{"id":"https://openalex.org/W2397740337","doi":"https://doi.org/10.4028/www.scientific.net/kem.695.252","title":"Structural and Ultrastructural Study, at Ovariectomised Female Rats, and their Reactivity to the Administration of Injectable Oestrogens","display_name":"Structural and Ultrastructural Study, at Ovariectomised Female Rats, and their Reactivity to the Administration of Injectable Oestrogens","publication_year":2016,"publication_date":"2016-05-01","ids":{"openalex":"https://openalex.org/W2397740337","doi":"https://doi.org/10.4028/www.scientific.net/kem.695.252","mag":"2397740337"},"language":"en","primary_location":{"id":"doi:10.4028/www.scientific.net/kem.695.252","doi":"https://doi.org/10.4028/www.scientific.net/kem.695.252","is_oa":false,"landing_page_url":"https://doi.org/10.4028/www.scientific.net/kem.695.252","pdf_url":null,"source":{"id":"https://openalex.org/S75411654","display_name":"Key engineering materials","issn_l":"1013-9826","issn":["1013-9826","1662-9795","1662-9809"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","norway-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317839","host_organization_name":"Trans Tech Publications","host_organization_lineage":["https://openalex.org/P4310317839"],"host_organization_lineage_names":["Trans Tech Publications"],"type":"book series"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Key Engineering Materials","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078153817","display_name":"Radu Florin Mocan-Hognogi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I208470662","display_name":"Iuliu Ha\u021bieganu University of Medicine and Pharmacy","ror":"https://ror.org/051h0cw83","country_code":"RO","type":"education","lineage":["https://openalex.org/I208470662"]}],"countries":["RO"],"is_corresponding":true,"raw_author_name":"Mocan- Hognogi Radu Florin","raw_affiliation_strings":["\u201cIuliu Hatieganu\u201d University of Medicine and Pharmacy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\u201cIuliu Hatieganu\u201d University of Medicine and Pharmacy","institution_ids":["https://openalex.org/I208470662"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089289337","display_name":"Nicolae Costin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I208470662","display_name":"Iuliu Ha\u021bieganu University of Medicine and Pharmacy","ror":"https://ror.org/051h0cw83","country_code":"RO","type":"education","lineage":["https://openalex.org/I208470662"]}],"countries":["RO"],"is_corresponding":false,"raw_author_name":"Costin Nicolae","raw_affiliation_strings":["Iuliu Hatieganu\u201d University of Medicine and Pharmacy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Iuliu Hatieganu\u201d University of Medicine and Pharmacy","institution_ids":["https://openalex.org/I208470662"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109091458","display_name":"Constantin Cr\u0103ciun","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3125347698","display_name":"Babe\u0219-Bolyai University","ror":"https://ror.org/02rmd1t30","country_code":"RO","type":"education","lineage":["https://openalex.org/I3125347698"]}],"countries":["RO"],"is_corresponding":false,"raw_author_name":"Constantin Craciun","raw_affiliation_strings":["Babes Bloyai University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Babes Bloyai University","institution_ids":["https://openalex.org/I3125347698"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011442034","display_name":"M Andrei","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I208470662","display_name":"Iuliu Ha\u021bieganu University of Medicine and Pharmacy","ror":"https://ror.org/051h0cw83","country_code":"RO","type":"education","lineage":["https://openalex.org/I208470662"]}],"countries":["RO"],"is_corresponding":false,"raw_author_name":"Malutan Andrei","raw_affiliation_strings":["Iuliu Hatieganu\u201d University of Medicine and Pharmacy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Iuliu Hatieganu\u201d University of Medicine and Pharmacy","institution_ids":["https://openalex.org/I208470662"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001377777","display_name":"Trif Ioana","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I208470662","display_name":"Iuliu Ha\u021bieganu University of Medicine and Pharmacy","ror":"https://ror.org/051h0cw83","country_code":"RO","type":"education","lineage":["https://openalex.org/I208470662"]}],"countries":["RO"],"is_corresponding":false,"raw_author_name":"Trif Ioana","raw_affiliation_strings":["Iuliu Hatieganu\u201d University of Medicine and Pharmacy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Iuliu Hatieganu\u201d University of Medicine and Pharmacy","institution_ids":["https://openalex.org/I208470662"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062482447","display_name":"R\u0103zvan Ciortea","orcid":"https://orcid.org/0000-0001-8454-4133","observed_orcids":["https://orcid.org/0000-0001-8454-4133"]},"institutions":[{"id":"https://openalex.org/I208470662","display_name":"Iuliu Ha\u021bieganu University of Medicine and Pharmacy","ror":"https://ror.org/051h0cw83","country_code":"RO","type":"education","lineage":["https://openalex.org/I208470662"]}],"countries":["RO"],"is_corresponding":false,"raw_author_name":"Ciortea Razvan","raw_affiliation_strings":["Iuliu Hatieganu\u201d University of Medicine and Pharmacy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Iuliu Hatieganu\u201d University of Medicine and Pharmacy","institution_ids":["https://openalex.org/I208470662"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5078645784","display_name":"Dan Mihu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I208470662","display_name":"Iuliu Ha\u021bieganu University of Medicine and Pharmacy","ror":"https://ror.org/051h0cw83","country_code":"RO","type":"education","lineage":["https://openalex.org/I208470662"]}],"countries":["RO"],"is_corresponding":false,"raw_author_name":"Mihu Dan","raw_affiliation_strings":["Iuliu Hatieganu\u201d University of Medicine and Pharmacy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Iuliu Hatieganu\u201d University of Medicine and Pharmacy","institution_ids":["https://openalex.org/I208470662"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5078153817"],"corresponding_institution_ids":["https://openalex.org/I208470662"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"695","issue":null,"first_page":"252","last_page":"259"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10694","display_name":"Menopause: Health Impacts and Treatments","score":0.9154999852180481,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10694","display_name":"Menopause: Health Impacts and Treatments","score":0.9154999852180481,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.07699999958276749,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11146","display_name":"Hormonal and reproductive studies","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/vaginal-epithelium","display_name":"vaginal epithelium","score":0.9369999766349792},{"id":"https://openalex.org/keywords/ovariectomy","display_name":"ovariectomy","score":0.9909999966621399},{"id":"https://openalex.org/keywords/menopause","display_name":"menopause","score":0.6230000257492065},{"id":"https://openalex.org/keywords/estradiol","display_name":"estradiol","score":0.7940000295639038},{"id":"https://openalex.org/keywords/hormone-replacement-therapy","display_name":"hormone replacement therapy","score":0.7369999885559082},{"id":"https://openalex.org/keywords/epithelial-hyperplasia","display_name":"epithelial hyperplasia","score":0.9509999752044678},{"id":"https://openalex.org/keywords/ultrastructure","display_name":"ultrastructure","score":0.718999981880188},{"id":"https://openalex.org/keywords/chorion","display_name":"chorion","score":0.6110000014305115},{"id":"https://openalex.org/keywords/female-rats","display_name":"female rats","score":0.421999990940094}],"concepts":[{"id":"https://openalex.org/C529295009","wikidata":"https://www.wikidata.org/wiki/Q41301","display_name":"Epithelium","level":2,"score":0.7579220533370972},{"id":"https://openalex.org/C87555872","wikidata":"https://www.wikidata.org/wiki/Q3141316","display_name":"Ultrastructure","level":2,"score":0.6511347889900208},{"id":"https://openalex.org/C2777562237","wikidata":"https://www.wikidata.org/wiki/Q835051","display_name":"Hyperplasia","level":2,"score":0.5499080419540405},{"id":"https://openalex.org/C2778024521","wikidata":"https://www.wikidata.org/wiki/Q55639806","display_name":"Basal (medicine)","level":3,"score":0.5356947779655457},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3982199430465698},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3907761871814728},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.38532906770706177},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.3576326072216034},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.2668991982936859},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.06545776128768921}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.4028/www.scientific.net/kem.695.252","doi":"https://doi.org/10.4028/www.scientific.net/kem.695.252","is_oa":false,"landing_page_url":"https://doi.org/10.4028/www.scientific.net/kem.695.252","pdf_url":null,"source":{"id":"https://openalex.org/S75411654","display_name":"Key engineering materials","issn_l":"1013-9826","issn":["1013-9826","1662-9795","1662-9809"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","norway-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317839","host_organization_name":"Trans Tech Publications","host_organization_lineage":["https://openalex.org/P4310317839"],"host_organization_lineage_names":["Trans Tech Publications"],"type":"book series"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Key Engineering Materials","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9476000070571899}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7084262151","https://openalex.org/W2356831917","https://openalex.org/W2174016401","https://openalex.org/W2370623137","https://openalex.org/W1995048165","https://openalex.org/W1994129791","https://openalex.org/W2083419800","https://openalex.org/W2509557831","https://openalex.org/W7097462977","https://openalex.org/W2161950114"],"abstract_inverted_index":{"The":[0],"purpose":[1],"of":[2,32,47,103,110,157,162,165,174,193,200,203,224,228,237,256,288,294,319,333],"this":[3],"study":[4,240,270],"has":[5,250,271,277,306],"been":[6,41,338],"to":[7,29,78,214,285],"identify":[8],"and":[9,12,71,75,106,116,139,152,160,211,252,262,329],"emphasise":[10],"structural":[11,239],"ultrastructural":[13,289],"modifications":[14],"occurring":[15],"in":[16,20,129,171,182],"the":[17,30,88,125,147,158,163,166,172,180,183,191,198,201,204,218,229,235,238,246,254,257,260,263,292,295,310,316],"vaginal":[18,121,148,230,258,297,311],"epithelium":[19,149,202,312],"ovariectomised":[21],"female":[22,36],"rats,":[23],"as":[24,26,51,245],"well":[25],"their":[27],"reactivity":[28],"administration":[31],"injectable":[33,93,247],"oestrogens.":[34],"30":[35],"Wistar":[37],"white":[38],"rats":[39],"have":[40,336],"used,":[42],"with":[43,57,68,92,100,131,168,283,303,315],"an":[44,330],"average":[45],"weight":[46],"200":[48],"g,":[49],"distributed":[50],"follows:":[52],"group":[53,63,145,215],"1,":[54],"control":[55],"group,":[56,67],"no":[58,69,188],"treatment":[59,81,249],"or":[60,325],"intervention":[61],"whatsoever,":[62],"2,":[64,146,216],"menopausal,":[65],"operated":[66],"treatment,":[70,111],"groups":[72,208,301],"3,":[73,209],"4":[74,210],"5,":[76,212],"operated,":[77],"which":[79,124,186],"oestrogenic":[80],"was":[82,95,150],"administered.":[83],"15":[84],"days":[85,109],"after":[86,107,123],"surgery,":[87],"hormone":[89],"replacement":[90],"therapy":[91],"oestrogens":[94],"initiated":[96],"(Estradiol,":[97],"Estradurin,":[98],"Sintofolin),":[99],"a":[101,169,323],"dosage":[102],"0.2":[104],"mg/rat/day,":[105],"14":[108],"all":[112,194,225,300],"animals":[113],"were":[114,118,127],"sacrificed":[115],"biopsies":[117],"taken":[119],"from":[120],"epithelium,":[122,167,259],"samples":[126],"processed":[128],"accordance":[130],"optical":[132],"microscopy":[133,142],"techniques":[134],"(the":[135],"semi-thin":[136,219,243],"section":[137],"technique)":[138],"transmission":[140],"electron":[141],"(TEM).":[143],"In":[144,207,299],"congested":[151],"exhibited":[153],"relatively":[154],"numerous":[155],"invaginations":[156],"mucosa":[159],"irregularities":[161],"surface":[164],"decrease":[170],"number":[173],"cells":[175,195,321],"forming":[176],"every":[177],"layer,":[178,185],"including":[179],"ones":[181],"basal":[184],"could":[187],"longer":[189],"ensure":[190],"regeneration":[192],"lost":[196],"at":[197,291],"level":[199,293],"superficial":[205],"layer.":[206],"compared":[213],"ovariectomised,":[217],"sections":[220],"obtained":[221],"revealed":[222],"hyperplasia":[223],"cellular":[226],"layers":[227,265],"epithelium.":[231,298],"Ultrastructural":[232],"investigations":[233],"confirm":[234],"results":[236],"based":[241],"on":[242],"sections,":[244],"oestrogen":[248],"protected":[251],"rebuilt":[253],"structure":[255],"chorion":[261],"muscular":[264],"affected":[266],"by":[267],"ovariectomy.":[268],"Our":[269],"shown":[272],"that":[273,309,335],"experimentally":[274],"induced":[275],"menopause":[276],"caused":[278],"significant":[279],"modifications,":[280],"expressed":[281],"polymorphically":[282],"alterations":[284],"various":[286],"degrees":[287],"visualisation":[290],"entire":[296],"treated":[302],"oestrogens,":[304],"it":[305],"become":[307],"apparent":[308],"is":[313],"hyperplased,":[314],"vast":[317],"majority":[318],"its":[320],"having":[322],"normal":[324,327],"almost":[326],"aspect,":[328],"isolated":[331],"presence":[332],"structures":[334],"not":[337],"completely":[339],"rebuilt.":[340]},"counts_by_year":[],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2016-06-24T00:00:00"}