{"id":"https://openalex.org/W2397129146","doi":null,"title":"Temporal kinetics of calcium in neocortical neuronal nuclei after global cerebral ischemia and reperfusion. An ultrastructural study.","display_name":"Temporal kinetics of calcium in neocortical neuronal nuclei after global cerebral ischemia and reperfusion. An ultrastructural study.","publication_year":2001,"publication_date":"2001-01-01","ids":{"openalex":"https://openalex.org/W2397129146","mag":"2397129146","pmid":"https://pubmed.ncbi.nlm.nih.gov/12092097"},"language":"en","primary_location":{"id":"pmid:12092097","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12092097","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sbornik lekarsky","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"J Franko","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204881574","display_name":"University of Pavol Jozef \u0160af\u00e1rik","ror":"https://ror.org/039965637","country_code":"SK","type":"education","lineage":["https://openalex.org/I204881574"]}],"countries":["SK"],"is_corresponding":false,"raw_author_name":"J Franko","raw_affiliation_strings":["Department of Surgery, Safarik University Hospital, Kosice, Slovak Republic. franko@upjs.sk","Department of Surgery, Safarik University Hospital, Kosice, Slovak Republic"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Safarik University Hospital, Kosice, Slovak Republic. franko@upjs.sk","institution_ids":["https://openalex.org/I204881574"]},{"raw_affiliation_string":"Department of Surgery, Safarik University Hospital, Kosice, Slovak Republic","institution_ids":["https://openalex.org/I204881574"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032367968","display_name":"Mikul\u00e1s Pomfy","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Pomfy","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022545020","display_name":"T Prosbov\u00e1","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T Prosbov\u00e1","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5012453767","display_name":"Ta\u0165iana Kim\u00e1kov\u00e1","orcid":"https://orcid.org/0000-0002-2060-7534","observed_orcids":["https://orcid.org/0000-0002-2060-7534"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T Kim\u00e1kov\u00e1","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.1937,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.57154977,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"102","issue":"2","first_page":"149","last_page":"52"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T14144","display_name":"Neurological Disease Mechanisms and Treatments","score":0.25780001282691956,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T14144","display_name":"Neurological Disease Mechanisms and Treatments","score":0.25780001282691956,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13796","display_name":"Neuroprotection in Cerebral Ischemia","score":0.16279999911785126,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10706","display_name":"Traumatic Brain Injury and Neurovascular Disturbances","score":0.15119999647140503,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/calcium-kinetics","display_name":"calcium kinetics","score":0.796999990940094},{"id":"https://openalex.org/keywords/neun","display_name":"NeuN","score":0.7519999742507935},{"id":"https://openalex.org/keywords/global-cerebral-ischemia","display_name":"global cerebral ischemia","score":0.8289999961853027},{"id":"https://openalex.org/keywords/ischemia-reperfusion-injury","display_name":"ischemia-reperfusion injury","score":0.9300000071525574},{"id":"https://openalex.org/keywords/neocortex","display_name":"neocortex","score":0.8970000147819519},{"id":"https://openalex.org/keywords/calcium-deposits","display_name":"calcium deposits","score":0.5609999895095825},{"id":"https://openalex.org/keywords/canine-brain","display_name":"canine brain","score":0.8109999895095825}],"concepts":[{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.8563854694366455},{"id":"https://openalex.org/C2777222312","wikidata":"https://www.wikidata.org/wiki/Q726562","display_name":"Neocortex","level":2,"score":0.8555916547775269},{"id":"https://openalex.org/C541997718","wikidata":"https://www.wikidata.org/wiki/Q188151","display_name":"Ischemia","level":2,"score":0.7147454619407654},{"id":"https://openalex.org/C87555872","wikidata":"https://www.wikidata.org/wiki/Q3141316","display_name":"Ultrastructure","level":2,"score":0.6145440340042114},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.47990477085113525},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4528440535068512},{"id":"https://openalex.org/C2781041448","wikidata":"https://www.wikidata.org/wiki/Q75839","display_name":"Cerebral cortex","level":2,"score":0.43778523802757263},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.4360220432281494},{"id":"https://openalex.org/C148898269","wikidata":"https://www.wikidata.org/wiki/Q1108792","display_name":"Kinetics","level":2,"score":0.4306834638118744},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.3612721264362335},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3387296199798584},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.33187341690063477},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.24335187673568726},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2380020022392273},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002467","descriptor_name":"Cell Nucleus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002467","descriptor_name":"Cell Nucleus","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D002545","descriptor_name":"Brain Ischemia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002545","descriptor_name":"Brain Ischemia","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D004285","descriptor_name":"Dogs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015427","descriptor_name":"Reperfusion Injury","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015427","descriptor_name":"Reperfusion Injury","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D019579","descriptor_name":"Neocortex","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D019579","descriptor_name":"Neocortex","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:12092097","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12092097","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sbornik lekarsky","raw_type":"Journal Article"},{"id":"mag:2397129146","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12092097","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8048999905586243,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2085871362","https://openalex.org/W2390140763","https://openalex.org/W1979668799","https://openalex.org/W1975931233","https://openalex.org/W2063271495","https://openalex.org/W2383204845","https://openalex.org/W1985516583","https://openalex.org/W2058208051","https://openalex.org/W2065358457","https://openalex.org/W2736496248"],"abstract_inverted_index":{"New":[0],"facts":[1],"about":[2],"control":[3],"of":[4,54,98,117,120,132],"nuclear":[5,118],"milieu":[6],"were":[7,81],"recently":[8],"described.":[9],"Because":[10],"calcium":[11,26,70,99,121,133],"is":[12,126],"known":[13],"as":[14],"an":[15],"important":[16],"cellular":[17],"regulator":[18],"we":[19,112],"designed":[20],"this":[21],"study":[22],"to":[23,49],"describe":[24],"temporal":[25],"kinetics":[27],"in":[28,31,78,83,122,127,135],"neuronal":[29,137],"nuclei":[30],"canine":[32],"neocortex":[33],"after":[34],"ischemia-reperfusion":[35],"injury.":[36],"Seven-minute":[37],"global":[38],"cerebral":[39],"ischemia":[40],"was":[41,57,74],"followed":[42],"by":[43],"reperfusion":[44,84],"phase":[45],"lasting":[46],"from":[47],"0":[48],"24":[50,89],"hours.":[51,90],"Ultrastructural":[52],"histopathology":[53],"brain":[55],"tissue":[56],"assessed":[58],"both":[59],"qualitatively":[60],"and":[61,88],"semi":[62],"quantitatively":[63],"using":[64],"scoring":[65],"system.":[66],"For":[67],"electron":[68],"microscopic":[69],"detection":[71],"pyroantimonate":[72],"histochemistry":[73],"used.":[75],"Significant":[76],"increases":[77],"calcium-pyroantimonate":[79],"deposits":[80,100],"noted":[82],"time":[85,92],"0,":[86],"8":[87],"Reperfusion":[91],"30":[93],"minutes":[94],"showed":[95],"lower":[96],"load":[97],"than":[101],"control,":[102],"this,":[103],"however,":[104],"did":[105],"not":[106],"reach":[107],"statistical":[108],"significance.":[109],"In":[110],"conclusion":[111],"have":[113],"found":[114],"biphasic":[115],"pattern":[116],"sequestration":[119],"neocortical":[123],"neurons,":[124],"which":[125],"agreement":[128],"with":[129],"phasic":[130],"changes":[131],"content":[134],"other":[136],"compartments.":[138]},"counts_by_year":[{"year":2015,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}