{"id":"https://openalex.org/W2397480662","doi":"https://doi.org/10.1158/1557-3125.advbc15-b01","title":"Abstract B01: B cell lymphoma 9 mediates a cross talk between the canonical Wnt and EGFR signaling in breast cancer","display_name":"Abstract B01: B cell lymphoma 9 mediates a cross talk between the canonical Wnt and EGFR signaling in breast cancer","publication_year":2016,"publication_date":"2016-02-01","ids":{"openalex":"https://openalex.org/W2397480662","doi":"https://doi.org/10.1158/1557-3125.advbc15-b01","mag":"2397480662"},"language":"en","primary_location":{"id":"doi:10.1158/1557-3125.advbc15-b01","doi":"https://doi.org/10.1158/1557-3125.advbc15-b01","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1557-3125.advbc15-b01","pdf_url":null,"source":{"id":"https://openalex.org/S192067876","display_name":"Molecular Cancer Research","issn_l":"1541-7786","issn":["1541-7786","1557-3125"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5072024080","display_name":"Hanan S. Elsarraj","orcid":"https://orcid.org/0000-0001-9926-7167","observed_orcids":["https://orcid.org/0000-0001-9926-7167"]},"institutions":[{"id":"https://openalex.org/I146416000","display_name":"University of Kansas","ror":"https://ror.org/001tmjg57","country_code":"US","type":"education","lineage":["https://openalex.org/I146416000"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hanan Elsarraj","raw_affiliation_strings":["1University of Kansas, Kansas City, KS,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1University of Kansas, Kansas City, KS,","institution_ids":["https://openalex.org/I146416000"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Hong Yan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I146416000","display_name":"University of Kansas","ror":"https://ror.org/001tmjg57","country_code":"US","type":"education","lineage":["https://openalex.org/I146416000"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hong Yan","raw_affiliation_strings":["1University of Kansas, Kansas City, KS,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1University of Kansas, Kansas City, KS,","institution_ids":["https://openalex.org/I146416000"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055503863","display_name":"Jennifer R. Knapp","orcid":"https://orcid.org/0000-0003-4342-5378","observed_orcids":["https://orcid.org/0000-0003-4342-5378"]},"institutions":[{"id":"https://openalex.org/I146416000","display_name":"University of Kansas","ror":"https://ror.org/001tmjg57","country_code":"US","type":"education","lineage":["https://openalex.org/I146416000"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jennifer Knapp","raw_affiliation_strings":["1University of Kansas, Kansas City, KS,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1University of Kansas, Kansas City, KS,","institution_ids":["https://openalex.org/I146416000"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080914070","display_name":"Anna I. Tsimelzon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anna Tsimelzon","raw_affiliation_strings":["2Baylor College of Medicine, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Baylor College of Medicine, Houston, TX","institution_ids":["https://openalex.org/I181547552"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030664006","display_name":"Shixia Huang","orcid":"https://orcid.org/0000-0003-2878-4129","observed_orcids":["https://orcid.org/0000-0003-2878-4129"]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shixia Huang","raw_affiliation_strings":["2Baylor College of Medicine, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Baylor College of Medicine, Houston, TX","institution_ids":["https://openalex.org/I181547552"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033625395","display_name":"Andrew K. Godwin","orcid":"https://orcid.org/0000-0002-3987-9580","observed_orcids":["https://orcid.org/0000-0002-3987-9580"]},"institutions":[{"id":"https://openalex.org/I146416000","display_name":"University of Kansas","ror":"https://ror.org/001tmjg57","country_code":"US","type":"education","lineage":["https://openalex.org/I146416000"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew Godwin","raw_affiliation_strings":["1University of Kansas, Kansas City, KS,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1University of Kansas, Kansas City, KS,","institution_ids":["https://openalex.org/I146416000"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112763357","display_name":"Sue G Hilsenbeck","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sue Hilsenbeck","raw_affiliation_strings":["2Baylor College of Medicine, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Baylor College of Medicine, Houston, TX","institution_ids":["https://openalex.org/I181547552"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109436041","display_name":"Dean P. Edwards","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dean Edwards","raw_affiliation_strings":["2Baylor College of Medicine, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Baylor College of Medicine, Houston, TX","institution_ids":["https://openalex.org/I181547552"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5030002890","display_name":"Fariba Behbod","orcid":"https://orcid.org/0000-0001-6281-2651","observed_orcids":["https://orcid.org/0000-0001-6281-2651"]},"institutions":[{"id":"https://openalex.org/I146416000","display_name":"University of Kansas","ror":"https://ror.org/001tmjg57","country_code":"US","type":"education","lineage":["https://openalex.org/I146416000"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Fariba Behbod","raw_affiliation_strings":["1University of Kansas, Kansas City, KS,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1University of Kansas, Kansas City, KS,","institution_ids":["https://openalex.org/I146416000"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"14","issue":"2_Supplement","first_page":"B01","last_page":"B01"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10929","display_name":"Wnt/\u03b2-catenin signaling in development and cancer","score":0.9765999913215637,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10929","display_name":"Wnt/\u03b2-catenin signaling in development and cancer","score":0.9765999913215637,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.012400000356137753,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.002899999963119626,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bcl9","display_name":"BCL9","score":0.9660000205039978},{"id":"https://openalex.org/keywords/ductal-carcinoma-in-situ","display_name":"ductal carcinoma in situ","score":0.8159999847412109},{"id":"https://openalex.org/keywords/invasive-ductal-carcinoma","display_name":"invasive ductal carcinoma","score":0.9539999961853027},{"id":"https://openalex.org/keywords/wnt-beta-catenin-signaling","display_name":"Wnt/\u03b2-catenin signaling","score":0.871999979019165},{"id":"https://openalex.org/keywords/egfr-signaling","display_name":"EGFR signaling","score":0.9909999966621399},{"id":"https://openalex.org/keywords/epithelial-mesenchymal-transition","display_name":"epithelial-mesenchymal transition","score":0.9390000104904175},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.40799999237060547},{"id":"https://openalex.org/keywords/her2","display_name":"HER2","score":0.5830000042915344},{"id":"https://openalex.org/keywords/estrogen-receptor","display_name":"estrogen receptor","score":0.628000020980835},{"id":"https://openalex.org/keywords/basal-like-breast-cancer","display_name":"basal-like breast cancer","score":0.8830000162124634},{"id":"https://openalex.org/keywords/gene-amplification","display_name":"gene amplification","score":0.6150000095367432},{"id":"https://openalex.org/keywords/stat3","display_name":"STAT3","score":0.3050000071525574}],"concepts":[{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6720815896987915},{"id":"https://openalex.org/C137620995","wikidata":"https://www.wikidata.org/wiki/Q155769","display_name":"Wnt signaling pathway","level":3,"score":0.6705794334411621},{"id":"https://openalex.org/C2780862961","wikidata":"https://www.wikidata.org/wiki/Q5311598","display_name":"Ductal carcinoma","level":4,"score":0.6641668677330017},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.5981070399284363},{"id":"https://openalex.org/C173396325","wikidata":"https://www.wikidata.org/wiki/Q1501275","display_name":"Gene knockdown","level":3,"score":0.5670948624610901},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.48358458280563354},{"id":"https://openalex.org/C119056186","wikidata":"https://www.wikidata.org/wiki/Q1431332","display_name":"Gene silencing","level":3,"score":0.42471766471862793},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.41614097356796265},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3895834982395172},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3588505685329437},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.32617712020874023},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.25095024704933167},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.24163231253623962},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.198529452085495},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.10505998134613037},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.07596665620803833},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1557-3125.advbc15-b01","doi":"https://doi.org/10.1158/1557-3125.advbc15-b01","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1557-3125.advbc15-b01","pdf_url":null,"source":{"id":"https://openalex.org/S192067876","display_name":"Molecular Cancer Research","issn_l":"1541-7786","issn":["1541-7786","1557-3125"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.8500000238418579,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2763385810","https://openalex.org/W4299132159","https://openalex.org/W2398632459","https://openalex.org/W6940217949","https://openalex.org/W3201590296","https://openalex.org/W7136851938","https://openalex.org/W7136331810","https://openalex.org/W7136644882","https://openalex.org/W2792417341","https://openalex.org/W2052092123"],"abstract_inverted_index":{"Abstract":[0],"Human":[1],"ductal":[2,53],"carcinoma":[3,54],"in":[4,73,139,174,249,274,331,336,363,371,413,426],"situ":[5,140],"(DCIS)":[6],"are":[7,117],"the":[8,29,97,127,240,302,337,369,372,407,420],"most":[9],"common":[10],"type":[11],"of":[12,83,100,131,138,166,177,182,187,204,211,239,251,282,304,334,353,419],"non-invasive":[13,24],"breast":[14,36,252,275,286,291,306,364,414],"cancers.":[15,253,276,307],"The":[16,357],"five-year":[17,30],"survival":[18,31],"rate":[19],"for":[20,35,360],"women":[21],"diagnosed":[22],"with":[23,155,228],"DCIS":[25,58,75,90,101,119,156,183,213,229,316,354],"is":[26,161,255,349,367],"98%":[27],"while":[28],"plummets":[32],"to":[33,45,50,66,102,124,141,152,158,180,246,262,289,301],"83-27%":[34],"cancers":[37,287,292],"that":[38,62,79,120,173,297,326],"have":[39,43,69,110,190,309],"become":[40],"invasive":[41,52,285,355],"and":[42,60,92,133,185,199,201,224,235,267,345,375,410],"spread":[44],"distant":[46],"sites":[47],"[also":[48],"referred":[49],"as":[51],"(IDC)].":[55],"To":[56],"study":[57],"pathobiology":[59],"factors":[61],"promote":[63],"their":[64],"transition":[65,123,157],"IDC,":[67],"we":[68,109],"developed":[70],"a":[71,106,122,162,193,216,256,278,332,350,403],"novel":[72],"vivo":[74,175],"model,":[76],"MIND":[77],"(mouse-intraductal),":[78],"involves":[80],"intraductal":[81],"injection":[82],"epithelial":[84],"cells":[85],"derived":[86],"from":[87],"primary":[88],"human":[89,112],"biopsy":[91],"surgical":[93],"samples":[94,214],"thus":[95],"mimicking":[96],"entire":[98],"process":[99],"IDC":[103,125,142],"transition.":[104],"As":[105],"complementary":[107],"approach,":[108],"utilized":[111],"DCIS/IDC":[113],"tandem":[114],"lesions,":[115],"which":[116],"patient":[118,212],"show":[121],"within":[126],"same":[128],"breast.":[129],"Analysis":[130,210],"RNA":[132],"protein":[134],"at":[135],"distinct":[136],"stages":[137],"using":[143],"both":[144],"models":[145],"showed":[146,172,202,243,293,329],"B":[147,398],"cell":[148,317,399],"lymphoma-9":[149],"(BCL9)":[150],"up-regulation":[151],"be":[153,247],"associated":[154,227],"IDC.":[159],"BCL9":[160,178,198,208,222,244,294,298,320,327,348],"recently":[163],"identified":[164],"co-activator":[165],"Wnt-stimulated":[167],"beta-catenin-mediated":[168,205],"transcription.":[169],"Our":[170],"studies":[171],"silencing":[176],"led":[179],"inhibition":[181],"invasion":[184],"reversal":[186],"EMT.":[188],"We":[189,308],"also":[191],"demonstrated":[192],"direct":[194],"binding":[195],"interaction":[196],"between":[197,219,406],"beta-catenin":[200],"suppression":[203],"transcription":[206],"by":[207],"knockdown.":[209],"revealed":[215],"significant":[217,257],"correlation":[218],"high":[220],"nuclear":[221],"expression":[223],"pathologic":[225],"characteristics":[226],"recurrence:":[230],"Estrogen":[231],"receptor":[232,269],"(ER)":[233],"negative":[234],"Ki67.":[236],"Furthermore,":[237],"analysis":[238,313,324],"TCGA":[241],"data":[242],"gene":[245,258,265,271],"upregulated":[248],"26%":[250],"This":[254,323],"alteration":[259],"when":[260],"compared":[261,288],"HER2":[263],"(ERBB2)":[264],"(19%)":[266],"estrogen":[268],"(ESR1)":[270],"(8%)":[272],"alterations":[273],"Interestingly,":[277],"significantly":[279],"higher":[280],"proportion":[281],"basal":[283,305],"like":[284],"luminal":[290],"amplification":[295],"suggesting":[296],"may":[299],"predispose":[300],"development":[303],"performed":[310],"an":[311],"RPPA":[312],"on":[314,424],"our":[315],"lines":[318],"KD":[319,328],"vs.":[321],"control.":[322],"indicated":[325],"down-regulation":[330],"number":[333],"genes":[335],"EGFR":[338,376,411],"signaling":[339,412],"pathway":[340],"including":[341],"p-EGFR,":[342],"p-HER2,":[343],"p-STAT3,":[344],"p-Src.":[346],"Conclusion:":[347],"molecular":[351,358],"driver":[352],"progression.":[356],"mechanism":[359],"BCL9's":[361],"role":[362],"cancer":[365],"progression":[366],"through":[368],"enhancement":[370],"canonical":[373,408],"Wnt":[374,409],"signaling.":[377],"Citation":[378],"Format:":[379],"Hanan":[380],"Elsarraj,":[381],"Hong":[382],"Yan,":[383],"Jennifer":[384],"Knapp,":[385],"Anna":[386],"Tsimelzon,":[387],"Shixia":[388],"Huang,":[389],"Andrew":[390],"Godwin,":[391],"Sue":[392],"Hilsenbeck,":[393],"Dean":[394],"Edwards,":[395],"Fariba":[396],"Behbod.":[397],"lymphoma":[400],"9":[401],"mediates":[402],"cross":[404],"talk":[405],"cancer.":[415],"[abstract].":[416],"In:":[417],"Proceedings":[418],"AACR":[421],"Special":[422],"Conference":[423],"Advances":[425],"Breast":[427],"Cancer":[428,439],"Research;":[429],"Oct":[430],"17-20,":[431],"2015;":[432],"Bellevue,":[433],"WA.":[434],"Philadelphia":[435],"(PA):":[436],"AACR;":[437],"Mol":[438],"Res":[440],"2016;14(2_Suppl):Abstract":[441],"nr":[442],"B01.":[443]},"counts_by_year":[],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2016-06-24T00:00:00"}
