{"id":"https://openalex.org/W2397196282","doi":"https://doi.org/10.1097/ico.0000000000000438","title":"Can Riboflavin Penetrate Stroma Without Disrupting Integrity of Corneal Epithelium in Rabbits? Iontophoresis and Ultraperformance Liquid Chromatography With Electrospray Ionization Tandem Mass Spectrometry","display_name":"Can Riboflavin Penetrate Stroma Without Disrupting Integrity of Corneal Epithelium in Rabbits? Iontophoresis and Ultraperformance Liquid Chromatography With Electrospray Ionization Tandem Mass Spectrometry","publication_year":2015,"publication_date":"2015-06-13","ids":{"openalex":"https://openalex.org/W2397196282","doi":"https://doi.org/10.1097/ico.0000000000000438","mag":"2397196282","pmid":"https://pubmed.ncbi.nlm.nih.gov/26075452"},"language":"en","primary_location":{"id":"doi:10.1097/ico.0000000000000438","doi":"https://doi.org/10.1097/ico.0000000000000438","is_oa":false,"landing_page_url":"https://doi.org/10.1097/ico.0000000000000438","pdf_url":null,"source":{"id":"https://openalex.org/S145806103","display_name":"Cornea","issn_l":"0277-3740","issn":["0277-3740","1536-4798"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cornea","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5032898287","display_name":"\u015eahin Novruzlu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79946792","display_name":"Mu\u011fla University","ror":"https://ror.org/05n2cz176","country_code":"TR","type":"education","lineage":["https://openalex.org/I79946792"]},{"id":"https://openalex.org/I95634034","display_name":"Gazi University","ror":"https://ror.org/054xkpr46","country_code":"TR","type":"education","lineage":["https://openalex.org/I95634034"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"\u015eahin Novruzlu","raw_affiliation_strings":["*Department of Ophthalmology, Gazi University School of Medicine, Ankara, Turkey; \u2020Mugla School of Health Sciences, Mugla Sitki Kocman University, Mugla, Turkey; \u2021Mugla Vocational School, Mugla Sitki Ko\u00e7man University, Mugla, Turkey; and \u00a7Department of Medical Biochemistry, Gazi University School of Medicine, Ankara, Turkey","*Department of Ophthalmology, Gazi University School of Medicine, Ankara, Turkey","Accepted February 24, 2015","Received October 30, 2014","Received in revised form February 17, 2015","Reprints: \u015eahin Novruzlu, MD, Department of Ophthalmology, Gazi University School of Medicine, Ankara 06000, Turkey (e-mail: [email\u00a0protected])","The authors declare that there are no conflicts of interest. This project was supported by Ankara Office of the Turkish Ophthalmology Association","This study, as laboratory and experimental research, was supported by Ankara Office of the Turkish Ophthalmology Association","\u00a7Department of Medical Biochemistry, Gazi University School of Medicine, Ankara, Turkey","\u2020Mugla School of Health Sciences, Mugla Sitki Kocman University, Mugla, Turkey","\u2021Mugla Vocational School, Mugla Sitki Ko\u00e7man University, Mugla, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"*Department of Ophthalmology, Gazi University School of Medicine, Ankara, Turkey; \u2020Mugla School of Health Sciences, Mugla Sitki Kocman University, Mugla, Turkey; \u2021Mugla Vocational School, Mugla Sitki Ko\u00e7man University, Mugla, Turkey; and \u00a7Department of Medical Biochemistry, Gazi University School of Medicine, Ankara, Turkey","institution_ids":["https://openalex.org/I79946792","https://openalex.org/I95634034"]},{"raw_affiliation_string":"*Department of Ophthalmology, Gazi University School of Medicine, Ankara, Turkey","institution_ids":["https://openalex.org/I95634034"]},{"raw_affiliation_string":"Accepted February 24, 2015","institution_ids":[]},{"raw_affiliation_string":"Received October 30, 2014","institution_ids":[]},{"raw_affiliation_string":"Received in revised form February 17, 2015","institution_ids":[]},{"raw_affiliation_string":"Reprints: \u015eahin Novruzlu, MD, Department of Ophthalmology, Gazi University School of Medicine, Ankara 06000, Turkey (e-mail: [email\u00a0protected])","institution_ids":["https://openalex.org/I95634034"]},{"raw_affiliation_string":"The authors declare that there are no conflicts of interest. This project was supported by Ankara Office of the Turkish Ophthalmology Association","institution_ids":[]},{"raw_affiliation_string":"This study, as laboratory and experimental research, was supported by Ankara Office of the Turkish Ophthalmology Association","institution_ids":[]},{"raw_affiliation_string":"\u00a7Department of Medical Biochemistry, Gazi University School of Medicine, Ankara, Turkey","institution_ids":["https://openalex.org/I95634034"]},{"raw_affiliation_string":"\u2020Mugla School of Health Sciences, Mugla Sitki Kocman University, Mugla, Turkey","institution_ids":["https://openalex.org/I79946792"]},{"raw_affiliation_string":"\u2021Mugla Vocational School, Mugla Sitki Ko\u00e7man University, Mugla, Turkey","institution_ids":["https://openalex.org/I79946792"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036858212","display_name":"\u00dcmm\u00fchani \u00d6zel T\u00fcrk\u00e7\u00fc","orcid":"https://orcid.org/0000-0003-2244-7965","observed_orcids":["https://orcid.org/0000-0003-2244-7965"]},"institutions":[{"id":"https://openalex.org/I79946792","display_name":"Mu\u011fla University","ror":"https://ror.org/05n2cz176","country_code":"TR","type":"education","lineage":["https://openalex.org/I79946792"]},{"id":"https://openalex.org/I95634034","display_name":"Gazi University","ror":"https://ror.org/054xkpr46","country_code":"TR","type":"education","lineage":["https://openalex.org/I95634034"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"\u00dcmm\u00fchani \u00d6zel T\u00fcrkc\u00fc","raw_affiliation_strings":["","*Department of Ophthalmology, Gazi University School of Medicine, Ankara, Turkey","Accepted February 24, 2015","Received October 30, 2014","Received in revised form February 17, 2015","Reprints: \u015eahin Novruzlu, MD, Department of Ophthalmology, Gazi University School of Medicine, Ankara 06000, Turkey (e-mail: [email\u00a0protected])","The authors declare that there are no conflicts of interest. This project was supported by Ankara Office of the Turkish Ophthalmology Association","This study, as laboratory and experimental research, was supported by Ankara Office of the Turkish Ophthalmology Association","\u00a7Department of Medical Biochemistry, Gazi University School of Medicine, Ankara, Turkey","\u2020Mugla School of Health Sciences, Mugla Sitki Kocman University, Mugla, Turkey","\u2021Mugla Vocational School, Mugla Sitki Ko\u00e7man University, Mugla, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]},{"raw_affiliation_string":"*Department of Ophthalmology, Gazi University School of Medicine, Ankara, Turkey","institution_ids":["https://openalex.org/I95634034"]},{"raw_affiliation_string":"Accepted February 24, 2015","institution_ids":[]},{"raw_affiliation_string":"Received October 30, 2014","institution_ids":[]},{"raw_affiliation_string":"Received in revised form February 17, 2015","institution_ids":[]},{"raw_affiliation_string":"Reprints: \u015eahin Novruzlu, MD, Department of Ophthalmology, Gazi University School of Medicine, Ankara 06000, Turkey (e-mail: [email\u00a0protected])","institution_ids":["https://openalex.org/I95634034"]},{"raw_affiliation_string":"The authors declare that there are no conflicts of interest. This project was supported by Ankara Office of the Turkish Ophthalmology Association","institution_ids":[]},{"raw_affiliation_string":"This study, as laboratory and experimental research, was supported by Ankara Office of the Turkish Ophthalmology Association","institution_ids":[]},{"raw_affiliation_string":"\u00a7Department of Medical Biochemistry, Gazi University School of Medicine, Ankara, Turkey","institution_ids":["https://openalex.org/I95634034"]},{"raw_affiliation_string":"\u2020Mugla School of Health Sciences, Mugla Sitki Kocman University, Mugla, Turkey","institution_ids":["https://openalex.org/I79946792"]},{"raw_affiliation_string":"\u2021Mugla Vocational School, Mugla Sitki Ko\u00e7man University, Mugla, Turkey","institution_ids":["https://openalex.org/I79946792"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038493234","display_name":"\u0130brahim Kvrak","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79946792","display_name":"Mu\u011fla University","ror":"https://ror.org/05n2cz176","country_code":"TR","type":"education","lineage":["https://openalex.org/I79946792"]},{"id":"https://openalex.org/I95634034","display_name":"Gazi University","ror":"https://ror.org/054xkpr46","country_code":"TR","type":"education","lineage":["https://openalex.org/I95634034"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"\u0130brahim Kvrak","raw_affiliation_strings":["","*Department of Ophthalmology, Gazi University School of Medicine, Ankara, Turkey","Accepted February 24, 2015","Received October 30, 2014","Received in revised form February 17, 2015","Reprints: \u015eahin Novruzlu, MD, Department of Ophthalmology, Gazi University School of Medicine, Ankara 06000, Turkey (e-mail: [email\u00a0protected])","The authors declare that there are no conflicts of interest. This project was supported by Ankara Office of the Turkish Ophthalmology Association","This study, as laboratory and experimental research, was supported by Ankara Office of the Turkish Ophthalmology Association","\u00a7Department of Medical Biochemistry, Gazi University School of Medicine, Ankara, Turkey","\u2020Mugla School of Health Sciences, Mugla Sitki Kocman University, Mugla, Turkey","\u2021Mugla Vocational School, Mugla Sitki Ko\u00e7man University, Mugla, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]},{"raw_affiliation_string":"*Department of Ophthalmology, Gazi University School of Medicine, Ankara, Turkey","institution_ids":["https://openalex.org/I95634034"]},{"raw_affiliation_string":"Accepted February 24, 2015","institution_ids":[]},{"raw_affiliation_string":"Received October 30, 2014","institution_ids":[]},{"raw_affiliation_string":"Received in revised form February 17, 2015","institution_ids":[]},{"raw_affiliation_string":"Reprints: \u015eahin Novruzlu, MD, Department of Ophthalmology, Gazi University School of Medicine, Ankara 06000, Turkey (e-mail: [email\u00a0protected])","institution_ids":["https://openalex.org/I95634034"]},{"raw_affiliation_string":"The authors declare that there are no conflicts of interest. This project was supported by Ankara Office of the Turkish Ophthalmology Association","institution_ids":[]},{"raw_affiliation_string":"This study, as laboratory and experimental research, was supported by Ankara Office of the Turkish Ophthalmology Association","institution_ids":[]},{"raw_affiliation_string":"\u00a7Department of Medical Biochemistry, Gazi University School of Medicine, Ankara, Turkey","institution_ids":["https://openalex.org/I95634034"]},{"raw_affiliation_string":"\u2020Mugla School of Health Sciences, Mugla Sitki Kocman University, Mugla, Turkey","institution_ids":["https://openalex.org/I79946792"]},{"raw_affiliation_string":"\u2021Mugla Vocational School, Mugla Sitki Ko\u00e7man University, Mugla, Turkey","institution_ids":["https://openalex.org/I79946792"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065889826","display_name":"\u015eeyda Kvrak","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79946792","display_name":"Mu\u011fla University","ror":"https://ror.org/05n2cz176","country_code":"TR","type":"education","lineage":["https://openalex.org/I79946792"]},{"id":"https://openalex.org/I95634034","display_name":"Gazi University","ror":"https://ror.org/054xkpr46","country_code":"TR","type":"education","lineage":["https://openalex.org/I95634034"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"\u015eeyda Kvrak","raw_affiliation_strings":["","*Department of Ophthalmology, Gazi University School of Medicine, Ankara, Turkey","Accepted February 24, 2015","Received October 30, 2014","Received in revised form February 17, 2015","Reprints: \u015eahin Novruzlu, MD, Department of Ophthalmology, Gazi University School of Medicine, Ankara 06000, Turkey (e-mail: [email\u00a0protected])","The authors declare that there are no conflicts of interest. This project was supported by Ankara Office of the Turkish Ophthalmology Association","This study, as laboratory and experimental research, was supported by Ankara Office of the Turkish Ophthalmology Association","\u00a7Department of Medical Biochemistry, Gazi University School of Medicine, Ankara, Turkey","\u2020Mugla School of Health Sciences, Mugla Sitki Kocman University, Mugla, Turkey","\u2021Mugla Vocational School, Mugla Sitki Ko\u00e7man University, Mugla, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]},{"raw_affiliation_string":"*Department of Ophthalmology, Gazi University School of Medicine, Ankara, Turkey","institution_ids":["https://openalex.org/I95634034"]},{"raw_affiliation_string":"Accepted February 24, 2015","institution_ids":[]},{"raw_affiliation_string":"Received October 30, 2014","institution_ids":[]},{"raw_affiliation_string":"Received in revised form February 17, 2015","institution_ids":[]},{"raw_affiliation_string":"Reprints: \u015eahin Novruzlu, MD, Department of Ophthalmology, Gazi University School of Medicine, Ankara 06000, Turkey (e-mail: [email\u00a0protected])","institution_ids":["https://openalex.org/I95634034"]},{"raw_affiliation_string":"The authors declare that there are no conflicts of interest. This project was supported by Ankara Office of the Turkish Ophthalmology Association","institution_ids":[]},{"raw_affiliation_string":"This study, as laboratory and experimental research, was supported by Ankara Office of the Turkish Ophthalmology Association","institution_ids":[]},{"raw_affiliation_string":"\u00a7Department of Medical Biochemistry, Gazi University School of Medicine, Ankara, Turkey","institution_ids":["https://openalex.org/I95634034"]},{"raw_affiliation_string":"\u2020Mugla School of Health Sciences, Mugla Sitki Kocman University, Mugla, Turkey","institution_ids":["https://openalex.org/I79946792"]},{"raw_affiliation_string":"\u2021Mugla Vocational School, Mugla Sitki Ko\u00e7man University, Mugla, Turkey","institution_ids":["https://openalex.org/I79946792"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081742592","display_name":"Erdem Y\u00fcksel","orcid":"https://orcid.org/0000-0003-3713-8815","observed_orcids":["https://orcid.org/0000-0003-3713-8815","https://orcid.org/0000-0001-7459-9835"]},"institutions":[{"id":"https://openalex.org/I79946792","display_name":"Mu\u011fla University","ror":"https://ror.org/05n2cz176","country_code":"TR","type":"education","lineage":["https://openalex.org/I79946792"]},{"id":"https://openalex.org/I95634034","display_name":"Gazi University","ror":"https://ror.org/054xkpr46","country_code":"TR","type":"education","lineage":["https://openalex.org/I95634034"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Erdem Y\u00fcksel","raw_affiliation_strings":["","*Department of Ophthalmology, Gazi University School of Medicine, Ankara, Turkey","Accepted February 24, 2015","Received October 30, 2014","Received in revised form February 17, 2015","Reprints: \u015eahin Novruzlu, MD, Department of Ophthalmology, Gazi University School of Medicine, Ankara 06000, Turkey (e-mail: [email\u00a0protected])","The authors declare that there are no conflicts of interest. This project was supported by Ankara Office of the Turkish Ophthalmology Association","This study, as laboratory and experimental research, was supported by Ankara Office of the Turkish Ophthalmology Association","\u00a7Department of Medical Biochemistry, Gazi University School of Medicine, Ankara, Turkey","\u2020Mugla School of Health Sciences, Mugla Sitki Kocman University, Mugla, Turkey","\u2021Mugla Vocational School, Mugla Sitki Ko\u00e7man University, Mugla, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]},{"raw_affiliation_string":"*Department of Ophthalmology, Gazi University School of Medicine, Ankara, Turkey","institution_ids":["https://openalex.org/I95634034"]},{"raw_affiliation_string":"Accepted February 24, 2015","institution_ids":[]},{"raw_affiliation_string":"Received October 30, 2014","institution_ids":[]},{"raw_affiliation_string":"Received in revised form February 17, 2015","institution_ids":[]},{"raw_affiliation_string":"Reprints: \u015eahin Novruzlu, MD, Department of Ophthalmology, Gazi University School of Medicine, Ankara 06000, Turkey (e-mail: [email\u00a0protected])","institution_ids":["https://openalex.org/I95634034"]},{"raw_affiliation_string":"The authors declare that there are no conflicts of interest. This project was supported by Ankara Office of the Turkish Ophthalmology Association","institution_ids":[]},{"raw_affiliation_string":"This study, as laboratory and experimental research, was supported by Ankara Office of the Turkish Ophthalmology Association","institution_ids":[]},{"raw_affiliation_string":"\u00a7Department of Medical Biochemistry, Gazi University School of Medicine, Ankara, Turkey","institution_ids":["https://openalex.org/I95634034"]},{"raw_affiliation_string":"\u2020Mugla School of Health Sciences, Mugla Sitki Kocman University, Mugla, Turkey","institution_ids":["https://openalex.org/I79946792"]},{"raw_affiliation_string":"\u2021Mugla Vocational School, Mugla Sitki Ko\u00e7man University, Mugla, Turkey","institution_ids":["https://openalex.org/I79946792"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047905364","display_name":"Nuriye G\u00f6k\u00e7en Deniz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79946792","display_name":"Mu\u011fla University","ror":"https://ror.org/05n2cz176","country_code":"TR","type":"education","lineage":["https://openalex.org/I79946792"]},{"id":"https://openalex.org/I95634034","display_name":"Gazi University","ror":"https://ror.org/054xkpr46","country_code":"TR","type":"education","lineage":["https://openalex.org/I95634034"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Nuriye G\u00f6k\u00e7en Deniz","raw_affiliation_strings":["","*Department of Ophthalmology, Gazi University School of Medicine, Ankara, Turkey","Accepted February 24, 2015","Received October 30, 2014","Received in revised form February 17, 2015","Reprints: \u015eahin Novruzlu, MD, Department of Ophthalmology, Gazi University School of Medicine, Ankara 06000, Turkey (e-mail: [email\u00a0protected])","The authors declare that there are no conflicts of interest. This project was supported by Ankara Office of the Turkish Ophthalmology Association","This study, as laboratory and experimental research, was supported by Ankara Office of the Turkish Ophthalmology Association","\u00a7Department of Medical Biochemistry, Gazi University School of Medicine, Ankara, Turkey","\u2020Mugla School of Health Sciences, Mugla Sitki Kocman University, Mugla, Turkey","\u2021Mugla Vocational School, Mugla Sitki Ko\u00e7man University, Mugla, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]},{"raw_affiliation_string":"*Department of Ophthalmology, Gazi University School of Medicine, Ankara, Turkey","institution_ids":["https://openalex.org/I95634034"]},{"raw_affiliation_string":"Accepted February 24, 2015","institution_ids":[]},{"raw_affiliation_string":"Received October 30, 2014","institution_ids":[]},{"raw_affiliation_string":"Received in revised form February 17, 2015","institution_ids":[]},{"raw_affiliation_string":"Reprints: \u015eahin Novruzlu, MD, Department of Ophthalmology, Gazi University School of Medicine, Ankara 06000, Turkey (e-mail: [email\u00a0protected])","institution_ids":["https://openalex.org/I95634034"]},{"raw_affiliation_string":"The authors declare that there are no conflicts of interest. This project was supported by Ankara Office of the Turkish Ophthalmology Association","institution_ids":[]},{"raw_affiliation_string":"This study, as laboratory and experimental research, was supported by Ankara Office of the Turkish Ophthalmology Association","institution_ids":[]},{"raw_affiliation_string":"\u00a7Department of Medical Biochemistry, Gazi University School of Medicine, Ankara, Turkey","institution_ids":["https://openalex.org/I95634034"]},{"raw_affiliation_string":"\u2020Mugla School of Health Sciences, Mugla Sitki Kocman University, Mugla, Turkey","institution_ids":["https://openalex.org/I79946792"]},{"raw_affiliation_string":"\u2021Mugla Vocational School, Mugla Sitki Ko\u00e7man University, Mugla, Turkey","institution_ids":["https://openalex.org/I79946792"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056564408","display_name":"Ay\u015fe Bi\u0307lgi\u0307han","orcid":"https://orcid.org/0000-0003-1307-2794","observed_orcids":["https://orcid.org/0000-0003-1307-2794"]},"institutions":[{"id":"https://openalex.org/I79946792","display_name":"Mu\u011fla University","ror":"https://ror.org/05n2cz176","country_code":"TR","type":"education","lineage":["https://openalex.org/I79946792"]},{"id":"https://openalex.org/I95634034","display_name":"Gazi University","ror":"https://ror.org/054xkpr46","country_code":"TR","type":"education","lineage":["https://openalex.org/I95634034"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Ay\u015fe Bilgihan","raw_affiliation_strings":["","Accepted February 24, 2015","Received October 30, 2014","Received in revised form February 17, 2015","The authors declare that there are no conflicts of interest. This project was supported by Ankara Office of the Turkish Ophthalmology Association","This study, as laboratory and experimental research, was supported by Ankara Office of the Turkish Ophthalmology Association","\u00a7Department of Medical Biochemistry, Gazi University School of Medicine, Ankara, Turkey","\u2020Mugla School of Health Sciences, Mugla Sitki Kocman University, Mugla, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]},{"raw_affiliation_string":"Accepted February 24, 2015","institution_ids":[]},{"raw_affiliation_string":"Received October 30, 2014","institution_ids":[]},{"raw_affiliation_string":"Received in revised form February 17, 2015","institution_ids":[]},{"raw_affiliation_string":"The authors declare that there are no conflicts of interest. This project was supported by Ankara Office of the Turkish Ophthalmology Association","institution_ids":[]},{"raw_affiliation_string":"This study, as laboratory and experimental research, was supported by Ankara Office of the Turkish Ophthalmology Association","institution_ids":[]},{"raw_affiliation_string":"\u00a7Department of Medical Biochemistry, Gazi University School of Medicine, Ankara, Turkey","institution_ids":["https://openalex.org/I95634034"]},{"raw_affiliation_string":"\u2020Mugla School of Health Sciences, Mugla Sitki Kocman University, Mugla, Turkey","institution_ids":["https://openalex.org/I79946792"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5046753144","display_name":"Kamil B\u00eflg\u00efhan","orcid":"https://orcid.org/0000-0002-7562-1173","observed_orcids":["https://orcid.org/0000-0002-7562-1173"]},"institutions":[{"id":"https://openalex.org/I79946792","display_name":"Mu\u011fla University","ror":"https://ror.org/05n2cz176","country_code":"TR","type":"education","lineage":["https://openalex.org/I79946792"]},{"id":"https://openalex.org/I95634034","display_name":"Gazi University","ror":"https://ror.org/054xkpr46","country_code":"TR","type":"education","lineage":["https://openalex.org/I95634034"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Kamil Bilgihan","raw_affiliation_strings":["","*Department of Ophthalmology, Gazi University School of Medicine, Ankara, Turkey","Accepted February 24, 2015","Received October 30, 2014","Received in revised form February 17, 2015","Reprints: \u015eahin Novruzlu, MD, Department of Ophthalmology, Gazi University School of Medicine, Ankara 06000, Turkey (e-mail: [email\u00a0protected])","The authors declare that there are no conflicts of interest. This project was supported by Ankara Office of the Turkish Ophthalmology Association","This study, as laboratory and experimental research, was supported by Ankara Office of the Turkish Ophthalmology Association","\u00a7Department of Medical Biochemistry, Gazi University School of Medicine, Ankara, Turkey","\u2020Mugla School of Health Sciences, Mugla Sitki Kocman University, Mugla, Turkey","\u2021Mugla Vocational School, Mugla Sitki Ko\u00e7man University, Mugla, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]},{"raw_affiliation_string":"*Department of Ophthalmology, Gazi University School of Medicine, Ankara, Turkey","institution_ids":["https://openalex.org/I95634034"]},{"raw_affiliation_string":"Accepted February 24, 2015","institution_ids":[]},{"raw_affiliation_string":"Received October 30, 2014","institution_ids":[]},{"raw_affiliation_string":"Received in revised form February 17, 2015","institution_ids":[]},{"raw_affiliation_string":"Reprints: \u015eahin Novruzlu, MD, Department of Ophthalmology, Gazi University School of Medicine, Ankara 06000, Turkey (e-mail: [email\u00a0protected])","institution_ids":["https://openalex.org/I95634034"]},{"raw_affiliation_string":"The authors declare that there are no conflicts of interest. This project was supported by Ankara Office of the Turkish Ophthalmology Association","institution_ids":[]},{"raw_affiliation_string":"This study, as laboratory and experimental research, was supported by Ankara Office of the Turkish Ophthalmology Association","institution_ids":[]},{"raw_affiliation_string":"\u00a7Department of Medical Biochemistry, Gazi University School of Medicine, Ankara, Turkey","institution_ids":["https://openalex.org/I95634034"]},{"raw_affiliation_string":"\u2020Mugla School of Health Sciences, Mugla Sitki Kocman University, Mugla, Turkey","institution_ids":["https://openalex.org/I79946792"]},{"raw_affiliation_string":"\u2021Mugla Vocational School, Mugla Sitki Ko\u00e7man University, Mugla, Turkey","institution_ids":["https://openalex.org/I79946792"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.0968,"has_fulltext":false,"cited_by_count":10,"citation_normalized_percentile":{"value":0.86068063,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"34","issue":"8","first_page":"932","last_page":"936"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10563","display_name":"Corneal surgery and disorders","score":0.9154999852180481,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10563","display_name":"Corneal surgery and disorders","score":0.9154999852180481,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11826","display_name":"Ocular Infections and Treatments","score":0.02800000086426735,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10997","display_name":"Ocular Surface and Contact Lens","score":0.012199999764561653,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/riboflavin","display_name":"riboflavin","score":0.9639999866485596},{"id":"https://openalex.org/keywords/corneal-cross-linking","display_name":"corneal cross-linking","score":0.902999997138977},{"id":"https://openalex.org/keywords/iontophoresis","display_name":"iontophoresis","score":0.8299999833106995},{"id":"https://openalex.org/keywords/aqueous-humor","display_name":"aqueous humor","score":0.800000011920929},{"id":"https://openalex.org/keywords/corneal-stroma","display_name":"corneal stroma","score":0.8169999718666077},{"id":"https://openalex.org/keywords/rabbit-eye","display_name":"rabbit eye","score":0.3709999918937683},{"id":"https://openalex.org/keywords/corneal-epithelium","display_name":"corneal epithelium","score":0.4560000002384186}],"concepts":[{"id":"https://openalex.org/C2776155809","wikidata":"https://www.wikidata.org/wiki/Q130365","display_name":"Riboflavin","level":2,"score":0.9230910539627075},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7696312665939331},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.673714280128479},{"id":"https://openalex.org/C183529106","wikidata":"https://www.wikidata.org/wiki/Q1528394","display_name":"Iontophoresis","level":2,"score":0.5935195684432983},{"id":"https://openalex.org/C2775919038","wikidata":"https://www.wikidata.org/wiki/Q108126784","display_name":"Benzalkonium chloride","level":2,"score":0.49390774965286255},{"id":"https://openalex.org/C2776882836","wikidata":"https://www.wikidata.org/wiki/Q168291","display_name":"Cornea","level":2,"score":0.48888105154037476},{"id":"https://openalex.org/C31827203","wikidata":"https://www.wikidata.org/wiki/Q874296","display_name":"Tandem mass spectrometry","level":3,"score":0.4860871136188507},{"id":"https://openalex.org/C2993390227","wikidata":"https://www.wikidata.org/wiki/Q827681","display_name":"Aqueous humor","level":2,"score":0.4372691512107849},{"id":"https://openalex.org/C162356407","wikidata":"https://www.wikidata.org/wiki/Q180809","display_name":"Mass spectrometry","level":2,"score":0.4328119456768036},{"id":"https://openalex.org/C40684141","wikidata":"https://www.wikidata.org/wiki/Q902061","display_name":"Electrospray ionization","level":3,"score":0.4265422523021698},{"id":"https://openalex.org/C179998833","wikidata":"https://www.wikidata.org/wiki/Q381233","display_name":"High-performance liquid chromatography","level":2,"score":0.4186166226863861},{"id":"https://openalex.org/C118487528","wikidata":"https://www.wikidata.org/wiki/Q161437","display_name":"Ophthalmology","level":1,"score":0.23946291208267212},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.22408130764961243},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.11612135171890259},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001082","descriptor_name":"Aqueous Humor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002851","descriptor_name":"Chromatography, High Pressure Liquid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003319","descriptor_name":"Corneal Stroma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D003646","descriptor_name":"Debridement","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007478","descriptor_name":"Iontophoresis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012256","descriptor_name":"Riboflavin","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D014018","descriptor_name":"Tissue Distribution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017319","descriptor_name":"Photosensitizing Agents","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D019573","descriptor_name":"Epithelium, Corneal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D019573","descriptor_name":"Epithelium, Corneal","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D021241","descriptor_name":"Spectrometry, Mass, Electrospray Ionization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053719","descriptor_name":"Tandem Mass Spectrometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1097/ico.0000000000000438","doi":"https://doi.org/10.1097/ico.0000000000000438","is_oa":false,"landing_page_url":"https://doi.org/10.1097/ico.0000000000000438","pdf_url":null,"source":{"id":"https://openalex.org/S145806103","display_name":"Cornea","issn_l":"0277-3740","issn":["0277-3740","1536-4798"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cornea","raw_type":"journal-article"},{"id":"pmid:26075452","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26075452","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cornea","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8213000297546387,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":27,"referenced_works":["https://openalex.org/W3989653","https://openalex.org/W88741957","https://openalex.org/W176373562","https://openalex.org/W1559096380","https://openalex.org/W1973714380","https://openalex.org/W1975634954","https://openalex.org/W1979482694","https://openalex.org/W1986938496","https://openalex.org/W2002883364","https://openalex.org/W2006089462","https://openalex.org/W2006746185","https://openalex.org/W2007901463","https://openalex.org/W2013939642","https://openalex.org/W2019255253","https://openalex.org/W2028044239","https://openalex.org/W2028582017","https://openalex.org/W2036526397","https://openalex.org/W2074055274","https://openalex.org/W2078061793","https://openalex.org/W2084548428","https://openalex.org/W2093781936","https://openalex.org/W2113430923","https://openalex.org/W2114207233","https://openalex.org/W2135524729","https://openalex.org/W2138446795","https://openalex.org/W2151302276","https://openalex.org/W6600156888"],"related_works":["https://openalex.org/W7219183520","https://openalex.org/W2207512507","https://openalex.org/W2093781936","https://openalex.org/W3142193273","https://openalex.org/W2099905459","https://openalex.org/W1554742674","https://openalex.org/W3044622993","https://openalex.org/W4416144591","https://openalex.org/W2208580586","https://openalex.org/W7154501494"],"abstract_inverted_index":{"PURPOSE:":[0],"To":[1],"examine":[2],"riboflavin":[3,62,88,97,103,143,148,232,247,252,285,302],"concentrations":[4,149,171,233,248,286],"in":[5,150,172,180,188,196,204,230,283],"corneas":[6,154],"and":[7,14,17,60,75,87,153,175,214,237,245],"aqueous":[8,151,176,246],"humor":[9,152,177],"from":[10],"rabbits":[11,39],"with":[12,113,157,162,289],"standard":[13,58,270],"transepithelial":[15,73,278],"methods":[16],"iontophoresis":[18,117,255,294],"without":[19,118,256,307],"disrupting":[20,121,257,310],"the":[21,24,57,72,114,122,125,131,173,189,258,261,269,277,299,305],"integrity":[22,123,259],"of":[23,34,116,124,251,260,301],"corneal":[25,28,126,231,262],"epithelium":[26,263],"before":[27],"collagen":[29],"cross-linking.":[30],"METHODS:":[31],"Twenty-four":[32],"eyes":[33],"12":[35],"adult":[36],"New":[37],"Zealand":[38],"were":[40,43,155,178,193,264,287],"used.":[41],"They":[42,192],"assigned":[44],"to":[45,56,71,297],"4":[46,129,198],"groups,":[47],"each":[48],"including":[49],"6":[50],"eyes.":[51],"Group":[52,67,99,128],"1":[53,182],"was":[54,69,101,141,225,295],"exposed":[55,70],"method":[59,74],"given":[61,76,102,142],"0.1%":[63,104],"after":[64,249,268,276],"epithelial":[65,311],"debridement.":[66],"2":[68,206,236],"benzalkonium":[77],"chloride":[78],"(BAC),":[79],"ethylenediaminetetraacetic":[80],"acid":[81],"(EDTA),":[82],"trometamol":[83],"(TRIS),":[84],"hydroxypropylmethylcellulose":[85],"(HPMC),":[86],"0.2%":[89,253],"3":[90,100,216,239],"times":[91],"at":[92],"1.5-minute":[93],"intervals":[94],"followed":[95],"by":[96,105],"0.2%.":[98,144],"using":[106,119,308],"1-mA":[107],"electric":[108],"current":[109],"for":[110],"10":[111],"minutes":[112],"help":[115],"substances":[120,309],"epithelium.":[127],"received":[130],"same":[132],"treatment":[133],"as":[134],"did":[135],"group":[136,181,197,205,215,235,238],"3,":[137],"except":[138],"that":[139],"it":[140],"Following":[145],"these":[146],"treatments,":[147],"measured":[156,288],"ultraperformance":[158],"liquid":[159],"chromatography":[160],"coupled":[161],"electrospray":[163],"ionization":[164],"tandem":[165],"mass":[166],"spectrometry":[167],"(UPLC-ESI-MS/MS).":[168],"RESULTS:":[169],"Riboflavin":[170],"cornea":[174,306],"higher":[179,195,273],"(42.4":[183],"\u00b1":[184,200,208,218],"5.4":[185],"\u03bcg/g)":[186,202,210,220],"than":[187,203,266,274],"other":[190],"groups.":[191],"significantly":[194],"(34.2":[199],"6.6":[201],"(24.4":[207],"1.2":[209],"(P":[211,221,240],"=":[212,222,241],"0.009)":[213],"(23.6":[217],"6.1":[219],"0.026).":[223],"There":[224],"not":[226],"a":[227,290],"significant":[228],"difference":[229],"between":[234],"0.937).":[242],"CONCLUSIONS:":[243],"Intrastromal":[244],"administration":[250],"through":[254],"lower":[265],"those":[267,275],"method,":[271,293],"but":[272],"method.":[279],"In":[280],"this":[281],"study,":[282],"which":[284],"very":[291],"sensitive":[292],"observed":[296],"increase":[298],"transmission":[300],"molecules":[303],"into":[304],"integrity.":[312]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
