{"id":"https://openalex.org/W2397621937","doi":"https://doi.org/10.1158/1538-7445.compsysbio-b1-32","title":"Abstract B1-32: Genome-wide integrative analysis correlating locus-specific DNA methylation and hydroxymethylation to gene expression in normal prostate cells","display_name":"Abstract B1-32: Genome-wide integrative analysis correlating locus-specific DNA methylation and hydroxymethylation to gene expression in normal prostate cells","publication_year":2015,"publication_date":"2015-11-15","ids":{"openalex":"https://openalex.org/W2397621937","doi":"https://doi.org/10.1158/1538-7445.compsysbio-b1-32","mag":"2397621937"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.compsysbio-b1-32","doi":"https://doi.org/10.1158/1538-7445.compsysbio-b1-32","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.compsysbio-b1-32","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5029133774","display_name":"Shivani N. Kamdar","orcid":"https://orcid.org/0000-0003-2812-3865","observed_orcids":["https://orcid.org/0000-0003-2812-3865"]},"institutions":[{"id":"https://openalex.org/I1291836623","display_name":"Mount Sinai Hospital","ror":"https://ror.org/05deks119","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1291836623","https://openalex.org/I4210130843"]},{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]},{"id":"https://openalex.org/I210557978","display_name":"Lunenfeld-Tanenbaum Research Institute","ror":"https://ror.org/01s5axj25","country_code":"CA","type":"facility","lineage":["https://openalex.org/I1291836623","https://openalex.org/I210557978","https://openalex.org/I4210130843"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Shivani N. Kamdar","raw_affiliation_strings":["1Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital & University of Toronto, Toronto, ON, Canada,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital & University of Toronto, Toronto, ON, Canada,","institution_ids":["https://openalex.org/I1291836623","https://openalex.org/I185261750","https://openalex.org/I210557978"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088634252","display_name":"Linh Ho","orcid":"https://orcid.org/0000-0001-9252-8539","observed_orcids":["https://orcid.org/0000-0001-9252-8539"]},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Linh T. Ho","raw_affiliation_strings":["2University of Toronto, Toronto, ON, Canada,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2University of Toronto, Toronto, ON, Canada,","institution_ids":["https://openalex.org/I185261750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060081041","display_name":"Ruth Isserlin","orcid":"https://orcid.org/0000-0002-6805-2080","observed_orcids":["https://orcid.org/0000-0002-6805-2080"]},"institutions":[{"id":"https://openalex.org/I4405287053","display_name":"Donnelly Centre for Cellular and Biomolecular Research","ror":"https://ror.org/0400kyd42","country_code":"CA","type":"facility","lineage":["https://openalex.org/I185261750","https://openalex.org/I4405287053"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Ruth Isserlin","raw_affiliation_strings":["3The Donnelly Centre for Cellular and Biomolecular Research, Toronto, ON, Canada,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3The Donnelly Centre for Cellular and Biomolecular Research, Toronto, ON, Canada,","institution_ids":["https://openalex.org/I4405287053"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076255258","display_name":"Ken J. Kron","orcid":"https://orcid.org/0009-0008-8790-1130","observed_orcids":["https://orcid.org/0009-0008-8790-1130"]},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Ken J. Kron","raw_affiliation_strings":["2University of Toronto, Toronto, ON, Canada,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2University of Toronto, Toronto, ON, Canada,","institution_ids":["https://openalex.org/I185261750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057500759","display_name":"Theodorus van der Kwast","orcid":"https://orcid.org/0000-0001-8640-5786","observed_orcids":["https://orcid.org/0000-0001-8640-5786"]},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Theodorus van der Kwast","raw_affiliation_strings":["2University of Toronto, Toronto, ON, Canada,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2University of Toronto, Toronto, ON, Canada,","institution_ids":["https://openalex.org/I185261750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012397578","display_name":"Alexandre R. Zlotta","orcid":"https://orcid.org/0000-0003-2315-5809","observed_orcids":["https://orcid.org/0000-0003-2315-5809"]},"institutions":[{"id":"https://openalex.org/I1291836623","display_name":"Mount Sinai Hospital","ror":"https://ror.org/05deks119","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1291836623","https://openalex.org/I4210130843"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Alexandre R. Zlotta","raw_affiliation_strings":["4Division of Urology, Mount Sinai Hospital, Toronto, ON, Canada,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4Division of Urology, Mount Sinai Hospital, Toronto, ON, Canada,","institution_ids":["https://openalex.org/I1291836623"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007710281","display_name":"Neil Eric Fleshner","orcid":"https://orcid.org/0000-0001-7407-7463","observed_orcids":["https://orcid.org/0000-0001-7407-7463"]},"institutions":[{"id":"https://openalex.org/I1325899441","display_name":"University Health Network","ror":"https://ror.org/042xt5161","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441"]},{"id":"https://openalex.org/I2802654988","display_name":"Princess Margaret Cancer Centre","ror":"https://ror.org/03zayce58","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441","https://openalex.org/I2802654988"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Neil E. Fleshner","raw_affiliation_strings":["5Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"5Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada","institution_ids":["https://openalex.org/I1325899441","https://openalex.org/I2802654988"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010789029","display_name":"Gary D. Bader","orcid":"https://orcid.org/0000-0003-0185-8861","observed_orcids":["https://orcid.org/0000-0003-0185-8861"]},"institutions":[{"id":"https://openalex.org/I4405287053","display_name":"Donnelly Centre for Cellular and Biomolecular Research","ror":"https://ror.org/0400kyd42","country_code":"CA","type":"facility","lineage":["https://openalex.org/I185261750","https://openalex.org/I4405287053"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Gary Bader","raw_affiliation_strings":["3The Donnelly Centre for Cellular and Biomolecular Research, Toronto, ON, Canada,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3The Donnelly Centre for Cellular and Biomolecular Research, Toronto, ON, Canada,","institution_ids":["https://openalex.org/I4405287053"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5057092796","display_name":"Bharati V. Bapat","orcid":"https://orcid.org/0000-0002-7684-1338","observed_orcids":["https://orcid.org/0000-0002-7684-1338"]},"institutions":[{"id":"https://openalex.org/I1291836623","display_name":"Mount Sinai Hospital","ror":"https://ror.org/05deks119","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1291836623","https://openalex.org/I4210130843"]},{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]},{"id":"https://openalex.org/I210557978","display_name":"Lunenfeld-Tanenbaum Research Institute","ror":"https://ror.org/01s5axj25","country_code":"CA","type":"facility","lineage":["https://openalex.org/I1291836623","https://openalex.org/I210557978","https://openalex.org/I4210130843"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Bharati Bapat","raw_affiliation_strings":["1Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital & University of Toronto, Toronto, ON, Canada,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital & University of Toronto, Toronto, ON, Canada,","institution_ids":["https://openalex.org/I1291836623","https://openalex.org/I185261750","https://openalex.org/I210557978"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"75","issue":"22_Supplement_2","first_page":"B1","last_page":"32"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dna-methylation","display_name":"DNA methylation","score":0.8989999890327454},{"id":"https://openalex.org/keywords/5-hydroxymethylcytosine","display_name":"5-hydroxymethylcytosine","score":0.9779999852180481},{"id":"https://openalex.org/keywords/hydroxymethylation","display_name":"hydroxymethylation","score":0.8370000123977661},{"id":"https://openalex.org/keywords/gene-expression","display_name":"gene expression","score":0.6389999985694885},{"id":"https://openalex.org/keywords/prostate-cancer","display_name":"prostate cancer","score":0.7279999852180481},{"id":"https://openalex.org/keywords/promoter-methylation","display_name":"promoter methylation","score":0.7799999713897705},{"id":"https://openalex.org/keywords/cpg-islands","display_name":"CpG islands","score":0.9549999833106995},{"id":"https://openalex.org/keywords/dnase-i-hypersensitive-sites","display_name":"DNase I hypersensitive sites","score":0.8960000276565552},{"id":"https://openalex.org/keywords/open-chromatin","display_name":"open chromatin","score":0.9089999794960022},{"id":"https://openalex.org/keywords/mbd-seq","display_name":"MBD-seq","score":0.6980000138282776},{"id":"https://openalex.org/keywords/prostate-tumorigenesis","display_name":"prostate tumorigenesis","score":0.7020000219345093}],"concepts":[{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.8180190920829773},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7030744552612305},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.6249913573265076},{"id":"https://openalex.org/C121912465","wikidata":"https://www.wikidata.org/wiki/Q3589153","display_name":"Epigenomics","level":5,"score":0.5591459274291992},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5551443696022034},{"id":"https://openalex.org/C140173407","wikidata":"https://www.wikidata.org/wiki/Q1138358","display_name":"CpG site","level":5,"score":0.5361129641532898},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.5339044332504272},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.46674591302871704},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.45554935932159424},{"id":"https://openalex.org/C111936080","wikidata":"https://www.wikidata.org/wiki/Q913367","display_name":"Enhancer","level":4,"score":0.4428198039531708},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.441715806722641},{"id":"https://openalex.org/C33288867","wikidata":"https://www.wikidata.org/wiki/Q518328","display_name":"Methylation","level":3,"score":0.42259982228279114},{"id":"https://openalex.org/C101762097","wikidata":"https://www.wikidata.org/wiki/Q224093","display_name":"Promoter","level":4,"score":0.41640934348106384}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.compsysbio-b1-32","doi":"https://doi.org/10.1158/1538-7445.compsysbio-b1-32","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.compsysbio-b1-32","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2898530667","https://openalex.org/W2299160489","https://openalex.org/W2999227809","https://openalex.org/W2498735961","https://openalex.org/W4306412026","https://openalex.org/W2887974597","https://openalex.org/W7163305486","https://openalex.org/W2070166913","https://openalex.org/W4307862138","https://openalex.org/W2071642351"],"abstract_inverted_index":{"Abstract":[0],"Aberrant":[1],"epigenetic":[2,512],"modification":[3],"in":[4,16,22,39,54,75,85,97,132,151,302,331,367,382,389,397,442,458,473,487,514,547,590],"the":[5,17,40,76,344,364,447,509,598],"form":[6],"of":[7,19,42,78,114,284,338,363,379,511,522,597,607],"regional":[8],"hypermethylation":[9],"and":[10,94,101,129,144,147,169,174,199,208,235,238,273,300,306,326,360,392,414,420,422,439,470,478,485,505,585,604],"global":[11,52,453],"hypomethylation":[12],"has":[13,465],"been":[14,47],"implicated":[15,546],"dysregulation":[18],"gene":[20,79,83,109,258,262,289,333,517,588],"expression":[21,80,149,203,215,223,263,290,369,408,457,486,589],"various":[23],"cancers,":[24],"including":[25],"prostate":[26,133,154,460,504,548,592],"cancer":[27,515,549],"(PCa).":[28],"Recently":[29],"discovered":[30],"5-hydroxymethylated":[31],"marks":[32,117,146,252,381,441,534],"(5hmC),":[33],"considered":[34],"to":[35,49,59,63,188,202,264,282,293,310,350,402,431,450,456,507,539,587],"be":[36,294,496],"key":[37,73,433,523],"intermediates":[38],"process":[41],"DNA":[43,583],"demethylation,":[44],"have":[45,161,175,239],"also":[46,70,209],"shown":[48,466],"exhibit":[50,265],"significant":[51],"loss":[53],"solid":[55],"tumors":[56],"as":[57,193,195,411],"compared":[58],"normal":[60,153,443,459,503,591],"tissue.":[61],"Similar":[62],"cytosine":[64],"base":[65],"methylation":[66,116,283,299,584],"(5mC),":[67],"5hmC":[68,95,145,251,359,393,438,454,469,531],"may":[69,118,327],"play":[71,328],"a":[72,152,266,278,329,372],"role":[74,330,375],"regulation":[77],"and,":[81],"consequently,":[82],"function":[84],"PCa.":[86],"We":[87,160,221,260],"hypothesize":[88],"that":[89],"dynamic":[90,527],"interplay":[91],"between":[92,468,502],"5mC":[93,143,249,361,391,440,471,533],"enrichment":[96,362,396,455,472,528],"promoter,":[98,196,475],"CpG":[99,197,274,476],"island,":[100,198,477],"intragenic":[102,200,304,377,390],"regions":[103,186,305,308,484],"shows":[104],"specific":[105],"association":[106],"patterns":[107,529],"with":[108,230,270,277,297,323,354],"expression.":[110,518],"A":[111],"systematic":[112],"investigation":[113],"these":[115,285,339,380,429],"provide":[119],"novel":[120,127],"insights":[121],"into":[122,225],"epigenomic":[123],"architecture":[124],"by":[125,183,257,437],"elucidating":[126],"pathways":[128,366,387,430,525],"candidate":[130,434],"genes":[131,181,229,244,435,545],"tumorigenesis.":[134,550],"Using":[135],"Next":[136],"Generation":[137],"Sequencing":[138],"(NGS),":[139],"we":[140,426],"characterized":[141],"genome-wide":[142],"RNA":[148,423],"data":[150,204,216,224],"tissue-derived":[155],"representative":[156],"cell":[157],"line":[158],"(RWPE-1).":[159],"completed":[162],"NGS":[163],"following":[164],"methyl-binding":[165],"protein":[166,421],"capture":[167],"(MBD-seq)":[168],"hydroxymethyl-selective":[170],"chemical":[171],"labeling":[172],"(hMe-Seal),":[173],"performed":[176,240],"integrative":[177,579],"analysis":[178,242,337,464,501,580],"correlating":[179,581],"enriched":[180,246],"stratified":[182,256,340],"region":[184],"(intergenic":[185],"proximal":[187,309],"DNase":[189,312,480],"I":[190,313,481],"hypersensitivity":[191,314,482],"sites,":[192],"well":[194],"regions)":[201],"obtained":[205],"from":[206,491],"RNA-seq":[207],"validated":[210],"using":[211],"publicly":[212],"available":[213],"microarray":[214],"(GEO":[217,316],"Accession":[218,317],"Number:":[219,318],"GSM375783)":[220],"divided":[222],"equal":[226],"tiers":[227],"representing":[228],"no":[231],"expression,":[232,234,237],"low":[233],"high":[236,355],"pathway-based":[241,336],"on":[243,516,602],"significantly":[245],"for":[247,253,376,530],"either":[248],"or":[250,532],"each":[254,368,407],"tier":[255],"region.":[259],"found":[261,292],"strong":[267,395],"positive":[268],"correlation":[269,281,467],"core":[271,403],"promoter":[272],"island":[275],"hydroxymethylation,":[276],"corresponding":[279],"negative":[280],"regions.":[286],"In":[287],"contrast,":[288],"was":[291],"positively":[295],"correlated":[296],"both":[298,303],"hydroxymethylation":[301,586],"intergenic":[307],"ENCODE":[311],"sites":[315],"GSM1008595),":[319],"which":[320],"are":[321,427],"associated":[322],"open":[324],"chromatin":[325],"downstream":[332],"regulation.":[334],"Interestingly,":[335],"tiers,":[341],"grouped":[342],"via":[343,498],"Molecular":[345],"Complex":[346],"Detection":[347],"algorithm":[348],"(MCODE)":[349],"identify":[351,432,540],"pathway":[352],"clusters":[353],"biological":[356,384],"significance,":[357],"showed":[358,394],"same":[365],"tier,":[370,409],"suggesting":[371],"possible":[373],"co-operative":[374],"co-expression":[378],"regulating":[383],"pathways.":[385],"Clustered":[386],"co-enriched":[388],"Gene":[398],"Ontology":[399],"terms":[400],"related":[401],"cellular":[404,524],"functions":[405],"within":[406],"such":[410],"ion":[412],"channel":[413],"transport":[415],"regulation,":[416],"primary":[417],"metabolic":[418],"processes,":[419],"binding.":[424],"Currently,":[425],"investigating":[428],"regulated":[436],"prostate.":[444],"This":[445],"is":[446],"first":[448],"study":[449],"correlate":[451],"locus-specific":[452,582],"cells.":[461,489,593],"Our":[462],"preliminary":[463],"genic,":[474],"upstream":[479],"site-proximal":[483],"RWPE-1":[488],"Insights":[490],"this":[492],"model":[493],"will":[494,535],"subsequently":[495],"explored":[497],"whole-genome":[499],"differential":[500],"PCa":[506],"determine":[508],"effect":[510],"alterations":[513],"Subsequently,":[519],"our":[520],"characterization":[521],"exhibiting":[526],"potentially":[536],"allow":[537],"us":[538],"differentially":[541],"epigenetically":[542],"modified":[543],"target":[544],"Citation":[551],"Format:":[552],"Shivani":[553],"N.":[554],"Kamdar,":[555],"Linh":[556],"T.":[557],"Ho,":[558],"Ruth":[559],"Isserlin,":[560],"Ken":[561],"J.":[562],"Kron,":[563],"Theodorus":[564],"van":[565],"der":[566],"Kwast,":[567],"Alexandre":[568],"R.":[569],"Zlotta,":[570],"Neil":[571],"E.":[572],"Fleshner,":[573],"Gary":[574],"Bader,":[575],"Bharati":[576],"Bapat.":[577],"Genome-wide":[578],"[abstract].":[594],"In:":[595],"Proceedings":[596],"AACR":[599],"Special":[600],"Conference":[601],"Computational":[603],"Systems":[605],"Biology":[606],"Cancer;":[608],"Feb":[609],"8-11":[610],"2015;":[611],"San":[612],"Francisco,":[613],"CA.":[614],"Philadelphia":[615],"(PA):":[616],"AACR;":[617],"Cancer":[618],"Res":[619],"2015;75(22":[620],"Suppl":[621],"2):Abstract":[622],"nr":[623],"B1-32.":[624]},"counts_by_year":[],"updated_date":"2026-10-24T09:50:30.924529","created_date":"2016-06-24T00:00:00"}