{"id":"https://openalex.org/W2397909996","doi":"https://doi.org/10.2174/1381612822666160216145107","title":"Interrelationship Between Periapical Lesion and Systemic Metabolic Disorders","display_name":"Interrelationship Between Periapical Lesion and Systemic Metabolic Disorders","publication_year":2016,"publication_date":"2016-04-27","ids":{"openalex":"https://openalex.org/W2397909996","doi":"https://doi.org/10.2174/1381612822666160216145107","mag":"2397909996","pmid":"https://pubmed.ncbi.nlm.nih.gov/26881444","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4856634"},"language":"en","primary_location":{"id":"doi:10.2174/1381612822666160216145107","doi":"https://doi.org/10.2174/1381612822666160216145107","is_oa":false,"landing_page_url":"https://doi.org/10.2174/1381612822666160216145107","pdf_url":null,"source":{"id":"https://openalex.org/S55674637","display_name":"Current Pharmaceutical Design","issn_l":"1381-6128","issn":["1381-6128","1873-4286"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Pharmaceutical Design","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4856634","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5090554854","display_name":"Hajime Sasaki","orcid":"https://orcid.org/0000-0001-7639-0912","observed_orcids":["https://orcid.org/0000-0001-7639-0912"]},"institutions":[{"id":"https://openalex.org/I4405268108","display_name":"The Forsyth Institute","ror":"https://ror.org/05tr9gt18","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4405268108"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hajime Sasaki","raw_affiliation_strings":["Department of Immunology & Infectious Diseases, The Forsyth Institute, 245 First Street, Cambridge, MA 02494, U.S.A. hsasaki@forsyth.org","Department of Immunology & Infectious Diseases, The Forsyth Institute, 245 First Street, Cambridge, MA 02494, U.S.A.,United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology & Infectious Diseases, The Forsyth Institute, 245 First Street, Cambridge, MA 02494, U.S.A. hsasaki@forsyth.org","institution_ids":["https://openalex.org/I4405268108"]},{"raw_affiliation_string":"Department of Immunology & Infectious Diseases, The Forsyth Institute, 245 First Street, Cambridge, MA 02494, U.S.A.,United States","institution_ids":["https://openalex.org/I4405268108"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109837616","display_name":"Kimito Hirai","orcid":"https://orcid.org/0009-0008-4035-9890","observed_orcids":["https://orcid.org/0009-0008-4035-9890"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kimito Hirai","raw_affiliation_strings":[",0"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":",0","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020752792","display_name":"Christine Men Martins","orcid":"https://orcid.org/0000-0002-5429-509X","observed_orcids":["https://orcid.org/0000-0002-5429-509X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Christine M. Martins","raw_affiliation_strings":[",0"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":",0","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077064679","display_name":"Hisako Furusho","orcid":"https://orcid.org/0000-0001-6816-6697","observed_orcids":["https://orcid.org/0000-0001-6816-6697"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hisako Furusho","raw_affiliation_strings":[",0"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":",0","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070275930","display_name":"Ricardo A. Battaglino","orcid":"https://orcid.org/0000-0002-0272-1763","observed_orcids":["https://orcid.org/0000-0002-0272-1763"]},"institutions":[{"id":"https://openalex.org/I4405268108","display_name":"The Forsyth Institute","ror":"https://ror.org/05tr9gt18","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4405268108"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ricardo Battaglino","raw_affiliation_strings":[",0","The Forsyth Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":",0","institution_ids":[]},{"raw_affiliation_string":"The Forsyth Institute","institution_ids":["https://openalex.org/I4405268108"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101578859","display_name":"Koshi Hashimoto","orcid":"https://orcid.org/0000-0002-3530-689X","observed_orcids":["https://orcid.org/0000-0002-3530-689X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Koshi Hashimoto","raw_affiliation_strings":[",0"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":",0","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":8.9277,"has_fulltext":false,"cited_by_count":142,"citation_normalized_percentile":{"value":0.98629949,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":100},"biblio":{"volume":"22","issue":"15","first_page":"2204","last_page":"2215"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10536","display_name":"Endodontics and Root Canal Treatments","score":0.8398000001907349,"subfield":{"id":"https://openalex.org/subfields/3504","display_name":"Oral Surgery"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10536","display_name":"Endodontics and Root Canal Treatments","score":0.8398000001907349,"subfield":{"id":"https://openalex.org/subfields/3504","display_name":"Oral Surgery"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10257","display_name":"Oral microbiology and periodontitis research","score":0.1128000020980835,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.01549999974668026,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/apical-periodontitis","display_name":"apical periodontitis","score":0.9869999885559082},{"id":"https://openalex.org/keywords/metabolic-disorders","display_name":"metabolic disorders","score":0.7850000262260437},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.984000027179718},{"id":"https://openalex.org/keywords/hypertension","display_name":"hypertension","score":0.9990000128746033},{"id":"https://openalex.org/keywords/non-alcoholic-fatty-liver-disease","display_name":"non-alcoholic fatty liver disease","score":1.0},{"id":"https://openalex.org/keywords/non-alcoholic-steatohepatitis","display_name":"nonalcoholic steatohepatitis","score":0.9409999847412109},{"id":"https://openalex.org/keywords/chronic-low-grade-inflammation","display_name":"low-grade inflammation","score":0.8489999771118164},{"id":"https://openalex.org/keywords/osteoimmunology","display_name":"osteoimmunology","score":0.8399999737739563},{"id":"https://openalex.org/keywords/cytokines","display_name":"cytokines","score":0.890999972820282},{"id":"https://openalex.org/keywords/endodontic-infection","display_name":"root canal infection","score":0.7770000100135803},{"id":"https://openalex.org/keywords/immune-regulation","display_name":"immune regulation","score":0.5410000085830688},{"id":"https://openalex.org/keywords/insulin-sensitivity","display_name":"insulin sensitivity","score":0.8019999861717224},{"id":"https://openalex.org/keywords/adipose-tissue","display_name":"adipose tissue","score":0.847000002861023}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8231583833694458},{"id":"https://openalex.org/C2780385504","wikidata":"https://www.wikidata.org/wiki/Q520127","display_name":"Periodontitis","level":2,"score":0.6817454099655151},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6747964024543762},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.5838956236839294},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.49590620398521423},{"id":"https://openalex.org/C26374806","wikidata":"https://www.wikidata.org/wiki/Q7107616","display_name":"Osteoimmunology","level":5,"score":0.487368643283844},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.48635178804397583},{"id":"https://openalex.org/C2781156865","wikidata":"https://www.wikidata.org/wiki/Q827023","display_name":"Lesion","level":2,"score":0.44443196058273315},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.42455458641052246},{"id":"https://openalex.org/C171089720","wikidata":"https://www.wikidata.org/wiki/Q193583","display_name":"Adipose tissue","level":2,"score":0.41693738102912903},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.37235385179519653},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.22832533717155457},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.09146448969841003},{"id":"https://openalex.org/C2779428903","wikidata":"https://www.wikidata.org/wiki/Q418934","display_name":"RANKL","level":4,"score":0.08804967999458313},{"id":"https://openalex.org/C88045685","wikidata":"https://www.wikidata.org/wiki/Q174576","display_name":"Activator (genetics)","level":3,"score":0.0},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008659","descriptor_name":"Metabolic Diseases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010485","descriptor_name":"Periapical Periodontitis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.2174/1381612822666160216145107","doi":"https://doi.org/10.2174/1381612822666160216145107","is_oa":false,"landing_page_url":"https://doi.org/10.2174/1381612822666160216145107","pdf_url":null,"source":{"id":"https://openalex.org/S55674637","display_name":"Current Pharmaceutical Design","issn_l":"1381-6128","issn":["1381-6128","1873-4286"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Pharmaceutical Design","raw_type":"journal-article"},{"id":"pmid:26881444","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26881444","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current pharmaceutical design","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:3858958","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4856634","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4856634","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4856634/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Curr Pharm Des","raw_type":"Text"},{"id":"pmh:oai:repositorio.unesp.br:11449/173076","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11449/173076","pdf_url":null,"source":{"id":"https://openalex.org/S4377196277","display_name":"UNESP Institutional Repository (S\u00e3o Paulo State University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I879563668","host_organization_name":"Universidade Estadual Paulista (Unesp)","host_organization_lineage":["https://openalex.org/I879563668"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:3858958","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4856634","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1300515096","display_name":"HIF-1alpha Mediated Wound Healing in Periapical Lesion","funder_award_id":"R21DE023178","funder_id":"https://openalex.org/F4320337365","funder_display_name":"National Institute of Dental and Craniofacial Research"},{"id":"https://openalex.org/G6308477887","display_name":"Functional role of serum Amyloid A in periapical inflammation","funder_award_id":"R01DE024796","funder_id":"https://openalex.org/F4320337365","funder_display_name":"National Institute of Dental and Craniofacial Research"}],"funders":[{"id":"https://openalex.org/F4320337365","display_name":"National Institute of Dental and Craniofacial Research","ror":"https://ror.org/004a2wv92"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":203,"referenced_works":["https://openalex.org/W73990277","https://openalex.org/W123758279","https://openalex.org/W312449622","https://openalex.org/W1200540518","https://openalex.org/W1489454155","https://openalex.org/W1596485921","https://openalex.org/W1657582305","https://openalex.org/W1753749227","https://openalex.org/W1792973268","https://openalex.org/W1848942918","https://openalex.org/W1849648692","https://openalex.org/W1855737037","https://openalex.org/W1893220973","https://openalex.org/W1902733438","https://openalex.org/W1962869168","https://openalex.org/W1963874458","https://openalex.org/W1964935717","https://openalex.org/W1967481896","https://openalex.org/W1967972402","https://openalex.org/W1968203812","https://openalex.org/W1970595375","https://openalex.org/W1971400919","https://openalex.org/W1971527569","https://openalex.org/W1972455777","https://openalex.org/W1974478076","https://openalex.org/W1975350881","https://openalex.org/W1976010325","https://openalex.org/W1977428675","https://openalex.org/W1977858494","https://openalex.org/W1981056525","https://openalex.org/W1981905227","https://openalex.org/W1982139136","https://openalex.org/W1983087752","https://openalex.org/W1983780683","https://openalex.org/W1985123547","https://openalex.org/W1990579821","https://openalex.org/W1991121464","https://openalex.org/W1991155033","https://openalex.org/W1991882891","https://openalex.org/W1994080141","https://openalex.org/W2000013300","https://openalex.org/W2000054651","https://openalex.org/W2002439142","https://openalex.org/W2006122998","https://openalex.org/W2007424370","https://openalex.org/W2009416961","https://openalex.org/W2016575029","https://openalex.org/W2018602999","https://openalex.org/W2018768907","https://openalex.org/W2019270353","https://openalex.org/W2020066699","https://openalex.org/W2020267609","https://openalex.org/W2020864463","https://openalex.org/W2021520246","https://openalex.org/W2022384691","https://openalex.org/W2022765352","https://openalex.org/W2023529531","https://openalex.org/W2024070385","https://openalex.org/W2024594848","https://openalex.org/W2025492790","https://openalex.org/W2025497909","https://openalex.org/W2026585836","https://openalex.org/W2026973240","https://openalex.org/W2027508666","https://openalex.org/W2028536701","https://openalex.org/W2030751466","https://openalex.org/W2031336281","https://openalex.org/W2031504111","https://openalex.org/W2032873215","https://openalex.org/W2033220681","https://openalex.org/W2033346442","https://openalex.org/W2033516113","https://openalex.org/W2034035669","https://openalex.org/W2035797927","https://openalex.org/W2038460784","https://openalex.org/W2039812349","https://openalex.org/W2041425805","https://openalex.org/W2042881479","https://openalex.org/W2043018206","https://openalex.org/W2043248182","https://openalex.org/W2043784314","https://openalex.org/W2044116566","https://openalex.org/W2044818959","https://openalex.org/W2049853835","https://openalex.org/W2050259497","https://openalex.org/W2051303794","https://openalex.org/W2051978541","https://openalex.org/W2051999166","https://openalex.org/W2053272547","https://openalex.org/W2053957743","https://openalex.org/W2057132709","https://openalex.org/W2057631007","https://openalex.org/W2058071218","https://openalex.org/W2058606248","https://openalex.org/W2059133726","https://openalex.org/W2062287632","https://openalex.org/W2062961817","https://openalex.org/W2064414391","https://openalex.org/W2068831921","https://openalex.org/W2070746014","https://openalex.org/W2074131627","https://openalex.org/W2076080772","https://openalex.org/W2080424444","https://openalex.org/W2081979358","https://openalex.org/W2082027639","https://openalex.org/W2082466238","https://openalex.org/W2083554582","https://openalex.org/W2085503736","https://openalex.org/W2085664155","https://openalex.org/W2085684863","https://openalex.org/W2089158871","https://openalex.org/W2089443962","https://openalex.org/W2090543816","https://openalex.org/W2093025818","https://openalex.org/W2097034504","https://openalex.org/W2097664171","https://openalex.org/W2102305776","https://openalex.org/W2103524419","https://openalex.org/W2104632083","https://openalex.org/W2104791256","https://openalex.org/W2106163877","https://openalex.org/W2107779094","https://openalex.org/W2108797135","https://openalex.org/W2108916652","https://openalex.org/W2109294976","https://openalex.org/W2109704767","https://openalex.org/W2110046705","https://openalex.org/W2110821097","https://openalex.org/W2111200491","https://openalex.org/W2111423499","https://openalex.org/W2111610133","https://openalex.org/W2112986924","https://openalex.org/W2113339061","https://openalex.org/W2116537360","https://openalex.org/W2117185007","https://openalex.org/W2117517020","https://openalex.org/W2119224792","https://openalex.org/W2119518338","https://openalex.org/W2119678071","https://openalex.org/W2121501744","https://openalex.org/W2124095779","https://openalex.org/W2126052469","https://openalex.org/W2126125759","https://openalex.org/W2126862979","https://openalex.org/W2129359337","https://openalex.org/W2131750038","https://openalex.org/W2132154261","https://openalex.org/W2132477505","https://openalex.org/W2133301955","https://openalex.org/W2134239872","https://openalex.org/W2134830083","https://openalex.org/W2135507245","https://openalex.org/W2136693277","https://openalex.org/W2137608879","https://openalex.org/W2137657400","https://openalex.org/W2138510167","https://openalex.org/W2138827736","https://openalex.org/W2140342647","https://openalex.org/W2141260918","https://openalex.org/W2141265733","https://openalex.org/W2142730314","https://openalex.org/W2143461874","https://openalex.org/W2144275312","https://openalex.org/W2145697808","https://openalex.org/W2146005260","https://openalex.org/W2147528180","https://openalex.org/W2147973575","https://openalex.org/W2148582980","https://openalex.org/W2150107812","https://openalex.org/W2150235832","https://openalex.org/W2150702412","https://openalex.org/W2150835417","https://openalex.org/W2151010505","https://openalex.org/W2151553951","https://openalex.org/W2152002902","https://openalex.org/W2153626991","https://openalex.org/W2153709975","https://openalex.org/W2159809881","https://openalex.org/W2162114949","https://openalex.org/W2163527016","https://openalex.org/W2164123970","https://openalex.org/W2165275387","https://openalex.org/W2165609128","https://openalex.org/W2167049000","https://openalex.org/W2167130513","https://openalex.org/W2168126833","https://openalex.org/W2169684278","https://openalex.org/W2170474721","https://openalex.org/W2171961740","https://openalex.org/W2174186379","https://openalex.org/W2180071684","https://openalex.org/W2200280275","https://openalex.org/W2280269944","https://openalex.org/W2321281984","https://openalex.org/W2333291852","https://openalex.org/W2410065151","https://openalex.org/W2418292160","https://openalex.org/W2520432709","https://openalex.org/W2615637571","https://openalex.org/W4210990778","https://openalex.org/W4241151929","https://openalex.org/W4242324454","https://openalex.org/W4323872959"],"related_works":["https://openalex.org/W4402129778","https://openalex.org/W4294392045","https://openalex.org/W2137657400","https://openalex.org/W4406513343","https://openalex.org/W4408989758","https://openalex.org/W7101145360","https://openalex.org/W4379093812","https://openalex.org/W4206187887","https://openalex.org/W4205560149","https://openalex.org/W3017172614"],"abstract_inverted_index":{"BACKGROUND:":[0],"Periapical":[1,18],"periodontitis,":[2],"also":[3],"known":[4],"as":[5,49,55],"periapical":[6,65,97,139,156],"lesion,":[7],"is":[8,20,32,75],"a":[9,21,56],"common":[10,79,116],"dental":[11],"disease,":[12,24],"along":[13],"with":[14,64,143],"periodontitis":[15,19,66],"(gum":[16],"disease).":[17],"chronic":[22],"inflammatory":[23,127],"caused":[25,129],"by":[26,34,67,130,172],"endodontic":[27,147],"infection,":[28],"and":[29,61,99,108,114,121,141,163,179],"its":[30],"development":[31],"regulated":[33],"the":[35,78,94,135],"host":[36,72],"immune/inflammatory":[37],"response.":[38],"Metabolic":[39],"disorders,":[40],"which":[41],"are":[42,154],"largely":[43],"dependent":[44],"on":[45],"life":[46],"style":[47],"such":[48],"eating":[50],"habits,":[51],"have":[52,88],"been":[53],"interpreted":[54],"\"metabolically-triggered\"":[57],"low-grade":[58],"systemic":[59],"inflammation":[60],"may":[62],"interact":[63],"triggering":[68],"immune":[69,73,177],"modulation.":[70],"The":[71],"system":[74],"therefore":[76],"considered":[77],"fundamental":[80],"mechanism":[81],"of":[82,138],"both":[83],"disease":[84],"conditions.":[85],"METHOD:":[86],"We":[87],"reviewed":[89],">200":[90],"articles":[91],"to":[92,159],"discuss":[93],"interrelationship":[95],"between":[96],"lesions":[98,140,157],"metabolic":[100,131],"disorders":[101,132],"including":[102,176],"type":[103],"2":[104],"diabetes":[105],"mellitus,":[106],"hypertension,":[107],"non-alcoholic":[109,165],"fatty":[110],"liver":[111],"diseases":[112],"(NAFLD),":[113],"their":[115],"pathological":[117],"background":[118],"in":[119,186],"immunology/osteoimmunology":[120],"cytokine":[122],"biology.":[123],"RESULTS:":[124],"An":[125],"elevated":[126],"state":[128],"can":[133],"impact":[134],"clinical":[136,152],"outcome":[137],"interfere":[142],"wound":[144],"healing":[145],"after":[146],"treatment.":[148],"Although":[149],"additional":[150],"well-designed":[151],"studies":[153],"needed,":[155],"appear":[158],"affect":[160],"insulin":[161],"sensitivity":[162],"exacerbate":[164],"steatohepatitis.":[166],"CONCLUSION:":[167],"Immune":[168],"regulatory":[169],"cytokines":[170],"produced":[171],"various":[173],"cell":[174],"types,":[175],"cells":[178],"adipose":[180],"tissue,":[181],"play":[182],"an":[183],"important":[184],"role":[185],"this":[187],"interrelationship.":[188]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":12},{"year":2024,"cited_by_count":47},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":14},{"year":2021,"cited_by_count":21},{"year":2020,"cited_by_count":10},{"year":2019,"cited_by_count":12},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":2}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2016-06-24T00:00:00"}
