{"id":"https://openalex.org/W2397673249","doi":null,"title":"Intrauterine factors as determinants of depressive disorder.","display_name":"Intrauterine factors as determinants of depressive disorder.","publication_year":2010,"publication_date":"2010-01-01","ids":{"openalex":"https://openalex.org/W2397673249","mag":"2397673249","pmid":"https://pubmed.ncbi.nlm.nih.gov/20686198"},"language":"en","primary_location":{"id":"pmid:20686198","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20686198","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Israel journal of psychiatry and related sciences","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5089887580","display_name":"Marta Weinstock","orcid":"https://orcid.org/0000-0002-4254-6779","observed_orcids":["https://orcid.org/0000-0002-4254-6779"]},"institutions":[{"id":"https://openalex.org/I197251160","display_name":"Hebrew University of Jerusalem","ror":"https://ror.org/03qxff017","country_code":"IL","type":"education","lineage":["https://openalex.org/I197251160"]},{"id":"https://openalex.org/I2799899409","display_name":"Hadassah Medical Center","ror":"https://ror.org/01cqmqj90","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2799899409"]}],"countries":["IL"],"is_corresponding":true,"raw_author_name":"Marta Weinstock","raw_affiliation_strings":["Department of Pharmacology, The Hebrew University Hadassah Medical Center, Jerusalem, Israel. martar@ekmd.huji.ac.il","Department of Pharmacology, The Hebrew University Hadassah Medical Center, Jerusalem, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, The Hebrew University Hadassah Medical Center, Jerusalem, Israel. martar@ekmd.huji.ac.il","institution_ids":["https://openalex.org/I197251160","https://openalex.org/I2799899409"]},{"raw_affiliation_string":"Department of Pharmacology, The Hebrew University Hadassah Medical Center, Jerusalem, Israel","institution_ids":["https://openalex.org/I197251160","https://openalex.org/I2799899409"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5089887580"],"corresponding_institution_ids":["https://openalex.org/I197251160","https://openalex.org/I2799899409"],"apc_list":null,"apc_paid":null,"fwci":2.061,"has_fulltext":false,"cited_by_count":33,"citation_normalized_percentile":{"value":0.82582781,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"47","issue":"1","first_page":"36","last_page":"45"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10529","display_name":"Stress Responses and Cortisol","score":0.8393999934196472,"subfield":{"id":"https://openalex.org/subfields/2802","display_name":"Behavioral Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10529","display_name":"Stress Responses and Cortisol","score":0.8393999934196472,"subfield":{"id":"https://openalex.org/subfields/2802","display_name":"Behavioral Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10786","display_name":"Maternal Mental Health During Pregnancy and Postpartum","score":0.1509000062942505,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11629","display_name":"Birth, Development, and Health","score":0.0032999999821186066,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/major-depressive-disorder","display_name":"major depressive disorder","score":0.9480000138282776},{"id":"https://openalex.org/keywords/intrauterine-factors","display_name":"intrauterine factors","score":0.781000018119812},{"id":"https://openalex.org/keywords/prenatal-stress","display_name":"prenatal stress","score":0.9649999737739563},{"id":"https://openalex.org/keywords/maternal-alcohol-exposure","display_name":"maternal alcohol exposure","score":0.8330000042915344},{"id":"https://openalex.org/keywords/corticotropin-releasing-factor","display_name":"corticotropin-releasing factor","score":0.9110000133514404},{"id":"https://openalex.org/keywords/cortisol","display_name":"cortisol","score":0.9950000047683716},{"id":"https://openalex.org/keywords/hypothalamic-pituitary-adrenal-axis","display_name":"hypothalamic-pituitary-adrenal axis","score":0.8939999938011169},{"id":"https://openalex.org/keywords/5-ht1a-receptor","display_name":"5-HT1A receptor","score":0.7730000019073486},{"id":"https://openalex.org/keywords/5-ht2a-receptor","display_name":"5-HT2A receptor","score":0.9990000128746033},{"id":"https://openalex.org/keywords/birth-weight","display_name":"birth weight","score":0.9169999957084656},{"id":"https://openalex.org/keywords/circadian-rhythm","display_name":"circadian rhythm","score":0.656000018119812},{"id":"https://openalex.org/keywords/sleep","display_name":"sleep","score":0.652999997138977},{"id":"https://openalex.org/keywords/antidepressants","display_name":"antidepressants","score":0.656000018119812},{"id":"https://openalex.org/keywords/animal-models-of-depression","display_name":"animal models of depression","score":0.6159999966621399}],"concepts":[{"id":"https://openalex.org/C2780051608","wikidata":"https://www.wikidata.org/wiki/Q42844","display_name":"Major depressive disorder","level":3,"score":0.7490708827972412},{"id":"https://openalex.org/C37000724","wikidata":"https://www.wikidata.org/wiki/Q50430226","display_name":"Serotonergic","level":4,"score":0.7170110940933228},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.5783963203430176},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5086808800697327},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.49375900626182556},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4878571033477783},{"id":"https://openalex.org/C2776867660","wikidata":"https://www.wikidata.org/wiki/Q1814941","display_name":"Depression (economics)","level":2,"score":0.47243794798851013},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4588516354560852},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.33519506454467773},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.32575345039367676},{"id":"https://openalex.org/C2775864247","wikidata":"https://www.wikidata.org/wiki/Q167934","display_name":"Serotonin","level":3,"score":0.21584460139274597},{"id":"https://openalex.org/C2779144063","wikidata":"https://www.wikidata.org/wiki/Q338924","display_name":"Amygdala","level":2,"score":0.14452248811721802},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.12471473217010498},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.0},{"id":"https://openalex.org/C139719470","wikidata":"https://www.wikidata.org/wiki/Q39680","display_name":"Macroeconomics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000428","descriptor_name":"Alcohol Drinking","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002940","descriptor_name":"Circadian Rhythm","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003346","descriptor_name":"Corticotropin-Releasing Hormone","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D003865","descriptor_name":"Major Depressive Disorder","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D003865","descriptor_name":"Major Depressive Disorder","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003865","descriptor_name":"Major Depressive Disorder","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006854","descriptor_name":"Hydrocortisone","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D007030","descriptor_name":"Hypothalamo-Hypophyseal System","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010913","descriptor_name":"Pituitary-Adrenal System","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011262","descriptor_name":"Pregnancy Trimester, Second","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011263","descriptor_name":"Pregnancy Trimester, Third","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011297","descriptor_name":"Prenatal Exposure Delayed Effects","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011297","descriptor_name":"Prenatal Exposure Delayed Effects","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":false},{"descriptor_ui":"D012890","descriptor_name":"Sleep","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013315","descriptor_name":"Stress, Psychological","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D033261","descriptor_name":"Maternal-Fetal Relations","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":false},{"descriptor_ui":"D044282","descriptor_name":"Receptor, Serotonin, 5-HT1A","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D044402","descriptor_name":"Receptor, Serotonin, 5-HT2A","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D047109","descriptor_name":"Fetal Development","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:20686198","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20686198","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Israel journal of psychiatry and related sciences","raw_type":"Journal Article"},{"id":"mag:2397673249","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20686198","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2123057987","https://openalex.org/W42506012","https://openalex.org/W2075892266","https://openalex.org/W2044219781","https://openalex.org/W4233749414","https://openalex.org/W2883572200","https://openalex.org/W2086817773","https://openalex.org/W2209909397","https://openalex.org/W4292327220","https://openalex.org/W2969474098"],"abstract_inverted_index":{"Although":[0],"the":[1,22,34,38,49,70,74,141,144],"etiology":[2],"of":[3,24,37,57,73,124,132,140,143,148],"major":[4],"depressive":[5],"disorder":[6],"(MDD)":[7],"is":[8,11,136],"unknown,":[9],"it":[10],"precipitated":[12],"in":[13,33,86,94,99,115,118,126],"susceptible":[14],"individuals":[15],"by":[16,134,138],"adverse":[17],"events.":[18],"This":[19],"review":[20],"examines":[21],"role":[23],"intrauterine":[25],"factors":[26],"resulting":[27],"from":[28],"exposure":[29],"to":[30,40],"stress":[31,44,107],"hormones":[32,65],"increased":[35],"vulnerability":[36],"organism":[39],"MDD.":[41,129],"Severe":[42],"maternal":[43],"or":[45,108],"alcohol":[46],"intake":[47],"during":[48],"second":[50],"and":[51,62,81,83,98,120,147],"third":[52],"trimesters":[53],"causes":[54],"excess":[55],"release":[56],"corticotropin":[58],"releasing":[59],"hormone":[60],"(CRH)":[61],"cortisol.":[63],"These":[64],"reduce":[66],"birth":[67],"weight;":[68],"impair":[69],"feedback":[71],"regulation":[72,142],"hypothalamic":[75],"pituitary":[76],"adrenal":[77],"axis":[78,80,146],"(HPA)":[79],"5-HT1A":[82],"5-HT2A":[84],"signaling":[85],"key":[87],"brain":[88],"areas.":[89],"Similar":[90],"changes":[91],"are":[92],"seen":[93],"patients":[95],"with":[96,128],"MDD":[97,133],"experimental":[100],"animals":[101],"after":[102],"chronic":[103],"inescapable":[104],"stress,":[105],"prenatal":[106],"alcohol,":[109],"which":[110],"also":[111],"induce":[112],"depressive-like":[113],"behavior":[114],"rats,":[116],"alterations":[117],"sleep":[119],"circadian":[121],"rhythms":[122],"reminiscent":[123],"those":[125],"humans":[127],"Clinical":[130],"improvement":[131],"antidepressants":[135],"accompanied":[137],"normalization":[139],"HPA":[145],"serotoninergic":[149],"transmission.":[150]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}