{"id":"https://openalex.org/W2397865699","doi":null,"title":"Cytokine flexibility of early and differentiated memory T helper cells in juvenile idiopathic arthritis.","display_name":"Cytokine flexibility of early and differentiated memory T helper cells in juvenile idiopathic arthritis.","publication_year":2004,"publication_date":"2004-10-01","ids":{"openalex":"https://openalex.org/W2397865699","mag":"2397865699","pmid":"https://pubmed.ncbi.nlm.nih.gov/15468374"},"language":"en","primary_location":{"id":"pmid:15468374","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15468374","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of rheumatology","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5009206134","display_name":"Sabrina Chiesa","orcid":"https://orcid.org/0000-0002-0392-1927","observed_orcids":["https://orcid.org/0000-0002-0392-1927"]},"institutions":[{"id":"https://openalex.org/I2801463291","display_name":"Istituto Giannina Gaslini","ror":"https://ror.org/0424g0k78","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I2801463291","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Sabrina Chiesa","raw_affiliation_strings":["2nd Division of Pediatrics, \"G. Gaslini\" Scientific Institute for Children, Genoa, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2nd Division of Pediatrics, \"G. Gaslini\" Scientific Institute for Children, Genoa, Italy","institution_ids":["https://openalex.org/I2801463291"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022542784","display_name":"Ignazia Prigione","orcid":"https://orcid.org/0000-0002-0877-6255","observed_orcids":["https://orcid.org/0000-0002-0877-6255"]},"institutions":[{"id":"https://openalex.org/I2801463291","display_name":"Istituto Giannina Gaslini","ror":"https://ror.org/0424g0k78","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I2801463291","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Ignazia Prigione","raw_affiliation_strings":["Istituto \u201cGiannina Gaslini\u201d"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Istituto \u201cGiannina Gaslini\u201d","institution_ids":["https://openalex.org/I2801463291"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038931842","display_name":"Fabio Morandi","orcid":"https://orcid.org/0000-0002-2849-7595","observed_orcids":["https://orcid.org/0000-0002-2849-7595"]},"institutions":[{"id":"https://openalex.org/I2801463291","display_name":"Istituto Giannina Gaslini","ror":"https://ror.org/0424g0k78","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I2801463291","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Fabio Morandi","raw_affiliation_strings":["Istituto \u201cGiannina Gaslini\u201d"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Istituto \u201cGiannina Gaslini\u201d","institution_ids":["https://openalex.org/I2801463291"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022610031","display_name":"Antonella Buoncompagni","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801463291","display_name":"Istituto Giannina Gaslini","ror":"https://ror.org/0424g0k78","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I2801463291","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Antonella Buoncompagni","raw_affiliation_strings":["Istituto \u201cGiannina Gaslini\u201d"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Istituto \u201cGiannina Gaslini\u201d","institution_ids":["https://openalex.org/I2801463291"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031685879","display_name":"Paolo P Picco","orcid":"https://orcid.org/0000-0003-0686-0725","observed_orcids":["https://orcid.org/0000-0003-0686-0725"]},"institutions":[{"id":"https://openalex.org/I2801463291","display_name":"Istituto Giannina Gaslini","ror":"https://ror.org/0424g0k78","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I2801463291","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Paolo Picco","raw_affiliation_strings":["Istituto \u201cGiannina Gaslini\u201d"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Istituto \u201cGiannina Gaslini\u201d","institution_ids":["https://openalex.org/I2801463291"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073823326","display_name":"Paola Bocca","orcid":"https://orcid.org/0000-0002-7498-209X","observed_orcids":["https://orcid.org/0000-0002-7498-209X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Paola Bocca","raw_affiliation_strings":["Laboratory of Oncology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Oncology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027612338","display_name":"Alberto Martini","orcid":"https://orcid.org/0000-0001-7642-1459","observed_orcids":["https://orcid.org/0000-0001-7642-1459"]},"institutions":[{"id":"https://openalex.org/I2801463291","display_name":"Istituto Giannina Gaslini","ror":"https://ror.org/0424g0k78","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I2801463291","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Alberto Martini","raw_affiliation_strings":["Istituto \u201cGiannina Gaslini\u201d"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Istituto \u201cGiannina Gaslini\u201d","institution_ids":["https://openalex.org/I2801463291"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079474442","display_name":"Vito Pistoia","orcid":"https://orcid.org/0000-0003-0528-9563","observed_orcids":["https://orcid.org/0000-0003-0528-9563"]},"institutions":[{"id":"https://openalex.org/I2801463291","display_name":"Istituto Giannina Gaslini","ror":"https://ror.org/0424g0k78","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I2801463291","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Vito Pistoia","raw_affiliation_strings":["Istituto \u201cGiannina Gaslini\u201d"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Istituto \u201cGiannina Gaslini\u201d","institution_ids":["https://openalex.org/I2801463291"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5067354798","display_name":"Marco Gattorno","orcid":"https://orcid.org/0000-0003-0704-1916","observed_orcids":["https://orcid.org/0000-0003-0704-1916"]},"institutions":[{"id":"https://openalex.org/I2801463291","display_name":"Istituto Giannina Gaslini","ror":"https://ror.org/0424g0k78","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I2801463291","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Marco Gattorno","raw_affiliation_strings":["Istituto \u201cGiannina Gaslini\u201d"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Istituto \u201cGiannina Gaslini\u201d","institution_ids":["https://openalex.org/I2801463291"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.4601,"has_fulltext":false,"cited_by_count":14,"citation_normalized_percentile":{"value":0.62717681,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"31","issue":"10","first_page":"2048","last_page":"54"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.7875999808311462,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.7875999808311462,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":0.12790000438690186,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11616","display_name":"Autoimmune and Inflammatory Disorders Research","score":0.07199999690055847,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/juvenile-idiopathic-arthritis","display_name":"juvenile idiopathic arthritis","score":0.9990000128746033},{"id":"https://openalex.org/keywords/memory-t-cells","display_name":"memory T cells","score":0.8569999933242798},{"id":"https://openalex.org/keywords/cd27","display_name":"CD27","score":0.8820000290870667},{"id":"https://openalex.org/keywords/cd45ro","display_name":"CD45RO","score":0.9549999833106995},{"id":"https://openalex.org/keywords/ccr7","display_name":"CCR7","score":0.8140000104904175},{"id":"https://openalex.org/keywords/ccr5","display_name":"CCR5","score":0.9990000128746033},{"id":"https://openalex.org/keywords/synovial-fluid","display_name":"synovial fluid","score":0.8859999775886536},{"id":"https://openalex.org/keywords/cytokine-production","display_name":"cytokine production","score":0.6650000214576721},{"id":"https://openalex.org/keywords/interferon-gamma","display_name":"interferon-gamma","score":0.9729999899864197},{"id":"https://openalex.org/keywords/il-4","display_name":"IL-4","score":0.9929999709129333},{"id":"https://openalex.org/keywords/t-cell-differentiation","display_name":"T cell differentiation","score":0.6349999904632568},{"id":"https://openalex.org/keywords/th1-th2-balance","display_name":"Th1/Th2 balance","score":0.7260000109672546}],"concepts":[{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.6104351282119751},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.5638071894645691},{"id":"https://openalex.org/C2776268809","wikidata":"https://www.wikidata.org/wiki/Q25581","display_name":"Synovial fluid","level":4,"score":0.5470037460327148},{"id":"https://openalex.org/C148125776","wikidata":"https://www.wikidata.org/wiki/Q1622348","display_name":"CD28","level":4,"score":0.5302186608314514},{"id":"https://openalex.org/C81444415","wikidata":"https://www.wikidata.org/wiki/Q7243535","display_name":"Priming (agriculture)","level":3,"score":0.509994387626648},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5049572587013245},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.5020544528961182},{"id":"https://openalex.org/C129374314","wikidata":"https://www.wikidata.org/wiki/Q909381","display_name":"Interleukin 21","level":4,"score":0.46956825256347656},{"id":"https://openalex.org/C79484868","wikidata":"https://www.wikidata.org/wiki/Q5971673","display_name":"IL-2 receptor","level":4,"score":0.4345250427722931},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.4076900780200958},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.3145964741706848},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.27409493923187256},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.2485867440700531},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.21463242173194885},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.1419791281223297},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0},{"id":"https://openalex.org/C100701293","wikidata":"https://www.wikidata.org/wiki/Q193838","display_name":"Germination","level":2,"score":0.0},{"id":"https://openalex.org/C2776164576","wikidata":"https://www.wikidata.org/wiki/Q62736","display_name":"Osteoarthritis","level":3,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D001171","descriptor_name":"Arthritis, Juvenile","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006377","descriptor_name":"T-Lymphocytes, Helper-Inducer","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D006377","descriptor_name":"T-Lymphocytes, Helper-Inducer","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007156","descriptor_name":"Immunologic Memory","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007223","descriptor_name":"Infant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008213","descriptor_name":"Lymphocyte Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013582","descriptor_name":"Synovial Fluid","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D013582","descriptor_name":"Synovial Fluid","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D016176","descriptor_name":"T-Lymphocyte Subsets","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D017493","descriptor_name":"Leukocyte Common Antigens","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D018127","descriptor_name":"Tumor Necrosis Factor Receptor Superfamily, Member 7","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D019707","descriptor_name":"Receptors, Chemokine","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D019713","descriptor_name":"Receptors, CCR5","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D054400","descriptor_name":"Receptors, CCR7","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmid:15468374","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15468374","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of rheumatology","raw_type":"Journal Article"},{"id":"pmh:oai:iris.unige.it:11567/207045","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11567/207045","pdf_url":null,"source":{"id":"https://openalex.org/S4377196291","display_name":"CINECA IRIS Institutial Research Information System (University of Genoa)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I83816512","host_organization_name":"University of Genoa","host_organization_lineage":["https://openalex.org/I83816512"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},{"id":"mag:2397865699","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15468374","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9763000011444092}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":36,"referenced_works":["https://openalex.org/W107023457","https://openalex.org/W1495821552","https://openalex.org/W1508333056","https://openalex.org/W1523405737","https://openalex.org/W1542817770","https://openalex.org/W1572465651","https://openalex.org/W1578385768","https://openalex.org/W1579994957","https://openalex.org/W1602799572","https://openalex.org/W1616189793","https://openalex.org/W1648671938","https://openalex.org/W1678352491","https://openalex.org/W1801847401","https://openalex.org/W1827939854","https://openalex.org/W1922855985","https://openalex.org/W1965857682","https://openalex.org/W1981480494","https://openalex.org/W1989483459","https://openalex.org/W2008354469","https://openalex.org/W2008419958","https://openalex.org/W2011038290","https://openalex.org/W2030174650","https://openalex.org/W2039841229","https://openalex.org/W2043271825","https://openalex.org/W2044206351","https://openalex.org/W2051816448","https://openalex.org/W2052100845","https://openalex.org/W2066682180","https://openalex.org/W2077884399","https://openalex.org/W2079653398","https://openalex.org/W2081945470","https://openalex.org/W2103666188","https://openalex.org/W2132391114","https://openalex.org/W2147024894","https://openalex.org/W2399271375","https://openalex.org/W2411676826"],"related_works":["https://openalex.org/W1695458232","https://openalex.org/W1801847401","https://openalex.org/W2319951211","https://openalex.org/W2411676826","https://openalex.org/W7099089883","https://openalex.org/W2044206351","https://openalex.org/W2157717999","https://openalex.org/W1555151169","https://openalex.org/W4412054220","https://openalex.org/W2086871439"],"abstract_inverted_index":{"OBJECTIVE:":[0],"It":[1],"has":[2],"been":[3],"suggested":[4],"that":[5],"CD45RO+CD27+":[6],"T":[7,16,21,52,74,138,145,182,199],"cells":[8,17,22,53,75,116,134,147,170,184,201],"represent":[9],"recently":[10],"activated":[11,19],"memory":[12,20,50,73,144,181,198],"cells,":[13],"whereas":[14],"CD45RO+CD27-":[15],"are":[18],"in":[23,44,95,103,165],"the":[24,104,166],"process":[25],"of":[26,41,61,106,120,129,168,189,213],"differentiating":[27],"into":[28],"effector":[29],"cells.":[30,139],"We":[31],"investigated":[32],"(1)":[33],"CCR7":[34],"and":[35,38,47,57,71,90,100,108,126,142,176,195],"CCR5":[36],"expression":[37,43],"(2)":[39],"modulation":[40],"cytokine":[42,214],"\"early\"":[45],"(CD27+)":[46],"\"differentiated\"":[48],"(CD27-)":[49],"CD4+":[51],"from":[54,76,148,185,206],"peripheral":[55,157],"blood":[56,158],"synovial":[58],"fluid":[59],"(SF)":[60],"patients":[62,78],"with":[63,79,98,111],"juvenile":[64],"idiopathic":[65],"arthritis":[66],"(JIA).":[67],"METHODS:":[68],"SF":[69,114,149,197],"CD4+CD45RO+CD27+":[70,115],"CD27-":[72,137,143,177,196],"6":[77],"JIA":[80],"were":[81,202],"tested":[82],"by":[83],"flow":[84],"cytometry":[85],"for":[86],"intracellular":[87],"interferon-gamma":[88],"(IFN-gamma)":[89],"interleukin":[91],"4":[92],"(IL-4)":[93],"after":[94],"vitro":[96],"priming":[97],"CD3":[99],"CD28":[101],"mAb":[102],"presence":[105],"IL-4,":[107],"subsequent":[109],"culture":[110],"IL-2.":[112],"RESULTS:":[113],"contained":[117],"higher":[118,152],"proportions":[119,128],"CCR7+":[121],"(median":[122],"46%":[123],"vs":[124,132],"23%)":[125],"lower":[127],"CCR5+":[130],"(73%":[131],"90%)":[133],"than":[135,155],"paired":[136],"Both":[140],"CD27+":[141,172,194],"helper":[146,183,200],"displayed":[150],"a":[151,207],"IFN-gamma/IL-4":[153],"ratio":[154],"their":[156,190],"counterparts.":[159],"No":[160],"significant":[161],"difference":[162],"was":[163],"observed":[164],"percentage":[167],"IFN-gamma-expressing":[169],"between":[171],"(32%,":[173],"range":[174,179],"4-47%)":[175],"(29.4%,":[178],"5-52%)":[180],"SF.":[186],"CONCLUSION:":[187],"Irrespective":[188],"differentiation":[191],"stage,":[192],"both":[193],"found":[203],"to":[204,209],"switch":[205],"proinflammatory":[208],"an":[210],"antiinflammatory":[211],"pattern":[212],"production.":[215]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}