{"id":"https://openalex.org/W2397065958","doi":"https://doi.org/10.1186/1753-6561-9-s9-p42","title":"Model-based DoE for feed batch cultivation of a CHO cell line","display_name":"Model-based DoE for feed batch cultivation of a CHO cell line","publication_year":2015,"publication_date":"2015-12-01","ids":{"openalex":"https://openalex.org/W2397065958","doi":"https://doi.org/10.1186/1753-6561-9-s9-p42","mag":"2397065958"},"language":"en","primary_location":{"id":"doi:10.1186/1753-6561-9-s9-p42","doi":"https://doi.org/10.1186/1753-6561-9-s9-p42","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1753-6561-9-s9-p42","pdf_url":"https://bmcproc.biomedcentral.com/track/pdf/10.1186/1753-6561-9-S9-P42","source":{"id":"https://openalex.org/S49206733","display_name":"BMC Proceedings","issn_l":"1753-6561","issn":["1753-6561"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","norway-1","poland-40","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Proceedings","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcproc.biomedcentral.com/track/pdf/10.1186/1753-6561-9-S9-P42","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5024204275","display_name":"Johannes M\u00f6llerl","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I858936495","display_name":"ZHAW Zurich University of Applied Sciences","ror":"https://ror.org/05pmsvm27","country_code":"CH","type":"education","lineage":["https://openalex.org/I858936495"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Johannes M\u00f6llerl","raw_affiliation_strings":["Institute of Biotechnology, Biochemical Engineering and Cell Cultivation Technique, Zurich University of Applied Sciences, 8820, W\u00e4denswil, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Biotechnology, Biochemical Engineering and Cell Cultivation Technique, Zurich University of Applied Sciences, 8820, W\u00e4denswil, Switzerland","institution_ids":["https://openalex.org/I858936495"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071528045","display_name":"Regine Eibl","orcid":"https://orcid.org/0000-0002-1840-8253","observed_orcids":["https://orcid.org/0000-0002-1840-8253"]},"institutions":[{"id":"https://openalex.org/I884043246","display_name":"Hamburg University of Technology","ror":"https://ror.org/04bs1pb34","country_code":"DE","type":"education","lineage":["https://openalex.org/I884043246"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Regine Eibl","raw_affiliation_strings":["Institute of Bioprocess and Biosystems Engineering, Hamburg University of Technology, Hamburg, D-21073, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Bioprocess and Biosystems Engineering, Hamburg University of Technology, Hamburg, D-21073, Germany","institution_ids":["https://openalex.org/I884043246"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058324074","display_name":"Dieter Eibl","orcid":"https://orcid.org/0000-0003-0033-3393","observed_orcids":["https://orcid.org/0000-0003-0033-3393"]},"institutions":[{"id":"https://openalex.org/I858936495","display_name":"ZHAW Zurich University of Applied Sciences","ror":"https://ror.org/05pmsvm27","country_code":"CH","type":"education","lineage":["https://openalex.org/I858936495"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Dieter Eibl","raw_affiliation_strings":["Institute of Biotechnology, Biochemical Engineering and Cell Cultivation Technique, Zurich University of Applied Sciences, 8820, W\u00e4denswil, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Biotechnology, Biochemical Engineering and Cell Cultivation Technique, Zurich University of Applied Sciences, 8820, W\u00e4denswil, Switzerland","institution_ids":["https://openalex.org/I858936495"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5043813704","display_name":"Ralf P\u00f6rtner","orcid":"https://orcid.org/0000-0003-1163-9718","observed_orcids":["https://orcid.org/0000-0003-1163-9718"]},"institutions":[{"id":"https://openalex.org/I884043246","display_name":"Hamburg University of Technology","ror":"https://ror.org/04bs1pb34","country_code":"DE","type":"education","lineage":["https://openalex.org/I884043246"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Ralf P\u00f6rtner","raw_affiliation_strings":["Institute of Bioprocess and Biosystems Engineering, Hamburg University of Technology, Hamburg, D-21073, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Bioprocess and Biosystems Engineering, Hamburg University of Technology, Hamburg, D-21073, Germany","institution_ids":["https://openalex.org/I884043246"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5043813704"],"corresponding_institution_ids":["https://openalex.org/I884043246"],"apc_list":{"value":2290,"currency":"USD","value_usd":2290},"apc_paid":{"value":2290,"currency":"USD","value_usd":2290},"fwci":0.3461,"has_fulltext":true,"cited_by_count":5,"citation_normalized_percentile":{"value":0.57083193,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"9","issue":"S9","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11663","display_name":"Viral Infectious Diseases and Gene Expression in Insects","score":0.9735999703407288,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11663","display_name":"Viral Infectious Diseases and Gene Expression in Insects","score":0.9735999703407288,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11798","display_name":"Optimal Experimental Design Methods","score":0.020400000736117363,"subfield":{"id":"https://openalex.org/subfields/1803","display_name":"Management Science and Operations Research"},"field":{"id":"https://openalex.org/fields/18","display_name":"Decision Sciences"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T10864","display_name":"Fluid Dynamics and Mixing","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1507","display_name":"Fluid Flow and Transfer Processes"},"field":{"id":"https://openalex.org/fields/15","display_name":"Chemical Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/experimental-design","display_name":"experimental design","score":0.8159999847412109},{"id":"https://openalex.org/keywords/cho-cell-culture","display_name":"CHO cell culture","score":0.7289999723434448},{"id":"https://openalex.org/keywords/fed-batch-fermentation","display_name":"fed-batch fermentation","score":0.7649999856948853},{"id":"https://openalex.org/keywords/bioprocess-modeling","display_name":"bioprocess modeling","score":0.6549999713897705},{"id":"https://openalex.org/keywords/recombinant-protein-expression","display_name":"recombinant protein expression","score":0.7799999713897705}],"concepts":[{"id":"https://openalex.org/C34559072","wikidata":"https://www.wikidata.org/wiki/Q2334061","display_name":"Design of experiments","level":2,"score":0.7597720623016357},{"id":"https://openalex.org/C2775905019","wikidata":"https://www.wikidata.org/wiki/Q192572","display_name":"In silico","level":3,"score":0.6599303483963013},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.648859977722168},{"id":"https://openalex.org/C98045186","wikidata":"https://www.wikidata.org/wiki/Q205663","display_name":"Process (computing)","level":2,"score":0.6136976480484009},{"id":"https://openalex.org/C157764524","wikidata":"https://www.wikidata.org/wiki/Q1383412","display_name":"Throughput","level":3,"score":0.5899251699447632},{"id":"https://openalex.org/C173801870","wikidata":"https://www.wikidata.org/wiki/Q201413","display_name":"Heuristic","level":2,"score":0.5756534934043884},{"id":"https://openalex.org/C183696295","wikidata":"https://www.wikidata.org/wiki/Q2487696","display_name":"Biochemical engineering","level":1,"score":0.513948380947113},{"id":"https://openalex.org/C204320433","wikidata":"https://www.wikidata.org/wiki/Q7268772","display_name":"Quality by Design","level":3,"score":0.4881018102169037},{"id":"https://openalex.org/C21880701","wikidata":"https://www.wikidata.org/wiki/Q2144042","display_name":"Process engineering","level":1,"score":0.4394083321094513},{"id":"https://openalex.org/C117671659","wikidata":"https://www.wikidata.org/wiki/Q11049265","display_name":"Manufacturing engineering","level":1,"score":0.3352971076965332},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.15801173448562622},{"id":"https://openalex.org/C2776207758","wikidata":"https://www.wikidata.org/wiki/Q5303302","display_name":"Downstream (manufacturing)","level":2,"score":0.13781684637069702},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.10746902227401733},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.09843656420707703},{"id":"https://openalex.org/C21547014","wikidata":"https://www.wikidata.org/wiki/Q1423657","display_name":"Operations management","level":1,"score":0.09360188245773315},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.08667084574699402},{"id":"https://openalex.org/C76155785","wikidata":"https://www.wikidata.org/wiki/Q418","display_name":"Telecommunications","level":1,"score":0.0},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C555944384","wikidata":"https://www.wikidata.org/wiki/Q249","display_name":"Wireless","level":2,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1186/1753-6561-9-s9-p42","doi":"https://doi.org/10.1186/1753-6561-9-s9-p42","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1753-6561-9-s9-p42","pdf_url":"https://bmcproc.biomedcentral.com/track/pdf/10.1186/1753-6561-9-S9-P42","source":{"id":"https://openalex.org/S49206733","display_name":"BMC Proceedings","issn_l":"1753-6561","issn":["1753-6561"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","norway-1","poland-40","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Proceedings","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4685411","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4685411","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Proc","raw_type":"Text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.776.8289","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.776.8289","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/b8/a2/1753-6561-9-S9-P42.PMC4685411.pdf","raw_type":"text"}],"best_oa_location":{"id":"doi:10.1186/1753-6561-9-s9-p42","doi":"https://doi.org/10.1186/1753-6561-9-s9-p42","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1753-6561-9-s9-p42","pdf_url":"https://bmcproc.biomedcentral.com/track/pdf/10.1186/1753-6561-9-S9-P42","source":{"id":"https://openalex.org/S49206733","display_name":"BMC Proceedings","issn_l":"1753-6561","issn":["1753-6561"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","norway-1","poland-40","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Proceedings","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2397065958.pdf","grobid_xml":"https://content.openalex.org/works/W2397065958.grobid-xml"},"referenced_works_count":2,"referenced_works":["https://openalex.org/W2026737836","https://openalex.org/W2171074980"],"related_works":["https://openalex.org/W7096215076","https://openalex.org/W2074515747","https://openalex.org/W2379567646","https://openalex.org/W4413997198","https://openalex.org/W4289878062","https://openalex.org/W2581303103","https://openalex.org/W2272270100","https://openalex.org/W1998908967","https://openalex.org/W1516770884","https://openalex.org/W2567677822"],"abstract_inverted_index":{"Process":[0],"optimization":[1],"deals":[2],"with":[3,40,79,98],"various":[4],"parameters":[5],"and":[6,89,110],"statistical":[7],"methods":[8,85],"to":[9,51,68,108,111],"guarantee":[10],"consistent":[11],"cell":[12],"grow":[13],"than":[14],"product":[15],"quality.":[16],"Even":[17],"if":[18],"high":[19],"throughput":[20],"systems":[21],"can":[22,35,44],"handle":[23],"these":[24,70],"parameter":[25],"combinations":[26],"in":[27,37,96],"parallel":[28],"experiments,":[29],"the":[30,46,66],"heuristic":[31],"restriction":[32],"of":[33,74,82,93],"boundaries":[34],"result":[36],"stepwise":[38],"iterations":[39],"many":[41],"experiments.":[42,71],"This":[43],"make":[45],"way":[47],"from":[48],"process":[49,52],"development":[50],"establishment":[53],"even":[54],"more":[55],"troublesome,":[56],"since":[57],"academia":[58],"or":[59],"start-up":[60],"research":[61],"facilities":[62],"might":[63,103],"not":[64],"have":[65],"possibility":[67],"perform":[69],"The":[72,91],"opti-mization":[73],"complex":[75],"biotechnological":[76],"production":[77],"pro-cesses":[78],"approved":[80],"Design":[81],"Experiment":[83],"(DoE)":[84],"is":[86],"therefore":[87],"time-consuming":[88],"cost-intensive.":[90],"use":[92],"DoE":[94],"tools":[95],"combination":[97],"an":[99],"appropriate":[100],"growth":[101],"model":[102],"be":[104],"a":[105],"valuable":[106],"tool":[107],"develop":[109]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}