{"id":"https://openalex.org/W2397315759","doi":"https://doi.org/10.1177/1934578x1300800321","title":"Evaluation of the in vivo Anti-inflammatory and Analgesic and in vitro Anti-cancer Activities of Curcumin and its Derivatives","display_name":"Evaluation of the in vivo Anti-inflammatory and Analgesic and in vitro Anti-cancer Activities of Curcumin and its Derivatives","publication_year":2013,"publication_date":"2013-03-01","ids":{"openalex":"https://openalex.org/W2397315759","doi":"https://doi.org/10.1177/1934578x1300800321","mag":"2397315759","pmid":"https://pubmed.ncbi.nlm.nih.gov/23678811"},"language":"en","primary_location":{"id":"doi:10.1177/1934578x1300800321","doi":"https://doi.org/10.1177/1934578x1300800321","is_oa":true,"landing_page_url":"https://doi.org/10.1177/1934578x1300800321","pdf_url":"https://journals.sagepub.com/doi/pdf/10.1177/1934578X1300800321","source":{"id":"https://openalex.org/S124250138","display_name":"Natural Product Communications","issn_l":"1555-9475","issn":["1555-9475","1934-578X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","jufo-1","norway-1","oarl","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Natural Product Communications","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://journals.sagepub.com/doi/pdf/10.1177/1934578X1300800321","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5083417399","display_name":"James N. Jacob","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"James N. Jacob","raw_affiliation_strings":["Department of Medicinal Chemistry, Organomed Corporation, 11 Grandview St., Unit 8, Coventry, RI 02816, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicinal Chemistry, Organomed Corporation, 11 Grandview St., Unit 8, Coventry, RI 02816, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002933821","display_name":"Dinesh Kumar Badyal","orcid":"https://orcid.org/0000-0003-0773-2338","observed_orcids":["https://orcid.org/0000-0003-0773-2338"]},"institutions":[{"id":"https://openalex.org/I4210108783","display_name":"Christian Medical College","ror":"https://ror.org/01vj9qy35","country_code":"IN","type":"education","lineage":["https://openalex.org/I4210108783"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Dinesh K. Badyal","raw_affiliation_strings":["Department of Pharmacology, Christian Medical College, Ludhiana-141008, Punjab, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Christian Medical College, Ludhiana-141008, Punjab, India","institution_ids":["https://openalex.org/I4210108783"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088506485","display_name":"Suman Bala","orcid":"https://orcid.org/0000-0002-5102-7372","observed_orcids":["https://orcid.org/0000-0002-5102-7372"]},"institutions":[{"id":"https://openalex.org/I4210108783","display_name":"Christian Medical College","ror":"https://ror.org/01vj9qy35","country_code":"IN","type":"education","lineage":["https://openalex.org/I4210108783"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Suman Bala","raw_affiliation_strings":["Department of Pharmacology, Christian Medical College, Ludhiana-141008, Punjab, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Christian Medical College, Ludhiana-141008, Punjab, India","institution_ids":["https://openalex.org/I4210108783"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5000000300","display_name":"Masoud Toloue","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210133184","display_name":"Bioo Scientific (United States)","ror":"https://ror.org/045v29b75","country_code":"US","type":"company","lineage":["https://openalex.org/I4210133184"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Masoud Toloue","raw_affiliation_strings":["BIOO Scientific Corporation 3913 Todd Lane Suite 312, Austin, TX 78744, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BIOO Scientific Corporation 3913 Todd Lane Suite 312, Austin, TX 78744, USA","institution_ids":["https://openalex.org/I4210133184"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5083417399"],"corresponding_institution_ids":[],"apc_list":{"value":2650,"currency":"USD","value_usd":2650},"apc_paid":null,"fwci":0.9216,"has_fulltext":false,"cited_by_count":21,"citation_normalized_percentile":{"value":0.70671299,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"8","issue":"3","first_page":"359","last_page":"62"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11319","display_name":"Curcumin's Biomedical Applications","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1313","display_name":"Molecular Medicine"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11319","display_name":"Curcumin's Biomedical Applications","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1313","display_name":"Molecular Medicine"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10274","display_name":"Synthesis and biological activity","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12347","display_name":"Ginger and Zingiberaceae research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/curcumin","display_name":"curcumin","score":0.9900000095367432},{"id":"https://openalex.org/keywords/curcumin-derivatives","display_name":"curcumin derivatives","score":0.8980000019073486},{"id":"https://openalex.org/keywords/anti-inflammatory-activity","display_name":"anti-inflammatory activity","score":0.9710000157356262},{"id":"https://openalex.org/keywords/analgesic-activity","display_name":"analgesic activity","score":0.9990000128746033},{"id":"https://openalex.org/keywords/anticancer-activity","display_name":"anticancer activity","score":0.8999999761581421},{"id":"https://openalex.org/keywords/cancer-cell-lines","display_name":"cancer cell lines","score":0.5879999995231628},{"id":"https://openalex.org/keywords/paw-edema","display_name":"paw edema","score":0.7039999961853027},{"id":"https://openalex.org/keywords/carrageenan-induced-edema","display_name":"carrageenan-induced edema","score":0.7269999980926514},{"id":"https://openalex.org/keywords/aspirin-comparison","display_name":"aspirin comparison","score":0.8500000238418579},{"id":"https://openalex.org/keywords/turmeric","display_name":"turmeric","score":0.5910000205039978}],"concepts":[{"id":"https://openalex.org/C2778250585","wikidata":"https://www.wikidata.org/wiki/Q312266","display_name":"Curcumin","level":2,"score":0.9888946413993835},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.7587395310401917},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.7018098831176758},{"id":"https://openalex.org/C2777628954","wikidata":"https://www.wikidata.org/wiki/Q18216","display_name":"Aspirin","level":2,"score":0.63229900598526},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6320714950561523},{"id":"https://openalex.org/C2779703632","wikidata":"https://www.wikidata.org/wiki/Q581996","display_name":"Anti-inflammatory","level":2,"score":0.6307437419891357},{"id":"https://openalex.org/C2780820201","wikidata":"https://www.wikidata.org/wiki/Q173235","display_name":"Analgesic","level":2,"score":0.5643543004989624},{"id":"https://openalex.org/C2781227287","wikidata":"https://www.wikidata.org/wiki/Q421991","display_name":"Carrageenan","level":2,"score":0.5367829203605652},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.49988269805908203},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.214119553565979},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.19517043232917786},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.07287275791168213},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.07181835174560547}],"mesh":[{"descriptor_ui":"D000700","descriptor_name":"Analgesics","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000700","descriptor_name":"Analgesics","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000700","descriptor_name":"Analgesics","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000893","descriptor_name":"Anti-Inflammatory Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000893","descriptor_name":"Anti-Inflammatory Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000893","descriptor_name":"Anti-Inflammatory Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D001241","descriptor_name":"Aspirin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D001241","descriptor_name":"Aspirin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003474","descriptor_name":"Curcumin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D003474","descriptor_name":"Curcumin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D003474","descriptor_name":"Curcumin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004487","descriptor_name":"Edema","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1177/1934578x1300800321","doi":"https://doi.org/10.1177/1934578x1300800321","is_oa":true,"landing_page_url":"https://doi.org/10.1177/1934578x1300800321","pdf_url":"https://journals.sagepub.com/doi/pdf/10.1177/1934578X1300800321","source":{"id":"https://openalex.org/S124250138","display_name":"Natural Product Communications","issn_l":"1555-9475","issn":["1555-9475","1934-578X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","jufo-1","norway-1","oarl","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Natural Product Communications","raw_type":"journal-article"},{"id":"pmid:23678811","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23678811","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Natural product communications","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:6e1d7e3a0ab84b4f94024b7c86663cc2","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/6e1d7e3a0ab84b4f94024b7c86663cc2","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Natural Product Communications, Vol 8 (2013)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1177/1934578x1300800321","doi":"https://doi.org/10.1177/1934578x1300800321","is_oa":true,"landing_page_url":"https://doi.org/10.1177/1934578x1300800321","pdf_url":"https://journals.sagepub.com/doi/pdf/10.1177/1934578X1300800321","source":{"id":"https://openalex.org/S124250138","display_name":"Natural Product Communications","issn_l":"1555-9475","issn":["1555-9475","1934-578X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","jufo-1","norway-1","oarl","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Natural Product Communications","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9763000011444092,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320309070","display_name":"Brown University","ror":"https://ror.org/05gq02987"}],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W2397315759.pdf"},"referenced_works_count":20,"referenced_works":["https://openalex.org/W112445417","https://openalex.org/W149792954","https://openalex.org/W1967578143","https://openalex.org/W1981819970","https://openalex.org/W2026012172","https://openalex.org/W2037222034","https://openalex.org/W2068821865","https://openalex.org/W2070878775","https://openalex.org/W2088496138","https://openalex.org/W2091747761","https://openalex.org/W2116660246","https://openalex.org/W2132870913","https://openalex.org/W2206043426","https://openalex.org/W2242111441","https://openalex.org/W2261454648","https://openalex.org/W2275249742","https://openalex.org/W2301979987","https://openalex.org/W2304131176","https://openalex.org/W2409746082","https://openalex.org/W4206816879"],"related_works":["https://openalex.org/W2737253223","https://openalex.org/W2068821865","https://openalex.org/W2104989681","https://openalex.org/W2897462389","https://openalex.org/W241508787","https://openalex.org/W2946684939","https://openalex.org/W4410377647","https://openalex.org/W4396750793","https://openalex.org/W3130869290","https://openalex.org/W4389056890"],"abstract_inverted_index":{"Curcumin,":[0],"obtained":[1],"from":[2],"turmeric,":[3],"has":[4],"several":[5],"biological":[6],"properties":[7],"to":[8,80],"make":[9],"it":[10],"a":[11,26,71],"desirable":[12],"template":[13],"for":[14,159],"drug":[15],"development.":[16],"A":[17],"lipophilic":[18],"derivative":[19],"of":[20,46,55,86,146,154],"curcumin,":[21,106],"diacetyl":[22],"curcumin":[23,30,47,56,87,149],"(DAC)":[24],"and":[25,34,39,48,57,83,108,164],"hydrophilic":[27],"derivative,":[28],"diglutaryl":[29],"(DGC)":[31],"were":[32,42,66,78],"synthesized":[33],"their":[35],"in":[36,51],"vivo":[37],"analgesic":[38],"anti-inflammatory":[40,144],"activities":[41,54],"compared":[43,67],"with":[44,68,132],"those":[45,69],"aspirin.":[49,124],"The":[50,75,99,125,137,151],"vitro":[52],"anti-cancer":[53],"the":[58,95],"two":[59],"derivatives":[60],"against":[61,70],"three":[62,148],"cell":[63,73,97],"cancer":[64],"lines":[65],"non-cancerous":[72,96],"line.":[74,98],"inhibitory":[76,92],"effects":[77],"comparable":[79],"each":[81],"other":[82],"nearing":[84],"that":[85,105],"while":[88],"they":[89],"showed":[90,104],"low":[91],"effect":[93,128],"towards":[94],"mouse":[100],"tail":[101],"flick":[102],"assay":[103],"DAC":[107],"DGC":[109,113,133],"increased":[110],"latency":[111],"time.":[112],"was":[114,130,157],"most":[115],"effective":[116],"as":[117],"an":[118],"analgesic,":[119],"even":[120],"more":[121],"so":[122],"than":[123],"maximum":[126,158],"percentage":[127,152],"(MPE)":[129],"highest":[131],"at":[134],"3":[135],"hours.":[136],"carrageenan":[138],"induced":[139],"paw":[140,155],"edema":[141,156],"model":[142],"indicated":[143],"activity":[145],"all":[147],"formulations.":[150],"inhibition":[153],"DAC,":[160],"followed":[161],"by":[162],"aspirin":[163],"curcumin.":[165]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
