,325],"fly":[101],"larvae":[102,326],"(Diptera),":[103],"has":[104],"considerably":[105],"improved":[106],"toxin":[108,202],"delivery":[109],"system":[110,195],"target":[112],"insects.":[113,360],"However,":[114,342],"first":[117],"experiments,":[118],"which":[120,316,402],"Bti":[121,170,210,340],"were":[123,173,188,235],"cloned":[124],"cyanobacteria":[126],"(Agmenellum":[127],"quadruplicatum,":[128],"Synechocystis":[129],"PCC6803),":[130],"low":[132,161],"gene":[133,162],"expression":[134,163],"was":[135,139,220,328],"observed.":[136],"Thus,":[137],"it":[138],"necessary":[140],"integrate":[142],"strong":[146],"promoters":[147],"or":[148],"increase":[150,200],"number":[152],"vector-introduced":[154],"copies.":[155],"To":[156],"obstacles":[159],"regulatory":[165],"restriction":[166],"recombinant":[168],"organisms,":[169],"spore/crystal":[171],"formulations":[172],"encapsulated":[174],"protozoan,":[178],"Tetrahymena":[179],"pyriformis.":[180],"Large":[181],"numbers":[182],"crystals":[184,234],"(180":[185],"240/cell)":[187],"accumulated":[189],"its":[191],"food":[192],"vacuoles.":[193],"This":[194],"also":[197,216,300],"an":[199,224,334],"24":[205],"71":[207],"h.":[208],"Cloning":[209],"sphaericus":[214,240,260,273],"(which":[215],"produces":[217],"proteins)":[219],"another":[221],"way":[222],"increasing":[225],"crystal":[227],"activity.":[229],"In":[230,321],"this":[231,390],"case,":[232],"additionally":[236],"protected":[237],"exosporium.":[241],"These":[242],"transgenic":[243,337,343,362],"bacteria":[244,290],"produced":[245],"large":[246],"amounts":[247],"delta-endotoxins":[249],"that":[250],"remained":[251],"under":[252],"surface":[254],"longer":[255],"than":[256],"wild":[258],"strains.":[261],"Moreover,":[262],"they":[263],"had":[264],"broader":[266],"insecticidal":[269],"activity,":[270],"because":[271],"is":[274,365,371],"toxic":[275],"mostly":[276],"Culex":[278],"Anopheles,":[280],"Bti--mostly":[282],"Culex,":[284],"Aedes":[285],"Simmulidae.":[288],"Gram-negative":[289],"(Asticcacaulis":[291],"excentricus,":[292],"Caulobacter":[293],"crescentus":[294],"Ancylobacter":[296],"aquaticus)":[297],"turned":[298],"out":[299],"be":[302],"effective":[303],"delta-endotoxin":[304],"producers.":[305],"They":[306],"grow":[307],"on":[308],"simple":[309],"media":[310],"do":[312],"not":[313,347],"contain":[314],"proteases":[315],"could":[317,392],"degrade":[318],"proteins.":[320],"cases,":[323],"100%":[324],"mortality":[327],"observed":[329],"result":[332],"exposure":[335],"containing":[339],"genes.":[341],"techniques":[344],"very":[348],"popular":[349],"world,":[352],"despite":[353],"their":[354],"efficacy":[355],"organism":[363],"construction":[364],"expensive":[366],"time-consuming.":[368],"Genetic":[369],"engineering":[370],"raising":[373],"lot":[375],"anxieties":[377],"doubts":[379],"concerning":[380],"inappropriate":[381],"use":[382],"modified":[384],"organisms.":[385],"On":[386],"other":[388],"hand,":[389],"technology":[391],"solve":[393],"many":[394],"problems":[395],"vectors":[398],"diseases,":[401],"unapproachable":[405],"contemporary":[407],"medicine.":[408]},"counts_by_year":[{"year":2016,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}