{"id":"https://openalex.org/W2397811463","doi":"https://doi.org/10.1024/1023-9332.7.2.51","title":"Postoperative Heparin- induzierte Thrombopenie mit Thromboembolie (HITT) - Eine seltene Komplikation der Heparintherapie?","display_name":"Postoperative Heparin- induzierte Thrombopenie mit Thromboembolie (HITT) - Eine seltene Komplikation der Heparintherapie?","publication_year":2001,"publication_date":"2001-01-01","ids":{"openalex":"https://openalex.org/W2397811463","doi":"https://doi.org/10.1024/1023-9332.7.2.51","mag":"2397811463","pmid":"https://pubmed.ncbi.nlm.nih.gov/11332264"},"language":"de","primary_location":{"id":"doi:10.1024/1023-9332.7.2.51","doi":"https://doi.org/10.1024/1023-9332.7.2.51","is_oa":false,"landing_page_url":"https://doi.org/10.1024/1023-9332.7.2.51","pdf_url":null,"source":{"id":"https://openalex.org/S184222500","display_name":"Swiss Surgery","issn_l":"1023-9332","issn":["1023-9332","2235-1884"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310319871","host_organization_name":"Hogrefe Verlag","host_organization_lineage":["https://openalex.org/P4310319871"],"host_organization_lineage_names":["Hogrefe Verlag"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Swiss Surgery","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5054354948","display_name":"Federico Goti","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210099681","display_name":"Kantonsspital Winterthur","ror":"https://ror.org/014gb2s11","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I4210099681"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"F. Goti","raw_affiliation_strings":["Chirurgische Klinik, Kantonsspital Winterthur, Schweiz. fgoti@bluewin.ch"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chirurgische Klinik, Kantonsspital Winterthur, Schweiz. fgoti@bluewin.ch","institution_ids":["https://openalex.org/I4210099681"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052028221","display_name":"Duri Gianom","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D. Gianom","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001761071","display_name":"Wolfgang C. Korte","orcid":"https://orcid.org/0000-0003-0076-5022","observed_orcids":["https://orcid.org/0000-0003-0076-5022"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"W. Korte","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025048385","display_name":"D Sege","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D. Sege","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5007878451","display_name":"Marco Decurtins","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M. Decurtins","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"7","issue":"2","first_page":"0051","last_page":"0056"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12352","display_name":"Heparin-Induced Thrombocytopenia and Thrombosis","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12352","display_name":"Heparin-Induced Thrombocytopenia and Thrombosis","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10993","display_name":"Complement system in diseases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/postoperative-complications","display_name":"postoperative complications","score":0.7860000133514404},{"id":"https://openalex.org/keywords/heparin-therapy","display_name":"heparin therapy","score":0.6830000281333923},{"id":"https://openalex.org/keywords/low-molecular-weight-heparin","display_name":"low molecular weight heparin","score":0.8859999775886536},{"id":"https://openalex.org/keywords/thromboembolism","display_name":"thromboembolism","score":0.8109999895095825},{"id":"https://openalex.org/keywords/platelet-count","display_name":"platelet count","score":0.550000011920929},{"id":"https://openalex.org/keywords/direct-thrombin-inhibitors","display_name":"direct thrombin inhibitors","score":0.7509999871253967},{"id":"https://openalex.org/keywords/recombinant-hirudin","display_name":"recombinant hirudin","score":0.8840000033378601},{"id":"https://openalex.org/keywords/surgical-patients","display_name":"surgical patients","score":0.7760000228881836}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9320808053016663},{"id":"https://openalex.org/C2777557582","wikidata":"https://www.wikidata.org/wiki/Q190016","display_name":"Heparin","level":2,"score":0.8414058685302734},{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.594124972820282},{"id":"https://openalex.org/C2780868729","wikidata":"https://www.wikidata.org/wiki/Q261327","display_name":"Thrombosis","level":2,"score":0.5297204852104187},{"id":"https://openalex.org/C2778205648","wikidata":"https://www.wikidata.org/wiki/Q215118","display_name":"Anticoagulant","level":2,"score":0.46481308341026306},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.4643248915672302},{"id":"https://openalex.org/C3018697912","wikidata":"https://www.wikidata.org/wiki/Q179217","display_name":"Platelet activation","level":3,"score":0.44003283977508545},{"id":"https://openalex.org/C2776884760","wikidata":"https://www.wikidata.org/wiki/Q2750727","display_name":"Low molecular weight heparin","level":3,"score":0.4329116642475128},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.4030245542526245},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.19284126162528992}],"mesh":[{"descriptor_ui":"D006493","descriptor_name":"Heparin","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010976","descriptor_name":"Platelet Count","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011183","descriptor_name":"Postoperative Complications","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D012306","descriptor_name":"Risk","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013921","descriptor_name":"Thrombocytopenia","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D013923","descriptor_name":"Thromboembolism","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1024/1023-9332.7.2.51","doi":"https://doi.org/10.1024/1023-9332.7.2.51","is_oa":false,"landing_page_url":"https://doi.org/10.1024/1023-9332.7.2.51","pdf_url":null,"source":{"id":"https://openalex.org/S184222500","display_name":"Swiss Surgery","issn_l":"1023-9332","issn":["1023-9332","2235-1884"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310319871","host_organization_name":"Hogrefe Verlag","host_organization_lineage":["https://openalex.org/P4310319871"],"host_organization_lineage_names":["Hogrefe Verlag"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Swiss Surgery","raw_type":"journal-article"},{"id":"pmid:11332264","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11332264","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Swiss surgery = Schweizer Chirurgie = Chirurgie suisse = Chirurgia svizzera","raw_type":"Case Reports"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W392519430","https://openalex.org/W2052920099","https://openalex.org/W2074708435","https://openalex.org/W40983256","https://openalex.org/W1970311996","https://openalex.org/W2245012717","https://openalex.org/W2889009801","https://openalex.org/W2043352724","https://openalex.org/W2416716297","https://openalex.org/W1564135489"],"abstract_inverted_index":{"Many":[0],"surgical":[1],"patients":[2,153],"receive":[3],"either":[4],"unfractionated":[5],"or":[6,13,57],"low-molecular":[7],"weight":[8],"heparin":[9,21,32],"in":[10,89,152],"a":[11,99,114],"prophylactic":[12,150],"therapeutic":[14,148],"intention.":[15],"Feared":[16],"upon":[17],"the":[18,23,31,36,62,85,90,125,147],"administration":[19,50],"of":[20,51,87,98,113,117],"is":[22,93],"heparin-induced":[24],"thrombopenia":[25],"(HIT).":[26],"In":[27,53,96],"HIT":[28,54,58],"type":[29,55],"1,":[30],"directly":[33],"interacts":[34],"with":[35,59,154],"platelets.":[37],"The":[38],"platelet":[39,63,75],"count":[40,64],"rarely":[41],"falls":[42,66],"below":[43],"100,000/microliter":[44],"and":[45,70,106,133,141,149],"normalizes":[46],"again":[47],"despite":[48],"continuous":[49],"heparin.":[52],"2":[56],"thrombosis":[60],"(HITT)":[61],"usually":[65],"more":[67],"than":[68],"50%":[69],"due":[71],"to":[72,82,130,145],"an":[73,109],"antibody-dependent":[74],"activation,":[76],"thromboembolic":[77,119],"episodes":[78],"may":[79],"occur.":[80],"Compared":[81],"non-surgical":[83],"patients,":[84],"incidence":[86],"HITT":[88],"postoperative":[91],"phase":[92],"markedly":[94],"increased.":[95],"suspicion":[97],"HITT,":[100],"heparins":[101],"should":[102],"immediately":[103],"be":[104,131],"stopped":[105],"replaced":[107],"by":[108],"alternative":[110],"coagulant":[111],"because":[112],"high":[115],"risk":[116],"further":[118],"complications.":[120],"Direct":[121],"thrombin-inhibitors":[122],"such":[123],"as":[124],"recombinant":[126],"hirudins":[127],"are":[128],"considered":[129],"safe":[132],"effective.":[134],"They":[135],"have":[136],"no":[137],"heparin-like":[138],"immunological":[139],"properties":[140],"therefore,":[142],"they":[143],"seem":[144],"become":[146],"\"gold-standard\"":[151],"HITT.":[155]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}