{"id":"https://openalex.org/W2397670832","doi":"https://doi.org/10.1158/1535-7163.targ-15-a166","title":"Abstract A166: BELLE-4: A Phase II study of buparlisib and paclitaxel in women with HER2- advanced breast cancer, with or without PI3K pathway activation","display_name":"Abstract A166: BELLE-4: A Phase II study of buparlisib and paclitaxel in women with HER2- advanced breast cancer, with or without PI3K pathway activation","publication_year":2015,"publication_date":"2015-12-01","ids":{"openalex":"https://openalex.org/W2397670832","doi":"https://doi.org/10.1158/1535-7163.targ-15-a166","mag":"2397670832"},"language":"en","primary_location":{"id":"doi:10.1158/1535-7163.targ-15-a166","doi":"https://doi.org/10.1158/1535-7163.targ-15-a166","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1535-7163.targ-15-a166","pdf_url":null,"source":{"id":"https://openalex.org/S48437117","display_name":"Molecular Cancer Therapeutics","issn_l":"1535-7163","issn":["1535-7163","1538-8514"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Cancer Therapeutics","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100671433","display_name":"Miguel Mart\u00edn","orcid":"https://orcid.org/0000-0001-9237-3231","observed_orcids":["https://orcid.org/0000-0001-9237-3231"]},"institutions":[{"id":"https://openalex.org/I2960094004","display_name":"Hospital General Universitario Gregorio Mara\u00f1\u00f3n","ror":"https://ror.org/0111es613","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I2960094004","https://openalex.org/I4210139293"]},{"id":"https://openalex.org/I4405268975","display_name":"Instituto de Investigaci\u00f3n Sanitaria Gregorio Mara\u00f1\u00f3n","ror":"https://ror.org/02p8e3h61","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4405268975"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Miguel Mart\u00edn","raw_affiliation_strings":["1Instituto de Investigaci\u00f3n Sanitaria Gregorio Mara\u00f1\u00f3n, Madrid, Spain;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Instituto de Investigaci\u00f3n Sanitaria Gregorio Mara\u00f1\u00f3n, Madrid, Spain;","institution_ids":["https://openalex.org/I2960094004","https://openalex.org/I4405268975"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005769474","display_name":"Arlene Chan","orcid":"https://orcid.org/0000-0003-2135-2286","observed_orcids":["https://orcid.org/0000-0003-2135-2286"]},"institutions":[{"id":"https://openalex.org/I205640436","display_name":"Curtin University","ror":"https://ror.org/02n415q13","country_code":"AU","type":"education","lineage":["https://openalex.org/I205640436"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Arlene Chan","raw_affiliation_strings":["2Breast Cancer Research Centre WA & Curtin University, Perth, Australia;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Breast Cancer Research Centre WA & Curtin University, Perth, Australia;","institution_ids":["https://openalex.org/I205640436"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022173747","display_name":"Luc Yves Dirix","orcid":"https://orcid.org/0000-0002-7792-9964","observed_orcids":["https://orcid.org/0000-0002-7792-9964"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Luc Dirix","raw_affiliation_strings":["3Sint-Augustinus Hospital, Antwerp, Belgium;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Sint-Augustinus Hospital, Antwerp, Belgium;","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071432873","display_name":"Joyce O\u2019Shaughnessy","orcid":"https://orcid.org/0000-0002-2955-5523","observed_orcids":["https://orcid.org/0000-0002-2955-5523","https://orcid.org/0000-0001-6764-2807"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Joyce O'Shaughnessy","raw_affiliation_strings":["4Texas Oncology Baylor-Sammons Cancer Center, US Oncology, Dallas, TX;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4Texas Oncology Baylor-Sammons Cancer Center, US Oncology, Dallas, TX;","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018564985","display_name":"Roberto Hegg","orcid":"https://orcid.org/0000-0002-6453-8155","observed_orcids":["https://orcid.org/0000-0002-6453-8155"]},"institutions":[{"id":"https://openalex.org/I4210143548","display_name":"Hospital da Mulher S\u00e3o Paulo","ror":"https://ror.org/0495f8j82","country_code":"BR","type":"healthcare","lineage":["https://openalex.org/I4210143548"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Roberto Hegg","raw_affiliation_strings":["5Hospital P\u00e9rola Byigton Centro de Refer\u00eancia da Sa\u00fade da Mulher, S\u00e3o Paolo, Brazil;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"5Hospital P\u00e9rola Byigton Centro de Refer\u00eancia da Sa\u00fade da Mulher, S\u00e3o Paolo, Brazil;","institution_ids":["https://openalex.org/I4210143548"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076418700","display_name":"Alexey Manikhas","orcid":"https://orcid.org/0000-0001-9616-6635","observed_orcids":["https://orcid.org/0000-0001-9616-6635"]},"institutions":[{"id":"https://openalex.org/I4210120731","display_name":"City Clinical Oncology Center","ror":"https://ror.org/02jwr3j75","country_code":"RU","type":"healthcare","lineage":["https://openalex.org/I4210120731"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Alexey Manikhas","raw_affiliation_strings":["6City Clinical Oncological Dispensery, Saint Petersburg, Russian Federation;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"6City Clinical Oncological Dispensery, Saint Petersburg, Russian Federation;","institution_ids":["https://openalex.org/I4210120731"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017742334","display_name":"Mikhail I. Shtivelband","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mikhail Shtivelband","raw_affiliation_strings":["7Ironwood Cancer and Research Centers, Chandler, AZ;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"7Ironwood Cancer and Research Centers, Chandler, AZ;","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026321163","display_name":"\u041f\u0435\u0442\u0440 \u0412\u043b\u0430\u0434\u0438\u043c\u0438\u0440\u043e\u0432\u0438\u0447 \u041a\u0440\u0438\u0432\u043e\u0440\u043e\u0442\u044c\u043a\u043e","orcid":"https://orcid.org/0000-0002-4898-9159","observed_orcids":["https://orcid.org/0000-0002-4898-9159"]},"institutions":[{"id":"https://openalex.org/I4210116304","display_name":"Institute of Oncology NN Petrov","ror":"https://ror.org/01mfpjp46","country_code":"RU","type":"healthcare","lineage":["https://openalex.org/I4210116304","https://openalex.org/I4210117042"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Petr Krivorotko","raw_affiliation_strings":["8Petrov Research Institute of Oncology, Saint Petersburg, Russian Federation;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"8Petrov Research Institute of Oncology, Saint Petersburg, Russian Federation;","institution_ids":["https://openalex.org/I4210116304"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066275566","display_name":"Norberto Batista L\u00f3pez","orcid":"https://orcid.org/0009-0009-6938-5133","observed_orcids":["https://orcid.org/0009-0009-6938-5133"]},"institutions":[{"id":"https://openalex.org/I2800401438","display_name":"Hospital Universitario de Canarias","ror":"https://ror.org/05qndj312","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I2800401438"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Norberto Batista L\u00f3pez","raw_affiliation_strings":["9Hospital Universitario de Canarias, Tenerife, Spain;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"9Hospital Universitario de Canarias, Tenerife, Spain;","institution_ids":["https://openalex.org/I2800401438"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071553983","display_name":"Mario Campone","orcid":"https://orcid.org/0000-0002-5196-5908","observed_orcids":["https://orcid.org/0000-0002-5196-5908"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mario Campone","raw_affiliation_strings":["10Institut de Canc\u00e9rologie de l'Ouest \u2013 Ren\u00e9 Gauducheau Centre de Recherche en Canc\u00e9rologie, Nantes, France;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"10Institut de Canc\u00e9rologie de l'Ouest \u2013 Ren\u00e9 Gauducheau Centre de Recherche en Canc\u00e9rologie, Nantes, France;","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111876641","display_name":"Manuel Ru\u00edz Borrego","orcid":"https://orcid.org/0000-0002-1181-5622","observed_orcids":["https://orcid.org/0000-0002-1181-5622"]},"institutions":[{"id":"https://openalex.org/I4210153139","display_name":"Hospital Universitario Virgen del Roc\u00edo","ror":"https://ror.org/04vfhnm78","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210153139"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Manuel Ruiz Borrego","raw_affiliation_strings":["11Department of Medical Oncology, Hospital Universitario Virgen del Roc\u00edo, Seville, Spain;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"11Department of Medical Oncology, Hospital Universitario Virgen del Roc\u00edo, Seville, Spain;","institution_ids":["https://openalex.org/I4210153139"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028067020","display_name":"Qamar J. Khan","orcid":"https://orcid.org/0000-0002-6287-020X","observed_orcids":["https://orcid.org/0000-0002-6287-020X"]},"institutions":[{"id":"https://openalex.org/I4210128618","display_name":"University of Kansas Medical Center","ror":"https://ror.org/036c9yv20","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210128618"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Qamar J. Khan","raw_affiliation_strings":["12University of Kansas Medical Center, Kansas City, KS;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"12University of Kansas Medical Center, Kansas City, KS;","institution_ids":["https://openalex.org/I4210128618"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003887338","display_name":"Joseph Thaddeus Beck","orcid":"https://orcid.org/0000-0002-3341-9903","observed_orcids":["https://orcid.org/0000-0002-3341-9903"]},"institutions":[{"id":"https://openalex.org/I4210107699","display_name":"Highlands Oncology Group","ror":"https://ror.org/01k1j7593","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210107699"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. Thaddeus Beck","raw_affiliation_strings":["13Highlands Oncology Group, Fayetteville, AZ;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"13Highlands Oncology Group, Fayetteville, AZ;","institution_ids":["https://openalex.org/I4210107699"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089006820","display_name":"Manuel Ramos-V\u00e1zquez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210096786","display_name":"Centro Oncol\u00f3gico de Galicia","ror":"https://ror.org/00swmft88","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210096786"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Manuel Ramos Vasquez","raw_affiliation_strings":["14Centro Oncol\u00f3gico de Galicia, La Coru\u00f1a, Spain;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"14Centro Oncol\u00f3gico de Galicia, La Coru\u00f1a, Spain;","institution_ids":["https://openalex.org/I4210096786"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014122300","display_name":"Patrick Urban","orcid":"https://orcid.org/0000-0002-5370-199X","observed_orcids":["https://orcid.org/0000-0002-5370-199X"]},"institutions":[{"id":"https://openalex.org/I1283582996","display_name":"Novartis (Switzerland)","ror":"https://ror.org/02f9zrr09","country_code":"CH","type":"company","lineage":["https://openalex.org/I1283582996"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Patrick Urban","raw_affiliation_strings":["15Novartis Pharma AG, Basel, Switzerland;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"15Novartis Pharma AG, Basel, Switzerland;","institution_ids":["https://openalex.org/I1283582996"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061398917","display_name":"Pantelia Roussou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1283582996","display_name":"Novartis (Switzerland)","ror":"https://ror.org/02f9zrr09","country_code":"CH","type":"company","lineage":["https://openalex.org/I1283582996"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Pantelia Roussou","raw_affiliation_strings":["15Novartis Pharma AG, Basel, Switzerland;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"15Novartis Pharma AG, Basel, Switzerland;","institution_ids":["https://openalex.org/I1283582996"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019864381","display_name":"Emmanuelle di Tomaso","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Emmanuelle Di Tomaso","raw_affiliation_strings":["16Novartis Institutes for BioMedical Research, Cambridge, MA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"16Novartis Institutes for BioMedical Research, Cambridge, MA;","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045631199","display_name":"Cristian Massacesi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210092929","display_name":"Novartis (France)","ror":"https://ror.org/00geypp27","country_code":"FR","type":"company","lineage":["https://openalex.org/I1283582996","https://openalex.org/I4210092929"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Cristian Massacesi","raw_affiliation_strings":["17Novartis Oncology, Paris, France;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"17Novartis Oncology, Paris, France;","institution_ids":["https://openalex.org/I4210092929"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5083142899","display_name":"Suzette Delaloge","orcid":"https://orcid.org/0000-0003-2106-9165","observed_orcids":["https://orcid.org/0000-0003-2106-9165"]},"institutions":[{"id":"https://openalex.org/I2801843802","display_name":"Institut Gustave Roussy","ror":"https://ror.org/0321g0743","country_code":"FR","type":"facility","lineage":["https://openalex.org/I2801843802"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Suzette Delaloge","raw_affiliation_strings":["18Institut Gustave Roussy, Villejuif, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"18Institut Gustave Roussy, Villejuif, France","institution_ids":["https://openalex.org/I2801843802"]}]}],"institutions":[],"countries_distinct_count":7,"institutions_distinct_count":14,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"14","issue":"12_Supplement_2","first_page":"A166","last_page":"A166"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12829","display_name":"Advanced Breast Cancer Therapies","score":0.8461999893188477,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12829","display_name":"Advanced Breast Cancer Therapies","score":0.8461999893188477,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.12790000438690186,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.010300000198185444,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/buparlisib","display_name":"buparlisib","score":0.996999979019165},{"id":"https://openalex.org/keywords/paclitaxel","display_name":"paclitaxel","score":0.968999981880188},{"id":"https://openalex.org/keywords/her2-negative-breast-cancer","display_name":"HER2-negative breast cancer","score":0.953000009059906},{"id":"https://openalex.org/keywords/pi3k-pathway-activation","display_name":"PI3K pathway activation","score":0.9039999842643738},{"id":"https://openalex.org/keywords/pi3k-inhibitors","display_name":"PI3K inhibitors","score":0.6899999976158142},{"id":"https://openalex.org/keywords/combination-chemotherapy","display_name":"combination chemotherapy","score":0.5339999794960022},{"id":"https://openalex.org/keywords/progression-free-survival","display_name":"progression-free survival","score":0.9319999814033508},{"id":"https://openalex.org/keywords/hormone-receptor-status","display_name":"hormone receptor status","score":0.5070000290870667},{"id":"https://openalex.org/keywords/chemoresistance","display_name":"chemoresistance","score":0.5009999871253967},{"id":"https://openalex.org/keywords/metastatic-breast-cancer","display_name":"metastatic breast cancer","score":0.6079999804496765},{"id":"https://openalex.org/keywords/locally-advanced-breast-cancer","display_name":"locally advanced breast cancer","score":0.9430000185966492},{"id":"https://openalex.org/keywords/biomarker-guided-therapy","display_name":"biomarker-guided therapy","score":0.3160000145435333},{"id":"https://openalex.org/keywords/her2-positive-breast-cancer","display_name":"HER2-positive breast cancer","score":0.3529999852180481}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7773528695106506},{"id":"https://openalex.org/C203092338","wikidata":"https://www.wikidata.org/wiki/Q1340863","display_name":"Clinical endpoint","level":3,"score":0.6502603888511658},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6230906844139099},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5714606642723083},{"id":"https://openalex.org/C31760486","wikidata":"https://www.wikidata.org/wiki/Q7180990","display_name":"Phases of clinical research","level":3,"score":0.5333822965621948},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.5288202166557312},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5147181153297424},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.5119138956069946},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4802451431751251},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.4801428020000458},{"id":"https://openalex.org/C204243189","wikidata":"https://www.wikidata.org/wiki/Q1363085","display_name":"Randomization","level":3,"score":0.4751149117946625},{"id":"https://openalex.org/C2779984678","wikidata":"https://www.wikidata.org/wiki/Q2145898","display_name":"Response Evaluation Criteria in Solid Tumors","level":4,"score":0.4619581699371338},{"id":"https://openalex.org/C2775930923","wikidata":"https://www.wikidata.org/wiki/Q12859063","display_name":"Metastatic breast cancer","level":4,"score":0.4423191249370575},{"id":"https://openalex.org/C61943457","wikidata":"https://www.wikidata.org/wiki/Q6046661","display_name":"Interim analysis","level":3,"score":0.44072383642196655},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.3869464695453644},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.351313054561615},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.11832985281944275},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0766785740852356},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.06613832712173462},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1535-7163.targ-15-a166","doi":"https://doi.org/10.1158/1535-7163.targ-15-a166","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1535-7163.targ-15-a166","pdf_url":null,"source":{"id":"https://openalex.org/S48437117","display_name":"Molecular Cancer Therapeutics","issn_l":"1535-7163","issn":["1535-7163","1538-8514"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Cancer Therapeutics","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9940000176429749,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2546933714","https://openalex.org/W2035797119","https://openalex.org/W2619858681","https://openalex.org/W2076901919","https://openalex.org/W4250558149","https://openalex.org/W2337490679","https://openalex.org/W2519383580","https://openalex.org/W2148181778","https://openalex.org/W2754374743","https://openalex.org/W2403219295"],"abstract_inverted_index":{"Abstract":[0],"Introduction:":[1],"Phosphatidylinositol":[2],"3-kinase":[3],"(PI3K)":[4],"pathway":[5,117,438,517,593],"activation":[6],"in":[7,41,46,59,79,138,191,354,375,455,466,501,523,582],"breast":[8,587],"cancer":[9],"(BC)":[10],"is":[11,65],"associated":[12],"with":[13,26,81,88,108,410,428,447,463,584,589],"tumor":[14],"growth":[15],"and":[16,50,54,122,141,157,194,259,290,345,378,470,484,580,605],"resistance":[17,522],"to":[18,101,200,215,235,499,511],"anticancer":[19],"therapies,":[20],"including":[21],"paclitaxel":[22,581],"(PAC).":[23],"Combined":[24],"treatment":[25,301,513],"the":[27,139,168,192,203,210,216,361,369,372,376,384,399,418,436,456,467,475,478,503,515,599],"pan-Class":[28],"I":[29],"PI3K":[30,116,142,195,217,256,379,419,437,468,506,516,592],"inhibitor":[31],"buparlisib":[32,76,103,237,498,579],"(BKM120)":[33],"+":[34,77,238,245],"PAC":[35,57,78,109,239,246,500,521],"has":[36],"shown":[37],"signs":[38],"of":[39,75,170,185,189,227,299,318,358,497,578,598],"activity":[40],"a":[42,66],"Phase":[43,71,171,207,485,575],"Ib":[44],"study":[45,74,204,300,370,577],"advanced":[47,84,94,586],"solid":[48],"tumors,":[49,258],"may":[51,518],"delay":[52],"chemoresistance":[53],"progression":[55,286],"on":[56,182,365],"therapy":[58],"BC.":[60],"Study":[61],"design:":[62],"BELLE-4":[63],"(NCT01572727)":[64],"randomized,":[67],"double-blind,":[68],"placebo-controlled,":[69],"adaptive,":[70],"II/III":[72],"seamless":[73],"women":[80,232,583],"HER2-":[82,525,585],"locally":[83,133],"or":[85,106,213,220,243,505,590],"metastatic":[86],"BC":[87,95],"no":[89],"prior":[90],"systemic":[91],"chemotherapy":[92],"for":[93,223,284],"(ABC).":[96],"Patients":[97],"were":[98,198,233,263,320,482],"randomized":[99,234],"(1:1)":[100],"receive":[102,236],"(100":[104],"mg/day)":[105],"placebo":[107,244,277,393],"(80":[110],"mg/m2/week).":[111],"Randomization":[112],"was":[113,129,165,303,405,423,442,459,487,493],"stratified":[114],"by":[115,495],"status":[118],"(activated":[119],"vs":[120,271,276,288,295,308,323,327,331,335,339,343,348,356,392,414,432,451,461],"non-activated)":[121],"hormone":[123,264],"receptor":[124],"status.":[125],"The":[126,313],"primary":[127],"endpoint":[128],"progression-free":[130],"survival":[131],"(PFS;":[132],"assessed":[134],"per":[135,383],"RECIST":[136],"v1.1)":[137],"full":[140,193,211,377,400,457,504],"pathway-activated":[143,196,218,257,380,420,469,507],"populations.":[144,472],"Secondary":[145],"endpoints":[146],"included":[147],"overall":[148,150],"survival,":[149],"response":[151],"rate":[152],"(ORR),":[153],"clinical":[154],"benefit":[155,492],"rate,":[156],"safety":[158],"(CTCAE":[159],"v4.03).":[160],"An":[161],"adaptive":[162],"interim":[163,362,476],"analysis":[164,363],"planned":[166],"at":[167],"end":[169],"II":[172,576],"after":[173],"\u2265125":[174],"PFS":[175,186,367,412,430,449,491],"events":[176,292],"had":[177,255,279],"occurred.":[178],"Decision":[179],"rules":[180],"based":[181],"predefined":[183,385,479],"thresholds":[184],"predictive":[187],"probabilities":[188],"success":[190],"populations":[197,381],"used":[199],"decide":[201],"whether":[202],"would":[205],"enter":[206],"III":[208,486],"(in":[209],"population":[212,458],"restricted":[214],"population),":[219],"be":[221],"stopped":[222],"futility.":[224],"Results:":[225],"As":[226],"June":[228],"7,":[229],"2014,":[230],"338":[231],"(n":[240,247],"=":[241,248],"168)":[242],"170).":[249],"In":[250,398,417,435],"total,":[251],"125":[252],"(37%)":[253],"patients":[254,274],"248":[260],"(73%)":[261],"tumors":[262],"receptor-positive.":[265],"At":[266,360,474],"data":[267],"cut-off,":[268],"112":[269],"(67%)":[270],"93":[272],"(55%)":[273],"(buparlisib":[275,391],"arm)":[278,394],"discontinued":[280],"treatment,":[281],"most":[282,314],"commonly":[283],"disease":[285],"(30%":[287],"35%)":[289],"adverse":[291],"(AEs;":[293],"22%":[294],"8%).":[296],"Median":[297],"duration":[298],"exposure":[302],"3.4":[304],"months":[305,310],"(range:":[306,311],"0.2-16.2)":[307],"4.6":[309],"0.2-20.1).":[312],"frequent":[315],"AEs":[316,352],"(\u226535%":[317],"patients)":[319],"diarrhea":[321],"(55%":[322],"34%),":[324,344],"alopecia":[325],"(49%":[326],"52%),":[328],"nausea":[329],"(45%":[330,334],"27%),":[332],"hyperglycemia":[333],"11%),":[336],"rash":[337],"(40%":[338],"24%),":[340],"fatigue":[341],"(37%":[342],"neutropenia":[346],"(35%":[347],"30%).":[349],"Grade":[350],"3/4":[351],"occurred":[353],"79%":[355],"52%":[357],"patients.":[359],"(based":[364],"131":[366],"events),":[368],"met":[371,483],"futility":[373,480],"criteria":[374,481],"as":[382,396],"decision":[386],"rules.":[387],"Primary":[388],"efficacy":[389],"results":[390],"are":[395],"follows:":[397],"population,":[401,421,440],"hazard":[402],"ratio":[403],"(HR)":[404],"1.18":[406,443],"(95%":[407,425,444],"CI:":[408,426,445],"0.82-1.68)":[409],"median":[411,429,448],"8.0":[413],"9.2":[415,433,452],"months.":[416,434,453],"HR":[422,441],"1.17":[424],"0.63-2.17)":[427],"9.1":[431],"non-activated":[439,471],"0.76-1.83)":[446],"7.3":[450],"ORR":[454],"23%":[460],"27%,":[462],"similar":[464],"trends":[465],"Conclusions:":[473],"analysis,":[477],"not":[488,519],"initiated.":[489],"No":[490],"conferred":[494],"addition":[496],"either":[502],"populations,":[508],"possibly":[509],"due":[510],"limited":[512],"exposure;":[514],"drive":[520],"untreated":[524],"ABC.":[526],"Citation":[527],"Format:":[528],"Miguel":[529],"Mart\u00edn,":[530],"Arlene":[531],"Chan,":[532],"Luc":[533],"Dirix,":[534],"Joyce":[535],"O'Shaughnessy,":[536],"Roberto":[537],"Hegg,":[538],"Alexey":[539],"Manikhas,":[540],"Mikhail":[541],"Shtivelband,":[542],"Petr":[543],"Krivorotko,":[544],"Norberto":[545],"Batista":[546],"L\u00f3pez,":[547],"Mario":[548],"Campone,":[549],"Manuel":[550,559],"Ruiz":[551],"Borrego,":[552],"Qamar":[553],"J.":[554,556],"Khan,":[555],"Thaddeus":[557],"Beck,":[558],"Ramos":[560],"Vasquez,":[561],"Patrick":[562],"Urban,":[563],"Pantelia":[564],"Roussou,":[565],"Emmanuelle":[566],"Di":[567],"Tomaso,":[568],"Cristian":[569],"Massacesi,":[570],"Suzette":[571],"Delaloge.":[572],"BELLE-4:":[573],"A":[574],"cancer,":[588],"without":[591],"activation.":[594],"[abstract].":[595],"In:":[596],"Proceedings":[597],"AACR-NCI-EORTC":[600],"International":[601],"Conference:":[602],"Molecular":[603],"Targets":[604],"Cancer":[606,617],"Therapeutics;":[607],"2015":[608],"Nov":[609],"5-9;":[610],"Boston,":[611],"MA.":[612],"Philadelphia":[613],"(PA):":[614],"AACR;":[615],"Mol":[616],"Ther":[618],"2015;14(12":[619],"Suppl":[620],"2):Abstract":[621],"nr":[622],"A166.":[623]},"counts_by_year":[{"year":2017,"cited_by_count":1}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2016-06-24T00:00:00"}