{"id":"https://openalex.org/W2397633579","doi":null,"title":"[Laboratory and clinical studies of BRL 25000 (clavulanic acid-amoxicillin) granules in the pediatric field].","display_name":"[Laboratory and clinical studies of BRL 25000 (clavulanic acid-amoxicillin) granules in the pediatric field].","publication_year":1985,"publication_date":"1985-02-01","ids":{"openalex":"https://openalex.org/W2397633579","mag":"2397633579","pmid":"https://pubmed.ncbi.nlm.nih.gov/4009952"},"language":"ja","primary_location":{"id":"pmid:4009952","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/4009952","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Japanese journal of antibiotics","raw_type":"English Abstract"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113734686","display_name":"T Nishimura","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T Nishimura","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060728725","display_name":"Kazuo TABUKI","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K Tabuki","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018529587","display_name":"T Takashima","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T Takashima","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5007871975","display_name":"M Takagi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Takagi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"38","issue":"2","first_page":"431","last_page":"40"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11036","display_name":"Antibiotics Pharmacokinetics and Efficacy","score":0.9340999722480774,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11036","display_name":"Antibiotics Pharmacokinetics and Efficacy","score":0.9340999722480774,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10147","display_name":"Antibiotic Resistance in Bacteria","score":0.04569999873638153,"subfield":{"id":"https://openalex.org/subfields/2726","display_name":"Microbiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10897","display_name":"Antibiotic Use and Resistance","score":0.004900000058114529,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/amoxicillin-clavulanic-acid","display_name":"amoxicillin-clavulanic acid","score":0.9179999828338623},{"id":"https://openalex.org/keywords/pediatric-antibiotic-therapy","display_name":"pediatric antibiotic therapy","score":0.6859999895095825},{"id":"https://openalex.org/keywords/antibacterial-activity","display_name":"antibacterial activity","score":0.7170000076293945},{"id":"https://openalex.org/keywords/beta-lactamase","display_name":"beta-lactamase","score":0.7559999823570251},{"id":"https://openalex.org/keywords/staphylococcus-aureus","display_name":"Staphylococcus aureus","score":0.9340000152587891},{"id":"https://openalex.org/keywords/escherichia-coli","display_name":"Escherichia coli","score":0.9990000128746033},{"id":"https://openalex.org/keywords/klebsiella-pneumoniae","display_name":"Klebsiella pneumoniae","score":1.0},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.859000027179718},{"id":"https://openalex.org/keywords/oral-granules","display_name":"oral granules","score":0.5699999928474426},{"id":"https://openalex.org/keywords/serum-drug-levels","display_name":"serum drug concentration","score":0.47699999809265137},{"id":"https://openalex.org/keywords/beta-lactamase-inhibitors","display_name":"beta-lactamase inhibitors","score":0.578000009059906}],"concepts":[{"id":"https://openalex.org/C2779454058","wikidata":"https://www.wikidata.org/wiki/Q415709","display_name":"Clavulanic acid","level":4,"score":0.8279305696487427},{"id":"https://openalex.org/C2779708577","wikidata":"https://www.wikidata.org/wiki/Q201928","display_name":"Amoxicillin","level":3,"score":0.7360525727272034},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.6117127537727356},{"id":"https://openalex.org/C2779766023","wikidata":"https://www.wikidata.org/wiki/Q415167","display_name":"Cefaclor","level":4,"score":0.5866401195526123},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.5681231021881104},{"id":"https://openalex.org/C2776205632","wikidata":"https://www.wikidata.org/wiki/Q415709","display_name":"Amoxicillin/clavulanic acid","level":5,"score":0.5346996188163757},{"id":"https://openalex.org/C51296783","wikidata":"https://www.wikidata.org/wiki/Q1645498","display_name":"Microgram","level":3,"score":0.5147038102149963},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.5023961067199707},{"id":"https://openalex.org/C2910641391","wikidata":"https://www.wikidata.org/wiki/Q310286","display_name":"Beta-Lactamase Inhibitors","level":3,"score":0.49715903401374817},{"id":"https://openalex.org/C3019249092","wikidata":"https://www.wikidata.org/wiki/Q274493","display_name":"Antibacterial agent","level":3,"score":0.47486424446105957},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.39009663462638855},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3838844299316406},{"id":"https://openalex.org/C64778159","wikidata":"https://www.wikidata.org/wiki/Q271021","display_name":"Cephalosporin","level":3,"score":0.3355696201324463},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3201982378959656},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3008619248867035},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.22429877519607544},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.12840285897254944}],"mesh":[{"descriptor_ui":"D000284","descriptor_name":"Administration, Oral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000658","descriptor_name":"Amoxicillin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000658","descriptor_name":"Amoxicillin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000658","descriptor_name":"Amoxicillin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000658","descriptor_name":"Amoxicillin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D001419","descriptor_name":"Bacteria","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001424","descriptor_name":"Bacterial Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002969","descriptor_name":"Clavulanic Acids","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D002969","descriptor_name":"Clavulanic Acids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002969","descriptor_name":"Clavulanic Acids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002969","descriptor_name":"Clavulanic Acids","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D004304","descriptor_name":"Dosage Forms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004338","descriptor_name":"Drug Combinations","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D004338","descriptor_name":"Drug Combinations","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004338","descriptor_name":"Drug Combinations","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004338","descriptor_name":"Drug Combinations","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D004341","descriptor_name":"Drug Evaluation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006207","descriptor_name":"Half-Life","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007223","descriptor_name":"Infant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019980","descriptor_name":"Amoxicillin-Potassium Clavulanate Combination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:4009952","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/4009952","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Japanese journal of antibiotics","raw_type":"English Abstract"},{"id":"mag:2397633579","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/4009952","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2408095995","https://openalex.org/W2408881394","https://openalex.org/W2413219686","https://openalex.org/W2153951363","https://openalex.org/W7100873753","https://openalex.org/W612107063","https://openalex.org/W3149429907","https://openalex.org/W374699944","https://openalex.org/W208280880","https://openalex.org/W355286672"],"abstract_inverted_index":{"The":[0,23,66,107,227,253],"authors":[1],"have":[2],"carried":[3],"out":[4,292],"laboratory":[5,312],"and":[6,18,40,140,156,224,235,243,249,261,273,308,327],"clinical":[7,278],"studies":[8],"on":[9],"the":[10,47,63,81,118,141,157,215,280],"BRL":[11,27,69,190,206,281],"25000":[12,28,70,191,207,282],"granule":[13,283],"(containing":[14],"2":[15,304],"parts":[16],"amoxicillin":[17],"1":[19,239,265],"part":[20],"clavulanic":[21],"acid).":[22],"antibacterial":[24],"activity":[25],"of":[26,34,55,68,83,96,130,150,178,221,231,247,257,271,289,293,296,306,316,322],"against":[29,71,109,160],"29":[30],"clinically":[31],"isolated":[32],"strains":[33,84,95,129,149],"S.":[35,72,97],"aureus,":[36],"30":[37,41],"E.":[38,110,131],"coli":[39,111,132],"K.":[42,151,161,188],"pneumoniae":[43,152,162],"were":[44,99,133,153,180,209,233,259,301,314],"measured":[45],"by":[46,62,87,102,121,135,143,172,182],"agar":[48],"dilution":[49],"method":[50],"using":[51],"an":[52],"inoculum":[53],"size":[54],"10(6)":[56],"cells/ml.":[57],"beta-Lactamase":[58],"production":[59],"was":[60,112,163,284],"detected":[61],"Nitrocefin":[64],"method.":[65],"MICs":[67],"aureus":[73,98],"ranged":[74],"from":[75],"0.2":[76],"approximately":[77,114,137,165,238],"12.5":[78,105],"micrograms/ml,":[79,116,167],"with":[80,117,168,200,245,269],"majority":[82,119,142,170],"being":[85],"inhibited":[86,101,120,134,171,181],"1.56":[88,113,164],"micrograms/ml":[89,123,139,145,174,237,263],"or":[90,124,146,175],"less.":[91,125,147],"Seven":[92],"beta-lactamase":[93,127,154],"producing":[94,128],"all":[100],"less":[103,183],"than":[104,184],"micrograms/ml.":[106,186],"range":[108],"100":[115,138],"6.25":[122,136,185],"Fifteen":[126],"25":[144],"All":[148],"producers":[155],"MIC":[158],"distribution":[159],"50":[166],"a":[169,193,203,294],"3.13":[173],"less,":[176],"96%":[177],"strains,":[179],"Against":[187],"pneumoniae,":[189],"showed":[192],"8":[194],"to":[195,212,303],"16-fold":[196],"superiority":[197],"when":[198],"compared":[199],"AMPC.":[201],"In":[202,277],"pharmacokinetic":[204],"study,":[205],"granules":[208],"orally":[210],"administered":[211],"children":[213],"in":[214,286,311],"fasting":[216],"state":[217],"at":[218,264],"single":[219],"doses":[220],"7.5":[222],"mg/kg":[223],"20":[225],"mg/kg.":[226],"peak":[228],"serum":[229,255,317,323],"levels":[230,256],"AMPC":[232],"6.13":[234],"6.94":[236],"hour":[240,266],"after":[241,267],"administration":[242],"decreased":[244],"half-lives":[246,270],"1.08":[248],"0.97":[250],"hours,":[251],"respectively.":[252,276],"corresponding":[254],"CVA":[258],"1.16":[260],"1.90":[262],"administration,":[268],"0.99":[272],"0.87":[274],"hour,":[275],"studies,":[279],"effective":[285],"39":[287],"cases":[288,305],"bacterial":[290],"infection":[291],"total":[295],"41":[297],"treated.":[298],"Side":[299],"effects":[300],"limited":[302],"diarrhea":[307],"minor":[309],"changes":[310],"findings":[313],"elevation":[315,321],"GOT":[318],"(1":[319,325],"case),":[320,326],"GPT":[324],"eosinophilia":[328],"(2":[329],"cases).":[330]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
