{"id":"https://openalex.org/W2397615042","doi":null,"title":"[Assessment of CYP2D6 activity as a form of optimizing antidepressant therapy].","display_name":"[Assessment of CYP2D6 activity as a form of optimizing antidepressant therapy].","publication_year":2004,"publication_date":"2004-11-01","ids":{"openalex":"https://openalex.org/W2397615042","mag":"2397615042","pmid":"https://pubmed.ncbi.nlm.nih.gov/15779673"},"language":"pl","primary_location":{"id":"pmid:15779673","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15779673","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Psychiatria polska","raw_type":"English Abstract"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5062495093","display_name":"Monika Szewczuk-Bogus\u0142awska","orcid":"https://orcid.org/0000-0001-6768-6623","observed_orcids":["https://orcid.org/0000-0001-6768-6623"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Monika Szewczuk-Bogus\u0142awska","raw_affiliation_strings":["Kliniki Psychiatrii AM we Wroc\u0142awiu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kliniki Psychiatrii AM we Wroc\u0142awiu","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059105945","display_name":"Magdalena Grzesiak","orcid":"https://orcid.org/0009-0005-2361-1917","observed_orcids":["https://orcid.org/0009-0005-2361-1917"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Magdalena Grzesiak","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079080626","display_name":"Jan Aleksander Besz\u0142ej","orcid":"https://orcid.org/0000-0003-1257-6923","observed_orcids":["https://orcid.org/0000-0003-1257-6923"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jan Aleksander Besz\u0142ej","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5028874131","display_name":"Andrzej Kiejna","orcid":"https://orcid.org/0000-0002-3708-3853","observed_orcids":["https://orcid.org/0000-0002-3708-3853"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Andrzej Kiejna","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.30865817,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"38","issue":"6","first_page":"1093","last_page":"104"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":1.0,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":1.0,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cyp2d6","display_name":"CYP2D6","score":0.9909999966621399},{"id":"https://openalex.org/keywords/antidepressants","display_name":"antidepressants","score":0.8009999990463257},{"id":"https://openalex.org/keywords/pharmacogenetics","display_name":"pharmacogenetics","score":0.8769999742507935},{"id":"https://openalex.org/keywords/cyp2d6-polymorphism","display_name":"CYP2D6 polymorphism","score":0.8870000243186951},{"id":"https://openalex.org/keywords/cyp2d6-genotyping","display_name":"CYP2D6 genotyping","score":0.9959999918937683},{"id":"https://openalex.org/keywords/drug-metabolism","display_name":"drug metabolism","score":0.4959999918937683},{"id":"https://openalex.org/keywords/tricyclic-antidepressants","display_name":"tricyclic antidepressants","score":0.7680000066757202},{"id":"https://openalex.org/keywords/selective-serotonin-reuptake-inhibitors","display_name":"selective serotonin reuptake inhibitors","score":0.8009999990463257},{"id":"https://openalex.org/keywords/narrow-therapeutic-index-drugs","display_name":"narrow therapeutic index drugs","score":0.6290000081062317},{"id":"https://openalex.org/keywords/polypharmacy","display_name":"polypharmacy","score":0.7549999952316284},{"id":"https://openalex.org/keywords/elderly-patients","display_name":"elderly patients","score":0.7599999904632568},{"id":"https://openalex.org/keywords/adverse-drug-reactions","display_name":"adverse drug reactions","score":0.609000027179718},{"id":"https://openalex.org/keywords/sparteine","display_name":"sparteine","score":0.6240000128746033},{"id":"https://openalex.org/keywords/debrisoquine","display_name":"debrisoquine","score":0.9229999780654907},{"id":"https://openalex.org/keywords/dextromethorphan","display_name":"dextromethorphan","score":0.9660000205039978},{"id":"https://openalex.org/keywords/metoprolol","display_name":"metoprolol","score":0.9950000047683716}],"concepts":[{"id":"https://openalex.org/C33664856","wikidata":"https://www.wikidata.org/wiki/Q3271142","display_name":"CYP2D6","level":4,"score":0.9528759717941284},{"id":"https://openalex.org/C31467283","wikidata":"https://www.wikidata.org/wiki/Q912147","display_name":"Genotyping","level":4,"score":0.7614428997039795},{"id":"https://openalex.org/C2777600422","wikidata":"https://www.wikidata.org/wiki/Q3704421","display_name":"Debrisoquine","level":5,"score":0.6835863590240479},{"id":"https://openalex.org/C2778694420","wikidata":"https://www.wikidata.org/wiki/Q419552","display_name":"Sparteine","level":2,"score":0.6253860592842102},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.6127958297729492},{"id":"https://openalex.org/C3946865","wikidata":"https://www.wikidata.org/wiki/Q5014962","display_name":"CYP2C9","level":4,"score":0.5844534635543823},{"id":"https://openalex.org/C55775858","wikidata":"https://www.wikidata.org/wiki/Q1152227","display_name":"Pharmacogenetics","level":4,"score":0.5812949538230896},{"id":"https://openalex.org/C2776466888","wikidata":"https://www.wikidata.org/wiki/Q898407","display_name":"Venlafaxine","level":4,"score":0.5380752682685852},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.5130337476730347},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.4714043140411377},{"id":"https://openalex.org/C2781245242","wikidata":"https://www.wikidata.org/wiki/Q407781","display_name":"Dextromethorphan","level":2,"score":0.4638775587081909},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.454452782869339},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4346710443496704},{"id":"https://openalex.org/C19831878","wikidata":"https://www.wikidata.org/wiki/Q659446","display_name":"Therapeutic index","level":3,"score":0.4146481454372406},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3076748251914978},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.27014127373695374},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.26305311918258667},{"id":"https://openalex.org/C2779177272","wikidata":"https://www.wikidata.org/wiki/Q76560","display_name":"Antidepressant","level":3,"score":0.22873881459236145},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.19364920258522034},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.09930726885795593},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000928","descriptor_name":"Antidepressive Agents","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D003863","descriptor_name":"Depression","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D003863","descriptor_name":"Depression","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011110","descriptor_name":"Polymorphism, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014149","descriptor_name":"Tranquilizing Agents","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D019389","descriptor_name":"Cytochrome P-450 CYP2D6","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D019389","descriptor_name":"Cytochrome P-450 CYP2D6","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D019389","descriptor_name":"Cytochrome P-450 CYP2D6","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":1,"locations":[{"id":"pmid:15779673","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15779673","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Psychiatria polska","raw_type":"English Abstract"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9940000176429749,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2007367734","https://openalex.org/W2032996390","https://openalex.org/W2089085494","https://openalex.org/W2279018639","https://openalex.org/W1988235147","https://openalex.org/W2409365350","https://openalex.org/W1493353223","https://openalex.org/W3152648389","https://openalex.org/W4395701034","https://openalex.org/W2535737287"],"abstract_inverted_index":{"Cytochrome":[0],"2D6":[1],"catalyzes":[2],"oxidation":[3],"processes":[4],"of":[5,50,57,72,112,125,130,155,159],"many":[6],"antidepressants":[7],"(TCAs,":[8],"SSRIs,":[9],"maprotyline,":[10],"mianserine,":[11],"nefazodon,":[12],"trazodon,":[13],"venlafaxine).":[14],"CYP2D6":[15,31,82,134,142,156],"is":[16,118,158],"characterized":[17,164],"by":[18,87,165],"genetically":[19],"determined":[20],"polymorphism":[21],"which":[22],"may":[23,65,75,84,139],"lead":[24],"to":[25],"serious":[26],"clinical":[27,73],"consequences.":[28],"Based":[29,107],"on":[30,108,147],"activity":[32,83,143],"four":[33],"phenotypes":[34],"are":[35,101,170],"distinguished:":[36],"poor":[37],"metabolism":[38],"(PM),":[39],"intermediate":[40],"(IM),":[41],"extensive":[42],"(normal)":[43],"EM":[44],"and":[45,52,60,70,99,144,172,175],"ultrarapid":[46,80],"(UM).":[47],"In":[48],"case":[49],"PM":[51],"IM":[53],"increased":[54],"plasma":[55,68],"concentration":[56],"a":[58,166],"drug":[59,114],"adverse":[61],"events":[62],"or":[63,89],"toxicity":[64],"appear.":[66],"Decreased":[67],"level":[69],"lack":[71],"effect":[74],"be":[76,85],"connected":[77],"with":[78],"the":[79,104,109,115,133,141],"phenotype.":[81],"assessed":[86],"phenotyping":[88,105,148],"genotyping":[90,151],".":[91],"Model":[92],"drugs":[93,163],"such":[94],"as":[95],"sparteine,":[96],"debrisoquine,":[97],"dextromethorphan":[98],"metoprolol":[100],"used":[102,171],"in":[103,122,173],"method.":[106],"metabolic":[110],"ratio":[111],"model":[113],"phenotype":[116,157],"status":[117],"established.":[119],"Genotyping":[120],"consists":[121],"an":[123,128],"assessment":[124],"genotype":[126],"i.e.":[127],"identification":[129],"alleles":[131],"coding":[132],"protein.":[135],"The":[136,153],"environmental":[137],"factors":[138],"modify":[140],"have":[145],"influence":[146],"but":[149],"not":[150],"results.":[152],"knowledge":[154],"special":[160],"value":[161],"when":[162],"narrow":[167],"therapeutic":[168],"index":[169],"polymedicated":[174],"older":[176],"patients.":[177]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
