{"id":"https://openalex.org/W2397589134","doi":"https://doi.org/10.1152/ajpheart.1996.270.1.h411","title":"Nitric oxide mediates mitogenic effect of VEGF on coronary venular endothelium","display_name":"Nitric oxide mediates mitogenic effect of VEGF on coronary venular endothelium","publication_year":1996,"publication_date":"1996-01-01","ids":{"openalex":"https://openalex.org/W2397589134","doi":"https://doi.org/10.1152/ajpheart.1996.270.1.h411","mag":"2397589134","pmid":"https://pubmed.ncbi.nlm.nih.gov/8769777"},"language":"en","primary_location":{"id":"doi:10.1152/ajpheart.1996.270.1.h411","doi":"https://doi.org/10.1152/ajpheart.1996.270.1.h411","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajpheart.1996.270.1.h411","pdf_url":null,"source":{"id":"https://openalex.org/S87338489","display_name":"American Journal of Physiology-Heart and Circulatory Physiology","issn_l":"0363-6135","issn":["0363-6135","1522-1539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320261","host_organization_name":"American Physical Society","host_organization_lineage":["https://openalex.org/P4310320261"],"host_organization_lineage_names":["American Physical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Heart and Circulatory Physiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5086541070","display_name":"Lucia Morbidelli","orcid":"https://orcid.org/0000-0001-8148-7049","observed_orcids":["https://orcid.org/0000-0001-8148-7049"]},"institutions":[{"id":"https://openalex.org/I45084792","display_name":"University of Florence","ror":"https://ror.org/04jr1s763","country_code":"IT","type":"education","lineage":["https://openalex.org/I45084792"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"L. Morbidelli","raw_affiliation_strings":["Department of Preclinical and Clinical Pharmacology, University ofFlorence, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Preclinical and Clinical Pharmacology, University ofFlorence, Italy","institution_ids":["https://openalex.org/I45084792"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101571230","display_name":"Chih-Hung Chang","orcid":"https://orcid.org/0000-0002-6992-7176","observed_orcids":["https://orcid.org/0000-0002-6992-7176","https://orcid.org/0000-0002-0275-9673"]},"institutions":[{"id":"https://openalex.org/I45084792","display_name":"University of Florence","ror":"https://ror.org/04jr1s763","country_code":"IT","type":"education","lineage":["https://openalex.org/I45084792"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"C. H. Chang","raw_affiliation_strings":["Department of Preclinical and Clinical Pharmacology, University ofFlorence, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Preclinical and Clinical Pharmacology, University ofFlorence, Italy","institution_ids":["https://openalex.org/I45084792"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072774542","display_name":"Janice G. Douglas","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I45084792","display_name":"University of Florence","ror":"https://ror.org/04jr1s763","country_code":"IT","type":"education","lineage":["https://openalex.org/I45084792"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"J. G. Douglas","raw_affiliation_strings":["Department of Preclinical and Clinical Pharmacology, University ofFlorence, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Preclinical and Clinical Pharmacology, University ofFlorence, Italy","institution_ids":["https://openalex.org/I45084792"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007631801","display_name":"Harris J. Granger","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I45084792","display_name":"University of Florence","ror":"https://ror.org/04jr1s763","country_code":"IT","type":"education","lineage":["https://openalex.org/I45084792"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"H. J. Granger","raw_affiliation_strings":["Department of Preclinical and Clinical Pharmacology, University ofFlorence, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Preclinical and Clinical Pharmacology, University ofFlorence, Italy","institution_ids":["https://openalex.org/I45084792"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022221237","display_name":"F. Ledda","orcid":"https://orcid.org/0000-0002-1650-6597","observed_orcids":["https://orcid.org/0000-0002-1650-6597"]},"institutions":[{"id":"https://openalex.org/I45084792","display_name":"University of Florence","ror":"https://ror.org/04jr1s763","country_code":"IT","type":"education","lineage":["https://openalex.org/I45084792"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"F. Ledda","raw_affiliation_strings":["Department of Preclinical and Clinical Pharmacology, University ofFlorence, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Preclinical and Clinical Pharmacology, University ofFlorence, Italy","institution_ids":["https://openalex.org/I45084792"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5076622030","display_name":"Marina Ziche","orcid":"https://orcid.org/0000-0002-9564-214X","observed_orcids":["https://orcid.org/0000-0002-9564-214X"]},"institutions":[{"id":"https://openalex.org/I45084792","display_name":"University of Florence","ror":"https://ror.org/04jr1s763","country_code":"IT","type":"education","lineage":["https://openalex.org/I45084792"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"M. Ziche","raw_affiliation_strings":["Department of Preclinical and Clinical Pharmacology, University ofFlorence, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Preclinical and Clinical Pharmacology, University ofFlorence, Italy","institution_ids":["https://openalex.org/I45084792"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I45084792"],"apc_list":null,"apc_paid":null,"fwci":7.0693,"has_fulltext":false,"cited_by_count":417,"citation_normalized_percentile":{"value":0.97846439,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":100},"biblio":{"volume":"270","issue":"1","first_page":"H411","last_page":"H415"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.9556000232696533,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.9556000232696533,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.04399999976158142,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14486","display_name":"Cardiovascular, Neuropeptides, and Oxidative Stress Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nitric-oxide","display_name":"nitric oxide","score":0.9459999799728394},{"id":"https://openalex.org/keywords/vascular-endothelial-growth-factor","display_name":"vascular endothelial growth factor","score":0.9810000061988831},{"id":"https://openalex.org/keywords/endothelial-cell-proliferation","display_name":"endothelial cell proliferation","score":0.8610000014305115},{"id":"https://openalex.org/keywords/postcapillary-venules","display_name":"postcapillary venules","score":0.9110000133514404},{"id":"https://openalex.org/keywords/nitric-oxide-synthase","display_name":"nitric oxide synthase","score":0.7940000295639038},{"id":"https://openalex.org/keywords/cgmp","display_name":"cyclic GMP","score":0.8849999904632568},{"id":"https://openalex.org/keywords/angiogenesis","display_name":"angiogenesis","score":0.8029999732971191},{"id":"https://openalex.org/keywords/superoxide-dismutase","display_name":"superoxide dismutase","score":0.8140000104904175},{"id":"https://openalex.org/keywords/microvascular-endothelium","display_name":"microvascular endothelium","score":0.7649999856948853}],"concepts":[{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.7405609488487244},{"id":"https://openalex.org/C2780994212","wikidata":"https://www.wikidata.org/wiki/Q422511","display_name":"Cyclic guanosine monophosphate","level":3,"score":0.7356190085411072},{"id":"https://openalex.org/C2777025900","wikidata":"https://www.wikidata.org/wiki/Q29725","display_name":"Vascular endothelial growth factor","level":3,"score":0.5968042612075806},{"id":"https://openalex.org/C2777622882","wikidata":"https://www.wikidata.org/wiki/Q417619","display_name":"Nitric oxide synthase","level":3,"score":0.5815999507904053},{"id":"https://openalex.org/C519581460","wikidata":"https://www.wikidata.org/wiki/Q207843","display_name":"Nitric oxide","level":2,"score":0.525301992893219},{"id":"https://openalex.org/C123012128","wikidata":"https://www.wikidata.org/wiki/Q5376430","display_name":"Endothelial stem cell","level":3,"score":0.521460235118866},{"id":"https://openalex.org/C2776992346","wikidata":"https://www.wikidata.org/wiki/Q111140","display_name":"Endothelium","level":2,"score":0.5134766697883606},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.4997673034667969},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.48526832461357117},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.43447232246398926},{"id":"https://openalex.org/C146285616","wikidata":"https://www.wikidata.org/wiki/Q7916455","display_name":"Vascular endothelial growth factor A","level":4,"score":0.4276340901851654},{"id":"https://openalex.org/C58207958","wikidata":"https://www.wikidata.org/wiki/Q33596","display_name":"Motility","level":2,"score":0.41826897859573364},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.41562947630882263},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3916054368019104},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3734801113605499},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.36725741624832153},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.22366276383399963},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.1962943971157074},{"id":"https://openalex.org/C167734588","wikidata":"https://www.wikidata.org/wiki/Q4356503","display_name":"VEGF receptors","level":2,"score":0.12541288137435913},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.10754275321960449}],"mesh":[{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003331","descriptor_name":"Coronary Vessels","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D003331","descriptor_name":"Coronary Vessels","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D003331","descriptor_name":"Coronary Vessels","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006152","descriptor_name":"Cyclic GMP","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008222","descriptor_name":"Lymphokines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D008934","descriptor_name":"Mitogens","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D009569","descriptor_name":"Nitric Oxide","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D009599","descriptor_name":"Nitroprusside","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D014699","descriptor_name":"Venules","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D014699","descriptor_name":"Venules","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D014699","descriptor_name":"Venules","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016222","descriptor_name":"Fibroblast Growth Factor 2","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D016228","descriptor_name":"Endothelial Growth Factors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D042442","descriptor_name":"Vascular Endothelial Growth Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D042461","descriptor_name":"Vascular Endothelial Growth Factor A","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1152/ajpheart.1996.270.1.h411","doi":"https://doi.org/10.1152/ajpheart.1996.270.1.h411","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajpheart.1996.270.1.h411","pdf_url":null,"source":{"id":"https://openalex.org/S87338489","display_name":"American Journal of Physiology-Heart and Circulatory Physiology","issn_l":"0363-6135","issn":["0363-6135","1522-1539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320261","host_organization_name":"American Physical Society","host_organization_lineage":["https://openalex.org/P4310320261"],"host_organization_lineage_names":["American Physical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Heart and Circulatory Physiology","raw_type":"journal-article"},{"id":"pmid:8769777","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8769777","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American journal of physiology","raw_type":"Comparative Study"},{"id":"pmh:oai:usiena-air.unisi.it:11365/28490","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11365/28490","pdf_url":null,"source":{"id":"https://openalex.org/S4377196319","display_name":"Use Siena air (University of Siena)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I102064193","host_organization_name":"University of Siena","host_organization_lineage":["https://openalex.org/I102064193"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.6240000128746033,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.41999998688697815,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1949560964","display_name":null,"funder_award_id":"HL21498","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2041034845","https://openalex.org/W2068435205","https://openalex.org/W2133353133","https://openalex.org/W2142943611","https://openalex.org/W1973484541","https://openalex.org/W2092921205","https://openalex.org/W2157986778","https://openalex.org/W2004297042","https://openalex.org/W2362908810","https://openalex.org/W1977017324"],"abstract_inverted_index":{"Vascular":[0],"endothelial":[1,16,40,165],"growth":[2,13,42],"factor":[3,14],"(VEGF)":[4],"is":[5,10],"a":[6,11,82,139],"secreted":[7],"protein":[8],"that":[9,22],"specific":[12],"for":[15],"cells.":[17],"We":[18],"have":[19],"recently":[20],"demonstrated":[21],"nitric":[23],"oxide":[24],"(NO)":[25],"donors":[26],"and":[27,43,88,109,153,172],"vasoactive":[28],"peptides":[29],"promoting":[30],"NO-mediated":[31],"vasorelaxation":[32],"induce":[33],"angiogenesis":[34],"in":[35,45,47,64,85,106,142],"vivo":[36],"as":[37,39],"well":[38],"cell":[41,86],"motility":[44],"vitro;":[46],"contrast,":[48],"inhibitors":[49],"of":[50,62,69,93,111,125,133,163,170],"NO":[51,63,94,112,129,157,171],"synthase":[52,113,130,158],"suppress":[53],"angiogenesis.":[54],"In":[55],"this":[56],"study":[57],"we":[58],"investigated":[59],"the":[60,66,107,126,134,168],"role":[61,92],"mediating":[65],"mitogenic":[67],"effect":[68,117,146],"VEGF":[70,80,120,137,160],"on":[71],"cultured":[72],"microvascular":[73],"endothelium":[74],"isolated":[75],"from":[76],"coronary":[77],"postcapillary":[78,164],"venules.":[79],"induced":[81,138],"dose-dependent":[83],"increase":[84],"proliferation":[87,99,162],"DNA":[89],"synthesis.":[90],"The":[91,115],"was":[95,121,147,154],"determined":[96],"by":[97,119,123,149,156],"monitoring":[98],"or":[100],"guanosine":[101],"3',5'-cyclic":[102],"monophosphate":[103],"(cGMP)":[104],"levels":[105],"presence":[108],"absence":[110],"blockers.":[114],"proliferative":[116],"evoked":[118],"reduced":[122],"pretreatment":[124],"cells":[127,135,166],"with":[128],"inhibitors.":[131,159],"Exposure":[132],"to":[136],"significant":[140],"increment":[141],"cGMP":[143,173],"levels.":[144],"This":[145],"potentiated":[148],"superoxide":[150],"dismutase":[151],"addition":[152],"abolished":[155],"stimulates":[161],"through":[167],"production":[169],"accumulation.":[174]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":9},{"year":2020,"cited_by_count":9},{"year":2019,"cited_by_count":12},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":14},{"year":2014,"cited_by_count":12},{"year":2013,"cited_by_count":12},{"year":2012,"cited_by_count":9}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}