{"id":"https://openalex.org/W2397449809","doi":"https://doi.org/10.1186/s41021-016-0044-x","title":"The micronucleus test\u2014most widely used in vivo genotoxicity test\u2014","display_name":"The micronucleus test\u2014most widely used in vivo genotoxicity test\u2014","publication_year":2016,"publication_date":"2016-05-23","ids":{"openalex":"https://openalex.org/W2397449809","doi":"https://doi.org/10.1186/s41021-016-0044-x","mag":"2397449809","pmid":"https://pubmed.ncbi.nlm.nih.gov/27733885","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5045625"},"language":"en","primary_location":{"id":"doi:10.1186/s41021-016-0044-x","doi":"https://doi.org/10.1186/s41021-016-0044-x","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s41021-016-0044-x","pdf_url":"https://genesenvironment.biomedcentral.com/track/pdf/10.1186/s41021-016-0044-x","source":{"id":"https://openalex.org/S69267003","display_name":"Genes and Environment","issn_l":"1880-7046","issn":["1880-7046","1880-7062"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","oarl","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genes and Environment","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://genesenvironment.biomedcentral.com/track/pdf/10.1186/s41021-016-0044-x","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5070698304","display_name":"Makoto Hayashi","orcid":"https://orcid.org/0000-0002-1195-8156","observed_orcids":["https://orcid.org/0000-0002-1195-8156"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Makoto Hayashi","raw_affiliation_strings":["makoto international consulting (mic), Kami-imaizumi, Ebina, Kanagawa, 243-0431, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"makoto international consulting (mic), Kami-imaizumi, Ebina, Kanagawa, 243-0431, Japan","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5070698304"],"corresponding_institution_ids":[],"apc_list":{"value":2590,"currency":"USD","value_usd":2590},"apc_paid":{"value":2590,"currency":"USD","value_usd":2590},"fwci":2.1177,"has_fulltext":true,"cited_by_count":313,"citation_normalized_percentile":{"value":0.91131498,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"38","issue":"1","first_page":"18","last_page":"18"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12281","display_name":"Animal testing and alternatives","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/3404","display_name":"Small Animals"},"field":{"id":"https://openalex.org/fields/34","display_name":"Veterinary"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14072","display_name":"Immunotoxicology and immune responses","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/micronucleus-test","display_name":"micronucleus test","score":0.9990000128746033},{"id":"https://openalex.org/keywords/genotoxicity-testing","display_name":"genotoxicity testing","score":0.9229999780654907},{"id":"https://openalex.org/keywords/in-vivo-genotoxicity","display_name":"in vivo genotoxicity","score":0.7820000052452087},{"id":"https://openalex.org/keywords/chemical-safety-assessment","display_name":"chemical safety assessment","score":0.9240000247955322},{"id":"https://openalex.org/keywords/animal-welfare","display_name":"animal welfare","score":0.8619999885559082},{"id":"https://openalex.org/keywords/alternatives-to-animal-testing","display_name":"alternatives to animal testing","score":0.8019999861717224},{"id":"https://openalex.org/keywords/pharmaceutical-chemicals","display_name":"pharmaceutical chemicals","score":0.6349999904632568},{"id":"https://openalex.org/keywords/agrochemicals","display_name":"agrochemicals","score":0.9229999780654907},{"id":"https://openalex.org/keywords/food-additives","display_name":"food additives","score":1.0}],"concepts":[{"id":"https://openalex.org/C2778959862","wikidata":"https://www.wikidata.org/wiki/Q1009245","display_name":"Genotoxicity","level":3,"score":0.9099351167678833},{"id":"https://openalex.org/C45080847","wikidata":"https://www.wikidata.org/wiki/Q1658004","display_name":"Micronucleus test","level":3,"score":0.7767228484153748},{"id":"https://openalex.org/C33070731","wikidata":"https://www.wikidata.org/wiki/Q7218","display_name":"Toxicology","level":1,"score":0.5933533906936646},{"id":"https://openalex.org/C2777267654","wikidata":"https://www.wikidata.org/wiki/Q3519023","display_name":"Test (biology)","level":2,"score":0.5715881586074829},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.5284502506256104},{"id":"https://openalex.org/C183696295","wikidata":"https://www.wikidata.org/wiki/Q2487696","display_name":"Biochemical engineering","level":1,"score":0.45672211050987244},{"id":"https://openalex.org/C2780465076","wikidata":"https://www.wikidata.org/wiki/Q1069289","display_name":"Chemical safety","level":2,"score":0.45291730761528015},{"id":"https://openalex.org/C520753416","wikidata":"https://www.wikidata.org/wiki/Q38344","display_name":"Animal testing","level":2,"score":0.4356539249420166},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.41571933031082153},{"id":"https://openalex.org/C523966790","wikidata":"https://www.wikidata.org/wiki/Q459426","display_name":"Animal welfare","level":2,"score":0.41363513469696045},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.33711233735084534},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.32217079401016235},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.2449629306793213},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.17498213052749634},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.161687433719635},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.11043626070022583},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.06630545854568481},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1186/s41021-016-0044-x","doi":"https://doi.org/10.1186/s41021-016-0044-x","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s41021-016-0044-x","pdf_url":"https://genesenvironment.biomedcentral.com/track/pdf/10.1186/s41021-016-0044-x","source":{"id":"https://openalex.org/S69267003","display_name":"Genes and Environment","issn_l":"1880-7046","issn":["1880-7046","1880-7062"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","oarl","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genes and Environment","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:5045625","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5045625","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genes Environ","raw_type":"Text"},{"id":"pmid:27733885","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27733885","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genes and environment : the official journal of the Japanese Environmental Mutagen Society","raw_type":"Review"}],"best_oa_location":{"id":"doi:10.1186/s41021-016-0044-x","doi":"https://doi.org/10.1186/s41021-016-0044-x","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s41021-016-0044-x","pdf_url":"https://genesenvironment.biomedcentral.com/track/pdf/10.1186/s41021-016-0044-x","source":{"id":"https://openalex.org/S69267003","display_name":"Genes and Environment","issn_l":"1880-7046","issn":["1880-7046","1880-7062"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","oarl","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genes and Environment","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.7246000170707703}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2397449809.pdf","grobid_xml":"https://content.openalex.org/works/W2397449809.grobid-xml"},"referenced_works_count":51,"referenced_works":["https://openalex.org/W29865316","https://openalex.org/W90094331","https://openalex.org/W152979372","https://openalex.org/W335160920","https://openalex.org/W1510454709","https://openalex.org/W1553597517","https://openalex.org/W1601932516","https://openalex.org/W1642047822","https://openalex.org/W1965724734","https://openalex.org/W1969978690","https://openalex.org/W1976430549","https://openalex.org/W1979792494","https://openalex.org/W1985990090","https://openalex.org/W1988342004","https://openalex.org/W1988636214","https://openalex.org/W1989339166","https://openalex.org/W1989579668","https://openalex.org/W1995960307","https://openalex.org/W1996102265","https://openalex.org/W1998389261","https://openalex.org/W2000264645","https://openalex.org/W2002798549","https://openalex.org/W2007979987","https://openalex.org/W2008161677","https://openalex.org/W2016571415","https://openalex.org/W2023506697","https://openalex.org/W2035002706","https://openalex.org/W2040305737","https://openalex.org/W2040927738","https://openalex.org/W2046908575","https://openalex.org/W2052373946","https://openalex.org/W2052825715","https://openalex.org/W2056204961","https://openalex.org/W2059613902","https://openalex.org/W2060258936","https://openalex.org/W2063987269","https://openalex.org/W2066494150","https://openalex.org/W2072054233","https://openalex.org/W2086942082","https://openalex.org/W2092740209","https://openalex.org/W2098831797","https://openalex.org/W2126073253","https://openalex.org/W2130515759","https://openalex.org/W2139763883","https://openalex.org/W2161309067","https://openalex.org/W2161477415","https://openalex.org/W2170445850","https://openalex.org/W2310873296","https://openalex.org/W4234736483","https://openalex.org/W4238095995","https://openalex.org/W4245671134"],"related_works":["https://openalex.org/W2759764601","https://openalex.org/W155958291","https://openalex.org/W2923058348","https://openalex.org/W3041450608","https://openalex.org/W2413406697","https://openalex.org/W2970044297","https://openalex.org/W2112062796","https://openalex.org/W1990658681","https://openalex.org/W2090510090","https://openalex.org/W2213502877"],"abstract_inverted_index":{"Genotoxicity":[0],"is":[1,17],"commonly":[2],"evaluated":[3],"during":[4],"the":[5,41,44,61,65,75,91,98,104,115],"chemical":[6],"safety":[7,45],"assessment":[8,46],"together":[9],"with":[10],"other":[11],"toxicological":[12],"endpoints.":[13],"The":[14],"micronucleus":[15],"test":[16,23,68,99,105],"always":[18],"included":[19],"in":[20,28,54,62,66,74],"many":[21,29],"genotoxic":[22],"guidelines":[24],"for":[25],"long":[26],"time":[27],"classes":[30],"of":[31,43,47,77,80,83,97,103],"chemicals,":[32,35,37],"e.g.,":[33],"pharmaceutical":[34],"agricultural":[36],"food":[38],"additives.":[39],"Although":[40],"trend":[42],"chemicals":[48],"faces":[49],"to":[50,114],"animal":[51,116],"welfare":[52],"and":[53,108],"vitro":[55],"systems":[56,69],"are":[57,70],"more":[58,72],"welcome":[59],"than":[60],"vivo":[63,67],"systems,":[64],"paid":[71],"attention":[73],"field":[76],"genotoxicity":[78],"because":[79],"its":[81],"weight":[82],"evidence.":[84],"In":[85],"this":[86],"review,":[87],"I":[88],"will":[89],"summarize":[90],"following":[92],"points:":[93],"1)":[94],"historical":[95],"consideration":[96],"development,":[100],"2)":[101],"characteristics":[102],"including":[106],"advantages":[107],"limitations,":[109],"3)":[110],"new":[111],"approaches":[112],"considering":[113],"welfare.":[117]},"counts_by_year":[{"year":2026,"cited_by_count":20},{"year":2025,"cited_by_count":43},{"year":2024,"cited_by_count":46},{"year":2023,"cited_by_count":22},{"year":2022,"cited_by_count":34},{"year":2021,"cited_by_count":52},{"year":2020,"cited_by_count":28},{"year":2019,"cited_by_count":40},{"year":2018,"cited_by_count":16},{"year":2017,"cited_by_count":12}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
