{"id":"https://openalex.org/W2397453732","doi":"https://doi.org/10.1093/sleep/15.3.252","title":"Biperiden Administration During REM Sleep Deprivation Diminished the Frequency of REM Sleep Attempts","display_name":"Biperiden Administration During REM Sleep Deprivation Diminished the Frequency of REM Sleep Attempts","publication_year":1992,"publication_date":"1992-05-01","ids":{"openalex":"https://openalex.org/W2397453732","doi":"https://doi.org/10.1093/sleep/15.3.252","mag":"2397453732","pmid":"https://pubmed.ncbi.nlm.nih.gov/1621026"},"language":"en","primary_location":{"id":"doi:10.1093/sleep/15.3.252","doi":"https://doi.org/10.1093/sleep/15.3.252","is_oa":false,"landing_page_url":"https://doi.org/10.1093/sleep/15.3.252","pdf_url":null,"source":{"id":"https://openalex.org/S42921845","display_name":"SLEEP","issn_l":"0161-8105","issn":["0161-8105","1550-9109"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","erih-plus","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sleep","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5011112510","display_name":"Rafael J. Sal\u00edn-Pascual","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I164915025","display_name":"Mexican Social Security Institute","ror":"https://ror.org/03xddgg98","country_code":"MX","type":"government","lineage":["https://openalex.org/I164915025"]},{"id":"https://openalex.org/I2803043754","display_name":"Henry Ford Hospital","ror":"https://ror.org/0193sb042","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I154057602","https://openalex.org/I2803043754"]}],"countries":["MX","US"],"is_corresponding":true,"raw_author_name":"Rafael J. Salin-Pascual","raw_affiliation_strings":["Sleep Disorders Center, Henry Ford Hospital, Detroit, Michigan","Psychobiological Department, Mexican Psychiatric Institute, Mexico City, Mexico","Sleep Disorders Center, Henry Ford Hospital, Detroit, Michigan, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sleep Disorders Center, Henry Ford Hospital, Detroit, Michigan","institution_ids":["https://openalex.org/I2803043754"]},{"raw_affiliation_string":"Psychobiological Department, Mexican Psychiatric Institute, Mexico City, Mexico","institution_ids":["https://openalex.org/I164915025"]},{"raw_affiliation_string":"Sleep Disorders Center, Henry Ford Hospital, Detroit, Michigan, U.S.A","institution_ids":["https://openalex.org/I2803043754"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076424703","display_name":"Daniel Granados\u2010Fuentes","orcid":"https://orcid.org/0000-0003-4478-118X","observed_orcids":["https://orcid.org/0000-0003-4478-118X"]},"institutions":[{"id":"https://openalex.org/I164915025","display_name":"Mexican Social Security Institute","ror":"https://ror.org/03xddgg98","country_code":"MX","type":"government","lineage":["https://openalex.org/I164915025"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Daniel Grandos-Fuentes","raw_affiliation_strings":["Psychobiological Department, Mexican Psychiatric Institute, Mexico City, Mexico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Psychobiological Department, Mexican Psychiatric Institute, Mexico City, Mexico","institution_ids":["https://openalex.org/I164915025"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014202752","display_name":"Lourdes Galicia-Polo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I164915025","display_name":"Mexican Social Security Institute","ror":"https://ror.org/03xddgg98","country_code":"MX","type":"government","lineage":["https://openalex.org/I164915025"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Lourdes Galicia-Polo","raw_affiliation_strings":["Psychobiological Department, Mexican Psychiatric Institute, Mexico City, Mexico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Psychobiological Department, Mexican Psychiatric Institute, Mexico City, Mexico","institution_ids":["https://openalex.org/I164915025"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051204031","display_name":"Estela Nieves","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I164915025","display_name":"Mexican Social Security Institute","ror":"https://ror.org/03xddgg98","country_code":"MX","type":"government","lineage":["https://openalex.org/I164915025"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Estela Nieves","raw_affiliation_strings":["Psychobiological Department, Mexican Psychiatric Institute, Mexico City, Mexico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Psychobiological Department, Mexican Psychiatric Institute, Mexico City, Mexico","institution_ids":["https://openalex.org/I164915025"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041608204","display_name":"Timothy Roehrs","orcid":"https://orcid.org/0000-0001-9237-0153","observed_orcids":["https://orcid.org/0000-0001-9237-0153"]},"institutions":[{"id":"https://openalex.org/I2803043754","display_name":"Henry Ford Hospital","ror":"https://ror.org/0193sb042","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I154057602","https://openalex.org/I2803043754"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Timothy A. Roehrs","raw_affiliation_strings":["Sleep Disorders Center, Henry Ford Hospital, Detroit, Michigan, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sleep Disorders Center, Henry Ford Hospital, Detroit, Michigan, U.S.A","institution_ids":["https://openalex.org/I2803043754"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5011832419","display_name":"Thomas G. Roth","orcid":"https://orcid.org/0000-0001-8309-4134","observed_orcids":["https://orcid.org/0000-0001-8309-4134"]},"institutions":[{"id":"https://openalex.org/I2803043754","display_name":"Henry Ford Hospital","ror":"https://ror.org/0193sb042","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I154057602","https://openalex.org/I2803043754"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas Roth","raw_affiliation_strings":["Sleep Disorders Center, Henry Ford Hospital, Detroit, Michigan, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sleep Disorders Center, Henry Ford Hospital, Detroit, Michigan, U.S.A","institution_ids":["https://openalex.org/I2803043754"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5011112510"],"corresponding_institution_ids":["https://openalex.org/I164915025","https://openalex.org/I2803043754"],"apc_list":{"value":4388,"currency":"USD","value_usd":4388},"apc_paid":null,"fwci":0.7624,"has_fulltext":true,"cited_by_count":13,"citation_normalized_percentile":{"value":0.72180831,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"15","issue":"3","first_page":"252","last_page":"256"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10985","display_name":"Sleep and Wakefulness Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10985","display_name":"Sleep and Wakefulness Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10316","display_name":"Sleep and related disorders","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/3205","display_name":"Experimental and Cognitive Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T11373","display_name":"Sleep and Work-Related Fatigue","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/3205","display_name":"Experimental and Cognitive Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/biperiden","display_name":"biperiden","score":0.9980000257492065},{"id":"https://openalex.org/keywords/rem-sleep-deprivation","display_name":"REM sleep deprivation","score":0.9850000143051147},{"id":"https://openalex.org/keywords/rem-latency","display_name":"REM latency","score":0.824999988079071},{"id":"https://openalex.org/keywords/rem-sleep-suppression","display_name":"REM sleep suppression","score":0.8650000095367432},{"id":"https://openalex.org/keywords/anticholinergic-drugs","display_name":"anticholinergic agents","score":0.7310000061988831},{"id":"https://openalex.org/keywords/sleep-regulation","display_name":"sleep regulation","score":0.43700000643730164},{"id":"https://openalex.org/keywords/total-sleep-time","display_name":"total sleep time","score":0.7739999890327454}],"concepts":[{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.682404637336731},{"id":"https://openalex.org/C2779213384","wikidata":"https://www.wikidata.org/wiki/Q211402","display_name":"Rapid eye movement sleep","level":3,"score":0.6617367267608643},{"id":"https://openalex.org/C20566671","wikidata":"https://www.wikidata.org/wiki/Q1752878","display_name":"Non-rapid eye movement sleep","level":3,"score":0.6551147699356079},{"id":"https://openalex.org/C2778329153","wikidata":"https://www.wikidata.org/wiki/Q1364801","display_name":"Sleep deprivation","level":3,"score":0.6517337560653687},{"id":"https://openalex.org/C2775841894","wikidata":"https://www.wikidata.org/wiki/Q4683692","display_name":"Sleep (system call)","level":2,"score":0.6232035160064697},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.5826983451843262},{"id":"https://openalex.org/C2778321163","wikidata":"https://www.wikidata.org/wiki/Q7246269","display_name":"Privation","level":4,"score":0.5668274760246277},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.541768491268158},{"id":"https://openalex.org/C63759246","wikidata":"https://www.wikidata.org/wiki/Q7539762","display_name":"Sleep onset","level":3,"score":0.4677683711051941},{"id":"https://openalex.org/C110539466","wikidata":"https://www.wikidata.org/wiki/Q3964845","display_name":"Slow-wave sleep","level":3,"score":0.4574616849422455},{"id":"https://openalex.org/C95423882","wikidata":"https://www.wikidata.org/wiki/Q1043667","display_name":"Sleep debt","level":4,"score":0.4169997572898865},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4013584852218628},{"id":"https://openalex.org/C153050134","wikidata":"https://www.wikidata.org/wiki/Q760256","display_name":"Eye movement","level":2,"score":0.38844698667526245},{"id":"https://openalex.org/C548259974","wikidata":"https://www.wikidata.org/wiki/Q569965","display_name":"Audiology","level":1,"score":0.3411431908607483},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.27079063653945923},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.1948297917842865},{"id":"https://openalex.org/C121446783","wikidata":"https://www.wikidata.org/wiki/Q208353","display_name":"Circadian rhythm","level":2,"score":0.17469292879104614},{"id":"https://openalex.org/C2781210498","wikidata":"https://www.wikidata.org/wiki/Q1869874","display_name":"Insomnia","level":2,"score":0.13999775052070618},{"id":"https://openalex.org/C522805319","wikidata":"https://www.wikidata.org/wiki/Q179965","display_name":"Electroencephalography","level":2,"score":0.1251966953277588},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.06626436114311218},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001712","descriptor_name":"Biperiden","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D003700","descriptor_name":"Delta Rhythm","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004569","descriptor_name":"Electroencephalography","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011930","descriptor_name":"Reaction Time","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D012892","descriptor_name":"Sleep Deprivation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D012894","descriptor_name":"Sleep Stages","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D012895","descriptor_name":"Sleep, REM","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1093/sleep/15.3.252","doi":"https://doi.org/10.1093/sleep/15.3.252","is_oa":false,"landing_page_url":"https://doi.org/10.1093/sleep/15.3.252","pdf_url":null,"source":{"id":"https://openalex.org/S42921845","display_name":"SLEEP","issn_l":"0161-8105","issn":["0161-8105","1550-9109"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","erih-plus","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sleep","raw_type":"journal-article"},{"id":"pmid:1621026","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1621026","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sleep","raw_type":"Clinical Trial"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":3,"referenced_works":["https://openalex.org/W2016863258","https://openalex.org/W2151995555","https://openalex.org/W2409956438"],"related_works":["https://openalex.org/W2409956438","https://openalex.org/W1998864761","https://openalex.org/W2412694334","https://openalex.org/W2151995555","https://openalex.org/W1989271532","https://openalex.org/W2029426568","https://openalex.org/W1969971405","https://openalex.org/W2411662411","https://openalex.org/W2021871119","https://openalex.org/W1986759631"],"abstract_inverted_index":{"Sixteen":[0],"subjects":[1,14,44],"were":[2,20],"assigned":[3],"to":[4,103,114],"a":[5,168,211,237],"group":[6,133,178],"using":[7],"either":[8,46],"placebo":[9,47,74,115,172],"or":[10,48],"biperiden,":[11],"with":[12,200],"eight":[13],"in":[15,96,130,160,170,175,197,213,218],"each":[16,117],"group.":[17,163],"Both":[18],"groups":[19,72,220],"studied":[21],"for":[22,116],"one":[23,26],"acclimatization":[24],"night,":[25,28],"baseline":[27,66,94],"four":[29,58,120],"nights":[30,59,70],"of":[31,60,101,118,138,152,234],"rapid":[32],"eye":[33],"movement":[34],"(REM)":[35],"sleep":[36,55,62,81,86,106,122,128,140,147,154,165,180,193,208,239],"deprivation":[37,87,123,186],"and":[38,67],"two":[39],"recovery":[40,69,190,216,226],"nights.":[41,124,187],"All":[42],"the":[43,57,65,68,84,93,119,126,131,136,145,161,171,176,185,189,204,214,224,232],"received":[45,73],"4":[49],"mg":[50],"biperiden":[51,111,132,162,177,235],"1":[52],"hour":[53],"before":[54],"during":[56,83],"REM":[61,80,85,105,121,139,153,164,179,192,207,238],"deprivation.":[63],"During":[64],"both":[71,97,198,219],"capsules.":[75],"The":[76,99,149,206,228],"results":[77],"showed":[78,167,210],"that":[79,221],"time":[82,129,194],"was":[88,107,134,142,156,182,195],"reduced":[89,109,159],"by":[90,110,144],"70-75%":[91],"below":[92],"night":[95,191,217],"groups.":[98,205],"number":[100,137,151],"attempts":[102,141,155],"enter":[104],"significantly":[108,158],"as":[112,236],"compared":[113],"Because":[125],"total":[127,146],"reduced,":[135],"corrected":[143],"time.":[148],"adjusted":[150],"also":[157],"latency":[166,181,209],"reduction":[169,212],"group,":[173],"whereas":[174],"unchanged":[183],"throughout":[184],"In":[188],"increased":[196],"groups,":[199],"no":[201],"differences":[202],"between":[203],"first":[215],"persisted":[222],"through":[223],"second":[225],"night.":[227],"above":[229],"findings":[230],"support":[231],"role":[233],"suppressive":[240],"drug.":[241]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
