{"id":"https://openalex.org/W2397600134","doi":null,"title":"Acute and subacute (30-day) toxicological investigations of 4-(p-chlorophenylthio) butanol (W-2719) in mice, rats and dogs.","display_name":"Acute and subacute (30-day) toxicological investigations of 4-(p-chlorophenylthio) butanol (W-2719) in mice, rats and dogs.","publication_year":1979,"publication_date":"1979-01-01","ids":{"openalex":"https://openalex.org/W2397600134","mag":"2397600134","pmid":"https://pubmed.ncbi.nlm.nih.gov/583012"},"language":"en","primary_location":{"id":"pmid:583012","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/583012","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arzneimittel-Forschung","raw_type":"Comparative Study"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5005712235","display_name":"Banerjee Bn","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"B N Banerjee","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034730471","display_name":"Sofia Rd","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R D Sofia","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091212909","display_name":"Ivins Nj","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"N J Ivins","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5068032566","display_name":"Ludwig Bj","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"B J Ludwig","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.19340974,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"29","issue":"8","first_page":"1141","last_page":"5"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T14072","display_name":"Immunotoxicology and immune responses","score":0.8076000213623047,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T14072","display_name":"Immunotoxicology and immune responses","score":0.8076000213623047,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12229","display_name":"Pharmacological Effects and Toxicity Studies","score":0.1151999980211258,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12281","display_name":"Animal testing and alternatives","score":0.01720000058412552,"subfield":{"id":"https://openalex.org/subfields/3404","display_name":"Small Animals"},"field":{"id":"https://openalex.org/fields/34","display_name":"Veterinary"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acute-toxicity","display_name":"acute toxicity","score":0.8100000023841858},{"id":"https://openalex.org/keywords/subacute-toxicity","display_name":"subacute toxicity","score":0.9710000157356262},{"id":"https://openalex.org/keywords/oral-toxicity","display_name":"oral toxicity","score":0.6240000128746033},{"id":"https://openalex.org/keywords/ld50","display_name":"LD50","score":0.8980000019073486},{"id":"https://openalex.org/keywords/hematological-toxicity","display_name":"hematologic toxicity","score":0.6690000295639038},{"id":"https://openalex.org/keywords/weight-gain","display_name":"weight gain","score":0.7099999785423279},{"id":"https://openalex.org/keywords/drug-safety","display_name":"drug safety","score":0.4090000092983246}],"concepts":[{"id":"https://openalex.org/C147252523","wikidata":"https://www.wikidata.org/wiki/Q1320143","display_name":"Purebred","level":3,"score":0.7200392484664917},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.6626244187355042},{"id":"https://openalex.org/C2776820430","wikidata":"https://www.wikidata.org/wiki/Q21102","display_name":"Beagle","level":2,"score":0.6051614284515381},{"id":"https://openalex.org/C2777056448","wikidata":"https://www.wikidata.org/wiki/Q285166","display_name":"Oral administration","level":2,"score":0.5212015509605408},{"id":"https://openalex.org/C116263406","wikidata":"https://www.wikidata.org/wiki/Q3299024","display_name":"Acute toxicity","level":3,"score":0.5163939595222473},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5105143785476685},{"id":"https://openalex.org/C147583825","wikidata":"https://www.wikidata.org/wiki/Q620876","display_name":"Body weight","level":2,"score":0.49060311913490295},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.38958054780960083},{"id":"https://openalex.org/C140793950","wikidata":"https://www.wikidata.org/wiki/Q168091","display_name":"Animal science","level":1,"score":0.3703381419181824},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3439562916755676},{"id":"https://openalex.org/C2776482104","wikidata":"https://www.wikidata.org/wiki/Q38829","display_name":"Breed","level":2,"score":0.24256360530853271},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.183883398771286}],"mesh":[{"descriptor_ui":"D000440","descriptor_name":"Butanols","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002722","descriptor_name":"Chlorobenzenes","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D004285","descriptor_name":"Dogs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006633","descriptor_name":"Histamine Antagonists","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D007928","descriptor_name":"Lethal Dose 50","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009929","descriptor_name":"Organ Size","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D012737","descriptor_name":"Sex Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013045","descriptor_name":"Species Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:583012","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/583012","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arzneimittel-Forschung","raw_type":"Comparative Study"},{"id":"mag:2397600134","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/583012","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9476000070571899,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2404975983","https://openalex.org/W2466339726","https://openalex.org/W2011637849","https://openalex.org/W2404340744","https://openalex.org/W2418628319","https://openalex.org/W2405792070","https://openalex.org/W4381683562","https://openalex.org/W4206366348","https://openalex.org/W2041528668","https://openalex.org/W1531245206"],"abstract_inverted_index":{"The":[0,60],"acute":[1],"and":[2,17,28,35,117,121],"subacute":[3,61],"toxicity":[4,62,86,136],"of":[5,49,53,71,92,142],"4-(p-chlorophenylthio)":[6],"butanol":[7],"(W-2719),":[8],"on":[9],"anti-allergy":[10],"agent,":[11],"was":[12],"investigated":[13],"in":[14,22,39,110,150],"mice,":[15],"rats":[16],"dogs.":[18],"Acute":[19],"LD50":[20],"values":[21],"the":[23,40,72,78,126,145],"mouse":[24],"(1145.0":[25],"mg/kg":[26,33,43],"p.o.)":[27,34,44],"rat":[29],"(greater":[30],"than":[31],"1400.0":[32],"maximum":[36],"tolerated":[37],"dose":[38,90,140,147],"dog":[41],"(420.0":[42],"were":[45,64],"very":[46],"high,":[47],"indicative":[48],"a":[50,56,89,98,139],"high":[51],"degree":[52],"safety":[54],"following":[55],"single":[57],"oral":[58,69],"dose.":[59],"studies":[63],"conducted":[65],"by":[66],"repeated":[67],"daily":[68],"administration":[70],"compound":[73],"for":[74],"30":[75],"days.":[76],"In":[77,125],"rat,":[79],"W-2719":[80,130],"did":[81,131],"not":[82,132],"produce":[83,133],"any":[84,134],"significant":[85,135],"up":[87,137],"to":[88,138],"level":[91,141,148],"100.0":[93,143],"mg/kg/day,":[94,106,144],"when":[95],"administered":[96],"as":[97],"drug-diet":[99],"admixture.":[100],"A":[101],"higher":[102],"dose,":[103],"i.e.,":[104],"200.0":[105],"produced":[107],"marked":[108],"reductions":[109],"body":[111],"weight":[112],"gain,":[113],"food":[114],"consumption,":[115],"RBC":[116],"WBC":[118],"(females":[119],"especially),":[120],"other":[122],"hematological":[123],"parameters.":[124],"purebred":[127],"beagle":[128],"dog,":[129],"highest":[146],"tested":[149],"this":[151],"species.":[152]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
