{"id":"https://openalex.org/W2397279624","doi":"https://doi.org/10.1158/1535-7163.targ-15-a54","title":"Abstract A54: First-in-human study of the first-in-class fatty acid synthase (FASN) inhibitor, TVB-2640 as monotherapy or in combination - final results of dose escalation","display_name":"Abstract A54: First-in-human study of the first-in-class fatty acid synthase (FASN) inhibitor, TVB-2640 as monotherapy or in combination - final results of dose escalation","publication_year":2015,"publication_date":"2015-12-01","ids":{"openalex":"https://openalex.org/W2397279624","doi":"https://doi.org/10.1158/1535-7163.targ-15-a54","mag":"2397279624"},"language":"en","primary_location":{"id":"doi:10.1158/1535-7163.targ-15-a54","doi":"https://doi.org/10.1158/1535-7163.targ-15-a54","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1535-7163.targ-15-a54","pdf_url":null,"source":{"id":"https://openalex.org/S48437117","display_name":"Molecular Cancer Therapeutics","issn_l":"1535-7163","issn":["1535-7163","1538-8514"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Cancer Therapeutics","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5083922162","display_name":"Andrew Jacob Brenner","orcid":"https://orcid.org/0000-0002-3985-253X","observed_orcids":["https://orcid.org/0000-0002-3985-253X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Andrew Brenner","raw_affiliation_strings":["1Cancer Therapy & Research Center, San Antonio, TX;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Cancer Therapy & Research Center, San Antonio, TX;","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103514741","display_name":"Jeffrey R. Infante","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210100810","display_name":"Sarah Cannon","ror":"https://ror.org/014t21j89","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210100810"]},{"id":"https://openalex.org/I4210135086","display_name":"Tennessee Oncology","ror":"https://ror.org/03754ky26","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210135086"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeffrey Infante","raw_affiliation_strings":["2Sarah Cannon Research Institute/Tennessee Oncology, Nashville, TN;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Sarah Cannon Research Institute/Tennessee Oncology, Nashville, TN;","institution_ids":["https://openalex.org/I4210100810","https://openalex.org/I4210135086"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005718112","display_name":"Manish R. Patel","orcid":"https://orcid.org/0000-0001-6836-2364","observed_orcids":["https://orcid.org/0000-0001-6836-2364"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Manish Patel","raw_affiliation_strings":["3Sarah Cannon Research Institute/Florida Cancer Specialists, Sarasota, FL;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Sarah Cannon Research Institute/Florida Cancer Specialists, Sarasota, FL;","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012989377","display_name":"Hendrik\u2010Tobias Arkenau","orcid":"https://orcid.org/0000-0002-2015-1549","observed_orcids":["https://orcid.org/0000-0002-2015-1549","https://orcid.org/0000-0003-0372-0540"]},"institutions":[{"id":"https://openalex.org/I172427033","display_name":"Sarah Cannon Research Institute","ror":"https://ror.org/03cp5cj42","country_code":"GB","type":"education","lineage":["https://openalex.org/I172427033"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Hendrik-Tobias Arkenau","raw_affiliation_strings":["4Sarah Cannon Research Institute/London, London, United Kingdom;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4Sarah Cannon Research Institute/London, London, United Kingdom;","institution_ids":["https://openalex.org/I172427033"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002781091","display_name":"Mark Voskoboynik","orcid":"https://orcid.org/0000-0002-4242-1300","observed_orcids":["https://orcid.org/0000-0002-4242-1300"]},"institutions":[{"id":"https://openalex.org/I172427033","display_name":"Sarah Cannon Research Institute","ror":"https://ror.org/03cp5cj42","country_code":"GB","type":"education","lineage":["https://openalex.org/I172427033"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Mark Voskoboynik","raw_affiliation_strings":["4Sarah Cannon Research Institute/London, London, United Kingdom;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4Sarah Cannon Research Institute/London, London, United Kingdom;","institution_ids":["https://openalex.org/I172427033"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070523850","display_name":"Erkut Hasan Borazanci","orcid":"https://orcid.org/0000-0001-5136-5462","observed_orcids":["https://orcid.org/0000-0001-5136-5462"]},"institutions":[{"id":"https://openalex.org/I4210130412","display_name":"HonorHealth","ror":"https://ror.org/03szbwj17","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210130412"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Erkut Borazanci","raw_affiliation_strings":["5HonorHealth Research Institute, Scottsdale, AZ;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"5HonorHealth Research Institute, Scottsdale, AZ;","institution_ids":["https://openalex.org/I4210130412"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069777765","display_name":"Gerald Steven Falchook","orcid":"https://orcid.org/0000-0001-9165-2191","observed_orcids":["https://orcid.org/0000-0001-9165-2191"]},"institutions":[{"id":"https://openalex.org/I4210120438","display_name":"HealthONE","ror":"https://ror.org/032y5sx52","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210120438"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gerald Falchook","raw_affiliation_strings":["6Sarah Cannon Research Institute/HealthONE, Denver, CO;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"6Sarah Cannon Research Institute/HealthONE, Denver, CO;","institution_ids":["https://openalex.org/I4210120438"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013897432","display_name":"L. Rhoda Molife","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I142947616","display_name":"Institute of Cancer Research","ror":"https://ror.org/043jzw605","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I142947616"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"L.R. Molife","raw_affiliation_strings":["7The Royal Marsden/Institute of Cancer Research, Sutton, United Kingdom;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"7The Royal Marsden/Institute of Cancer Research, Sutton, United Kingdom;","institution_ids":["https://openalex.org/I142947616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084349853","display_name":"Shubham Pant","orcid":"https://orcid.org/0000-0001-9281-480X","observed_orcids":["https://orcid.org/0000-0001-9281-480X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shubham Pant","raw_affiliation_strings":["8Sarah Cannon Research Institute/Univ. of Oklahoma, Oklahoma City, OK;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"8Sarah Cannon Research Institute/Univ. of Oklahoma, Oklahoma City, OK;","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000462280","display_name":"Emma Jane Dean","orcid":"https://orcid.org/0000-0001-9956-257X","observed_orcids":["https://orcid.org/0000-0001-9956-257X"]},"institutions":[{"id":"https://openalex.org/I28407311","display_name":"University of Manchester","ror":"https://ror.org/027m9bs27","country_code":"GB","type":"education","lineage":["https://openalex.org/I28407311"]},{"id":"https://openalex.org/I4210133995","display_name":"The Christie NHS Foundation Trust","ror":"https://ror.org/03v9efr22","country_code":"GB","type":"funder","lineage":["https://openalex.org/I4210133995"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Emma Dean","raw_affiliation_strings":["9The Christie NHS Foundation Trust/University of Manchester, Manchester, United Kingdom;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"9The Christie NHS Foundation Trust/University of Manchester, Manchester, United Kingdom;","institution_ids":["https://openalex.org/I28407311","https://openalex.org/I4210133995"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041480735","display_name":"Lorraine Cheryl Pelosof","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lorraine Pelosof","raw_affiliation_strings":["10University of Texas Southwestern Medical Center, Dallas, TX;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"10University of Texas Southwestern Medical Center, Dallas, TX;","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076615101","display_name":"Suzanne Fields Jones","orcid":"https://orcid.org/0000-0001-6881-8050","observed_orcids":["https://orcid.org/0000-0001-6881-8050"]},"institutions":[{"id":"https://openalex.org/I4210100810","display_name":"Sarah Cannon","ror":"https://ror.org/014t21j89","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210100810"]},{"id":"https://openalex.org/I4210135086","display_name":"Tennessee Oncology","ror":"https://ror.org/03754ky26","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210135086"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Suzanne Jones","raw_affiliation_strings":["2Sarah Cannon Research Institute/Tennessee Oncology, Nashville, TN;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Sarah Cannon Research Institute/Tennessee Oncology, Nashville, TN;","institution_ids":["https://openalex.org/I4210100810","https://openalex.org/I4210135086"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110458689","display_name":"Chris M. Rubino","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Chris Rubino","raw_affiliation_strings":["11Institute for Clinical Pharmacodynamics, Buffalo, NY;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"11Institute for Clinical Pharmacodynamics, Buffalo, NY;","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027320590","display_name":"William F. McCulloch","orcid":"https://orcid.org/0000-0002-6916-9782","observed_orcids":["https://orcid.org/0000-0002-6916-9782"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"William McCulloch","raw_affiliation_strings":["123-V Biosciences, Menlo Park, CA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"123-V Biosciences, Menlo Park, CA;","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066623079","display_name":"Valentina Zhukova-Harrill","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Valentina Zhukova-Harrill","raw_affiliation_strings":["13Chiltern International, Cary, NC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"13Chiltern International, Cary, NC","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010601658","display_name":"George\u00a0W. Kemble","orcid":"https://orcid.org/0000-0003-4225-8774","observed_orcids":["https://orcid.org/0000-0003-4225-8774"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"George Kemble","raw_affiliation_strings":["123-V Biosciences, Menlo Park, CA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"123-V Biosciences, Menlo Park, CA;","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006152890","display_name":"Marie O\u2019Farrell","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Marie O'Farrell","raw_affiliation_strings":["123-V Biosciences, Menlo Park, CA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"123-V Biosciences, Menlo Park, CA;","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5072308451","display_name":"Howard A. Burris","orcid":"https://orcid.org/0000-0002-1501-2931","observed_orcids":["https://orcid.org/0000-0002-1501-2931"]},"institutions":[{"id":"https://openalex.org/I4210100810","display_name":"Sarah Cannon","ror":"https://ror.org/014t21j89","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210100810"]},{"id":"https://openalex.org/I4210135086","display_name":"Tennessee Oncology","ror":"https://ror.org/03754ky26","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210135086"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Howard A. Burris","raw_affiliation_strings":["2Sarah Cannon Research Institute/Tennessee Oncology, Nashville, TN;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Sarah Cannon Research Institute/Tennessee Oncology, Nashville, TN;","institution_ids":["https://openalex.org/I4210100810","https://openalex.org/I4210135086"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":9,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"14","issue":"12_Supplement_2","first_page":"A54","last_page":"A54"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12465","display_name":"Cancer, Lipids, and Metabolism","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12465","display_name":"Cancer, Lipids, and Metabolism","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11308","display_name":"Sphingolipid Metabolism and Signaling","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11844","display_name":"Lipid metabolism and biosynthesis","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tvb-2640","display_name":"TVB-2640","score":0.984000027179718},{"id":"https://openalex.org/keywords/fatty-acid-synthase-inhibitors","display_name":"fatty acid synthase inhibitors","score":0.921999990940094},{"id":"https://openalex.org/keywords/fatty-acid-synthase","display_name":"fatty acid synthase","score":0.6940000057220459},{"id":"https://openalex.org/keywords/dose-escalation","display_name":"dose escalation","score":0.7519999742507935},{"id":"https://openalex.org/keywords/maximum-tolerated-dose","display_name":"maximum tolerated dose","score":0.9100000262260437},{"id":"https://openalex.org/keywords/paclitaxel-combination-therapy","display_name":"paclitaxel combination therapy","score":0.7710000276565552},{"id":"https://openalex.org/keywords/corneal-edema","display_name":"corneal edema","score":0.7540000081062317},{"id":"https://openalex.org/keywords/keratitis","display_name":"keratitis","score":0.6349999904632568},{"id":"https://openalex.org/keywords/iritis","display_name":"iritis","score":0.7580000162124634},{"id":"https://openalex.org/keywords/hand-foot-syndrome","display_name":"hand-foot syndrome","score":0.9049999713897705},{"id":"https://openalex.org/keywords/qtc-prolongation","display_name":"QTc prolongation","score":0.8299999833106995},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.8790000081062317},{"id":"https://openalex.org/keywords/pharmacodynamics","display_name":"pharmacodynamics","score":0.8730000257492065}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7133551836013794},{"id":"https://openalex.org/C111113717","wikidata":"https://www.wikidata.org/wiki/Q725307","display_name":"Pharmacodynamics","level":3,"score":0.5899263024330139},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.5569119453430176},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5549893975257874},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.51358962059021},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5055477619171143},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.37704843282699585},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.357168048620224},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1535-7163.targ-15-a54","doi":"https://doi.org/10.1158/1535-7163.targ-15-a54","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1535-7163.targ-15-a54","pdf_url":null,"source":{"id":"https://openalex.org/S48437117","display_name":"Molecular Cancer Therapeutics","issn_l":"1535-7163","issn":["1535-7163","1538-8514"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Cancer Therapeutics","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8399999737739563}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2004556784","https://openalex.org/W2582907174","https://openalex.org/W2753834235","https://openalex.org/W2378945660","https://openalex.org/W2992709639","https://openalex.org/W1491964893","https://openalex.org/W1990414540","https://openalex.org/W2388069209","https://openalex.org/W1998587742","https://openalex.org/W2167792947"],"abstract_inverted_index":{"Abstract":[0],"Introduction":[1],"FASN":[2,34,453],"inhibition":[3],"is":[4,26,510],"a":[5,200,248,364,373,426,433,461,467],"novel":[6],"approach":[7],"to":[8,23,113,157,412],"cancer":[9,345],"treatment":[10],"involving":[11],"the":[12,56,66,70,310,492,517,565,588],"selective":[13],"disruption":[14],"of":[15,33,58,69,202,228,250,292,297,342,418,423,438,445,476,491,502,564,581,587],"palmitate":[16,434],"biosynthesis":[17],"that,":[18],"in":[19,37,40,151,167,177,218,305,329,351,363,376,382,390,393,436,471,483,494,505,513,576],"tumor":[20,134,377,391,401,496,508],"cells,":[21],"leads":[22],"apoptosis.":[24],"TVB-2640":[25,193,446,459,572],"an":[27],"oral,":[28],"first-in-class,":[29],"small-molecule":[30],"reversible":[31,225],"inhibitor":[32],"that":[35,103],"demonstrates":[36],"vitro":[38],"and":[39,62,79,88,100,117,123,133,162,172,187,221,226,237,241,256,267,280,325,337,379,392,430,464,482,497,594],"vivo":[41],"anti-tumor":[42],"effects.":[43],"We":[44],"previously":[45],"reported":[46,289],"(EORTC-NCI-AACR":[47],"2014:":[48],"3":[49,266],"LBA,":[50],"AACR/ASCO":[51],"2015:":[52],"CT203/":[53],"TPS2615)":[54],"on":[55,65],"design":[57],"this":[59],"trial":[60],"(NCT02223247)":[61],"now":[63,511],"report":[64],"final":[67,579],"results":[68,580],"dose":[71,463,582],"escalation":[72],"phase.":[73],"Methods":[74],"Patients":[75,93],"from":[76],"7":[77,311],"US":[78],"4":[80],"UK":[81],"sites":[82],"with":[83,94,106,179,197,199,307,323,331,372,399,452,466,473,485],"adequate":[84],"bone":[85],"marrow,":[86],"hepatic":[87],"renal":[89],"function":[90],"were":[91,109,130,144,149,165,224,275,285],"enrolled.":[92],"significant":[95],"cardiovascular":[96],"or":[97,259,575],"ophthalmological":[98,121],"disease":[99],"any":[101],"conditions":[102],"might":[104],"interfere":[105],"oral":[107,458],"absorption":[108],"excluded.":[110],"In":[111,395],"addition":[112],"standard":[114],"safety":[115],"assessments":[116,129,143],"pharmacokinetic":[118],"(PK)":[119],"sampling,":[120],"examinations":[122],"24-hour":[124],"Holter":[125],"monitoring":[126],"for":[127,139,213,320,335,355],"QTc":[128],"performed.":[131],"Blood":[132],"tissue":[135],"(archival":[136],"and/or":[137],"fresh)":[138],"various":[140,506],"pharmacodynamic":[141],"(PD)":[142],"obtained.":[145],"Results":[146],"Thirty-one":[147],"patients":[148,164,223,293,313,327,346,398,440],"enrolled":[150,166],"6":[152],"monotherapy":[153,324,481,574],"cohorts":[154,170,515],"(60":[155],"mg/m2":[156,212],"250":[158,173],"mg":[159,174],"flat":[160,175],"dose)":[161,176],"13":[163],"2":[168,240,326],"combination":[169,178,222,306,330,352,484,577],"(200":[171],"weekly":[180],"paclitaxel":[181,299,332],"(80":[182],"mg/m2,":[183],"days":[184,444],"1,":[185,269],"8":[186,443],"15":[188,204],"q":[189],"28":[190],"days).":[191],"Plasma":[192],"drug":[194],"levels":[195,422],"increased":[196,421],"dose,":[198],"half-life":[201],"approximately":[203],"hr.":[205],"The":[206],"MTD":[207,518],"was":[208,288,301,361,406],"declared":[209],"at":[210,516],"100":[211],"both":[214,219,479,495,520],"schedules.":[215,521],"DLTs":[216],"observed":[217,302,407],"mono-":[220],"consisted":[227],"corneal":[229],"edema":[230],"(Grade":[231,239,262],"3,":[232,242,263],"n":[233,243,264,270],"=":[234,244,265,271],"2),":[235],"keratitis":[236],"iritis":[238],"1":[245,317,409],"each),":[246],"probably":[247],"consequence":[249],"disrupted":[251],"tear":[252],"film":[253],"lipid":[254],"metabolism,":[255],"palmar-plantar":[257],"erythrodysesthesia":[258],"skin":[260],"peeling":[261],"Grade":[268,278],"1).":[272],"Other":[273],"toxicities":[274],"mild":[276],"(\u2264":[277],"2)":[279],"only":[281],"minor":[282],"GI":[283],"symptoms":[284],"observed;":[286],"alopecia":[287],"by":[290],"63%":[291],"overall.":[294],"No":[295],"enhancement":[296],"known":[298],"toxicity":[300,469],"when":[303],"given":[304],"TVB-2640.":[308],"Of":[309],"NSCLC":[312],"accrued":[314],"so":[315],"far,":[316],"achieved":[318],"SD":[319,334,354],"17":[321],"weeks":[322,339],"treated":[328,350],"had":[333,353,368],"24":[336],"21":[338],"respectively.":[340],"One":[341,358],"three":[343],"breast":[344],"(histology:":[347],"triple":[348],"negative)":[349],"20":[356],"weeks.":[357],"confirmed":[359],"PR":[360],"seen":[362],"combination-treated":[365],"patient":[366],"who":[367],"peritoneal":[369],"serous":[370],"carcinoma":[371],"42%":[374],"reduction":[375,381],"load":[378],"58%":[380],"CA-125":[383],"levels.":[384],"PD":[385,487],"biomarkers":[386],"have":[387],"been":[388],"identified":[389],"serum.":[394],"all":[396],"four":[397],"paired":[400],"biopsies,":[402],"decreased":[403,431],"pAKT":[404],"S473":[405],"after":[408,442],"cycle":[410],"compared":[411],"pretreatment":[413],"biopsies.":[414],"Global":[415],"metabolic":[416],"profiling":[417],"serum":[419],"showed":[420],"malonyl":[424,427],"carnitine,":[425],"coA":[428],"derivative,":[429,435],"tripalmitin,":[432],"9":[437],"10":[439],"tested,":[441],"treatment.":[447],"These":[448],"changes":[449],"are":[450],"consistent":[451],"inhibition.":[454],"Summary":[455],"Continuously":[456],"administered,":[457],"demonstrated":[460],"tolerated":[462],"schedule":[465],"manageable":[468],"profile":[470],"association":[472],"encouraging":[474],"signs":[475],"preliminary":[477],"activity":[478,504],"as":[480,573],"paclitaxel.":[486],"analyses":[488],"reveal":[489],"engagement":[490],"target":[493],"surrogate":[498],"tissue.":[499],"Further":[500],"exploration":[501],"biological":[503],"specific":[507],"types":[509],"underway":[512],"expansion":[514],"using":[519],"Citation":[522],"Format:":[523],"Andrew":[524],"Brenner,":[525],"Jeffrey":[526],"Infante,":[527],"Manish":[528],"Patel,":[529],"Hendrik-Tobias":[530],"Arkenau,":[531],"Mark":[532],"Voskoboynik,":[533],"Erkut":[534],"Borazanci,":[535],"Gerald":[536],"Falchook,":[537],"L.R.":[538],"Molife,":[539],"Shubham":[540],"Pant,":[541],"Emma":[542],"Dean,":[543],"Lorraine":[544],"Pelosof,":[545],"Suzanne":[546],"Jones,":[547],"Chris":[548],"Rubino,":[549],"William":[550],"McCulloch,":[551],"Valentina":[552],"Zhukova-Harrill,":[553],"George":[554],"Kemble,":[555],"Marie":[556],"O'Farrell,":[557],"Howard":[558],"A.":[559],"Burris,":[560],"III.":[561],"First-in-human":[562],"study":[563],"first-in-class":[566],"fatty":[567],"acid":[568],"synthase":[569],"(FASN)":[570],"inhibitor,":[571],"-":[578],"escalation.":[583],"[abstract].":[584],"In:":[585],"Proceedings":[586],"AACR-NCI-EORTC":[589],"International":[590],"Conference:":[591],"Molecular":[592],"Targets":[593],"Cancer":[595,606],"Therapeutics;":[596],"2015":[597],"Nov":[598],"5-9;":[599],"Boston,":[600],"MA.":[601],"Philadelphia":[602],"(PA):":[603],"AACR;":[604],"Mol":[605],"Ther":[607],"2015;14(12":[608],"Suppl":[609],"2):Abstract":[610],"nr":[611],"A54.":[612]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2025-10-10T00:00:00"}