{"id":"https://openalex.org/W2397098379","doi":null,"title":"[Cholesterol of circulating immune complexes as biomarker of atherosclerosis].","display_name":"[Cholesterol of circulating immune complexes as biomarker of atherosclerosis].","publication_year":2012,"publication_date":"2012-07-01","ids":{"openalex":"https://openalex.org/W2397098379","mag":"2397098379","pmid":"https://pubmed.ncbi.nlm.nih.gov/23072120"},"language":"ru","primary_location":{"id":"pmid:23072120","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23072120","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Patologicheskaia fiziologiia i eksperimental'naia terapiia","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5077715103","display_name":"Igor Alexandrovich Sobenin","orcid":"https://orcid.org/0000-0003-0978-6444","observed_orcids":["https://orcid.org/0000-0003-0978-6444"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"I A Sobenin","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023341344","display_name":"\u0412 \u041f \u041a\u0430\u0440\u0430\u0433\u043e\u0434\u0438\u043d","orcid":"https://orcid.org/0000-0003-0501-8499","observed_orcids":["https://orcid.org/0000-0003-0501-8499"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"V P Karagodin","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111182422","display_name":"Alexandra Alexandrovna Melnichenko","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A A Mel'nichenko","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5102778497","display_name":"Alexander Nikolaevich Orekhov","orcid":"https://orcid.org/0000-0002-6495-1628","observed_orcids":["https://orcid.org/0000-0002-6495-1628"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A N Orekhov","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.6191,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.75634091,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":null,"issue":"3","first_page":"99","last_page":"103"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":0.48019999265670776,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":0.48019999265670776,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12955","display_name":"Atherosclerosis and Cardiovascular Diseases","score":0.2612000107765198,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10924","display_name":"Cardiovascular Health and Disease Prevention","score":0.0982000008225441,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/circulating-immune-complexes","display_name":"circulating immune complexes","score":0.9800000190734863},{"id":"https://openalex.org/keywords/atherosclerosis","display_name":"atherosclerosis","score":0.9120000004768372},{"id":"https://openalex.org/keywords/carotid-intima-media-thickness","display_name":"carotid intima-media thickness","score":0.9559999704360962},{"id":"https://openalex.org/keywords/atherosclerosis-progression","display_name":"atherosclerosis progression","score":0.8420000076293945},{"id":"https://openalex.org/keywords/ldl-cholesterol","display_name":"LDL cholesterol","score":0.9350000023841858},{"id":"https://openalex.org/keywords/total-cholesterol","display_name":"total cholesterol","score":0.9049999713897705},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.8560000061988831},{"id":"https://openalex.org/keywords/early-atherosclerosis","display_name":"early atherosclerosis","score":0.7979999780654907},{"id":"https://openalex.org/keywords/asymptomatic-men","display_name":"asymptomatic men","score":0.7829999923706055}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7602525949478149},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7449773550033569},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.7335866093635559},{"id":"https://openalex.org/C2777910003","wikidata":"https://www.wikidata.org/wiki/Q1707292","display_name":"Asymptomatic","level":2,"score":0.6696906089782715},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6172855496406555},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.5370427966117859},{"id":"https://openalex.org/C2779339615","wikidata":"https://www.wikidata.org/wiki/Q2698596","display_name":"Intima-media thickness","level":3,"score":0.48524928092956543},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.45071494579315186},{"id":"https://openalex.org/C156957248","wikidata":"https://www.wikidata.org/wiki/Q1862216","display_name":"Odds ratio","level":2,"score":0.43107402324676514},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.33192986249923706},{"id":"https://openalex.org/C2987047532","wikidata":"https://www.wikidata.org/wiki/Q214275","display_name":"Carotid arteries","level":2,"score":0.3210420608520508},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.12204977869987488},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.08938875794410706},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000936","descriptor_name":"Antigen-Antibody Complex","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D002784","descriptor_name":"Cholesterol","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008076","descriptor_name":"Cholesterol, HDL","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D008078","descriptor_name":"Cholesterol, LDL","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011237","descriptor_name":"Predictive Value of Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014280","descriptor_name":"Triglycerides","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D014463","descriptor_name":"Ultrasonography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D017536","descriptor_name":"Carotid Artery, Common","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D017539","descriptor_name":"Tunica Intima","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050197","descriptor_name":"Atherosclerosis","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D050197","descriptor_name":"Atherosclerosis","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D050197","descriptor_name":"Atherosclerosis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:23072120","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23072120","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Patologicheskaia fiziologiia i eksperimental'naia terapiia","raw_type":"Journal Article"},{"id":"mag:2397098379","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23072120","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9922999739646912,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1991345470","https://openalex.org/W4399958158","https://openalex.org/W2123055062","https://openalex.org/W4252254641","https://openalex.org/W4413268940","https://openalex.org/W2026654001","https://openalex.org/W4401602019","https://openalex.org/W2401280808","https://openalex.org/W4403315859","https://openalex.org/W2409716309"],"abstract_inverted_index":{"In":[0],"the":[1,6,38,97,109,139,188,204,210,228],"present":[2],"2-years":[3],"prospective":[4],"study,":[5],"diagnostic":[7],"and":[8,66,91,104,107,115,179],"prognostic":[9,185,221,252],"significance":[10,186],"of":[11,27,45,55,64,79,99,112,130,143,171,190,196,212,223,227,244],"immune":[12,56,89,172,197,233],"cholesterol":[13,57,71,90,93,173,178,181,198,234],"was":[14,31,121,153,162,203],"assessed":[15],"in":[16,40,155,164],"98":[17],"asymptomatic":[18],"men":[19],"aged":[20],"40-74":[21],"with":[22,51,96,175,187],"early":[23,100,245],"atherosclerosis.":[24],"The":[25,49,168,193,225],"rate":[26,129],"carotid":[28,41,47,81,101,213],"atherosclerosis":[29,102,119,191,214],"progression":[30,120,215],"estimated":[32],"by":[33,60,123],"high-resolution":[34],"B-mode":[35],"ultrasonography":[36],"as":[37,72,74,241],"increase":[39,126,152],"intima-media":[42],"thickness":[43],"(IMT)":[44],"common":[46,80],"arteries.":[48,82],"patients":[50],"elevated":[52],"baseline":[53,85,141],"levels":[54,63,111],"were":[58,94],"characterized":[59,122],"significantly":[61,75],"higher":[62],"total":[65,176],"LDL":[67,92,180],"(low":[68],"density":[69],"lipoproteins)":[70],"well":[73],"increased":[76,169],"mean":[77,140],"IMT":[78,125,142,151,159],"Among":[83],"all":[84],"lipid":[86,206],"parameters,":[87],"only":[88,205,240],"contingent":[95],"extent":[98],"(p=0.042":[103],"p=0.049,":[105],"respectively)":[106],"had":[108,182],"highest":[110],"relative":[113],"risk":[114],"odds":[116],"ratio.":[117],"Carotid":[118],"slow":[124],"at":[127,220],"a":[128,242,250],"0.029":[131],"+/-":[132,145],"0.011":[133],"mm":[134,147],"per":[135],"two":[136,217],"years":[137,219],"over":[138],"0.939":[144],"0.015":[146],"(p=0.028).":[148],"A":[149],"significant":[150,160],"registered":[154],"53.1%":[156],"(n=52)":[157],"patients,":[158],"reduction":[161],"observed":[163],"21.4%":[165],"(n=21)":[166],"patients.":[167],"level":[170,195,235],"along":[174],"serum":[177],"rather":[183],"high":[184],"respect":[189],"progression.":[192],"normal":[194],"(below":[199],"than":[200],"16.0":[201],"mg/ml)":[202],"parameter":[207],"that":[208,232],"predicted":[209],"absence":[211],"for":[216,254],"following":[218],"value":[222,253],"78.3%.":[224],"results":[226],"study":[229],"allow":[230],"assuming":[231],"may":[236],"be":[237],"employed":[238],"not":[239],"marker":[243],"atherosclerosis,":[246],"but":[247],"also":[248],"has":[249],"sufficient":[251],"clinical":[255],"implications.":[256]},"counts_by_year":[{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}