{"id":"https://openalex.org/W2397791044","doi":"https://doi.org/10.1016/s0022-5347(17)35218-7","title":"Pharmacokinetics of Vasoactive Substances Administered into the Human Corpus Cavernosum","display_name":"Pharmacokinetics of Vasoactive Substances Administered into the Human Corpus Cavernosum","publication_year":1994,"publication_date":"1994-05-01","ids":{"openalex":"https://openalex.org/W2397791044","doi":"https://doi.org/10.1016/s0022-5347(17)35218-7","mag":"2397791044","pmid":"https://pubmed.ncbi.nlm.nih.gov/8158764"},"language":"en","primary_location":{"id":"doi:10.1016/s0022-5347(17)35218-7","doi":"https://doi.org/10.1016/s0022-5347(17)35218-7","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0022-5347(17)35218-7","pdf_url":null,"source":{"id":"https://openalex.org/S30525748","display_name":"The Journal of Urology","issn_l":"0022-5347","issn":["0022-5347","1527-3792"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Urology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5001114707","display_name":"H. van Ahlen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135140700","display_name":"University of Bonn","ror":"https://ror.org/041nas322","country_code":"DE","type":"education","lineage":["https://openalex.org/I135140700"]},{"id":"https://openalex.org/I180923762","display_name":"University of Cologne","ror":"https://ror.org/00rcxh774","country_code":"DE","type":"education","lineage":["https://openalex.org/I180923762"]},{"id":"https://openalex.org/I22465464","display_name":"University of M\u00fcnster","ror":"https://ror.org/00pd74e08","country_code":"DE","type":"education","lineage":["https://openalex.org/I22465464"]},{"id":"https://openalex.org/I904495901","display_name":"Ruhr University Bochum","ror":"https://ror.org/04tsk2644","country_code":"DE","type":"education","lineage":["https://openalex.org/I904495901"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Hermann van Ahlen","raw_affiliation_strings":["Department of Pharmacology and Toxicology, University of Bochum, Bochum","From the Department of Urology, University of M\u00fcnster, M\u00fcnster","Institute for Experimental Haematology and Transfusion Medicine, University of Bonn, Bonn, Germany","Institute for Forensic Medicine, University of Cologne, Cologne"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Toxicology, University of Bochum, Bochum","institution_ids":["https://openalex.org/I904495901"]},{"raw_affiliation_string":"From the Department of Urology, University of M\u00fcnster, M\u00fcnster","institution_ids":["https://openalex.org/I22465464"]},{"raw_affiliation_string":"Institute for Experimental Haematology and Transfusion Medicine, University of Bonn, Bonn, Germany","institution_ids":["https://openalex.org/I135140700"]},{"raw_affiliation_string":"Institute for Forensic Medicine, University of Cologne, Cologne","institution_ids":["https://openalex.org/I180923762"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110142794","display_name":"Bernhard A. Peskar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135140700","display_name":"University of Bonn","ror":"https://ror.org/041nas322","country_code":"DE","type":"education","lineage":["https://openalex.org/I135140700"]},{"id":"https://openalex.org/I180923762","display_name":"University of Cologne","ror":"https://ror.org/00rcxh774","country_code":"DE","type":"education","lineage":["https://openalex.org/I180923762"]},{"id":"https://openalex.org/I22465464","display_name":"University of M\u00fcnster","ror":"https://ror.org/00pd74e08","country_code":"DE","type":"education","lineage":["https://openalex.org/I22465464"]},{"id":"https://openalex.org/I904495901","display_name":"Ruhr University Bochum","ror":"https://ror.org/04tsk2644","country_code":"DE","type":"education","lineage":["https://openalex.org/I904495901"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Bernhard A. Peskar","raw_affiliation_strings":["Department of Pharmacology and Toxicology, University of Bochum, Bochum","From the Department of Urology, University of M\u00fcnster, M\u00fcnster","Institute for Experimental Haematology and Transfusion Medicine, University of Bonn, Bonn, Germany","Institute for Forensic Medicine, University of Cologne, Cologne"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Toxicology, University of Bochum, Bochum","institution_ids":["https://openalex.org/I904495901"]},{"raw_affiliation_string":"From the Department of Urology, University of M\u00fcnster, M\u00fcnster","institution_ids":["https://openalex.org/I22465464"]},{"raw_affiliation_string":"Institute for Experimental Haematology and Transfusion Medicine, University of Bonn, Bonn, Germany","institution_ids":["https://openalex.org/I135140700"]},{"raw_affiliation_string":"Institute for Forensic Medicine, University of Cologne, Cologne","institution_ids":["https://openalex.org/I180923762"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055390129","display_name":"Guido Sticht","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135140700","display_name":"University of Bonn","ror":"https://ror.org/041nas322","country_code":"DE","type":"education","lineage":["https://openalex.org/I135140700"]},{"id":"https://openalex.org/I180923762","display_name":"University of Cologne","ror":"https://ror.org/00rcxh774","country_code":"DE","type":"education","lineage":["https://openalex.org/I180923762"]},{"id":"https://openalex.org/I22465464","display_name":"University of M\u00fcnster","ror":"https://ror.org/00pd74e08","country_code":"DE","type":"education","lineage":["https://openalex.org/I22465464"]},{"id":"https://openalex.org/I904495901","display_name":"Ruhr University Bochum","ror":"https://ror.org/04tsk2644","country_code":"DE","type":"education","lineage":["https://openalex.org/I904495901"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Guido Sticht","raw_affiliation_strings":["Department of Pharmacology and Toxicology, University of Bochum, Bochum","From the Department of Urology, University of M\u00fcnster, M\u00fcnster","Institute for Experimental Haematology and Transfusion Medicine, University of Bonn, Bonn, Germany","Institute for Forensic Medicine, University of Cologne, Cologne"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Toxicology, University of Bochum, Bochum","institution_ids":["https://openalex.org/I904495901"]},{"raw_affiliation_string":"From the Department of Urology, University of M\u00fcnster, M\u00fcnster","institution_ids":["https://openalex.org/I22465464"]},{"raw_affiliation_string":"Institute for Experimental Haematology and Transfusion Medicine, University of Bonn, Bonn, Germany","institution_ids":["https://openalex.org/I135140700"]},{"raw_affiliation_string":"Institute for Forensic Medicine, University of Cologne, Cologne","institution_ids":["https://openalex.org/I180923762"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5040729270","display_name":"Hans\u2010J\u00f6rg Hertfelder","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135140700","display_name":"University of Bonn","ror":"https://ror.org/041nas322","country_code":"DE","type":"education","lineage":["https://openalex.org/I135140700"]},{"id":"https://openalex.org/I180923762","display_name":"University of Cologne","ror":"https://ror.org/00rcxh774","country_code":"DE","type":"education","lineage":["https://openalex.org/I180923762"]},{"id":"https://openalex.org/I22465464","display_name":"University of M\u00fcnster","ror":"https://ror.org/00pd74e08","country_code":"DE","type":"education","lineage":["https://openalex.org/I22465464"]},{"id":"https://openalex.org/I904495901","display_name":"Ruhr University Bochum","ror":"https://ror.org/04tsk2644","country_code":"DE","type":"education","lineage":["https://openalex.org/I904495901"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Hans-J\u00f6rg Hertfelder","raw_affiliation_strings":["Department of Pharmacology and Toxicology, University of Bochum, Bochum","From the Department of Urology, University of M\u00fcnster, M\u00fcnster","Institute for Experimental Haematology and Transfusion Medicine, University of Bonn, Bonn, Germany","Institute for Forensic Medicine, University of Cologne, Cologne"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Toxicology, University of Bochum, Bochum","institution_ids":["https://openalex.org/I904495901"]},{"raw_affiliation_string":"From the Department of Urology, University of M\u00fcnster, M\u00fcnster","institution_ids":["https://openalex.org/I22465464"]},{"raw_affiliation_string":"Institute for Experimental Haematology and Transfusion Medicine, University of Bonn, Bonn, Germany","institution_ids":["https://openalex.org/I135140700"]},{"raw_affiliation_string":"Institute for Forensic Medicine, University of Cologne, Cologne","institution_ids":["https://openalex.org/I180923762"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3000,"currency":"USD","value_usd":3000},"apc_paid":null,"fwci":3.4243,"has_fulltext":false,"cited_by_count":44,"citation_normalized_percentile":{"value":0.92970198,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"151","issue":"5","first_page":"1227","last_page":"1230"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10459","display_name":"Sexual function and dysfunction studies","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10459","display_name":"Sexual function and dysfunction studies","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10279","display_name":"Urinary Bladder and Prostate Research","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11815","display_name":"Urological Disorders and Treatments","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.875},{"id":"https://openalex.org/keywords/corpus-cavernosum","display_name":"corpus cavernosum","score":0.9110000133514404},{"id":"https://openalex.org/keywords/erectile-dysfunction","display_name":"erectile dysfunction","score":0.890999972820282},{"id":"https://openalex.org/keywords/intracavernosal-injection","display_name":"intracavernous injection","score":0.8820000290870667},{"id":"https://openalex.org/keywords/papaverine","display_name":"papaverine","score":0.996999979019165},{"id":"https://openalex.org/keywords/prostaglandin-e1","display_name":"prostaglandin E1","score":0.9980000257492065},{"id":"https://openalex.org/keywords/priapism","display_name":"priapism","score":0.8769999742507935},{"id":"https://openalex.org/keywords/systemic-absorption","display_name":"systemic absorption","score":0.4830000102519989}],"concepts":[{"id":"https://openalex.org/C133828647","wikidata":"https://www.wikidata.org/wiki/Q6159778","display_name":"Vasoactive","level":2,"score":0.9355790615081787},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9311001300811768},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.7403654456138611},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4564831256866455},{"id":"https://openalex.org/C8330315","wikidata":"https://www.wikidata.org/wiki/Q414964","display_name":"Vasoactive intestinal peptide","level":4,"score":0.445973664522171},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3482210040092468},{"id":"https://openalex.org/C118303440","wikidata":"https://www.wikidata.org/wiki/Q419968","display_name":"Neuropeptide","level":3,"score":0.08748912811279297},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.07902765274047852}],"mesh":[{"descriptor_ui":"D000527","descriptor_name":"Alprostadil","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000527","descriptor_name":"Alprostadil","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D000527","descriptor_name":"Alprostadil","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007267","descriptor_name":"Injections","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010208","descriptor_name":"Papaverine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D010208","descriptor_name":"Papaverine","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D010413","descriptor_name":"Penis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010646","descriptor_name":"Phentolamine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D010646","descriptor_name":"Phentolamine","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/s0022-5347(17)35218-7","doi":"https://doi.org/10.1016/s0022-5347(17)35218-7","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0022-5347(17)35218-7","pdf_url":null,"source":{"id":"https://openalex.org/S30525748","display_name":"The Journal of Urology","issn_l":"0022-5347","issn":["0022-5347","1527-3792"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Urology","raw_type":"journal-article"},{"id":"pmid:8158764","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8158764","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of urology","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9763000011444092}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":24,"referenced_works":["https://openalex.org/W5822409","https://openalex.org/W69206832","https://openalex.org/W72730318","https://openalex.org/W588819361","https://openalex.org/W1517902906","https://openalex.org/W1983717385","https://openalex.org/W2009458866","https://openalex.org/W2014834561","https://openalex.org/W2016237776","https://openalex.org/W2018528934","https://openalex.org/W2024510071","https://openalex.org/W2026425270","https://openalex.org/W2087868145","https://openalex.org/W2110100401","https://openalex.org/W2234741852","https://openalex.org/W2245880027","https://openalex.org/W2315281265","https://openalex.org/W2399845617","https://openalex.org/W2409427734","https://openalex.org/W2417756760","https://openalex.org/W2428149043","https://openalex.org/W2434357581","https://openalex.org/W2493834784","https://openalex.org/W6841224313"],"related_works":["https://openalex.org/W2022532590","https://openalex.org/W2087868145","https://openalex.org/W1879866773","https://openalex.org/W2464754711","https://openalex.org/W2258896643","https://openalex.org/W2068773284","https://openalex.org/W2397595810","https://openalex.org/W2428149043","https://openalex.org/W342561778","https://openalex.org/W2030068663"],"abstract_inverted_index":{"The":[0,68,161],"pharmacokinetics":[1],"of":[2,13,32,121,129,157,170,175,180,203],"vasoactive":[3],"substances":[4],"injected":[5],"into":[6,76,136],"the":[7,11,24,77,85,109,114,122,133,137,149,154,167,178,198],"corpus":[8,134,199],"cavernosum":[9,135,200],"for":[10,166],"treatment":[12],"erectile":[14],"dysfunction":[15],"have":[16],"not":[17],"been":[18],"investigated":[19],"to":[20,113,153,187,192],"date.":[21],"We":[22],"measured":[23,52,62],"local":[25,102,127],"intracavernous":[26,48],"and":[27,34,37,58,89],"peripheral":[28,86,150],"venous":[29],"concentration":[30],"curves":[31],"papaverine":[33,72],"prostaglandin":[35,59,130,181],"E1,":[36,141,182],"its":[38],"primary":[39,123],"metabolite":[40,124],"15-keto-13,14-dihydro-prostaglandin":[41,140],"E1":[42,60,95,131],"in":[43,84,101,108,132,148,197,201],"an":[44],"intra-individual":[45],"comparison":[46],"after":[47,92,117],"injection.":[49,93],"Papaverine":[50],"was":[51,61],"with":[53,63,104,177],"high":[54],"performance":[55],"liquid":[56],"chromatography":[57],"a":[64,97,126,145,171],"specially":[65],"adapted":[66],"radioimmunoassay.":[67],"results":[69],"demonstrate":[70],"that":[71],"is":[73,195],"slowly":[74],"draining":[75],"systemic":[78],"circulation,":[79],"showing":[80],"slightly":[81],"elevated":[82],"levels":[83],"blood":[87],"30":[88],"60":[90],"minutes":[91],"Prostaglandin":[94],"shows":[96,144],"much":[98],"faster":[99],"decrease":[100],"concentrations":[103],"no":[105],"measurable":[106],"increase":[107,147],"periphery,":[110],"probably":[111],"due":[112,152],"short":[115],"half-time":[116,156],"lung":[118],"passage.":[119],"Measurement":[120],"proves":[125],"degradation":[128],"biologically":[138],"inactive":[139],"which":[142,183,194],"also":[143],"slight":[146],"circulation":[151],"longer":[155],"approximately":[158],"8":[159],"minutes.":[160],"data":[162],"provide":[163],"good":[164],"explanation":[165],"clinical":[168],"finding":[169],"markedly":[172],"decreased":[173],"incidence":[174],"priapism":[176],"use":[179],"can":[184],"be":[185,188],"shown":[186],"locally":[189],"metabolized,":[190],"compared":[191],"papaverine,":[193],"retained":[196],"cases":[202],"nonvenogenic":[204],"impotence.":[205]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":3},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}