{"id":"https://openalex.org/W2397311688","doi":null,"title":"Differential effect of HTLV infection and HTLV Tax on interleukin 3 expression.","display_name":"Differential effect of HTLV infection and HTLV Tax on interleukin 3 expression.","publication_year":1993,"publication_date":"1993-07-01","ids":{"openalex":"https://openalex.org/W2397311688","mag":"2397311688","pmid":"https://pubmed.ncbi.nlm.nih.gov/8510934"},"language":"en","primary_location":{"id":"pmid:8510934","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8510934","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncogene","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109225699","display_name":"Maurice J. Wolin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M Wolin","raw_affiliation_strings":["Department of Medicine, UCLA School of Medicine 90024-1678"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, UCLA School of Medicine 90024-1678","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024328114","display_name":"Masayo Kornuc","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M Kornuc","raw_affiliation_strings":["University of California at Los Angeles"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California at Los Angeles","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":null,"display_name":"C Hong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C Hong","raw_affiliation_strings":["University of California at Los Angeles"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California at Los Angeles","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091121184","display_name":"Soon-Ki Shin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S K Shin","raw_affiliation_strings":["University of California at Los Angeles"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California at Los Angeles","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002488304","display_name":"F. Lee","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"F Lee","raw_affiliation_strings":["University of California at Los Angeles"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California at Los Angeles","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002457355","display_name":"Roy Lau","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R Lau","raw_affiliation_strings":["University of California at Los Angeles"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California at Los Angeles","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113755168","display_name":"S D Nimer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S Nimer","raw_affiliation_strings":["University of California at Los Angeles"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California at Los Angeles","institution_ids":["https://openalex.org/I161318765"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I161318765"],"apc_list":null,"apc_paid":null,"fwci":1.6839,"has_fulltext":false,"cited_by_count":16,"citation_normalized_percentile":{"value":0.85904311,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"8","issue":"7","first_page":"1905","last_page":"11"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12159","display_name":"T-cell and Retrovirus Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12159","display_name":"T-cell and Retrovirus Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10340","display_name":"Hepatitis B Virus Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/htlv-infection","display_name":"HTLV infection","score":0.875},{"id":"https://openalex.org/keywords/interleukin-3","display_name":"interleukin-3","score":0.9750000238418579},{"id":"https://openalex.org/keywords/transcriptional-repression","display_name":"transcriptional repression","score":0.824999988079071},{"id":"https://openalex.org/keywords/t-cell-leukemia-virus","display_name":"T-cell leukemia virus","score":0.6240000128746033},{"id":"https://openalex.org/keywords/t-cell-gene-expression","display_name":"T cell gene expression","score":0.5389999747276306},{"id":"https://openalex.org/keywords/promoter-binding-proteins","display_name":"promoter binding proteins","score":0.4959999918937683},{"id":"https://openalex.org/keywords/transcriptional-activation","display_name":"transcriptional activation","score":0.5099999904632568},{"id":"https://openalex.org/keywords/gm-csf","display_name":"GM-CSF","score":0.5529999732971191}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8801227807998657},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.6255413293838501},{"id":"https://openalex.org/C49382859","wikidata":"https://www.wikidata.org/wiki/Q286498","display_name":"Lymphokine","level":3,"score":0.5771281123161316},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.5224734544754028},{"id":"https://openalex.org/C102906071","wikidata":"https://www.wikidata.org/wiki/Q422467","display_name":"Provirus","level":4,"score":0.5221460461616516},{"id":"https://openalex.org/C54009773","wikidata":"https://www.wikidata.org/wiki/Q1429031","display_name":"Transfection","level":3,"score":0.5011224746704102},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.4763374924659729},{"id":"https://openalex.org/C131665280","wikidata":"https://www.wikidata.org/wiki/Q14866169","display_name":"Interleukin 3","level":5,"score":0.4700419306755066},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.4521239101886749},{"id":"https://openalex.org/C2776238826","wikidata":"https://www.wikidata.org/wiki/Q1280388","display_name":"Human T-lymphotropic virus 1","level":4,"score":0.44945022463798523},{"id":"https://openalex.org/C101762097","wikidata":"https://www.wikidata.org/wiki/Q224093","display_name":"Promoter","level":4,"score":0.43620991706848145},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.40843576192855835},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.3582758903503418},{"id":"https://openalex.org/C2776913467","wikidata":"https://www.wikidata.org/wiki/Q7667895","display_name":"T-cell leukemia","level":3,"score":0.28769823908805847},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2554967403411865},{"id":"https://openalex.org/C129374314","wikidata":"https://www.wikidata.org/wiki/Q909381","display_name":"Interleukin 21","level":4,"score":0.19761121273040771},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.16334843635559082},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1120833158493042},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.07932573556900024},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003850","descriptor_name":"Deoxyribonuclease I","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007377","descriptor_name":"Interleukin-3","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D015368","descriptor_name":"Human T-lymphotropic virus 1","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016356","descriptor_name":"Gene Products, tax","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:8510934","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8510934","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncogene","raw_type":"Journal Article"},{"id":"mag:2397311688","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8510934","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[{"id":"https://openalex.org/G6859385822","display_name":"MOLECULAR PATHOGENESIS OF MYELOID LEUKEMIA","funder_award_id":"R01DK043025","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2086276188","https://openalex.org/W2058074597","https://openalex.org/W2056430584","https://openalex.org/W122509597","https://openalex.org/W2069729178","https://openalex.org/W97221134","https://openalex.org/W2550055743","https://openalex.org/W1991248209","https://openalex.org/W258065988","https://openalex.org/W2059027587"],"abstract_inverted_index":{"To":[0,105],"characterize":[1],"the":[2,17,20,26,98,128,142,152,160,180,183,215],"interactions":[3],"between":[4,146,154],"human":[5],"T-cell":[6,207],"leukemia":[7],"virus":[8],"(HTLV)":[9],"infection":[10],"and":[11,28,87,116,150,156,165,185],"cellular":[12],"gene":[13,86,219],"expression,":[14],"we":[15],"examined":[16],"expression":[18,91,220],"of":[19,30,127,179,217],"lymphokine":[21,161],"interleukin":[22],"3":[23],"(IL-3)":[24],"in":[25,54,63,101,109,114,195,199,202,214,221],"presence":[27],"absence":[29],"HTLV":[31],"infection.":[32],"IL-3,":[33],"like":[34],"granulocyte-macrophage":[35],"colony-stimulating":[36],"factor":[37],"(GM-CSF),":[38],"is":[39,51],"produced":[40],"by":[41,70,169],"activated":[42],"but":[43,48,173,204],"not":[44,174,205],"resting":[45],"T":[46,56,103,118,176,223],"cells,":[47],"although":[49],"GM-CSF":[50],"constitutively":[52],"expressed":[53],"HTLV-infected":[55,68,115,172,203,222],"cells":[57,69,119],"IL-3":[58,83,99,110,129,143,190,218],"mRNA":[59],"cannot":[60],"be":[61],"detected":[62],"either":[64],"unstimulated":[65],"or":[66],"mitogen-stimulated":[67],"polymerase":[71],"chain":[72],"reaction":[73],"(PCR)":[74],"analysis.":[75],"In":[76],"contrast,":[77],"transient":[78],"co-transfection":[79],"studies":[80],"with":[81],"an":[82,88,189],"promoter-CAT":[84],"reporter":[85],"HTLV-II":[89],"Tax":[90,95],"construct":[92,193],"demonstrate":[93],"that":[94,210],"can":[96],"transactivate":[97],"promoter":[100,130,191,200],"HTLV-uninfected":[102,175],"cells.":[104,177,224],"determine":[106],"whether":[107],"differences":[108],"promoter-binding":[111],"proteins":[112],"present":[113],"uninfected":[117,206],"account":[120],"for":[121],"this":[122,211],"discrepancy,":[123],"DNAase":[124],"I":[125],"footprinting":[126],"was":[131],"performed.":[132],"Although":[133],"crude":[134],"nuclear":[135],"extracts":[136,170],"from":[137,171,188],"both":[138],"cell":[139],"types":[140],"protected":[141,168],"sequences":[144,153,163,187],"located":[145],"base":[147],"pairs":[148],"-168":[149],"-125,":[151],"-125":[155],"-103,":[157],"which":[158],"contain":[159],"consensus":[162],"CK-1":[164,184],"CK-2,":[166],"were":[167],"Deletion":[178],"region":[181,212],"containing":[182],"CK-2":[186],"CAT":[192],"resulted":[194],"a":[196],"sixfold":[197],"rise":[198],"activity":[201],"lines,":[208],"indicating":[209],"participates":[213],"repression":[216]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}