{"id":"https://openalex.org/W2397912814","doi":"https://doi.org/10.3389/fphys.2016.00183","title":"Metabolomic Analysis in Brain Research: Opportunities and Challenges","display_name":"Metabolomic Analysis in Brain Research: Opportunities and Challenges","publication_year":2016,"publication_date":"2016-05-24","ids":{"openalex":"https://openalex.org/W2397912814","doi":"https://doi.org/10.3389/fphys.2016.00183","mag":"2397912814","pmid":"https://pubmed.ncbi.nlm.nih.gov/27252656","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4878281"},"language":"en","primary_location":{"id":"doi:10.3389/fphys.2016.00183","doi":"https://doi.org/10.3389/fphys.2016.00183","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fphys.2016.00183","pdf_url":"https://www.frontiersin.org/articles/10.3389/fphys.2016.00183/pdf","source":{"id":"https://openalex.org/S52732750","display_name":"Frontiers in Physiology","issn_l":"1664-042X","issn":["1664-042X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Physiology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/articles/10.3389/fphys.2016.00183/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5017693247","display_name":"Catherine G. Vasilopoulou","orcid":"https://orcid.org/0000-0002-6622-1979","observed_orcids":["https://orcid.org/0000-0002-6622-1979"]},"institutions":[{"id":"https://openalex.org/I174878644","display_name":"University of Patras","ror":"https://ror.org/017wvtq80","country_code":"GR","type":"education","lineage":["https://openalex.org/I174878644"]},{"id":"https://openalex.org/I4210123829","display_name":"FORTH Institute of Chemical Engineering Sciences","ror":"https://ror.org/03e5bsk66","country_code":"GR","type":"facility","lineage":["https://openalex.org/I4210123829","https://openalex.org/I8901234"]},{"id":"https://openalex.org/I8901234","display_name":"Foundation for Research and Technology Hellas","ror":"https://ror.org/052rphn09","country_code":"GR","type":"facility","lineage":["https://openalex.org/I8901234"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Catherine G. Vasilopoulou","raw_affiliation_strings":["Metabolic Engineering and Systems Biology Laboratory, Institute of Chemical Engineering Sciences, Foundation for Research and Technology-Hellas (FORTH/ICE-HT)Patras, Greece; Human and Animal Physiology Laboratory, Department of Biology, University of PatrasPatras, Greece","Human and Animal Physiology Laboratory, Department of Biology, University of Patras, Patras, Greece","Metabolic Engineering and Systems Biology Laboratory, Institute of Chemical Engineering Sciences, Foundation for Research and Technology\u2014Hellas (FORTH/ICE-HT), Patras, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Metabolic Engineering and Systems Biology Laboratory, Institute of Chemical Engineering Sciences, Foundation for Research and Technology-Hellas (FORTH/ICE-HT)Patras, Greece; Human and Animal Physiology Laboratory, Department of Biology, University of PatrasPatras, Greece","institution_ids":["https://openalex.org/I174878644","https://openalex.org/I4210123829","https://openalex.org/I8901234"]},{"raw_affiliation_string":"Human and Animal Physiology Laboratory, Department of Biology, University of Patras, Patras, Greece","institution_ids":["https://openalex.org/I174878644"]},{"raw_affiliation_string":"Metabolic Engineering and Systems Biology Laboratory, Institute of Chemical Engineering Sciences, Foundation for Research and Technology\u2014Hellas (FORTH/ICE-HT), Patras, Greece","institution_ids":["https://openalex.org/I4210123829","https://openalex.org/I8901234"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028257697","display_name":"Marigoula Margarity","orcid":"https://orcid.org/0000-0002-5429-3465","observed_orcids":["https://orcid.org/0000-0002-5429-3465"]},"institutions":[{"id":"https://openalex.org/I174878644","display_name":"University of Patras","ror":"https://ror.org/017wvtq80","country_code":"GR","type":"education","lineage":["https://openalex.org/I174878644"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Marigoula Margarity","raw_affiliation_strings":["Human and Animal Physiology Laboratory, Department of Biology, University of Patras, Patras, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Human and Animal Physiology Laboratory, Department of Biology, University of Patras, Patras, Greece","institution_ids":["https://openalex.org/I174878644"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5026070090","display_name":"Maria I. Klapa","orcid":"https://orcid.org/0000-0002-2047-3185","observed_orcids":["https://orcid.org/0000-0002-2047-3185"]},"institutions":[{"id":"https://openalex.org/I4210123829","display_name":"FORTH Institute of Chemical Engineering Sciences","ror":"https://ror.org/03e5bsk66","country_code":"GR","type":"facility","lineage":["https://openalex.org/I4210123829","https://openalex.org/I8901234"]},{"id":"https://openalex.org/I66946132","display_name":"University of Maryland, College Park","ror":"https://ror.org/047s2c258","country_code":"US","type":"education","lineage":["https://openalex.org/I66946132"]},{"id":"https://openalex.org/I8901234","display_name":"Foundation for Research and Technology Hellas","ror":"https://ror.org/052rphn09","country_code":"GR","type":"facility","lineage":["https://openalex.org/I8901234"]}],"countries":["GR","US"],"is_corresponding":true,"raw_author_name":"Maria I. Klapa","raw_affiliation_strings":["Metabolic Engineering and Systems Biology Laboratory, Institute of Chemical Engineering Sciences, Foundation for Research and Technology-Hellas (FORTH/ICE-HT)Patras, Greece; Departments of Chemical and Biomolecular Engineering and Bioengineering, University of MarylandCollege Park, MD, USA","Departments of Chemical and Biomolecular Engineering and Bioengineering, University of Maryland, College Park, MD, USA","Metabolic Engineering and Systems Biology Laboratory, Institute of Chemical Engineering Sciences, Foundation for Research and Technology\u2014Hellas (FORTH/ICE-HT), Patras, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Metabolic Engineering and Systems Biology Laboratory, Institute of Chemical Engineering Sciences, Foundation for Research and Technology-Hellas (FORTH/ICE-HT)Patras, Greece; Departments of Chemical and Biomolecular Engineering and Bioengineering, University of MarylandCollege Park, MD, USA","institution_ids":["https://openalex.org/I4210123829","https://openalex.org/I66946132","https://openalex.org/I8901234"]},{"raw_affiliation_string":"Departments of Chemical and Biomolecular Engineering and Bioengineering, University of Maryland, College Park, MD, USA","institution_ids":["https://openalex.org/I66946132"]},{"raw_affiliation_string":"Metabolic Engineering and Systems Biology Laboratory, Institute of Chemical Engineering Sciences, Foundation for Research and Technology\u2014Hellas (FORTH/ICE-HT), Patras, Greece","institution_ids":["https://openalex.org/I4210123829","https://openalex.org/I8901234"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5026070090"],"corresponding_institution_ids":["https://openalex.org/I4210123829","https://openalex.org/I66946132","https://openalex.org/I8901234"],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":2.3046,"has_fulltext":true,"cited_by_count":62,"citation_normalized_percentile":{"value":0.88697552,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"7","issue":null,"first_page":"183","last_page":"183"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11027","display_name":"Metabolism and Genetic Disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/brain-metabolomics","display_name":"brain metabolomics","score":0.9330000281333923},{"id":"https://openalex.org/keywords/cerebral-metabolism","display_name":"brain metabolism","score":0.5839999914169312},{"id":"https://openalex.org/keywords/central-nervous-system","display_name":"central nervous system","score":0.6769999861717224},{"id":"https://openalex.org/keywords/neurological-disorders","display_name":"neurological disorders","score":0.9210000038146973},{"id":"https://openalex.org/keywords/sex-differences","display_name":"sex differences","score":0.5960000157356262},{"id":"https://openalex.org/keywords/study-design","display_name":"research design","score":0.5529999732971191},{"id":"https://openalex.org/keywords/reproducibility","display_name":"reproducibility","score":0.8539999723434448},{"id":"https://openalex.org/keywords/standardization","display_name":"standardization","score":0.4690000116825104},{"id":"https://openalex.org/keywords/small-molecule-metabolites","display_name":"small molecule metabolites","score":0.675000011920929}],"concepts":[{"id":"https://openalex.org/C21565614","wikidata":"https://www.wikidata.org/wiki/Q12149006","display_name":"Metabolomics","level":2,"score":0.869990885257721},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.6822901368141174},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.573635458946228},{"id":"https://openalex.org/C152662350","wikidata":"https://www.wikidata.org/wiki/Q815297","display_name":"Systems biology","level":2,"score":0.531191349029541},{"id":"https://openalex.org/C101810790","wikidata":"https://www.wikidata.org/wiki/Q2263094","display_name":"Metabolic network","level":2,"score":0.49706628918647766},{"id":"https://openalex.org/C192989942","wikidata":"https://www.wikidata.org/wiki/Q68685","display_name":"Metabolic pathway","level":3,"score":0.4718472957611084},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.4648299217224121},{"id":"https://openalex.org/C3018390542","wikidata":"https://www.wikidata.org/wiki/Q1073","display_name":"Brain function","level":2,"score":0.44217658042907715},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.44114983081817627},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.42405977845191956},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.4065322279930115},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.18591228127479553},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.11042004823684692},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.0}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.3389/fphys.2016.00183","doi":"https://doi.org/10.3389/fphys.2016.00183","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fphys.2016.00183","pdf_url":"https://www.frontiersin.org/articles/10.3389/fphys.2016.00183/pdf","source":{"id":"https://openalex.org/S52732750","display_name":"Frontiers in Physiology","issn_l":"1664-042X","issn":["1664-042X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Physiology","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:3857947","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4878281","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:27252656","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27252656","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in physiology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4878281","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4878281/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Physiol","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:79f0950383be4d99b2d7350392f57413","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/79f0950383be4d99b2d7350392f57413","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Physiology, Vol 7 (2016)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fphys.2016.00183","doi":"https://doi.org/10.3389/fphys.2016.00183","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fphys.2016.00183","pdf_url":"https://www.frontiersin.org/articles/10.3389/fphys.2016.00183/pdf","source":{"id":"https://openalex.org/S52732750","display_name":"Frontiers in Physiology","issn_l":"1664-042X","issn":["1664-042X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Physiology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.46810001134872437,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1575787450","display_name":null,"funder_award_id":"MIS-448301","funder_id":"https://openalex.org/F4320335322","funder_display_name":"European Regional Development Fund"},{"id":"https://openalex.org/G3207356259","display_name":null,"funder_award_id":"2007\u20132013","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G496129201","display_name":null,"funder_award_id":"2007 \u2013 2013","funder_id":"https://openalex.org/F4320335322","funder_display_name":"European Regional Development Fund"},{"id":"https://openalex.org/G5090392397","display_name":null,"funder_award_id":"project No MIS-448301","funder_id":"https://openalex.org/F4320321917","funder_display_name":"General Secretariat for Research and Technology"},{"id":"https://openalex.org/G5124063000","display_name":null,"funder_award_id":"NSRF 2007-2013","funder_id":"https://openalex.org/F4320335322","funder_display_name":"European Regional Development Fund"},{"id":"https://openalex.org/G8749782984","display_name":null,"funder_award_id":"2013SE01380036","funder_id":"https://openalex.org/F4320321917","funder_display_name":"General Secretariat for Research and Technology"},{"id":"https://openalex.org/G8787879865","display_name":null,"funder_award_id":"MIS-448301","funder_id":"https://openalex.org/F4320321917","funder_display_name":"General Secretariat for Research and Technology"},{"id":"https://openalex.org/G8809400247","display_name":null,"funder_award_id":"BIOSYS research project, Action KRIPIS, project No MIS-448301 (2013SE01380036)","funder_id":"https://openalex.org/F4320321917","funder_display_name":"General Secretariat for Research and Technology"}],"funders":[{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320321917","display_name":"General Secretariat for Research and Technology","ror":"https://ror.org/04yeh8h63"},{"id":"https://openalex.org/F4320335322","display_name":"European Regional Development Fund","ror":"https://ror.org/00k4n6c32"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2397912814.pdf","grobid_xml":"https://content.openalex.org/works/W2397912814.grobid-xml"},"referenced_works_count":76,"referenced_works":["https://openalex.org/W113859224","https://openalex.org/W751414124","https://openalex.org/W1510213933","https://openalex.org/W1556472699","https://openalex.org/W1579009647","https://openalex.org/W1839995968","https://openalex.org/W1895701197","https://openalex.org/W1965893904","https://openalex.org/W1971315623","https://openalex.org/W1971518203","https://openalex.org/W1975922633","https://openalex.org/W1978876811","https://openalex.org/W1986674928","https://openalex.org/W1990700247","https://openalex.org/W1994241903","https://openalex.org/W1997062226","https://openalex.org/W1998767819","https://openalex.org/W2000567681","https://openalex.org/W2006387633","https://openalex.org/W2009405916","https://openalex.org/W2009792683","https://openalex.org/W2013601412","https://openalex.org/W2017076975","https://openalex.org/W2017987913","https://openalex.org/W2018634461","https://openalex.org/W2022821750","https://openalex.org/W2025158417","https://openalex.org/W2026354831","https://openalex.org/W2030041505","https://openalex.org/W2030543475","https://openalex.org/W2031799277","https://openalex.org/W2031836549","https://openalex.org/W2043816787","https://openalex.org/W2044848395","https://openalex.org/W2046783336","https://openalex.org/W2051180998","https://openalex.org/W2055171044","https://openalex.org/W2057251357","https://openalex.org/W2057432519","https://openalex.org/W2059964587","https://openalex.org/W2061460715","https://openalex.org/W2063028213","https://openalex.org/W2065750082","https://openalex.org/W2069789607","https://openalex.org/W2074159140","https://openalex.org/W2075650547","https://openalex.org/W2077545398","https://openalex.org/W2086021750","https://openalex.org/W2091564445","https://openalex.org/W2098606715","https://openalex.org/W2099344720","https://openalex.org/W2099800073","https://openalex.org/W2104108767","https://openalex.org/W2118361518","https://openalex.org/W2118932150","https://openalex.org/W2121827237","https://openalex.org/W2124953625","https://openalex.org/W2128601422","https://openalex.org/W2133826923","https://openalex.org/W2139925812","https://openalex.org/W2145265944","https://openalex.org/W2149095531","https://openalex.org/W2150315679","https://openalex.org/W2157997018","https://openalex.org/W2159671087","https://openalex.org/W2161560128","https://openalex.org/W2162732635","https://openalex.org/W2170974939","https://openalex.org/W2179965730","https://openalex.org/W2183239453","https://openalex.org/W2247187546","https://openalex.org/W2317167530","https://openalex.org/W2343357155","https://openalex.org/W2402107718","https://openalex.org/W3189904176","https://openalex.org/W4230770774"],"related_works":["https://openalex.org/W2569383270","https://openalex.org/W751414124","https://openalex.org/W2039368043","https://openalex.org/W2906504723","https://openalex.org/W2463218221","https://openalex.org/W3089883854","https://openalex.org/W1968079312","https://openalex.org/W162567447","https://openalex.org/W4205121672","https://openalex.org/W4379285816"],"abstract_inverted_index":{"Metabolism":[0],"being":[1],"a":[2,20,137,172,204,242],"fundamental":[3],"part":[4],"of":[5,13,23,31,51,57,77,84,91,103,107,125,145,149,151,158,189,199,224],"molecular":[6,109],"physiology,":[7],"elucidating":[8],"the":[9,28,48,55,74,78,82,89,99,104,133,142,168,187,197,218,222],"structure":[10,76],"and":[11,26,81,116,121,153,167,201,221,240,247],"regulation":[12],"metabolic":[14,38,64,119,134,138],"pathways":[15],"is":[16,46,160],"crucial":[17],"for":[18,62,170],"obtaining":[19],"comprehensive":[21],"perspective":[22],"cellular":[24],"function":[25],"understanding":[27],"underlying":[29],"mechanisms":[30,83],"its":[32,162,229],"dysfunction(s).":[33],"Therefore,":[34],"quantifying":[35],"an":[36],"accurate":[37],"network":[39,65],"activity":[40,66,139],"map":[41],"under":[42],"various":[43],"physiological":[44],"conditions":[45],"among":[47,210],"major":[49],"objectives":[50],"systems":[52],"biology":[53],"in":[54,118,128,165,179,191,228],"context":[56],"many":[58,129],"biological":[59,130],"applications.":[60],"Especially":[61],"CNS,":[63],"analysis":[67,102,144],"can":[68],"substantially":[69],"enhance":[70],"our":[71],"knowledge":[72],"about":[73],"complex":[75],"mammalian":[79],"brain":[80,180,192,206,225],"neurological":[85],"disorders,":[86],"leading":[87],"to":[88,147,214,236],"design":[90,241],"effective":[92],"therapeutic":[93],"treatments.":[94],"Metabolomics":[95],"has":[96,213],"emerged":[97],"as":[98,114,122],"high-throughput":[100],"quantitative":[101],"concentration":[105],"profile":[106,135],"small":[108],"weight":[110],"metabolites,":[111],"which":[112],"act":[113],"reactants":[115],"products":[117],"reactions":[120],"regulatory":[123],"molecules":[124,150],"proteins":[126],"participating":[127],"processes.":[131],"Thus,":[132],"provides":[136],"fingerprint,":[140],"through":[141],"simultaneous":[143],"tens":[146],"hundreds":[148],"pathophysiological":[152],"pharmacological":[154],"interest.":[155],"The":[156],"application":[157],"metabolomics":[159,190],"at":[161],"standardization":[163],"phase":[164],"general,":[166],"challenges":[169,198,239],"paving":[171],"standardized":[173],"procedure":[174],"are":[175],"even":[176],"more":[177],"pronounced":[178],"studies.":[181],"In":[182],"this":[183],"review,":[184],"we":[185,195],"support":[186],"value":[188],"research.":[193],"Moreover,":[194],"demonstrate":[196],"designing":[200],"setting":[202],"up":[203],"reliable":[205],"metabolomic":[207],"study,":[208],"which,":[209],"other":[211],"parameters,":[212],"take":[215],"into":[216],"consideration":[217],"sex":[219],"differentiation":[220],"complexity":[223],"physiology":[226],"manifested":[227],"regional":[230],"variation.":[231],"We":[232],"finally":[233],"propose":[234],"ways":[235],"overcome":[237],"these":[238],"study":[243],"that":[244],"produces":[245],"reproducible":[246],"consistent":[248],"results.":[249]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":9},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":9},{"year":2020,"cited_by_count":8},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}