{"id":"https://openalex.org/W2397697188","doi":null,"title":"Development and characterization of an infection inhibiting urinary catheter.","display_name":"Development and characterization of an infection inhibiting urinary catheter.","publication_year":2003,"publication_date":"2003-07-01","ids":{"openalex":"https://openalex.org/W2397697188","mag":"2397697188","pmid":"https://pubmed.ncbi.nlm.nih.gov/12918589"},"language":"en","primary_location":{"id":"pmid:12918589","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12918589","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ASAIO journal (American Society for Artificial Internal Organs : 1992)","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5068258451","display_name":"Christopher L. Richards","orcid":"https://orcid.org/0000-0001-7047-3039","observed_orcids":["https://orcid.org/0000-0001-7047-3039"]},"institutions":[{"id":"https://openalex.org/I4210096050","display_name":"Whalen Biomedical","ror":"https://ror.org/00spnmn10","country_code":"US","type":"company","lineage":["https://openalex.org/I4210096050"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher L Richards","raw_affiliation_strings":["Whalen Biomedical Inc., Somerville, Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Whalen Biomedical Inc., Somerville, Massachusetts, USA","institution_ids":["https://openalex.org/I4210096050"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083416681","display_name":"Kimberly C. Hoffman","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kimberly C Hoffman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"John M Bernhard","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"John M Bernhard","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002479240","display_name":"September D. Winslow","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"September D Winslow","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5105530356","display_name":"John C. Norman","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"John C Norman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5044149939","display_name":"Robert L. Whalen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Robert L Whalen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.6713,"has_fulltext":false,"cited_by_count":10,"citation_normalized_percentile":{"value":0.6641604,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"49","issue":"4","first_page":"449","last_page":"53"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12526","display_name":"Antimicrobial agents and applications","score":0.7339000105857849,"subfield":{"id":"https://openalex.org/subfields/2402","display_name":"Applied Microbiology and Biotechnology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12526","display_name":"Antimicrobial agents and applications","score":0.7339000105857849,"subfield":{"id":"https://openalex.org/subfields/2402","display_name":"Applied Microbiology and Biotechnology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11232","display_name":"Urinary Tract Infections Management","score":0.24629999697208405,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10641","display_name":"Central Venous Catheters and Hemodialysis","score":0.004600000102072954,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/urinary-catheter","display_name":"urinary catheter","score":0.8849999904632568},{"id":"https://openalex.org/keywords/chlorhexidine-gluconate","display_name":"chlorhexidine gluconate","score":0.9850000143051147},{"id":"https://openalex.org/keywords/silicone-rubber","display_name":"silicone rubber","score":0.9319999814033508},{"id":"https://openalex.org/keywords/in-vitro-release-profile","display_name":"in vitro release profile","score":0.5239999890327454},{"id":"https://openalex.org/keywords/in-vivo-toxicity","display_name":"in vivo toxicity","score":0.753000020980835},{"id":"https://openalex.org/keywords/surface-colonization","display_name":"surface colonization","score":0.6800000071525574},{"id":"https://openalex.org/keywords/infection-control","display_name":"infection control","score":0.6330000162124634},{"id":"https://openalex.org/keywords/compression-molding","display_name":"compression molding","score":0.5080000162124634}],"concepts":[{"id":"https://openalex.org/C2781267111","wikidata":"https://www.wikidata.org/wiki/Q652297","display_name":"Catheter","level":2,"score":0.6465029120445251},{"id":"https://openalex.org/C2779769944","wikidata":"https://www.wikidata.org/wiki/Q146439","display_name":"Silicone","level":2,"score":0.6343531012535095},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.5120704770088196},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.498981237411499},{"id":"https://openalex.org/C2777397205","wikidata":"https://www.wikidata.org/wiki/Q275792","display_name":"Saline","level":2,"score":0.4912964701652527},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4883696436882019},{"id":"https://openalex.org/C38052585","wikidata":"https://www.wikidata.org/wiki/Q252266","display_name":"Elastomer","level":2,"score":0.44886669516563416},{"id":"https://openalex.org/C77411442","wikidata":"https://www.wikidata.org/wiki/Q181100","display_name":"Urinary system","level":2,"score":0.4134017825126648},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.3262636959552765},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3129582107067108},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.31101739406585693},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.3079172372817993},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.22674080729484558},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1793975532054901},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.14200377464294434},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.07791754603385925},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000892","descriptor_name":"Anti-Infective Agents, Urinary","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000892","descriptor_name":"Anti-Infective Agents, Urinary","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D001672","descriptor_name":"Biocompatible Materials","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D002710","descriptor_name":"Chlorhexidine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D002710","descriptor_name":"Chlorhexidine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D002710","descriptor_name":"Chlorhexidine","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D003692","descriptor_name":"Delayed-Action Preparations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004867","descriptor_name":"Equipment Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008422","descriptor_name":"Materials Testing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012826","descriptor_name":"Silicone Elastomers","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D014546","descriptor_name":"Urinary Catheterization","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":true},{"descriptor_ui":"D014552","descriptor_name":"Urinary Tract Infections","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:12918589","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12918589","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ASAIO journal (American Society for Artificial Internal Organs : 1992)","raw_type":"Journal Article"},{"id":"mag:2397697188","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12918589","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5176226500","display_name":"A DRUG RELEASING URINARY CATHETER","funder_award_id":"1r43dk057918-01","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2044473153","https://openalex.org/W2037330891","https://openalex.org/W4405856499","https://openalex.org/W2138986975","https://openalex.org/W7219463746","https://openalex.org/W6902203711","https://openalex.org/W1964023348","https://openalex.org/W3183708334","https://openalex.org/W1928396032","https://openalex.org/W2127982217"],"abstract_inverted_index":{"Catheter":[0],"associated":[1],"bacturia":[2],"is":[3],"common":[4,101],"in":[5,53,78,89,198],"hospitals":[6],"and":[7,38,87,143,152,179,215],"nursing":[8],"homes.":[9],"The":[10],"objective":[11],"of":[12,62,134,161],"this":[13],"study":[14],"was":[15,50,114],"to":[16,29,34,39,44,56,71,130,194],"develop":[17],"an":[18,106],"infection":[19,216],"inhibiting":[20],"urinary":[21,47,209],"catheter":[22],"for":[23,77,88,103,217],"prolonged":[24],"use.":[25],"Methods":[26],"were":[27,75,127,174,185,192],"established":[28],"add":[30],"chlorhexidine":[31],"digluconate":[32],"(CHG)":[33],"a":[35,46,83,93,100,117],"silicone":[36,207],"elastomer":[37,55],"compression":[40],"mold":[41],"the":[42,54,63,110,124,131,135,140,147,164],"material":[43],"form":[45],"catheter.":[48],"CHG":[49,66,120,132,154,162,170,181,205],"randomly":[51],"dispersed":[52],"be":[57,195],"released":[58,122,139,146,158],"through":[59],"elution.":[60],"Samples":[61],"material,":[64],"with":[65],"concentrations":[67],"ranging":[68],"from":[69],"1":[70],"4%":[72,137,153],"by":[73,116,155,171,182],"weight,":[74],"tested":[76],"vitro":[79],"release":[80],"characteristics":[81],"over":[82,92],"28":[84],"day":[85,95],"period":[86],"vivo":[90,199],"toxicity":[91],"7":[94],"period.":[96],"Release":[97],"profiles":[98],"followed":[99,115],"pattern":[102],"each":[104],"concentration:":[105],"initial":[107],"peak":[108],"during":[109,197],"first":[111],"24":[112],"hours":[113],"subsequent":[118],"decline.":[119],"amounts":[121,142,160],"into":[123],"saline":[125],"medium":[126],"directly":[128],"related":[129],"concentration":[133],"samples;":[136],"samples":[138,145,157,173,184,191],"largest":[141],"1%":[144,169],"least":[148],"amounts.":[149],"Both":[150],"3%":[151],"weight":[156,172,183],"measurable":[159],"throughout":[163],"entire":[165],"observation":[166],"period,":[167],"whereas":[168],"depleted":[175,186],"after":[176,187],"9":[177],"days,":[178],"2%":[180],"19":[188],"days.":[189],"No":[190],"found":[193],"toxic":[196],"evaluations.":[200],"These":[201],"studies":[202],"suggest":[203],"that":[204],"bearing":[206],"rubber":[208],"catheters":[210],"could":[211],"resist":[212],"surface":[213],"colonization":[214],"extended":[218],"periods":[219],"without":[220],"toxicity.":[221]},"counts_by_year":[{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}