{"id":"https://openalex.org/W2397686170","doi":null,"title":"Use of ektacytometry to determine red cell susceptibility to oxidative stress.","display_name":"Use of ektacytometry to determine red cell susceptibility to oxidative stress.","publication_year":1990,"publication_date":"1990-10-01","ids":{"openalex":"https://openalex.org/W2397686170","mag":"2397686170","pmid":"https://pubmed.ncbi.nlm.nih.gov/2212862"},"language":"en","primary_location":{"id":"pmid:2212862","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2212862","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of laboratory and clinical medicine","raw_type":"Journal Article"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5047162260","display_name":"Frans A. Kuypers","orcid":"https://orcid.org/0000-0003-0731-1007","observed_orcids":["https://orcid.org/0000-0003-0731-1007"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"F A Kuypers","raw_affiliation_strings":["Children's Hospital Oakland Research Institute CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children's Hospital Oakland Research Institute CA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113937662","display_name":"Scott","orcid":"https://orcid.org/0000-0003-2971-7673","observed_orcids":["https://orcid.org/0000-0003-2971-7673"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M D Scott","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004312404","display_name":"Schott Ma","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M A Schott","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108348524","display_name":"Bertram H. Lubin","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"B Lubin","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5041511988","display_name":"Chiu Dt","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D T Chiu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.0826,"has_fulltext":false,"cited_by_count":74,"citation_normalized_percentile":{"value":0.80542931,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"116","issue":"4","first_page":"535","last_page":"45"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11721","display_name":"Blood properties and coagulation","score":0.7890999913215637,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11721","display_name":"Blood properties and coagulation","score":0.7890999913215637,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12286","display_name":"Erythrocyte Function and Pathophysiology","score":0.16249999403953552,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":0.020999999716877937,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ektacytometry","display_name":"ektacytometry","score":0.9440000057220459},{"id":"https://openalex.org/keywords/erythrocyte-deformability","display_name":"erythrocyte deformability","score":0.9300000071525574},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.9729999899864197},{"id":"https://openalex.org/keywords/hydrogen-peroxide","display_name":"hydrogen peroxide","score":0.7979999780654907},{"id":"https://openalex.org/keywords/erythrocyte-ghosts","display_name":"erythrocyte ghosts","score":0.8069999814033508},{"id":"https://openalex.org/keywords/membrane-stiffness","display_name":"membrane rigidity","score":0.8429999947547913},{"id":"https://openalex.org/keywords/hemolysis","display_name":"hemolysis","score":0.6340000033378601},{"id":"https://openalex.org/keywords/lipid-peroxidation","display_name":"lipid peroxidation","score":0.8830000162124634},{"id":"https://openalex.org/keywords/hemoglobin-oxidation","display_name":"hemoglobin oxidation","score":0.9409999847412109},{"id":"https://openalex.org/keywords/sickle-cell-disease","display_name":"sickle cell disease","score":0.9739999771118164},{"id":"https://openalex.org/keywords/red-blood-cell-fragility","display_name":"red blood cell fragility","score":0.5609999895095825}],"concepts":[{"id":"https://openalex.org/C147509754","wikidata":"https://www.wikidata.org/wiki/Q3080327","display_name":"Erythrocyte fragility","level":3,"score":0.8959654569625854},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.783725380897522},{"id":"https://openalex.org/C2778113725","wikidata":"https://www.wikidata.org/wiki/Q414439","display_name":"Cumene hydroperoxide","level":3,"score":0.7061676383018494},{"id":"https://openalex.org/C2776185378","wikidata":"https://www.wikidata.org/wiki/Q5396464","display_name":"Erythrocyte deformability","level":3,"score":0.7004641890525818},{"id":"https://openalex.org/C2776557347","wikidata":"https://www.wikidata.org/wiki/Q37187","display_name":"Red blood cell","level":2,"score":0.6402660608291626},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6077849864959717},{"id":"https://openalex.org/C57600042","wikidata":"https://www.wikidata.org/wiki/Q227564","display_name":"Oxidative phosphorylation","level":2,"score":0.5486873984336853},{"id":"https://openalex.org/C2779902561","wikidata":"https://www.wikidata.org/wiki/Q471706","display_name":"Hemolysis","level":2,"score":0.5372965335845947},{"id":"https://openalex.org/C2780829032","wikidata":"https://www.wikidata.org/wiki/Q898539","display_name":"Lipid peroxidation","level":3,"score":0.48885029554367065},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.47918713092803955},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.4751322567462921},{"id":"https://openalex.org/C533411734","wikidata":"https://www.wikidata.org/wiki/Q171877","display_name":"Hydrogen peroxide","level":2,"score":0.46455806493759155},{"id":"https://openalex.org/C1448646","wikidata":"https://www.wikidata.org/wiki/Q1280691","display_name":"Echinocyte","level":3,"score":0.45682293176651},{"id":"https://openalex.org/C2778917026","wikidata":"https://www.wikidata.org/wiki/Q43041","display_name":"Hemoglobin","level":2,"score":0.4357554316520691},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2393658459186554},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.18115130066871643},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D004907","descriptor_name":"Erythrocyte Deformability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004910","descriptor_name":"Erythrocyte Membrane","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004912","descriptor_name":"Erythrocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004912","descriptor_name":"Erythrocytes","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D006400","descriptor_name":"Hematocrit","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006461","descriptor_name":"Hemolysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006861","descriptor_name":"Hydrogen Peroxide","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D009994","descriptor_name":"Osmolar Concentration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010545","descriptor_name":"Peroxides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D014783","descriptor_name":"Viscosity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:2212862","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2212862","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of laboratory and clinical medicine","raw_type":"Journal Article"},{"id":"mag:2397686170","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2212862","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/6","display_name":"Clean water and sanitation","score":0.5199999809265137}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1444368025","display_name":"NORTHERN CALIFORNIA COMPREHENSIVE SICKLE CELL CENTER","funder_award_id":"5p60hl020985-25","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G2530374312","display_name":"Red Cell Membrane Studies","funder_award_id":"P01DK032094","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1964670897","https://openalex.org/W2037036320","https://openalex.org/W7042018939","https://openalex.org/W4312548172","https://openalex.org/W4392856519","https://openalex.org/W1511306401","https://openalex.org/W7004888683","https://openalex.org/W2006634489","https://openalex.org/W4416418729","https://openalex.org/W2412435357"],"abstract_inverted_index":{"To":[0,115],"define":[1],"a":[2,23,83,132,146,159,184],"more":[3],"sensitive":[4],"and":[5,65,79,112,149,158],"reliable":[6],"method":[7,25,135],"to":[8,27],"determine":[9],"changes":[10,89],"in":[11,37,48,54,100,124,126,154],"the":[12,29,38,59,69,93,118,122,143],"overall":[13],"cellular":[14,56],"characteristics":[15],"of":[16,31,40,58,68,85,95,106,109,121,170,187],"erythrocytes":[17,128,165,171],"after":[18],"oxidative":[19,32,130,192],"damage,":[20],"we":[21],"used":[22],"viscodiffractometric":[24],"(ektacytometry)":[26],"measure":[28,117],"effect":[30],"stress.":[33,87,151,193],"Erythrocytes":[34,138],"were":[35,90,139],"incubated":[36],"presence":[39],"hydrogen":[41],"peroxide,":[42],"t-butyl":[43],"hydroperoxide,":[44],"or":[45],"cumene":[46],"hydroperoxide":[47],"phosphate":[49],"buffer.":[50],"This":[51],"treatment":[52],"resulted":[53],"decreased":[55],"deformability":[57,64,101,125,155],"intact":[60,127],"erythrocytes.":[61],"In":[62],"addition,":[63],"fragility":[66],"measurements":[67],"erythrocyte":[70],"ghost":[71],"membranes":[72],"indicated":[73],"an":[74],"increased":[75],"membrane":[76,110],"dynamic":[77],"rigidity":[78],"altered-mechanical":[80],"stability":[81],"as":[82],"consequence":[84],"oxidant":[86],"These":[88],"observed":[91,98],"before":[92],"onset":[94],"hemolysis.":[96],"The":[97,152],"decrease":[99,123],"was":[102,136,156,162],"accompanied":[103],"by":[104],"oxidation":[105],"hemoglobin,":[107],"alterations":[108],"proteins,":[111],"lipid":[113],"peroxidation.":[114],"continuously":[116],"time":[119],"course":[120],"under":[129],"stress,":[131],"new":[133],"ektacytometric":[134],"developed.":[137],"oxidatively":[140],"challenged":[141],"within":[142],"viscometer":[144],"at":[145],"constant":[147],"osmolality":[148],"shear":[150],"change":[153],"monitored":[157],"typical":[160],"range":[161],"defined":[163],"for":[164],"from":[166,172,180],"normal":[167,181],"individuals.":[168],"Comparison":[169],"patients":[173],"with":[174,178],"sickle":[175,188],"cell":[176],"disease":[177],"those":[179],"individuals":[182],"demonstrated":[183],"higher":[185],"susceptibility":[186],"red":[189],"cells":[190],"toward":[191]},"counts_by_year":[{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}