{"id":"https://openalex.org/W2397615744","doi":"https://doi.org/10.1152/ajpheart.1997.272.2.h859","title":"In vivo angiotensin II receptor blockade and converting enzyme inhibition on canine aortic viscoelasticity","display_name":"In vivo angiotensin II receptor blockade and converting enzyme inhibition on canine aortic viscoelasticity","publication_year":1997,"publication_date":"1997-02-01","ids":{"openalex":"https://openalex.org/W2397615744","doi":"https://doi.org/10.1152/ajpheart.1997.272.2.h859","mag":"2397615744","pmid":"https://pubmed.ncbi.nlm.nih.gov/9124449"},"language":"en","primary_location":{"id":"doi:10.1152/ajpheart.1997.272.2.h859","doi":"https://doi.org/10.1152/ajpheart.1997.272.2.h859","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajpheart.1997.272.2.h859","pdf_url":null,"source":{"id":"https://openalex.org/S87338489","display_name":"American Journal of Physiology-Heart and Circulatory Physiology","issn_l":"0363-6135","issn":["0363-6135","1522-1539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320261","host_organization_name":"American Physical Society","host_organization_lineage":["https://openalex.org/P4310320261"],"host_organization_lineage_names":["American Physical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Heart and Circulatory Physiology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5017116477","display_name":"Juan Gabriel Barra","orcid":"https://orcid.org/0000-0003-3504-9261","observed_orcids":["https://orcid.org/0000-0003-3504-9261"]},"institutions":[{"id":"https://openalex.org/I187398979","display_name":"Favaloro University","ror":"https://ror.org/05s004555","country_code":"AR","type":"education","lineage":["https://openalex.org/I187398979"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"J. G. Barra","raw_affiliation_strings":["Basic Sciences Research Institute, The Rene Favaloro UniversityFoundation, Buenos Aires, Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Basic Sciences Research Institute, The Rene Favaloro UniversityFoundation, Buenos Aires, Argentina","institution_ids":["https://openalex.org/I187398979"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110145364","display_name":"Jaime A. Levenson","orcid":"https://orcid.org/0009-0002-2345-1296","observed_orcids":["https://orcid.org/0009-0002-2345-1296"]},"institutions":[{"id":"https://openalex.org/I187398979","display_name":"Favaloro University","ror":"https://ror.org/05s004555","country_code":"AR","type":"education","lineage":["https://openalex.org/I187398979"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"J. Levenson","raw_affiliation_strings":["Basic Sciences Research Institute, The Rene Favaloro UniversityFoundation, Buenos Aires, Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Basic Sciences Research Institute, The Rene Favaloro UniversityFoundation, Buenos Aires, Argentina","institution_ids":["https://openalex.org/I187398979"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079077713","display_name":"Ricardo L. Armentano","orcid":"https://orcid.org/0000-0003-3455-2033","observed_orcids":["https://orcid.org/0000-0003-3455-2033"]},"institutions":[{"id":"https://openalex.org/I187398979","display_name":"Favaloro University","ror":"https://ror.org/05s004555","country_code":"AR","type":"education","lineage":["https://openalex.org/I187398979"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"R. L. Armentano","raw_affiliation_strings":["Basic Sciences Research Institute, The Rene Favaloro UniversityFoundation, Buenos Aires, Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Basic Sciences Research Institute, The Rene Favaloro UniversityFoundation, Buenos Aires, Argentina","institution_ids":["https://openalex.org/I187398979"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102433597","display_name":"Edmundo I. Cabrera Fischer","orcid":"https://orcid.org/0000-0002-5087-0106","observed_orcids":["https://orcid.org/0000-0002-5087-0106"]},"institutions":[{"id":"https://openalex.org/I187398979","display_name":"Favaloro University","ror":"https://ror.org/05s004555","country_code":"AR","type":"education","lineage":["https://openalex.org/I187398979"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"E. I. Cabrera Fischer","raw_affiliation_strings":["Basic Sciences Research Institute, The Rene Favaloro UniversityFoundation, Buenos Aires, Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Basic Sciences Research Institute, The Rene Favaloro UniversityFoundation, Buenos Aires, Argentina","institution_ids":["https://openalex.org/I187398979"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003880773","display_name":"Ricardo Horacio Pichel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I187398979","display_name":"Favaloro University","ror":"https://ror.org/05s004555","country_code":"AR","type":"education","lineage":["https://openalex.org/I187398979"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"R. H. Pichel","raw_affiliation_strings":["Basic Sciences Research Institute, The Rene Favaloro UniversityFoundation, Buenos Aires, Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Basic Sciences Research Institute, The Rene Favaloro UniversityFoundation, Buenos Aires, Argentina","institution_ids":["https://openalex.org/I187398979"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112141411","display_name":"Alain C. Simon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I187398979","display_name":"Favaloro University","ror":"https://ror.org/05s004555","country_code":"AR","type":"education","lineage":["https://openalex.org/I187398979"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"A. Simon","raw_affiliation_strings":["Basic Sciences Research Institute, The Rene Favaloro UniversityFoundation, Buenos Aires, Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Basic Sciences Research Institute, The Rene Favaloro UniversityFoundation, Buenos Aires, Argentina","institution_ids":["https://openalex.org/I187398979"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I187398979"],"apc_list":null,"apc_paid":null,"fwci":0.7656,"has_fulltext":false,"cited_by_count":32,"citation_normalized_percentile":{"value":0.76156314,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"272","issue":"2","first_page":"H859","last_page":"H868"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11001","display_name":"Renin-Angiotensin System Studies","score":0.8515999913215637,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11001","display_name":"Renin-Angiotensin System Studies","score":0.8515999913215637,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10924","display_name":"Cardiovascular Health and Disease Prevention","score":0.13220000267028809,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12067","display_name":"Renal and Vascular Pathologies","score":0.0052999998442828655,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/renin-angiotensin-system","display_name":"renin-angiotensin system","score":0.9340000152587891},{"id":"https://openalex.org/keywords/angiotensin-ii-receptor-blockade","display_name":"angiotensin II receptor blockade","score":0.9490000009536743},{"id":"https://openalex.org/keywords/angiotensin-converting-enzyme-inhibition","display_name":"angiotensin-converting enzyme inhibition","score":0.9430000185966492},{"id":"https://openalex.org/keywords/enalaprilat","display_name":"enalaprilat","score":0.9229999780654907},{"id":"https://openalex.org/keywords/aortic-stiffness","display_name":"aortic stiffness","score":0.824999988079071},{"id":"https://openalex.org/keywords/arterial-compliance","display_name":"arterial compliance","score":0.7120000123977661},{"id":"https://openalex.org/keywords/renovascular-hypertension","display_name":"renovascular hypertension","score":0.8240000009536743},{"id":"https://openalex.org/keywords/large-arteries","display_name":"large arteries","score":0.3959999978542328}],"concepts":[{"id":"https://openalex.org/C2777814262","wikidata":"https://www.wikidata.org/wiki/Q5375179","display_name":"Enalaprilat","level":5,"score":0.8656789660453796},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6966208219528198},{"id":"https://openalex.org/C123915805","wikidata":"https://www.wikidata.org/wiki/Q15332826","display_name":"Angiotensin II receptor type 1","level":4,"score":0.5976638197898865},{"id":"https://openalex.org/C2908929049","wikidata":"https://www.wikidata.org/wiki/Q65963433","display_name":"Angiotensin II","level":3,"score":0.5811148285865784},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5407931208610535},{"id":"https://openalex.org/C2781460075","wikidata":"https://www.wikidata.org/wiki/Q1399332","display_name":"Compliance (psychology)","level":2,"score":0.46339040994644165},{"id":"https://openalex.org/C198710026","wikidata":"https://www.wikidata.org/wiki/Q898218","display_name":"Renin\u2013angiotensin system","level":3,"score":0.45395392179489136},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4519984722137451},{"id":"https://openalex.org/C2780288358","wikidata":"https://www.wikidata.org/wiki/Q410074","display_name":"Losartan","level":4,"score":0.4184441566467285},{"id":"https://openalex.org/C27016395","wikidata":"https://www.wikidata.org/wiki/Q128861","display_name":"Angiotensin-converting enzyme","level":3,"score":0.40763595700263977},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.38573163747787476},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.3712628483772278},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3641813397407532},{"id":"https://openalex.org/C2779611605","wikidata":"https://www.wikidata.org/wiki/Q288280","display_name":"ACE inhibitor","level":4,"score":0.26437878608703613},{"id":"https://openalex.org/C77805123","wikidata":"https://www.wikidata.org/wiki/Q161272","display_name":"Social psychology","level":1,"score":0.0},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000803","descriptor_name":"Angiotensin I","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D000806","descriptor_name":"Angiotensin-Converting Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000959","descriptor_name":"Antihypertensive Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D001011","descriptor_name":"Aorta","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D001011","descriptor_name":"Aorta","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001011","descriptor_name":"Aorta","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004285","descriptor_name":"Dogs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004548","descriptor_name":"Elasticity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006978","descriptor_name":"Hypertension, Renovascular","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D007093","descriptor_name":"Imidazoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012016","descriptor_name":"Reference Values","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013777","descriptor_name":"Tetrazoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D014783","descriptor_name":"Viscosity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015773","descriptor_name":"Enalaprilat","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D019808","descriptor_name":"Losartan","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057911","descriptor_name":"Angiotensin Receptor Antagonists","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1152/ajpheart.1997.272.2.h859","doi":"https://doi.org/10.1152/ajpheart.1997.272.2.h859","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajpheart.1997.272.2.h859","pdf_url":null,"source":{"id":"https://openalex.org/S87338489","display_name":"American Journal of Physiology-Heart and Circulatory Physiology","issn_l":"0363-6135","issn":["0363-6135","1522-1539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320261","host_organization_name":"American Physical Society","host_organization_lineage":["https://openalex.org/P4310320261"],"host_organization_lineage_names":["American Physical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Heart and Circulatory Physiology","raw_type":"journal-article"},{"id":"pmid:9124449","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9124449","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American journal of physiology","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8560000061988831,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1997928493","https://openalex.org/W2399469128","https://openalex.org/W2436448593","https://openalex.org/W4233418264","https://openalex.org/W2094820435","https://openalex.org/W2124634432","https://openalex.org/W1974052403","https://openalex.org/W76533850","https://openalex.org/W2006095281","https://openalex.org/W4230218913"],"abstract_inverted_index":{"The":[0],"influence":[1],"of":[2,66,90,185,189],"the":[3,8,67,72,83,134,151,183,186],"renin-angiotensin":[4],"system":[5],"(RAS)":[6],"on":[7],"aortic":[9,59,68,95],"wall":[10,69,96,99],"mechanical":[11],"properties":[12],"under":[13],"angiotensin":[14,24],"I":[15],"converting":[16,170],"enzyme":[17,171],"inhibition":[18,172],"(enalaprilat,":[19],"0.3":[20],"mg/kg":[21,31],"iv)":[22,32],"or":[23],"II":[25],"receptor":[26],"(AT1)":[27],"blockade":[28],"(E-3174,":[29],"1":[30],"was":[33,116],"examined":[34],"in":[35,112,167],"eight":[36,39],"normotensive":[37,106,113,144,168],"and":[38,55,77,98,115,127,132,154,160],"renovascular":[40],"hypertensive":[41,124],"conscious":[42],"dogs.":[43],"Aortic":[44],"diameter":[45],"(D;":[46],"sonomicrometry)-pressure":[47],"(P;":[48],"microtransducer)":[49],"hysteresis":[50,63],"loops":[51],"during":[52,56,118],"steady":[53],"state":[54],"rapid":[57],"distal":[58],"occlusion":[60],"allowed":[61],"(after":[62],"elimination)":[64],"calculation":[65],"viscosity":[70,100,130,155,162],"index,":[71,156],"purely":[73],"elastic":[74],"P-D":[75],"relationship,":[76],"derivation":[78],"into":[79],"compliance-pressure":[80,135,152],"curves.":[81],"At":[82],"early":[84],"stage":[85],"ofrenovascular":[86],"hypertension":[87,119],"when":[88],"activation":[89],"RAS":[91],"is":[92],"more":[93],"pronounced,":[94],"stiffness":[97],"were":[101],"increased":[102,158],"as":[103],"compared":[104],"with":[105,138],"states.":[107],"Blood":[108],"pressure":[109],"remained":[110],"unchanged":[111],"animals":[114],"reduced":[117,161],"after":[120],"antihypertensive":[121],"treatments.":[122],"In":[123,143],"animals,":[125],"enalaprilat":[126,157],"E-3174":[128,147],"decreased":[129],"index":[131],"shifted":[133],"curve":[136,153],"upward":[137],"respect":[139],"to":[140,182],"pretreatment":[141],"conditions.":[142],"dogs,":[145],"whereas":[146],"did":[148],"not":[149],"change":[150],"compliance":[159],"index.":[163],"We":[164],"concluded":[165],"that":[166,180],"dogs":[169],"modifies":[173],"arterial":[174],"viscoelastic":[175],"parameters":[176],"by":[177],"angiotensin-independent":[178],"mechanisms":[179],"contribute":[181],"modulation":[184],"buffering":[187],"function":[188],"large":[190],"arteries.":[191]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":3},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}