{"id":"https://openalex.org/W2397801550","doi":null,"title":"DNA vaccines for prophylactic or therapeutic immunization against hepatitis B virus.","display_name":"DNA vaccines for prophylactic or therapeutic immunization against hepatitis B virus.","publication_year":1999,"publication_date":"1999-03-01","ids":{"openalex":"https://openalex.org/W2397801550","mag":"2397801550","pmid":"https://pubmed.ncbi.nlm.nih.gov/10100411"},"language":"en","primary_location":{"id":"pmid:10100411","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10100411","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Mount Sinai journal of medicine, New York","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113492616","display_name":"H. L. Davis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800722420","display_name":"Ottawa Hospital","ror":"https://ror.org/03c62dg59","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2800722420"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"H L Davis","raw_affiliation_strings":["Loeb Health Research Institute, Ottawa Hospital, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Loeb Health Research Institute, Ottawa Hospital, Canada","institution_ids":["https://openalex.org/I2800722420"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5113492616"],"corresponding_institution_ids":["https://openalex.org/I2800722420"],"apc_list":null,"apc_paid":null,"fwci":0.9218,"has_fulltext":false,"cited_by_count":17,"citation_normalized_percentile":{"value":0.75445675,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"66","issue":"2","first_page":"84","last_page":"90"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10340","display_name":"Hepatitis B Virus Studies","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10340","display_name":"Hepatitis B Virus Studies","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14126","display_name":"Intramuscular injections and effects","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2711","display_name":"Emergency Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dna-vaccine","display_name":"DNA vaccine","score":0.9980000257492065},{"id":"https://openalex.org/keywords/hepatitis-b-virus","display_name":"hepatitis B virus","score":0.9990000128746033},{"id":"https://openalex.org/keywords/prophylactic-vaccination","display_name":"prophylactic vaccination","score":0.902999997138977},{"id":"https://openalex.org/keywords/therapeutic-vaccination","display_name":"therapeutic vaccination","score":0.9259999990463257},{"id":"https://openalex.org/keywords/chronic-hepatitis-b-carriers","display_name":"chronic hepatitis B carriers","score":0.7310000061988831},{"id":"https://openalex.org/keywords/cpg-motifs","display_name":"CpG motifs","score":0.7120000123977661},{"id":"https://openalex.org/keywords/humoral-immunity","display_name":"humoral immunity","score":0.847000002861023},{"id":"https://openalex.org/keywords/cell-mediated-immunity","display_name":"cell-mediated immunity","score":0.9890000224113464},{"id":"https://openalex.org/keywords/cytotoxic-t-lymphocytes","display_name":"cytotoxic T lymphocytes","score":0.800000011920929},{"id":"https://openalex.org/keywords/t-helper-cells","display_name":"T helper cells","score":0.6729999780654907},{"id":"https://openalex.org/keywords/transgenic-mouse-model","display_name":"transgenic mouse model","score":0.6990000009536743}],"concepts":[{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.6894975900650024},{"id":"https://openalex.org/C167508917","wikidata":"https://www.wikidata.org/wiki/Q578537","display_name":"DNA vaccination","level":4,"score":0.6817534565925598},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.649351954460144},{"id":"https://openalex.org/C2780801004","wikidata":"https://www.wikidata.org/wiki/Q1415366","display_name":"Immunization","level":3,"score":0.5982661247253418},{"id":"https://openalex.org/C2780593183","wikidata":"https://www.wikidata.org/wiki/Q6844","display_name":"Hepatitis B virus","level":3,"score":0.596471905708313},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5887117981910706},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.5662094354629517},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5056126117706299},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.4716816544532776},{"id":"https://openalex.org/C2779341262","wikidata":"https://www.wikidata.org/wiki/Q182581","display_name":"Immunity","level":3,"score":0.46026140451431274},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.45580294728279114},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2679024338722229},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.13540726900100708},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006509","descriptor_name":"Hepatitis B","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D006509","descriptor_name":"Hepatitis B","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D006509","descriptor_name":"Hepatitis B","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014611","descriptor_name":"Vaccination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017325","descriptor_name":"Hepatitis B Vaccines","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D019444","descriptor_name":"Vaccines, DNA","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:10100411","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10100411","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Mount Sinai journal of medicine, New York","raw_type":"Journal Article"},{"id":"mag:2397801550","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10100411","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9763000011444092}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1967965262","https://openalex.org/W1996544339","https://openalex.org/W2369566843","https://openalex.org/W2012067981","https://openalex.org/W2461657009","https://openalex.org/W2070703178","https://openalex.org/W2147447339","https://openalex.org/W3197130353","https://openalex.org/W1972940293","https://openalex.org/W2089849369"],"abstract_inverted_index":{"DNA":[0,50,74,107,136],"vaccines,":[1,94],"with":[2],"which":[3],"the":[4,28,37,44,90,96,124,130],"antigen":[5,41],"is":[6],"synthesized":[7],"in":[8,39,118],"vivo":[9,40],"after":[10],"direct":[11],"introduction":[12],"of":[13,21,27,30,36,89,98,115,123,132,142],"its":[14],"encoding":[15],"sequences,":[16],"offer":[17],"a":[18,99,119],"unique":[19],"method":[20],"immunization":[22],"that":[23,88],"may":[24],"overcome":[25,110],"many":[26],"deficits":[29],"traditional":[31,92],"antigen-based":[32,93],"vaccines.":[33],"By":[34],"virtue":[35],"sustained":[38],"synthesis":[42],"and":[43,56,60,66,83,113],"comprised":[45],"stimulatory":[46],"CpG":[47],"motifs,":[48],"plasmid":[49],"vaccines":[51,75,108],"appear":[52],"to":[53,87,112,138],"induce":[54],"strong":[55],"long-lasting":[57],"humoral":[58,82],"(anti-bodies)":[59],"cell-mediated":[61,84],"(T-help,":[62],"other":[63],"cytokine":[64],"functions":[65],"cytotoxic":[67],"T-cells)":[68],"immune":[69],"responses.":[70],"In":[71],"animal":[72],"models,":[73],"against":[76,104],"hepatitis":[77],"B":[78],"virus":[79],"(HBV)":[80],"give":[81],"immunity":[85],"superior":[86],"current":[91],"indicating":[95],"possibility":[97,131],"more":[100],"effective":[101,134],"prophylactic":[102],"vaccine":[103,137],"HBV.":[105,143],"Furthermore,":[106],"can":[109],"tolerance":[111],"expression":[114],"HBV":[116,125],"proteins":[117],"transgenic":[120],"mouse":[121],"model":[122],"chronic":[126,140],"carrier,":[127],"opening":[128],"up":[129],"an":[133],"therapeutic":[135],"treat":[139],"carriers":[141]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}