{"id":"https://openalex.org/W2396984120","doi":"https://doi.org/10.1074/jbc.m116.726729","title":"Poly(ADP-ribose) Polymerase 1 Represses Liver X Receptor-mediated ABCA1 Expression and Cholesterol Efflux in Macrophages","display_name":"Poly(ADP-ribose) Polymerase 1 Represses Liver X Receptor-mediated ABCA1 Expression and Cholesterol Efflux in Macrophages","publication_year":2016,"publication_date":"2016-03-30","ids":{"openalex":"https://openalex.org/W2396984120","doi":"https://doi.org/10.1074/jbc.m116.726729","mag":"2396984120","pmid":"https://pubmed.ncbi.nlm.nih.gov/27026705","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4900266"},"language":"en","primary_location":{"id":"doi:10.1074/jbc.m116.726729","doi":"https://doi.org/10.1074/jbc.m116.726729","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m116.726729","pdf_url":"http://www.jbc.org/article/S0021925820408609/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"http://www.jbc.org/article/S0021925820408609/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5066129216","display_name":"Elina Shrestha","orcid":"https://orcid.org/0009-0002-7925-9383","observed_orcids":["https://orcid.org/0009-0002-7925-9383"]},"institutions":[{"id":"https://openalex.org/I4210086933","display_name":"NYU Langone Health","ror":"https://ror.org/005dvqh91","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210086933"]},{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elina Shrestha","raw_affiliation_strings":["From the Department of Microbiology, New York University School of Medicine, New York, New York 10016","Department of Microbiology, New York University School of Medicine, New York, New York 10016"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Microbiology, New York University School of Medicine, New York, New York 10016","institution_ids":["https://openalex.org/I57206974"]},{"raw_affiliation_string":"Department of Microbiology, New York University School of Medicine, New York, New York 10016","institution_ids":["https://openalex.org/I4210086933","https://openalex.org/I57206974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003470090","display_name":"Maryem A. Hussein","orcid":"https://orcid.org/0009-0006-8325-9529","observed_orcids":["https://orcid.org/0009-0006-8325-9529"]},"institutions":[{"id":"https://openalex.org/I4210086933","display_name":"NYU Langone Health","ror":"https://ror.org/005dvqh91","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210086933"]},{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Maryem A. Hussein","raw_affiliation_strings":["From the Department of Microbiology, New York University School of Medicine, New York, New York 10016","Department of Microbiology, New York University School of Medicine, New York, New York 10016"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Microbiology, New York University School of Medicine, New York, New York 10016","institution_ids":["https://openalex.org/I57206974"]},{"raw_affiliation_string":"Department of Microbiology, New York University School of Medicine, New York, New York 10016","institution_ids":["https://openalex.org/I4210086933","https://openalex.org/I57206974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080621027","display_name":"Jeffery N. Savas","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeffery N. Savas","raw_affiliation_strings":["the Department of Neurology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois 60611","Department of Neurology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois 60611"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"the Department of Neurology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois 60611","institution_ids":["https://openalex.org/I111979921"]},{"raw_affiliation_string":"Department of Neurology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois 60611","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084520170","display_name":"Mireille I. Ouimet","orcid":"https://orcid.org/0000-0002-6831-5047","observed_orcids":["https://orcid.org/0000-0002-6831-5047"]},"institutions":[{"id":"https://openalex.org/I4210086933","display_name":"NYU Langone Health","ror":"https://ror.org/005dvqh91","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210086933"]},{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mireille Ouimet","raw_affiliation_strings":["the Department of Medicine, Division of Cardiology, Marc and Ruti Bell Program in Vascular Biology, New York University School of Medicine, New York, New York 10016, and","Department of Medicine, Division of Cardiology, Marc and Ruti Bell Program in Vascular Biology, New York University School of Medicine, New York, New York 10016"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"the Department of Medicine, Division of Cardiology, Marc and Ruti Bell Program in Vascular Biology, New York University School of Medicine, New York, New York 10016, and","institution_ids":["https://openalex.org/I57206974"]},{"raw_affiliation_string":"Department of Medicine, Division of Cardiology, Marc and Ruti Bell Program in Vascular Biology, New York University School of Medicine, New York, New York 10016","institution_ids":["https://openalex.org/I4210086933","https://openalex.org/I57206974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046706301","display_name":"Tessa J. Barrett","orcid":"https://orcid.org/0000-0003-0751-1578","observed_orcids":["https://orcid.org/0000-0003-0751-1578"]},"institutions":[{"id":"https://openalex.org/I4210086933","display_name":"NYU Langone Health","ror":"https://ror.org/005dvqh91","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210086933"]},{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tessa J. Barrett","raw_affiliation_strings":["the Department of Medicine, Division of Cardiology, Marc and Ruti Bell Program in Vascular Biology, New York University School of Medicine, New York, New York 10016, and","Department of Medicine, Division of Cardiology, Marc and Ruti Bell Program in Vascular Biology, New York University School of Medicine, New York, New York 10016"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"the Department of Medicine, Division of Cardiology, Marc and Ruti Bell Program in Vascular Biology, New York University School of Medicine, New York, New York 10016, and","institution_ids":["https://openalex.org/I57206974"]},{"raw_affiliation_string":"Department of Medicine, Division of Cardiology, Marc and Ruti Bell Program in Vascular Biology, New York University School of Medicine, New York, New York 10016","institution_ids":["https://openalex.org/I4210086933","https://openalex.org/I57206974"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Sarah Leone","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210086933","display_name":"NYU Langone Health","ror":"https://ror.org/005dvqh91","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210086933"]},{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sarah Leone","raw_affiliation_strings":["From the Department of Microbiology, New York University School of Medicine, New York, New York 10016","Department of Microbiology, New York University School of Medicine, New York, New York 10016"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Microbiology, New York University School of Medicine, New York, New York 10016","institution_ids":["https://openalex.org/I57206974"]},{"raw_affiliation_string":"Department of Microbiology, New York University School of Medicine, New York, New York 10016","institution_ids":["https://openalex.org/I4210086933","https://openalex.org/I57206974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029671362","display_name":"John R. Yates","orcid":"https://orcid.org/0000-0001-5267-1672","observed_orcids":["https://orcid.org/0000-0001-5267-1672"]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John R. Yates","raw_affiliation_strings":["the Department of Chemical Physiology, Scripps Research Institute, La Jolla, California 92037","Department of Chemical Physiology, Scripps Research Institute, La Jolla, California 92037"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"the Department of Chemical Physiology, Scripps Research Institute, La Jolla, California 92037","institution_ids":["https://openalex.org/I123431417"]},{"raw_affiliation_string":"Department of Chemical Physiology, Scripps Research Institute, La Jolla, California 92037","institution_ids":["https://openalex.org/I123431417"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035258831","display_name":"Kathryn J. Moore","orcid":"https://orcid.org/0000-0003-2505-2547","observed_orcids":["https://orcid.org/0000-0003-2505-2547"]},"institutions":[{"id":"https://openalex.org/I4210086933","display_name":"NYU Langone Health","ror":"https://ror.org/005dvqh91","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210086933"]},{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kathryn J. Moore","raw_affiliation_strings":["the Department of Medicine, Division of Cardiology, Marc and Ruti Bell Program in Vascular Biology, New York University School of Medicine, New York, New York 10016, and","Department of Medicine, Division of Cardiology, Marc and Ruti Bell Program in Vascular Biology, New York University School of Medicine, New York, New York 10016"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"the Department of Medicine, Division of Cardiology, Marc and Ruti Bell Program in Vascular Biology, New York University School of Medicine, New York, New York 10016, and","institution_ids":["https://openalex.org/I57206974"]},{"raw_affiliation_string":"Department of Medicine, Division of Cardiology, Marc and Ruti Bell Program in Vascular Biology, New York University School of Medicine, New York, New York 10016","institution_ids":["https://openalex.org/I4210086933","https://openalex.org/I57206974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088448170","display_name":"Edward A A Fisher","orcid":"https://orcid.org/0000-0001-9802-143X","observed_orcids":["https://orcid.org/0000-0001-9802-143X"]},"institutions":[{"id":"https://openalex.org/I4210086933","display_name":"NYU Langone Health","ror":"https://ror.org/005dvqh91","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210086933"]},{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Edward A. Fisher","raw_affiliation_strings":["the Department of Medicine, Division of Cardiology, Marc and Ruti Bell Program in Vascular Biology, New York University School of Medicine, New York, New York 10016, and","Department of Medicine, Division of Cardiology, Marc and Ruti Bell Program in Vascular Biology, New York University School of Medicine, New York, New York 10016"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"the Department of Medicine, Division of Cardiology, Marc and Ruti Bell Program in Vascular Biology, New York University School of Medicine, New York, New York 10016, and","institution_ids":["https://openalex.org/I57206974"]},{"raw_affiliation_string":"Department of Medicine, Division of Cardiology, Marc and Ruti Bell Program in Vascular Biology, New York University School of Medicine, New York, New York 10016","institution_ids":["https://openalex.org/I4210086933","https://openalex.org/I57206974"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5060305478","display_name":"Michael J. Garabedian","orcid":"https://orcid.org/0000-0001-8915-7378","observed_orcids":["https://orcid.org/0000-0001-8915-7378"]},"institutions":[{"id":"https://openalex.org/I4210086933","display_name":"NYU Langone Health","ror":"https://ror.org/005dvqh91","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210086933"]},{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Michael J. Garabedian","raw_affiliation_strings":["From the Department of Microbiology, New York University School of Medicine, New York, New York 10016, michael.garabedian@nyumc.org","Department of Microbiology, New York University School of Medicine, New York, New York 10016"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Microbiology, New York University School of Medicine, New York, New York 10016, michael.garabedian@nyumc.org","institution_ids":["https://openalex.org/I57206974"]},{"raw_affiliation_string":"Department of Microbiology, New York University School of Medicine, New York, New York 10016","institution_ids":["https://openalex.org/I4210086933","https://openalex.org/I57206974"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5060305478"],"corresponding_institution_ids":["https://openalex.org/I4210086933","https://openalex.org/I57206974"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":6.6411,"has_fulltext":true,"cited_by_count":48,"citation_normalized_percentile":{"value":0.96873762,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"291","issue":"21","first_page":"11172","last_page":"11184"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11618","display_name":"Cholesterol and Lipid Metabolism","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11618","display_name":"Cholesterol and Lipid Metabolism","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11072","display_name":"Peroxisome Proliferator-Activated Receptors","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/parp-1","display_name":"PARP1","score":0.9679999947547913},{"id":"https://openalex.org/keywords/liver-x-receptor","display_name":"liver X receptor","score":0.9390000104904175},{"id":"https://openalex.org/keywords/lxralpha","display_name":"liver X receptor alpha","score":0.8560000061988831},{"id":"https://openalex.org/keywords/lxrbeta","display_name":"LXR\u03b2","score":0.9869999885559082},{"id":"https://openalex.org/keywords/abca1","display_name":"ABCA1","score":0.9729999899864197},{"id":"https://openalex.org/keywords/cholesterol-efflux","display_name":"cholesterol efflux","score":0.8820000290870667},{"id":"https://openalex.org/keywords/macrophages","display_name":"macrophages","score":0.9710000157356262},{"id":"https://openalex.org/keywords/reverse-cholesterol-transport","display_name":"reverse cholesterol transport","score":0.9179999828338623},{"id":"https://openalex.org/keywords/atherosclerosis","display_name":"atherosclerosis","score":0.8939999938011169},{"id":"https://openalex.org/keywords/poly-adp-ribosyl-ation","display_name":"poly(ADP-ribosyl)ation","score":0.8289999961853027},{"id":"https://openalex.org/keywords/3-aminobenzamide","display_name":"3-aminobenzamide","score":0.847000002861023},{"id":"https://openalex.org/keywords/apolipoprotein-a-i","display_name":"apolipoprotein A-I","score":0.8029999732971191},{"id":"https://openalex.org/keywords/oxysterols","display_name":"oxysterols","score":0.7379999756813049},{"id":"https://openalex.org/keywords/lipid-homeostasis","display_name":"lipid homeostasis","score":0.8550000190734863}],"concepts":[{"id":"https://openalex.org/C167400880","wikidata":"https://www.wikidata.org/wiki/Q3454539","display_name":"Liver X receptor","level":5,"score":0.9737558364868164},{"id":"https://openalex.org/C2777704780","wikidata":"https://www.wikidata.org/wiki/Q21115210","display_name":"ABCA1","level":4,"score":0.9002580642700195},{"id":"https://openalex.org/C2776330080","wikidata":"https://www.wikidata.org/wiki/Q21113668","display_name":"ABCG1","level":5,"score":0.8391963243484497},{"id":"https://openalex.org/C2778827360","wikidata":"https://www.wikidata.org/wiki/Q774795","display_name":"Geranylgeranyl pyrophosphate","level":4,"score":0.6760758757591248},{"id":"https://openalex.org/C134320426","wikidata":"https://www.wikidata.org/wiki/Q901026","display_name":"Chromatin immunoprecipitation","level":5,"score":0.6524356007575989},{"id":"https://openalex.org/C182979987","wikidata":"https://www.wikidata.org/wiki/Q3907241","display_name":"Poly ADP ribose polymerase","level":4,"score":0.6263442635536194},{"id":"https://openalex.org/C2778111914","wikidata":"https://www.wikidata.org/wiki/Q7116159","display_name":"Oxysterol","level":3,"score":0.6061895489692688},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5434191226959229},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4451712369918823},{"id":"https://openalex.org/C85051948","wikidata":"https://www.wikidata.org/wiki/Q416064","display_name":"Sterol regulatory element-binding protein","level":4,"score":0.4407891631126404},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.41766437888145447},{"id":"https://openalex.org/C63932345","wikidata":"https://www.wikidata.org/wiki/Q422500","display_name":"Nuclear receptor","level":4,"score":0.3953917622566223},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.35253193974494934},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.34435194730758667},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3396013081073761},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.2790425419807434},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2605065107345581},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.2468683421611786},{"id":"https://openalex.org/C2778718757","wikidata":"https://www.wikidata.org/wiki/Q143623","display_name":"Sterol","level":3,"score":0.21278613805770874},{"id":"https://openalex.org/C82381507","wikidata":"https://www.wikidata.org/wiki/Q416878","display_name":"Polymerase","level":3,"score":0.11685830354690552},{"id":"https://openalex.org/C101762097","wikidata":"https://www.wikidata.org/wiki/Q224093","display_name":"Promoter","level":4,"score":0.11341950297355652},{"id":"https://openalex.org/C149011108","wikidata":"https://www.wikidata.org/wiki/Q652985","display_name":"Transporter","level":3,"score":0.07429462671279907},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.06898429989814758},{"id":"https://openalex.org/C57790582","wikidata":"https://www.wikidata.org/wiki/Q901141","display_name":"Prenylation","level":3,"score":0.0},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000067996","descriptor_name":"RAW 264.7 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000070998","descriptor_name":"ATP Binding Cassette Transporter, Subfamily G, Member 1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000071137","descriptor_name":"Poly (ADP-Ribose) Polymerase-1","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D000071137","descriptor_name":"Poly (ADP-Ribose) Polymerase-1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000071137","descriptor_name":"Poly (ADP-Ribose) Polymerase-1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000071518","descriptor_name":"Liver X Receptors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000071518","descriptor_name":"Liver X Receptors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001693","descriptor_name":"Biological Transport, Active","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002784","descriptor_name":"Cholesterol","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015536","descriptor_name":"Down-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051780","descriptor_name":"Sterol Regulatory Element Binding Protein 1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D057809","descriptor_name":"HEK293 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064286","descriptor_name":"ATP Binding Cassette Transporter 1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D064286","descriptor_name":"ATP Binding Cassette Transporter 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1074/jbc.m116.726729","doi":"https://doi.org/10.1074/jbc.m116.726729","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m116.726729","pdf_url":"http://www.jbc.org/article/S0021925820408609/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:4285909","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4900266","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4900266","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4900266","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Biol Chem","raw_type":"Text"},{"id":"pmid:27026705","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27026705","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1074/jbc.m116.726729","doi":"https://doi.org/10.1074/jbc.m116.726729","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m116.726729","pdf_url":"http://www.jbc.org/article/S0021925820408609/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2022343112","display_name":"Quantitative Proteomic Approach to Identify the Mechanism of Alzheimer's Disease","funder_award_id":"F32AG039127","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G2266079415","display_name":null,"funder_award_id":"HEK293T","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G3667197282","display_name":"Medical Scientist Research Service Award","funder_award_id":"T32GM007308","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G4034719064","display_name":"Comprehensive Biology: Exploiting the Yeast Genome","funder_award_id":"P41GM103533","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G4050155381","display_name":"Proteome Biology of Noise Induced Hearing Loss","funder_award_id":"R00DC013805","funder_id":"https://openalex.org/F4320337352","funder_display_name":"National Institute on Deafness and Other Communication Disorders"},{"id":"https://openalex.org/G4200874266","display_name":"Quantitative Proteome Analysis of Brain Development","funder_award_id":"R01MH067880","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G4991771517","display_name":"miR-33 control of the immune response","funder_award_id":"15POST25090199","funder_id":"https://openalex.org/F4320306230","funder_display_name":"American Heart Association"},{"id":"https://openalex.org/G5054178729","display_name":"Institutional Clinical and Translational Science Award","funder_award_id":"UL1TR000038","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G508562864","display_name":"Graduate Program in Cellular and Molecular Biology","funder_award_id":"T32GM007238","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G5720280470","display_name":"Mechanisms of CD36 Signal Transduction - Resubmission - 1","funder_award_id":"R01HL117334","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G6386076924","display_name":"Infectious Disease and Basic Microbiological Mechanisms.","funder_award_id":"T32AI007180","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G6714694761","display_name":"Regulation of LXR alpha by glucose & cholesterol in diabetes & atherosclerosis","funder_award_id":"R01HL117226","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G9000881928","display_name":"Clinical and Translational Science Award","funder_award_id":"UL1TR001445","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320306230","display_name":"American Heart Association","ror":"https://ror.org/013kjyp64"},{"id":"https://openalex.org/F4320307087","display_name":"Vilcek Foundation","ror":"https://ror.org/02sjh4j59"},{"id":"https://openalex.org/F4320320286","display_name":"University College London","ror":"https://ror.org/02jx3x895"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337346","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08"},{"id":"https://openalex.org/F4320337352","display_name":"National Institute on Deafness and Other Communication Disorders","ror":"https://ror.org/04mhx6838"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"},{"id":"https://openalex.org/F4320337472","display_name":"National Center for Advancing Translational Sciences","ror":"https://ror.org/04pw6fb54"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2396984120.pdf","grobid_xml":"https://content.openalex.org/works/W2396984120.grobid-xml"},"referenced_works_count":64,"referenced_works":["https://openalex.org/W1499143025","https://openalex.org/W1542544035","https://openalex.org/W1570388980","https://openalex.org/W1597678601","https://openalex.org/W1632044028","https://openalex.org/W1650965741","https://openalex.org/W1729426031","https://openalex.org/W1824297940","https://openalex.org/W1972882837","https://openalex.org/W1974220331","https://openalex.org/W1977709885","https://openalex.org/W1980964357","https://openalex.org/W1986256219","https://openalex.org/W1989833877","https://openalex.org/W1996168740","https://openalex.org/W1998308002","https://openalex.org/W2003507204","https://openalex.org/W2004307609","https://openalex.org/W2005271745","https://openalex.org/W2011115717","https://openalex.org/W2016637704","https://openalex.org/W2017700461","https://openalex.org/W2023712548","https://openalex.org/W2033896075","https://openalex.org/W2035982512","https://openalex.org/W2040176292","https://openalex.org/W2040417680","https://openalex.org/W2043644194","https://openalex.org/W2045731066","https://openalex.org/W2048397414","https://openalex.org/W2058205407","https://openalex.org/W2072179781","https://openalex.org/W2077760013","https://openalex.org/W2079526339","https://openalex.org/W2081594562","https://openalex.org/W2081600877","https://openalex.org/W2081832076","https://openalex.org/W2084060660","https://openalex.org/W2093296161","https://openalex.org/W2094501936","https://openalex.org/W2103712420","https://openalex.org/W2108100915","https://openalex.org/W2113699634","https://openalex.org/W2118612419","https://openalex.org/W2121873730","https://openalex.org/W2126473569","https://openalex.org/W2138753328","https://openalex.org/W2140690866","https://openalex.org/W2146797307","https://openalex.org/W2149457192","https://openalex.org/W2153673003","https://openalex.org/W2159263105","https://openalex.org/W2159332620","https://openalex.org/W2159887824","https://openalex.org/W2161506097","https://openalex.org/W2164303034","https://openalex.org/W2165104851","https://openalex.org/W2166071408","https://openalex.org/W2166430298","https://openalex.org/W2168268248","https://openalex.org/W2169873114","https://openalex.org/W2169970994","https://openalex.org/W2171705910","https://openalex.org/W4234971544"],"related_works":["https://openalex.org/W7067709920","https://openalex.org/W2063804219","https://openalex.org/W3084738807","https://openalex.org/W7095116755","https://openalex.org/W7097153111","https://openalex.org/W1989036024","https://openalex.org/W1986256219","https://openalex.org/W2301430970","https://openalex.org/W426461269","https://openalex.org/W2069399923"],"abstract_inverted_index":{"Liver":[0],"X":[1],"receptors":[2,7],"(LXR)":[3],"are":[4],"oxysterol-activated":[5],"nuclear":[6,81],"that":[8,26,51,68,161],"play":[9],"a":[10,167],"central":[11],"role":[12,198],"in":[13,56,116,151],"reverse":[14],"cholesterol":[15,29,184],"transport":[16],"through":[17],"up-regulation":[18],"of":[19,33,41,66,104,108,133,154,199],"ATP-binding":[20],"cassette":[21],"transporters":[22],"(ABCA1":[23],"and":[24,38,76,84,100,106,122,138,210],"ABCG1)":[25],"mediate":[27],"cellular":[28],"efflux.":[30],"Mouse":[31],"models":[32],"atherosclerosis":[34,37],"exhibit":[35],"reduced":[36],"enhanced":[39,181],"regression":[40],"established":[42],"plaques":[43],"upon":[44],"LXR":[45,67,112,148,162,174,211],"activation.":[46],"However,":[47],"the":[48,117,147,152,155,177,187,196,206],"coregulatory":[49],"factors":[50],"affect":[52,130],"LXR-dependent":[53,131],"gene":[54],"activation":[55],"macrophages":[57,126],"remain":[58],"to":[59,79,186],"be":[60],"elucidated.":[61],"To":[62],"identify":[63],"novel":[64,217],"regulators":[65],"modulate":[69],"its":[70],"activity,":[71],"we":[72,159],"used":[73],"affinity":[74],"purification":[75],"mass":[77],"spectrometry":[78],"analyze":[80],"LXR\u03b1":[82,99],"complexes":[83],"identified":[85],"poly(ADP-ribose)":[86],"polymerase-1":[87],"(PARP-1)":[88],"as":[89],"an":[90],"LXR-associated":[91],"factor.":[92],"In":[93],"fact,":[94],"PARP-1":[95,105,109,144,172,200,209],"interacted":[96],"with":[97],"both":[98],"LXR\u03b2.":[101],"Both":[102],"depletion":[103],"inhibition":[107],"activity":[110],"augmented":[111],"ligand-induced":[113],"ABCA1":[114,156],"expression":[115,132],"RAW":[118],"264.7":[119],"macrophage":[120,182],"line":[121],"primary":[123],"bone":[124],"marrow-derived":[125],"but":[127],"did":[128],"not":[129],"other":[134],"target":[135],"genes,":[136],"ABCG1":[137],"SREBP-1c.":[139],"Chromatin":[140],"immunoprecipitation":[141],"experiments":[142],"confirmed":[143],"recruitment":[145],"at":[146],"response":[149],"element":[150],"promoter":[153],"gene.":[157],"Further,":[158],"demonstrated":[160],"is":[163],"poly(ADP-ribosyl)ated":[164],"by":[165,170],"PARP-1,":[166],"potential":[168],"mechanism":[169],"which":[171],"influences":[173],"function.":[175],"Importantly,":[176],"PARP":[178],"inhibitor":[179],"3-aminobenzamide":[180],"ABCA1-mediated":[183],"efflux":[185],"lipid-poor":[188],"apolipoprotein":[189],"AI.":[190],"These":[191],"findings":[192],"shed":[193],"light":[194],"on":[195,201],"important":[197],"LXR-regulated":[202],"lipid":[203],"homeostasis.":[204],"Understanding":[205],"interplay":[207],"between":[208],"may":[212],"provide":[213],"insights":[214],"into":[215],"developing":[216],"therapeutics":[218],"for":[219],"treating":[220],"atherosclerosis.":[221]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":8},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
