{"id":"https://openalex.org/W2397286014","doi":"https://doi.org/10.1159/000150144","title":"Human Xenografts","display_name":"Human Xenografts","publication_year":1990,"publication_date":"1990-01-01","ids":{"openalex":"https://openalex.org/W2397286014","doi":"https://doi.org/10.1159/000150144","mag":"2397286014","pmid":"https://pubmed.ncbi.nlm.nih.gov/2165039"},"language":"en","primary_location":{"id":"doi:10.1159/000150144","doi":"https://doi.org/10.1159/000150144","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000150144","pdf_url":null,"source":{"id":"https://openalex.org/S64836871","display_name":"Intervirology","issn_l":"0300-5526","issn":["0300-5526","1423-0100"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","medline","norway-1","oarl","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Intervirology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5060274748","display_name":"Mary K. Howett","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mary K. Howett","raw_affiliation_strings":["Department of Microbiology, Pennsylvania State University College of Medicine, Hershey 17033","Microbiology and Immunology and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, Pennsylvania State University College of Medicine, Hershey 17033","institution_ids":["https://openalex.org/I130769515"]},{"raw_affiliation_string":"Microbiology and Immunology and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082501160","display_name":"John W. Kreider","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John W. Kreider","raw_affiliation_strings":["Departments of Microbiology and Immunology and","Pathology, Pennsylvania State University College of Medicine, Hershey, Pa., USA","Microbiology and Immunology and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Microbiology and Immunology and","institution_ids":[]},{"raw_affiliation_string":"Pathology, Pennsylvania State University College of Medicine, Hershey, Pa., USA","institution_ids":["https://openalex.org/I130769515"]},{"raw_affiliation_string":"Microbiology and Immunology and","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5034605702","display_name":"Karen D. Cockley","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Karen D. Cockley","raw_affiliation_strings":["Departments of Microbiology and Immunology and","Microbiology and Immunology and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Microbiology and Immunology and","institution_ids":[]},{"raw_affiliation_string":"Microbiology and Immunology and","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":1250,"currency":"CHF","value_usd":1250},"apc_paid":null,"fwci":0.373,"has_fulltext":false,"cited_by_count":13,"citation_normalized_percentile":{"value":0.67604332,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":96},"biblio":{"volume":"31","issue":"2-4","first_page":"109","last_page":"115"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10146","display_name":"Cervical Cancer and HPV Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10146","display_name":"Cervical Cancer and HPV Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11713","display_name":"Genital Health and Disease","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hpv-11","display_name":"HPV 11","score":0.9909999966621399},{"id":"https://openalex.org/keywords/human-xenografts","display_name":"human xenografts","score":0.8119999766349792},{"id":"https://openalex.org/keywords/nude-mice","display_name":"nude mice","score":0.8009999990463257},{"id":"https://openalex.org/keywords/viral-transformation","display_name":"viral transformation","score":0.3959999978542328},{"id":"https://openalex.org/keywords/viral-genome-copy-number","display_name":"viral genome copy number","score":0.7609999775886536},{"id":"https://openalex.org/keywords/hpv-typing","display_name":"HPV typing","score":0.6150000095367432}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7505125999450684},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.6982173323631287},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.6081205010414124},{"id":"https://openalex.org/C128319531","wikidata":"https://www.wikidata.org/wiki/Q219715","display_name":"Restriction enzyme","level":3,"score":0.5935260057449341},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.5629638433456421},{"id":"https://openalex.org/C133307689","wikidata":"https://www.wikidata.org/wiki/Q48749","display_name":"Southern blot","level":3,"score":0.541526734828949},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5182552337646484},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.4507213234901428},{"id":"https://openalex.org/C2776270601","wikidata":"https://www.wikidata.org/wiki/Q9055203","display_name":"Papillomaviridae","level":4,"score":0.43797609210014343},{"id":"https://openalex.org/C130840561","wikidata":"https://www.wikidata.org/wiki/Q2344000","display_name":"Dot blot","level":3,"score":0.4200298488140106},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.29983264207839966},{"id":"https://openalex.org/C2778220009","wikidata":"https://www.wikidata.org/wiki/Q160105","display_name":"Cervical cancer","level":3,"score":0.18421408534049988},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.16121265292167664},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.07515591382980347}],"mesh":[{"descriptor_ui":"D000093667","descriptor_name":"Penile Transplantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002472","descriptor_name":"Cell Transformation, Viral","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002584","descriptor_name":"Cervix Uteri","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D002584","descriptor_name":"Cervix Uteri","qualifier_ui":"Q000637","qualifier_name":"transplantation","is_major_topic":false},{"descriptor_ui":"D003218","descriptor_name":"Condylomata Acuminata","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004279","descriptor_name":"DNA, Viral","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004848","descriptor_name":"Epithelium","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005814","descriptor_name":"Genes, Viral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009693","descriptor_name":"Nucleic Acid Hybridization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010413","descriptor_name":"Penis","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D010957","descriptor_name":"Plasmids","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014183","descriptor_name":"Transplantation, Heterologous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014412","descriptor_name":"Tumor Virus Infections","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015139","descriptor_name":"Blotting, Southern","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015183","descriptor_name":"Restriction Mapping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D027383","descriptor_name":"Papillomaviridae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D027383","descriptor_name":"Papillomaviridae","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1159/000150144","doi":"https://doi.org/10.1159/000150144","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000150144","pdf_url":null,"source":{"id":"https://openalex.org/S64836871","display_name":"Intervirology","issn_l":"0300-5526","issn":["0300-5526","1423-0100"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","medline","norway-1","oarl","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Intervirology","raw_type":"journal-article"},{"id":"pmid:2165039","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2165039","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Intervirology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9763000011444092}],"study_designs":[],"awards":[{"id":"https://openalex.org/G129131032","display_name":"DNA VIRUSES AND NEOPLASIA","funder_award_id":"5p01ca027503-10","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G4665072717","display_name":"MODULATION OF THE TUMORIGENICITY OF TRANSFORMED CELLS","funder_award_id":"5r01ca025305-13","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G4681732292","display_name":null,"funder_award_id":"CA25305","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G4742030586","display_name":null,"funder_award_id":"CA-27503","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1952246042","https://openalex.org/W1971436764","https://openalex.org/W1545236625","https://openalex.org/W2053199387","https://openalex.org/W1902123948","https://openalex.org/W7100948165","https://openalex.org/W2161300775","https://openalex.org/W1933016652","https://openalex.org/W1963620741","https://openalex.org/W2027344885"],"abstract_inverted_index":{"Epithelial":[0],"chips":[1],"of":[2,13,26,34,71,76,88,94,115,139,155,162,174,188,193],"human":[3,14,51,90],"foreskin":[4],"or":[5,108,184],"cervix":[6],"infected":[7],"in":[8,35,47,101,122,179,204],"vitro":[9],"with":[10],"one":[11],"strain":[12],"papillomavirus":[15,136],"type":[16],"11":[17],"(HPV-11)":[18],"and":[19,44,60,151,207],"subsequently":[20],"transplanted":[21],"to":[22,50,129],"the":[23,149,156,163,194],"renal":[24],"capsule":[25],"athymic":[27],"mice":[28],"will":[29],"yield,":[30],"after":[31],"3":[32],"months":[33],"vivo":[36],"incubation,":[37],"epithelial":[38],"cysts":[39,54,64,209],"that":[40,148,161,169],"are":[41,210],"morphologically":[42],"transformed":[43],"appear":[45],"identical":[46],"every":[48],"way":[49],"condylomata.":[52,92],"These":[53],"synthesize":[55],"virus":[56,72,117],"RNA,":[57],"DNA,":[58],"proteins,":[59],"infectious":[61],"virions.":[62],"The":[63,78,112],"can":[65],"be":[66],"utilized":[67],"as":[68,199,201],"a":[69,84,131,185],"source":[70],"for":[73,134],"continued":[74],"passage":[75],"infection.":[77],"original":[79],"HPV-11":[80,116,141,197],"infecting":[81],"material":[82,103],"was":[83],"cell-free":[85],"saline":[86],"extract":[87],"pooled":[89],"vulvar":[91],"DNAs":[93],"other":[95],"HPV":[96,202],"types":[97],"were":[98,170],"not":[99],"detected":[100,171],"this":[102],"by":[104],"either":[105,178],"dot":[106],"blot":[107,110],"Southern":[109],"analyses.":[111],"copy":[113],"number":[114],"genomes":[118],"per":[119],"cell":[120],"genome":[121],"experimental":[123,145,196,208],"condylomata":[124],"ranged":[125],"from":[126,144],"about":[127],"200":[128],"1,000,":[130],"range":[132],"expected":[133],"episomal":[135],"DNA.":[137],"Analyses":[138],"cloned":[140,195],"DNA":[142,176,198],"(pBT-1)":[143],"lesions":[146,206],"demonstrated":[147],"size":[150],"restriction":[152],"endonuclease":[153],"map":[154],"HPV-11-Hershey":[157],"isolate":[158],"closely":[159],"matched":[160],"prototype.":[164],"A":[165],"few":[166],"nucleotide":[167],"changes":[168],"during":[172],"analyses":[173],"pBT-1":[175],"resulted":[177],"no":[180],"amino":[181,189],"acid":[182],"change":[183,187],"conservative":[186],"acid.":[190],"Physical":[191],"characterization":[192],"well":[200],"typing":[203],"clinical":[205],"presented.":[211]},"counts_by_year":[{"year":2013,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}