{"id":"https://openalex.org/W2397419607","doi":null,"title":"Autoradiographic mapping of 5-HT1B- and 5-HT1D receptors in human brain using [3H]alniditan, a new radioligand.","display_name":"Autoradiographic mapping of 5-HT1B- and 5-HT1D receptors in human brain using [3H]alniditan, a new radioligand.","publication_year":1997,"publication_date":"1997-01-01","ids":{"openalex":"https://openalex.org/W2397419607","mag":"2397419607","pmid":"https://pubmed.ncbi.nlm.nih.gov/9606727"},"language":"en","primary_location":{"id":"pmid:9606727","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9606727","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Receptors & channels","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5038074049","display_name":"Pascal Bonaventure","orcid":"https://orcid.org/0000-0003-2971-6152","observed_orcids":["https://orcid.org/0000-0003-2971-6152"]},"institutions":[{"id":"https://openalex.org/I137982388","display_name":"Janssen (Belgium)","ror":"https://ror.org/04yzcpd71","country_code":"BE","type":"company","lineage":["https://openalex.org/I1330063522","https://openalex.org/I137982388"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"P Bonaventure","raw_affiliation_strings":["Department of Biochemical Pharmacology, Janssen Research Foundation, Beerse, Belgium. pbonaven@janbe.jnj.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemical Pharmacology, Janssen Research Foundation, Beerse, Belgium. pbonaven@janbe.jnj.com","institution_ids":["https://openalex.org/I137982388"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113650870","display_name":"Alain Schotte","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Schotte","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039638206","display_name":"Patrick P Cras","orcid":"https://orcid.org/0000-0002-7265-7429","observed_orcids":["https://orcid.org/0000-0002-7265-7429"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P Cras","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5111718348","display_name":"Jos\ufffde E. Leysen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J E Leysen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.6988,"has_fulltext":false,"cited_by_count":53,"citation_normalized_percentile":{"value":0.662514,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"5","issue":"3-4","first_page":"225","last_page":"30"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.6582000255584717,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.6582000255584717,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.20479999482631683,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10498","display_name":"Migraine and Headache Studies","score":0.04769999906420708,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/5-ht1b-receptor","display_name":"5-HT1B receptor","score":0.9129999876022339},{"id":"https://openalex.org/keywords/5-ht1d-receptor","display_name":"5-HT1D receptor","score":1.0},{"id":"https://openalex.org/keywords/radioligands","display_name":"radioligands","score":0.7129999995231628},{"id":"https://openalex.org/keywords/serotonin-receptors","display_name":"serotonin receptors","score":0.7049999833106995},{"id":"https://openalex.org/keywords/human-brain","display_name":"human brain","score":0.6990000009536743},{"id":"https://openalex.org/keywords/receptor-distribution","display_name":"receptor distribution","score":0.7269999980926514},{"id":"https://openalex.org/keywords/substantia-nigra","display_name":"substantia nigra","score":0.9430000185966492},{"id":"https://openalex.org/keywords/globus-pallidus","display_name":"globus pallidus","score":0.996999979019165},{"id":"https://openalex.org/keywords/ketanserin","display_name":"ketanserin","score":0.9129999876022339},{"id":"https://openalex.org/keywords/sumatriptan","display_name":"sumatriptan","score":0.8999999761581421},{"id":"https://openalex.org/keywords/autoradiography","display_name":"autoradiography","score":0.7089999914169312}],"concepts":[{"id":"https://openalex.org/C67847695","wikidata":"https://www.wikidata.org/wiki/Q626478","display_name":"Radioligand","level":3,"score":0.7492490410804749},{"id":"https://openalex.org/C2780278869","wikidata":"https://www.wikidata.org/wiki/Q1759633","display_name":"Globus pallidus","level":4,"score":0.7293847799301147},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.7010872960090637},{"id":"https://openalex.org/C2777785214","wikidata":"https://www.wikidata.org/wiki/Q415997","display_name":"Ketanserin","level":5,"score":0.6763973832130432},{"id":"https://openalex.org/C2909005528","wikidata":"https://www.wikidata.org/wiki/Q626478","display_name":"Radioligand Assay","level":3,"score":0.5926716327667236},{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.5923548340797424},{"id":"https://openalex.org/C2779714222","wikidata":"https://www.wikidata.org/wiki/Q550934","display_name":"Putamen","level":2,"score":0.5515206456184387},{"id":"https://openalex.org/C172773627","wikidata":"https://www.wikidata.org/wiki/Q753583","display_name":"5-HT1 receptor","level":5,"score":0.5281486511230469},{"id":"https://openalex.org/C192096249","wikidata":"https://www.wikidata.org/wiki/Q18027442","display_name":"5-HT4 receptor","level":4,"score":0.5217200517654419},{"id":"https://openalex.org/C53910766","wikidata":"https://www.wikidata.org/wiki/Q238516","display_name":"5-HT receptor","level":4,"score":0.5018742084503174},{"id":"https://openalex.org/C2777670902","wikidata":"https://www.wikidata.org/wiki/Q492038","display_name":"Human brain","level":2,"score":0.49290895462036133},{"id":"https://openalex.org/C2776552330","wikidata":"https://www.wikidata.org/wiki/Q1476178","display_name":"Nucleus accumbens","level":3,"score":0.4324151575565338},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.41258540749549866},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3925301134586334},{"id":"https://openalex.org/C2775864247","wikidata":"https://www.wikidata.org/wiki/Q167934","display_name":"Serotonin","level":3,"score":0.376287579536438},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.2878309488296509},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.20214170217514038},{"id":"https://openalex.org/C2778187257","wikidata":"https://www.wikidata.org/wiki/Q464210","display_name":"Basal ganglia","level":3,"score":0.14246860146522522},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.13034602999687195}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001578","descriptor_name":"Benzopyrans","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006168","descriptor_name":"Guinea Pigs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007553","descriptor_name":"Isotope Labeling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011437","descriptor_name":"Propylamines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011743","descriptor_name":"Pyrimidines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011985","descriptor_name":"Receptors, Serotonin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014316","descriptor_name":"Tritium","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D044302","descriptor_name":"Receptor, Serotonin, 5-HT1B","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D044346","descriptor_name":"Receptor, Serotonin, 5-HT1D","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:9606727","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9606727","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Receptors & channels","raw_type":"Journal Article"},{"id":"mag:2397419607","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9606727","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.766700029373169}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2052366663","https://openalex.org/W1994356583","https://openalex.org/W1964030516","https://openalex.org/W2035632600","https://openalex.org/W2019761068","https://openalex.org/W2035644626","https://openalex.org/W2321956104","https://openalex.org/W2005762757","https://openalex.org/W2029595985","https://openalex.org/W2017941198"],"abstract_inverted_index":{"[3H]alniditan,":[0],"a":[1,11,175],"new":[2],"potent":[3],"non-indole":[4],"serotonin":[5],"5-HT1B/1D":[6,47,180],"agonist,":[7],"was":[8,36,93,99,127,155],"used":[9],"as":[10],"radioligand":[12,177],"to":[13,61,112,136,158],"characterize":[14],"5-HT1B":[15,96,121,142,152,164,189],"and":[16,23,42,55,75,186],"5-HT1D":[17,21,24,114,166],"receptor":[18,34,97,115,153,181],"(previously":[19],"termed":[20],"beta":[22],"alpha)":[25],"in":[26,51,56,66,83,103,145,182,194],"various":[27,84],"regions":[28,198],"of":[29,46,106,109,119,132,150,161,163,199],"the":[30,52,57,67,88,104,120,130,148,159,183,188,195,200],"human":[31,141,184,201],"brain.":[32,202],"Quantitative":[33],"autoradiography":[35],"applied":[37],"for":[38,139,178],"high":[39],"anatomical":[40],"resolution":[41],"sensitivity.":[43],"Highest":[44],"densities":[45,63,80],"receptors":[48,143],"were":[49,64,81],"found":[50],"substantia":[53],"nigra":[54],"globus":[58],"pallidus.":[59],"High":[60],"moderate":[62],"measured":[65],"caudate":[68],"nucleus,":[69],"putamen,":[70],"nucleus":[71],"accumbens,":[72],"central":[73],"gray":[74],"hippocampal":[76],"formation.":[77],"Very":[78],"low":[79],"detected":[82],"cortical":[85],"regions.":[86],"In":[87],"cerebellum":[89],"no":[90],"[3H]alniditan":[91,102,173],"binding":[92,122,190],"detected.":[94],"Selective":[95],"labeling":[98,154,162],"achieved":[100],"using":[101],"presence":[105],"300":[107],"nM":[108],"ketanserin":[110],"(sufficient":[111],"block":[113],"labeling).":[116],"The":[117,168],"identity":[118],"sites":[123,191],"under":[124],"these":[125],"conditions":[126],"corroborated":[128],"by":[129],"pIC50":[131],"sumatriptan,":[133],"which":[134],"corresponded":[135],"its":[137],"affinity":[138],"cloned":[140],"expressed":[144],"cells.":[146],"Surprisingly,":[147],"distribution":[149,160],"selective":[151],"completely":[156],"identical":[157],"+":[165],"receptors.":[167],"present":[169],"data":[170],"indicate":[171],"that":[172,187],"is":[174],"suitable":[176],"measuring":[179],"brain":[185],"are":[192],"predominant":[193],"presently":[196],"investigated":[197]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
