{"id":"https://openalex.org/W2397793816","doi":null,"title":"[Ageing down-modulates the immune responses to Schistosoma japonicum infection in mice].","display_name":"[Ageing down-modulates the immune responses to Schistosoma japonicum infection in mice].","publication_year":2011,"publication_date":"2011-04-30","ids":{"openalex":"https://openalex.org/W2397793816","mag":"2397793816","pmid":"https://pubmed.ncbi.nlm.nih.gov/21826892"},"language":"zh","primary_location":{"id":"pmid:21826892","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21826892","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Zhongguo ji sheng chong xue yu ji sheng chong bing za zhi = Chinese journal of parasitology & parasitic diseases","raw_type":"English Abstract"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5030343111","display_name":"Yunfan Yang","orcid":"https://orcid.org/0000-0002-5266-7208","observed_orcids":["https://orcid.org/0000-0002-5266-7208"]},"institutions":[{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yun-fan Yang","raw_affiliation_strings":["Second Clinical School, Tongi Medical College, Huarzhong University of Science and Technology, Wuhan 430030, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Second Clinical School, Tongi Medical College, Huarzhong University of Science and Technology, Wuhan 430030, China","institution_ids":["https://openalex.org/I47720641"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044928436","display_name":"Qian Sun","orcid":"https://orcid.org/0000-0002-4458-6555","observed_orcids":["https://orcid.org/0000-0002-4458-6555"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Qian Sun","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058973220","display_name":"Bintao Su","orcid":"https://orcid.org/0000-0001-5803-7584","observed_orcids":["https://orcid.org/0000-0001-5803-7584"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bin-tao Su","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100342082","display_name":"Lin Lin","orcid":"https://orcid.org/0000-0003-4058-8243","observed_orcids":["https://orcid.org/0000-0003-4058-8243"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lin Lin","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000401339","display_name":"Man-jun Li","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Man-jun Li","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Lin Chen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lin Chen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108579286","display_name":"Hong Xu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hong Xu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012002175","display_name":"Jiahui Lei","orcid":"https://orcid.org/0000-0002-4223-5663","observed_orcids":["https://orcid.org/0000-0002-4223-5663"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jia-hui Lei","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100743530","display_name":"Wenqi Liu","orcid":"https://orcid.org/0000-0002-7917-3208","observed_orcids":["https://orcid.org/0000-0002-7917-3208"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wen-qi Liu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5101418478","display_name":"Yonglong Li","orcid":"https://orcid.org/0000-0002-2005-1206","observed_orcids":["https://orcid.org/0000-0002-2005-1206"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yong-long Li","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.25021592,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"29","issue":"2","first_page":"101","last_page":"4"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10695","display_name":"Parasites and Host Interactions","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2405","display_name":"Parasitology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10695","display_name":"Parasites and Host Interactions","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2405","display_name":"Parasitology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12234","display_name":"Mollusks and Parasites Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1109","display_name":"Insect Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11702","display_name":"Parasitic Diseases Research and Treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/schistosoma-japonicum","display_name":"Schistosoma japonicum","score":0.972000002861023},{"id":"https://openalex.org/keywords/schistosomiasis","display_name":"schistosomiasis","score":0.8830000162124634},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.8410000205039978},{"id":"https://openalex.org/keywords/immunosenescence","display_name":"immunosenescence","score":0.8769999742507935},{"id":"https://openalex.org/keywords/immune-response","display_name":"immune response","score":0.675000011920929},{"id":"https://openalex.org/keywords/granuloma","display_name":"granuloma","score":0.48899999260902405},{"id":"https://openalex.org/keywords/worm-burden","display_name":"worm burden","score":0.7739999890327454},{"id":"https://openalex.org/keywords/egg-burden","display_name":"egg burden","score":0.5889999866485596},{"id":"https://openalex.org/keywords/interferon-gamma","display_name":"interferon-gamma","score":0.8360000252723694},{"id":"https://openalex.org/keywords/il-4","display_name":"IL-4","score":1.0},{"id":"https://openalex.org/keywords/t-cell-proliferation","display_name":"T cell proliferation","score":0.7940000295639038},{"id":"https://openalex.org/keywords/splenocytes","display_name":"splenocytes","score":0.8949999809265137},{"id":"https://openalex.org/keywords/age-related-immunosenescence","display_name":"age-related immunosenescence","score":0.5299999713897705},{"id":"https://openalex.org/keywords/liver-schistosomiasis","display_name":"liver schistosomiasis","score":0.5950000286102295},{"id":"https://openalex.org/keywords/mice","display_name":"mice","score":0.4020000100135803},{"id":"https://openalex.org/keywords/balb-c-mice","display_name":"BALB/c mice","score":0.6119999885559082}],"concepts":[{"id":"https://openalex.org/C2777123769","wikidata":"https://www.wikidata.org/wiki/Q1256989","display_name":"Schistosoma japonicum","level":4,"score":0.9440075755119324},{"id":"https://openalex.org/C189976730","wikidata":"https://www.wikidata.org/wiki/Q3493700","display_name":"Splenocyte","level":3,"score":0.9241305589675903},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6465210318565369},{"id":"https://openalex.org/C500499127","wikidata":"https://www.wikidata.org/wiki/Q332154","display_name":"Ageing","level":2,"score":0.6023777723312378},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.5633493661880493},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4882228672504425},{"id":"https://openalex.org/C2780841837","wikidata":"https://www.wikidata.org/wiki/Q24741149","display_name":"Interferon gamma","level":3,"score":0.48666030168533325},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4523407816886902},{"id":"https://openalex.org/C71928629","wikidata":"https://www.wikidata.org/wiki/Q804206","display_name":"Parasite hosting","level":2,"score":0.42447537183761597},{"id":"https://openalex.org/C2776225656","wikidata":"https://www.wikidata.org/wiki/Q221159","display_name":"Schistosomiasis","level":3,"score":0.3213435113430023},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.27585113048553467},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.21804839372634888},{"id":"https://openalex.org/C165901193","wikidata":"https://www.wikidata.org/wiki/Q3129936","display_name":"Helminths","level":2,"score":0.1059102714061737},{"id":"https://openalex.org/C136764020","wikidata":"https://www.wikidata.org/wiki/Q466","display_name":"World Wide Web","level":1,"score":0.0},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007371","descriptor_name":"Interferon-gamma","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012549","descriptor_name":"Schistosoma japonicum","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D012549","descriptor_name":"Schistosoma japonicum","qualifier_ui":"Q000472","qualifier_name":"pathogenicity","is_major_topic":false},{"descriptor_ui":"D012554","descriptor_name":"Schistosomiasis japonica","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D012554","descriptor_name":"Schistosomiasis japonica","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D013154","descriptor_name":"Spleen","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015847","descriptor_name":"Interleukin-4","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059208","descriptor_name":"Parasite Load","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:21826892","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21826892","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Zhongguo ji sheng chong xue yu ji sheng chong bing za zhi = Chinese journal of parasitology & parasitic diseases","raw_type":"English Abstract"},{"id":"mag:2397793816","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21826892","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2056175445","https://openalex.org/W2977425417","https://openalex.org/W4210511298","https://openalex.org/W2057287428","https://openalex.org/W2124411320","https://openalex.org/W6884646214","https://openalex.org/W2001302118","https://openalex.org/W7100793753","https://openalex.org/W2316802069","https://openalex.org/W2465903475"],"abstract_inverted_index":{"OBJECTIVE:":[0],"To":[1],"investigate":[2],"the":[3,8,54,59,84,117,172,189,208,241,274,278],"effect":[4],"of":[5,35,66,81,110,133,151,168,171,188,202,236,259],"ageing":[6],"on":[7],"immune":[9,212,275,280],"responses":[10,103,276],"against":[11],"Schistosoma":[12,290],"japonicum":[13,48],"infection":[14],"in":[15,83,97,116,135,174,216,225,240,286],"mice.":[16,37],"METHODS:":[17],"Female":[18],"BALB/c":[19],"mice":[20,55,137,153,176,191,218,227,254,261,287],"were":[21,56,61,68,71,95,104,146,255],"divided":[22],"into":[23],"young":[24,152,190,226,260],"group":[25,30],"(2":[26],"months)":[27],"and":[28,58,63,77,113,129,238,277],"old":[29,136,175,217,253],"(18":[31],"months),":[32],"each":[33],"composed":[34],"8":[36],"Each":[38],"mouse":[39],"was":[40,86,121,183],"percutaneously":[41],"infected":[42,288],"with":[43,289],"40":[44],"+/-":[45,139,142,155,158,178,193,221,230,246,249,263,266],"1":[46],"S.":[47],"cercariae.":[49],"At":[50],"6":[51],"weeks":[52],"post-infection,":[53],"sacrificed,":[57],"spleens":[60],"removed":[62],"single-cell":[64],"suspensions":[65],"splenocytes":[67,209],"prepared.":[69],"Worms":[70],"perfused":[72],"from":[73,252],"hepatic":[74],"portal":[75],"system":[76],"counted.":[78],"The":[79,126,165],"number":[80],"eggs":[82],"liver":[85,134],"determined":[87,96,122],"after":[88],"KOH":[89],"digestion.":[90],"Mean":[91],"single-egg":[92,169],"granulomas":[93,170],"sizes":[94],"stained":[98],"histological":[99],"sections.":[100],"Splenocyte":[101],"proliferation":[102,205],"analyzed":[105],"by":[106,123],"MTT":[107],"colorimetry.":[108],"Level":[109],"interferon-gamma":[111],"(IFN-gamma)":[112],"interleukin-4":[114],"(IL-4)":[115],"splenocyte":[118,242],"culture":[119,243],"supernatants":[120,244],"ELISA.":[124],"RESULTS:":[125,201],"worm":[127],"burden":[128],"egg":[130],"per":[131],"gram":[132],"[19.75":[138],"1.95,":[140],"(1.59":[141],"1.05)":[143],"x":[144,160,180,195],"10(4)]":[145,161],"significantly":[147,184],"lower":[148,185,256],"than":[149,186,223,257],"that":[150,187,207,224,258],"[26.00":[154],"2.42,":[156],"(208":[157],"0.87)":[159],"(P":[162,198,232],"<":[163,199,233,269],"0.05).":[164,200,234,270],"mean":[166],"volume":[167],"livers":[173],"[(30.13":[177],"10.97)":[179],"10(3)":[181],"mm3]":[182,197],"[(47.02":[192],"24.13)":[194],"l0(3)":[196],"T":[203],"cell":[204],"showed":[206],"had":[210],"poorer":[211,279],"reactivity":[213,281],"to":[214],"ConA":[215],"(SI:":[219,228],"1.08":[220],"0.12)":[222],"131":[229],"0.14)":[231],"Levels":[235],"IFN-gamma":[237],"IL-4":[239],"[(24.05":[245],"6.24),":[247],"(4.15":[248],"0.68)":[250],"pg/ml]":[251],"[(34.25":[262],"869),":[264],"(7125":[265],"0.83)":[267],"pg/ml](P":[268],"CONCLUSION:":[271],"Ageing":[272],"down-modulates":[273],"might":[282],"decrease":[283],"pathological":[284],"alterations":[285],"japonicum.":[291]},"counts_by_year":[],"updated_date":"2026-11-02T09:45:03.842371","created_date":"2016-06-24T00:00:00"}
