{"id":"https://openalex.org/W2397412504","doi":null,"title":"A chronic hypercoagulable state and life-long platelet activation in beta thalassemia major.","display_name":"A chronic hypercoagulable state and life-long platelet activation in beta thalassemia major.","publication_year":1993,"publication_date":"1993-01-01","ids":{"openalex":"https://openalex.org/W2397412504","mag":"2397412504","pmid":"https://pubmed.ncbi.nlm.nih.gov/7886616"},"language":"en","primary_location":{"id":"pmid:7886616","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7886616","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Southeast Asian journal of tropical medicine and public health","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5019467798","display_name":"Amiram Eldor","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I197251160","display_name":"Hebrew University of Jerusalem","ror":"https://ror.org/03qxff017","country_code":"IL","type":"education","lineage":["https://openalex.org/I197251160"]},{"id":"https://openalex.org/I2799899409","display_name":"Hadassah Medical Center","ror":"https://ror.org/01cqmqj90","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2799899409"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"A Eldor","raw_affiliation_strings":["Department of Hematology, Hadassah-Hebrew University Medical School, Jerusalem"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Hadassah-Hebrew University Medical School, Jerusalem","institution_ids":["https://openalex.org/I197251160","https://openalex.org/I2799899409"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109294474","display_name":"Jacques Maclouf","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J Maclouf","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056694745","display_name":"Franck Lellouche","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"F Lellouche","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007412310","display_name":"Vered Ben-Yashar","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"V Ben-Yashar","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068725737","display_name":"Yechezkel Barenholz","orcid":"https://orcid.org/0000-0003-4429-9609","observed_orcids":["https://orcid.org/0000-0003-4429-9609"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Y Barenholz","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010326841","display_name":"Ronen Y. Durst","orcid":"https://orcid.org/0000-0003-3559-1050","observed_orcids":["https://orcid.org/0000-0003-3559-1050"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R Durst","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113645737","display_name":"Esti Hyam","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E Hy-Am","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108428583","display_name":"A. H. Goldfarb","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Goldfarb","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5113576353","display_name":"Eliezer A. Rachmilewitz","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E Rachmilewitz","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.3107,"has_fulltext":false,"cited_by_count":35,"citation_normalized_percentile":{"value":0.56471306,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"24 Suppl 1","issue":null,"first_page":"92","last_page":"5"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10554","display_name":"Hemoglobinopathies and Related Disorders","score":0.975600004196167,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10554","display_name":"Hemoglobinopathies and Related Disorders","score":0.975600004196167,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.010900000110268593,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.010200000368058681,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/beta-thalassemia-major","display_name":"beta-thalassemia major","score":0.968999981880188},{"id":"https://openalex.org/keywords/hypercoagulability","display_name":"hypercoagulability","score":0.9010000228881836},{"id":"https://openalex.org/keywords/thromboembolism","display_name":"thromboembolism","score":0.8100000023841858},{"id":"https://openalex.org/keywords/platelet-activation","display_name":"platelet activation","score":0.9279999732971191},{"id":"https://openalex.org/keywords/platelet-aggregation","display_name":"platelet aggregation","score":0.7929999828338623},{"id":"https://openalex.org/keywords/thromboxane-a2","display_name":"thromboxane A2","score":0.8330000042915344},{"id":"https://openalex.org/keywords/prostacyclin","display_name":"prostacyclin","score":0.8799999952316284},{"id":"https://openalex.org/keywords/protein-c","display_name":"protein C","score":0.9190000295639038},{"id":"https://openalex.org/keywords/protein-s","display_name":"protein S","score":0.9729999899864197},{"id":"https://openalex.org/keywords/antithrombin-iii","display_name":"antithrombin III","score":0.921999990940094},{"id":"https://openalex.org/keywords/thrombin-generation","display_name":"thrombin generation","score":0.6539999842643738},{"id":"https://openalex.org/keywords/pulmonary-infarction","display_name":"pulmonary infarction","score":0.7250000238418579},{"id":"https://openalex.org/keywords/renal-infarction","display_name":"renal infarction","score":0.8859999775886536},{"id":"https://openalex.org/keywords/accelerated-atherosclerosis","display_name":"premature atherosclerosis","score":0.9049999713897705},{"id":"https://openalex.org/keywords/antithrombotic-therapy","display_name":"antithrombotic therapy","score":0.8690000176429749}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7133050560951233},{"id":"https://openalex.org/C2777799968","wikidata":"https://www.wikidata.org/wiki/Q185137","display_name":"Thalassemia","level":2,"score":0.6541174650192261},{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.638574481010437},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6306225061416626},{"id":"https://openalex.org/C2781128415","wikidata":"https://www.wikidata.org/wiki/Q412050","display_name":"Prostacyclin","level":2,"score":0.5827076435089111},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4850098788738251},{"id":"https://openalex.org/C2777292125","wikidata":"https://www.wikidata.org/wiki/Q409166","display_name":"Thrombin","level":3,"score":0.4763386845588684},{"id":"https://openalex.org/C2780868729","wikidata":"https://www.wikidata.org/wiki/Q261327","display_name":"Thrombosis","level":2,"score":0.45201218128204346},{"id":"https://openalex.org/C3018697912","wikidata":"https://www.wikidata.org/wiki/Q179217","display_name":"Platelet activation","level":3,"score":0.4397295117378235},{"id":"https://openalex.org/C112516734","wikidata":"https://www.wikidata.org/wiki/Q423640","display_name":"Prothrombinase","level":4,"score":0.4315102696418762},{"id":"https://openalex.org/C2781024287","wikidata":"https://www.wikidata.org/wiki/Q774909","display_name":"Thromboxane A2","level":3,"score":0.4157719016075134},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.3812335133552551}],"mesh":[{"descriptor_ui":"D001791","descriptor_name":"Blood Platelet Disorders","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D001791","descriptor_name":"Blood Platelet Disorders","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D002908","descriptor_name":"Chronic Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013923","descriptor_name":"Thromboembolism","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D015539","descriptor_name":"Platelet Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017086","descriptor_name":"beta-Thalassemia","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:7886616","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7886616","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Southeast Asian journal of tropical medicine and public health","raw_type":"Journal Article"},{"id":"mag:2397412504","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7886616","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1981237191","https://openalex.org/W2310672476","https://openalex.org/W2106648935","https://openalex.org/W2005712358","https://openalex.org/W2098289478","https://openalex.org/W1971599430","https://openalex.org/W7100182980","https://openalex.org/W4384119575","https://openalex.org/W2101073547","https://openalex.org/W7019596246"],"abstract_inverted_index":{"Increased":[0],"frequency":[1],"of":[2,52,55,65],"thromboembolic":[3],"events":[4],"has":[5],"been":[6],"recently":[7],"observed":[8],"in":[9,80,94],"patients":[10,76,96],"with":[11],"thalassemia":[12],"major":[13],"(TM),":[14],"causing":[15],"hypoxemia":[16],"and":[17,24,27,59,61,101],"cor":[18],"pulmonale.":[19],"Autopsy":[20],"findings":[21],"demonstrated":[22],"\"old\"":[23],"recent":[25],"pulmonary":[26,102],"renal":[28],"infarcts":[29],"as":[30,32],"well":[31],"premature":[33],"atherosclerosis.":[34],"Studies":[35],"to":[36,97],"determine":[37],"hypercoagulability":[38],"showed:":[39],"impaired":[40],"platelet":[41,45,48],"aggregation,":[42],"increased":[43],"circulating":[44],"aggregates,":[46],"shortened":[47],"survival,":[49],"enhanced":[50,77],"excretion":[51],"urinary":[53],"metabolites":[54],"thromboxane":[56],"A2":[57],"(TXA2)":[58],"prostacyclin":[60],"decreased":[62],"plasma":[63],"levels":[64],"Protein":[66,68],"C,":[67],"S":[69],"or":[70],"anti-thrombin":[71],"III.":[72],"Erythrocytes":[73],"from":[74],"TM":[75],"thrombin":[78],"formation":[79],"a":[81,85],"\"prothrombinase\"":[82],"assay":[83],"(using":[84],"chromogenic":[86],"substrate).":[87],"Chronic":[88],"anti-thrombotic":[89],"therapy":[90],"may":[91],"be":[92],"indicated":[93],"thalassemic":[95],"prevent":[98],"the":[99],"cardiac":[100],"complications.":[103]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}