{"id":"https://openalex.org/W2397418801","doi":null,"title":"[Effect of bufalin on growth and differentiation of human skin carcinoma cells in vitro].","display_name":"[Effect of bufalin on growth and differentiation of human skin carcinoma cells in vitro].","publication_year":1999,"publication_date":"1999-12-01","ids":{"openalex":"https://openalex.org/W2397418801","mag":"2397418801","pmid":"https://pubmed.ncbi.nlm.nih.gov/10834107"},"language":"ja","primary_location":{"id":"pmid:10834107","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10834107","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human cell","raw_type":"English Abstract"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"M Akiyama","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I119182057","display_name":"SHOWA Medical University","ror":"https://ror.org/04mzk4q39","country_code":"JP","type":"education","lineage":["https://openalex.org/I119182057"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"M Akiyama","raw_affiliation_strings":["Department of Dermatology, Showa University School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, Showa University School of Medicine","institution_ids":["https://openalex.org/I119182057"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009895580","display_name":"Mai Ogura","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Ogura","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"M Iwai","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Iwai","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"M Iijima","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Iijima","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010304099","display_name":"Satoshi Numazawa","orcid":"https://orcid.org/0000-0002-4818-1061","observed_orcids":["https://orcid.org/0000-0002-4818-1061"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S Numazawa","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5113437220","display_name":"T Yoshida","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T Yoshida","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2752,"has_fulltext":false,"cited_by_count":14,"citation_normalized_percentile":{"value":0.5506786,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"12","issue":"4","first_page":"205","last_page":"9"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13185","display_name":"Phytochemistry and Bioactive Compounds","score":0.6880000233650208,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T13185","display_name":"Phytochemistry and Bioactive Compounds","score":0.6880000233650208,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11385","display_name":"Natural product bioactivities and synthesis","score":0.07989999651908875,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12215","display_name":"Phytochemical Studies and Bioactivities","score":0.0494999997317791,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bufalin","display_name":"bufalin","score":0.9990000128746033},{"id":"https://openalex.org/keywords/cardiac-glycosides","display_name":"cardiac glycosides","score":0.902999997138977},{"id":"https://openalex.org/keywords/cutaneous-squamous-cell-carcinoma","display_name":"cutaneous squamous cell carcinoma","score":0.9210000038146973},{"id":"https://openalex.org/keywords/growth-inhibition","display_name":"growth inhibition","score":0.6779999732971191},{"id":"https://openalex.org/keywords/differentiation-induction","display_name":"differentiation induction","score":0.9210000038146973},{"id":"https://openalex.org/keywords/dna-synthesis","display_name":"DNA synthesis","score":0.6309999823570251},{"id":"https://openalex.org/keywords/cornified-envelope","display_name":"cornified envelope","score":0.8960000276565552},{"id":"https://openalex.org/keywords/chinese-toad","display_name":"Chinese toad","score":0.5509999990463257}],"concepts":[{"id":"https://openalex.org/C2777151579","wikidata":"https://www.wikidata.org/wiki/Q18379323","display_name":"Bufalin","level":3,"score":0.9935612678527832},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.5511785745620728},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5024313926696777},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.45496875047683716},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.44994300603866577},{"id":"https://openalex.org/C148738053","wikidata":"https://www.wikidata.org/wiki/Q210861","display_name":"Cellular differentiation","level":3,"score":0.4428132176399231},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.42130792140960693},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4009600877761841},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.36710476875305176},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2997683882713318},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.2493513822555542},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.08314043283462524},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D002018","descriptor_name":"Bufanolides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D002301","descriptor_name":"Cardiac Glycosides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D003864","descriptor_name":"Depression, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004273","descriptor_name":"DNA, Neoplasm","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012878","descriptor_name":"Skin Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012878","descriptor_name":"Skin Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:10834107","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10834107","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human cell","raw_type":"English Abstract"},{"id":"mag:2397418801","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10834107","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8999999761581421}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2056534593","https://openalex.org/W2375805870","https://openalex.org/W2040172810","https://openalex.org/W7097457247","https://openalex.org/W2156883962","https://openalex.org/W4295517915","https://openalex.org/W2901113580","https://openalex.org/W2426922988","https://openalex.org/W2384866198","https://openalex.org/W2191947373"],"abstract_inverted_index":{"Bufalin,":[0],"a":[1,108],"cardiotonic":[2],"steroid":[3],"isolated":[4],"from":[5],"the":[6,29,80,113,119],"Chinese":[7],"toad,":[8],"was":[9,56,60,89],"previously":[10],"shown":[11],"to":[12],"have":[13],"growth":[14,34,51,100,133],"inhibitory":[15,101,134],"and":[16,23,35,66,118,124,135],"differentiation":[17,36,136],"inducing":[18,137],"activities":[19],"on":[20,33,139],"leukemia":[21],"cells":[22,43,55,70,85],"malignant":[24],"melanoma":[25],"cells.":[26,141],"We":[27],"examined":[28],"effect":[30,102],"of":[31,37,53,64,83,103,115,121],"bufalin":[32,76,130],"human":[38],"skin":[39],"squamous":[40],"cell":[41],"carcinoma":[42],"(SSCC-1)":[44],"in":[45,92],"vitro.":[46],"The":[47,96],"concentration":[48],"needed":[49],"for":[50,77],"inhibition":[52],"SSCC-1":[54,69,84,140],"10(-8)":[57,74],"M,":[58],"which":[59],"lower":[61],"than":[62],"those":[63],"gamabufotalin":[65],"ouabain.":[67],"When":[68],"were":[71],"treated":[72],"with":[73],"M":[75],"16":[78],"h,":[79],"DNA":[81],"synthesis":[82],"decreased,":[86],"but":[87],"there":[88],"no":[90],"change":[91],"their":[93],"survival":[94],"ratio.":[95],"results":[97],"suggest":[98],"that":[99,129],"buffalin":[104],"is":[105],"not":[106],"only":[107],"cytotoxic":[109],"effect.":[110],"Bufalin":[111],"increased":[112],"production":[114],"cornified":[116],"envelopes":[117],"expression":[120],"Keratin":[122],"K10/11":[123],"involurcin.":[125],"These":[126],"findings":[127],"indicate":[128],"has":[131],"both":[132],"effects":[138]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-02T09:45:03.842371","created_date":"2016-06-24T00:00:00"}