{"id":"https://openalex.org/W2396982863","doi":"https://doi.org/10.1016/s0022-5347(17)41926-4","title":"Uptake of Estramustine Phosphate (Estracyt) Metabolites in Prostatic Cancer","display_name":"Uptake of Estramustine Phosphate (Estracyt) Metabolites in Prostatic Cancer","publication_year":1988,"publication_date":"1988-11-01","ids":{"openalex":"https://openalex.org/W2396982863","doi":"https://doi.org/10.1016/s0022-5347(17)41926-4","mag":"2396982863","pmid":"https://pubmed.ncbi.nlm.nih.gov/3172360"},"language":"en","primary_location":{"id":"doi:10.1016/s0022-5347(17)41926-4","doi":"https://doi.org/10.1016/s0022-5347(17)41926-4","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0022-5347(17)41926-4","pdf_url":null,"source":{"id":"https://openalex.org/S30525748","display_name":"The Journal of Urology","issn_l":"0022-5347","issn":["0022-5347","1527-3792"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Urology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112384358","display_name":"B. J. Norl\u00e9n","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1342360035","display_name":"Uppsala University Hospital","ror":"https://ror.org/01apvbh93","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I1342360035"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"B.J. Norl\u00e9n","raw_affiliation_strings":["From the Department of Urology, Akademiska sjukhuset, Uppsala, and the Research Laboratories, Pharmacia LEO Therapeutics AB, Helsingborg, Sweden","Research Laboratories, Pharmacia LEO Therapeutics AB, Helsingborg, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Urology, Akademiska sjukhuset, Uppsala, and the Research Laboratories, Pharmacia LEO Therapeutics AB, Helsingborg, Sweden","institution_ids":["https://openalex.org/I1342360035"]},{"raw_affiliation_string":"Research Laboratories, Pharmacia LEO Therapeutics AB, Helsingborg, Sweden","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078944510","display_name":"Sven-B\u00f6rje Andersson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1342360035","display_name":"Uppsala University Hospital","ror":"https://ror.org/01apvbh93","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I1342360035"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"S.-B. Andersson","raw_affiliation_strings":["From the Department of Urology, Akademiska sjukhuset, Uppsala, and the Research Laboratories, Pharmacia LEO Therapeutics AB, Helsingborg, Sweden","Research Laboratories, Pharmacia LEO Therapeutics AB, Helsingborg, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Urology, Akademiska sjukhuset, Uppsala, and the Research Laboratories, Pharmacia LEO Therapeutics AB, Helsingborg, Sweden","institution_ids":["https://openalex.org/I1342360035"]},{"raw_affiliation_string":"Research Laboratories, Pharmacia LEO Therapeutics AB, Helsingborg, Sweden","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032227006","display_name":"P. Bj\u00f6rk","orcid":"https://orcid.org/0000-0002-5641-7791","observed_orcids":["https://orcid.org/0000-0002-5641-7791"]},"institutions":[{"id":"https://openalex.org/I1342360035","display_name":"Uppsala University Hospital","ror":"https://ror.org/01apvbh93","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I1342360035"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"P. Bj\u00f6rk","raw_affiliation_strings":["From the Department of Urology, Akademiska sjukhuset, Uppsala, and the Research Laboratories, Pharmacia LEO Therapeutics AB, Helsingborg, Sweden","Research Laboratories, Pharmacia LEO Therapeutics AB, Helsingborg, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Urology, Akademiska sjukhuset, Uppsala, and the Research Laboratories, Pharmacia LEO Therapeutics AB, Helsingborg, Sweden","institution_ids":["https://openalex.org/I1342360035"]},{"raw_affiliation_string":"Research Laboratories, Pharmacia LEO Therapeutics AB, Helsingborg, Sweden","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113669805","display_name":"Per Olov Gunnarsson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1342360035","display_name":"Uppsala University Hospital","ror":"https://ror.org/01apvbh93","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I1342360035"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"P.O. Gunnarsson","raw_affiliation_strings":["From the Department of Urology, Akademiska sjukhuset, Uppsala, and the Research Laboratories, Pharmacia LEO Therapeutics AB, Helsingborg, Sweden","Research Laboratories, Pharmacia LEO Therapeutics AB, Helsingborg, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Urology, Akademiska sjukhuset, Uppsala, and the Research Laboratories, Pharmacia LEO Therapeutics AB, Helsingborg, Sweden","institution_ids":["https://openalex.org/I1342360035"]},{"raw_affiliation_string":"Research Laboratories, Pharmacia LEO Therapeutics AB, Helsingborg, Sweden","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112151914","display_name":"\u00c5ke Fritjofsson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1342360035","display_name":"Uppsala University Hospital","ror":"https://ror.org/01apvbh93","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I1342360035"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"\u00c5. Fritjofsson","raw_affiliation_strings":["From the Department of Urology, Akademiska sjukhuset, Uppsala, and the Research Laboratories, Pharmacia LEO Therapeutics AB, Helsingborg, Sweden","Research Laboratories, Pharmacia LEO Therapeutics AB, Helsingborg, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Urology, Akademiska sjukhuset, Uppsala, and the Research Laboratories, Pharmacia LEO Therapeutics AB, Helsingborg, Sweden","institution_ids":["https://openalex.org/I1342360035"]},{"raw_affiliation_string":"Research Laboratories, Pharmacia LEO Therapeutics AB, Helsingborg, Sweden","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I1342360035"],"apc_list":{"value":3000,"currency":"USD","value_usd":3000},"apc_paid":null,"fwci":1.6642,"has_fulltext":false,"cited_by_count":34,"citation_normalized_percentile":{"value":0.84417629,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"140","issue":"5 Part 1","first_page":"1058","last_page":"1062"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.9262999892234802,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.9262999892234802,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11845","display_name":"Cancer therapeutics and mechanisms","score":0.014600000344216824,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.013100000098347664,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/estramustine-phosphate","display_name":"estramustine phosphate","score":0.9399999976158142},{"id":"https://openalex.org/keywords/estracyt","display_name":"Estracyt","score":0.8320000171661377},{"id":"https://openalex.org/keywords/prostate-cancer","display_name":"prostate cancer","score":0.7440000176429749},{"id":"https://openalex.org/keywords/estramustine","display_name":"estramustine","score":0.9559999704360962},{"id":"https://openalex.org/keywords/drug-metabolites","display_name":"drug metabolites","score":0.7860000133514404},{"id":"https://openalex.org/keywords/benign-prostatic-hyperplasia","display_name":"benign prostatic hyperplasia","score":0.8600000143051147},{"id":"https://openalex.org/keywords/plasma-drug-concentration","display_name":"plasma drug concentration","score":0.578000009059906},{"id":"https://openalex.org/keywords/estradiol","display_name":"estradiol","score":0.6790000200271606},{"id":"https://openalex.org/keywords/estrone","display_name":"estrone","score":0.9980000257492065}],"concepts":[{"id":"https://openalex.org/C2780201970","wikidata":"https://www.wikidata.org/wiki/Q412939","display_name":"Estramustine","level":5,"score":0.9889652132987976},{"id":"https://openalex.org/C2777477808","wikidata":"https://www.wikidata.org/wiki/Q407595","display_name":"Metabolite","level":2,"score":0.7477014064788818},{"id":"https://openalex.org/C2778656385","wikidata":"https://www.wikidata.org/wiki/Q414986","display_name":"Estrone","level":3,"score":0.6074293851852417},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.5883224010467529},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5453795790672302},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5290122628211975},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.49481695890426636},{"id":"https://openalex.org/C2779279991","wikidata":"https://www.wikidata.org/wiki/Q6058681","display_name":"Testosterone (patch)","level":2,"score":0.42008376121520996},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.39792266488075256},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.3612516522407532},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.327126681804657},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.25034016370773315},{"id":"https://openalex.org/C2994223898","wikidata":"https://www.wikidata.org/wiki/Q9625","display_name":"Prostate disease","level":4,"score":0.0}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002277","descriptor_name":"Carcinoma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D002352","descriptor_name":"Carrier Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004958","descriptor_name":"Estradiol","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D004961","descriptor_name":"Estramustine","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D004961","descriptor_name":"Estramustine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D004970","descriptor_name":"Estrone","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D004970","descriptor_name":"Estrone","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009588","descriptor_name":"Nitrogen Mustard Compounds","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D011467","descriptor_name":"Prostate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D029584","descriptor_name":"Prostatic Secretory Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/s0022-5347(17)41926-4","doi":"https://doi.org/10.1016/s0022-5347(17)41926-4","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0022-5347(17)41926-4","pdf_url":null,"source":{"id":"https://openalex.org/S30525748","display_name":"The Journal of Urology","issn_l":"0022-5347","issn":["0022-5347","1527-3792"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Urology","raw_type":"journal-article"},{"id":"pmid:3172360","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3172360","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of urology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":35,"referenced_works":["https://openalex.org/W101694661","https://openalex.org/W140056640","https://openalex.org/W577156888","https://openalex.org/W1491176375","https://openalex.org/W1493361393","https://openalex.org/W1503990829","https://openalex.org/W1509353528","https://openalex.org/W1589108012","https://openalex.org/W1856779397","https://openalex.org/W1972940971","https://openalex.org/W1996481062","https://openalex.org/W1997358099","https://openalex.org/W2003024052","https://openalex.org/W2041263852","https://openalex.org/W2045451331","https://openalex.org/W2053955357","https://openalex.org/W2057972012","https://openalex.org/W2058417825","https://openalex.org/W2060262177","https://openalex.org/W2060418038","https://openalex.org/W2069039300","https://openalex.org/W2073185164","https://openalex.org/W2103263281","https://openalex.org/W2164818959","https://openalex.org/W2407097190","https://openalex.org/W2409951438","https://openalex.org/W2414837331","https://openalex.org/W2415900883","https://openalex.org/W2417788784","https://openalex.org/W2419291030","https://openalex.org/W2423950142","https://openalex.org/W2470538364","https://openalex.org/W4250753488","https://openalex.org/W4300682041","https://openalex.org/W6635128727"],"related_works":["https://openalex.org/W1973856202","https://openalex.org/W2101756285","https://openalex.org/W2889097620","https://openalex.org/W2022417305","https://openalex.org/W1997358099","https://openalex.org/W2473111666","https://openalex.org/W2076083719","https://openalex.org/W1993485293","https://openalex.org/W2008756773","https://openalex.org/W2419291030"],"abstract_inverted_index":{"Plasma":[0],"and":[1,8,27,56,109,130,179,195,213,242,246],"tumour":[2,62,104,157,189,218,250],"concentrations":[3],"of":[4,13,34,53,69,75,146,172,177,209,232,244,257],"estramustine,":[5],"estromustine,":[6],"estradiol":[7,131],"estrone,":[9],"the":[10,61,66,73,79,94,103,144,156,163,173,188,204,249,254],"major":[11],"metabolites":[12,77,165,234],"estramustine":[14,55,116,147,212,245],"phosphate":[15],"(estracyt),":[16],"were":[17,138,167],"determined":[18,59],"in":[19,60,97,102,140,155,159,169,187,191,197,217,235,248,259],"patients":[20],"with":[21,30,84,162],"prostatic":[22,236,260],"carcinoma":[23],"treated":[24,222],"between":[25],"one":[26],"nine":[28],"years":[29],"repeated":[31],"oral":[32],"doses":[33],"estracyt":[35,221,258],"(560":[36],"to":[37,46,64,107,111,118,121,125,128,133,136,183],"840":[38],"mg./day).":[39],"The":[40,51,200,240],"last":[41],"dose":[42],"was":[43,58,82,93,148,181],"given":[44],"12":[45],"16":[47],"hours":[48],"before":[49],"sampling.":[50],"binding":[52,243],"radioactive":[54],"estromustine":[57,214,247],"tissue":[63,88,194,219],"examine":[65],"possible":[67],"role":[68],"estramustine-binding":[70],"protein":[71],"for":[72,229,253],"accumulation":[74],"these":[76,233],"into":[78],"tumour.":[80],"Comparison":[81],"made":[83],"benign":[85,192],"prostate":[86],"hyperplastic":[87,193],"from":[89,220],"untreated":[90],"patients.":[91,223],"Estromustine":[92],"main":[95],"metabolite":[96],"plasma":[98,160,198],"as":[99,101,149],"well":[100],"(range":[105],"235":[106],"450":[108],"205":[110],"485":[112],"ng./gm.,":[113],"respectively),":[114],"whereas":[115],"(20":[117],"45;":[119],"95":[120],"370),":[122],"estrone":[123],"(62":[124],"140;":[126],"63":[127],"160)":[129],"(8":[132],"15;":[134],"7":[135],"36)":[137],"found":[139],"lower":[141],"concentrations.":[142],"Interestingly":[143],"concentration":[145],"an":[150],"average":[151],"six":[152],"times":[153,185],"higher":[154,186],"than":[158,190],"contrasting":[161],"other":[164],"which":[166],"present":[168,201],"equal":[170],"amounts":[171,208],"two":[174,182],"localities.":[175],"Binding":[176],"3H-estramustine":[178],"3H-estromustine":[180],"three":[184],"negligible":[196],"samples.":[199],"study":[202],"is":[203],"first":[205],"where":[206],"substantial":[207],"cytotoxically":[210],"active":[211],"are":[215],"demonstrated":[216],"Our":[224],"findings":[225],"suggest":[226],"a":[227],"mechanism":[228],"selective":[230],"uptake":[231,241],"cancer":[237],"(estramustine-binding":[238],"protein).":[239],"may":[251],"account":[252],"clinical":[255],"effects":[256],"carcinoma.":[261]},"counts_by_year":[{"year":2018,"cited_by_count":1},{"year":2013,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}