{"id":"https://openalex.org/W2396982297","doi":null,"title":"Changes of Regional Cerebral Glucose Metabolism in Normal Aging Process : A Study With EDG PET","display_name":"Changes of Regional Cerebral Glucose Metabolism in Normal Aging Process : A Study With EDG PET","publication_year":2001,"publication_date":"2001-01-01","ids":{"openalex":"https://openalex.org/W2396982297","mag":"2396982297"},"language":"en","primary_location":{"id":"mag:2396982297","doi":null,"is_oa":false,"landing_page_url":"http://www.koreascience.or.kr/article/ArticleFullRecord.jsp?cn=HOOHBU_2001_v35n4_231","pdf_url":null,"source":{"id":"https://openalex.org/S4306532505","display_name":"The Korean Journal of Nuclear Medicine","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"The Korean Journal of Nuclear Medicine","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5083374763","display_name":"Joon\u2010Kee Yoon","orcid":"https://orcid.org/0000-0001-9934-0125","observed_orcids":["https://orcid.org/0000-0001-9934-0125"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Joon\u2010Kee Yoon","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-9934-0125","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045337799","display_name":"Sang Eun Kim","orcid":"https://orcid.org/0000-0002-5811-759X","observed_orcids":["https://orcid.org/0000-0002-5811-759X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sang Eun Kim","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016084625","display_name":"Kyung-Han Lee","orcid":"https://orcid.org/0000-0003-3565-5536","observed_orcids":["https://orcid.org/0000-0003-3565-5536"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kyung-Han Lee","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-3565-5536","affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Yong Choi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yong Choi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027262365","display_name":"Yearn Seong Choe","orcid":"https://orcid.org/0000-0002-5164-9809","observed_orcids":["https://orcid.org/0000-0002-5164-9809"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yearn-Seong Choe","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5110338774","display_name":"Byung\u2010Tae Kim","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Byung\u2010Tae Kim","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.28153115,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"35","issue":"4","first_page":"231","last_page":"240"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.6855000257492065,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.6855000257492065,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10522","display_name":"Medical Imaging Techniques and Applications","score":0.16110000014305115,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10241","display_name":"Functional Brain Connectivity Studies","score":0.053599998354911804,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/normal-aging","display_name":"normal aging","score":0.8809999823570251},{"id":"https://openalex.org/keywords/regional-cerebral-glucose-metabolism","display_name":"regional cerebral glucose metabolism","score":0.9509999752044678},{"id":"https://openalex.org/keywords/fdg-pet","display_name":"FDG-PET","score":0.7620000243186951},{"id":"https://openalex.org/keywords/prefrontal-cortex","display_name":"prefrontal cortex","score":0.8730000257492065},{"id":"https://openalex.org/keywords/cerebellar-cortex","display_name":"cerebellar cortex","score":0.8640000224113464},{"id":"https://openalex.org/keywords/caudate-nucleus","display_name":"caudate nucleus","score":0.828000009059906},{"id":"https://openalex.org/keywords/temporoparietal-cortex","display_name":"temporoparietal cortex","score":0.8199999928474426},{"id":"https://openalex.org/keywords/age-related-metabolic-decline","display_name":"age-related metabolic decline","score":0.7279999852180481},{"id":"https://openalex.org/keywords/neuroplasticity","display_name":"neuroplasticity","score":0.7559999823570251},{"id":"https://openalex.org/keywords/brain-aging","display_name":"brain aging","score":0.414000004529953}],"concepts":[{"id":"https://openalex.org/C2779714222","wikidata":"https://www.wikidata.org/wiki/Q550934","display_name":"Putamen","level":2,"score":0.702272891998291},{"id":"https://openalex.org/C2779246727","wikidata":"https://www.wikidata.org/wiki/Q184215","display_name":"Thalamus","level":2,"score":0.5955568552017212},{"id":"https://openalex.org/C2781041448","wikidata":"https://www.wikidata.org/wiki/Q75839","display_name":"Cerebral cortex","level":2,"score":0.5827621221542358},{"id":"https://openalex.org/C2781195155","wikidata":"https://www.wikidata.org/wiki/Q18680","display_name":"Prefrontal cortex","level":3,"score":0.5634769201278687},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.519076406955719},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.5147712230682373},{"id":"https://openalex.org/C2777348757","wikidata":"https://www.wikidata.org/wiki/Q2346577","display_name":"Cortex (anatomy)","level":2,"score":0.4633152484893799},{"id":"https://openalex.org/C2779695026","wikidata":"https://www.wikidata.org/wiki/Q4692577","display_name":"Aging brain","level":3,"score":0.41788846254348755},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3285370171070099},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3054453730583191},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.20449531078338623}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2396982297","doi":null,"is_oa":false,"landing_page_url":"http://www.koreascience.or.kr/article/ArticleFullRecord.jsp?cn=HOOHBU_2001_v35n4_231","pdf_url":null,"source":{"id":"https://openalex.org/S4306532505","display_name":"The Korean Journal of Nuclear Medicine","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"The Korean Journal of Nuclear Medicine","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2380690470","https://openalex.org/W2382727824","https://openalex.org/W2310188920","https://openalex.org/W4387578918","https://openalex.org/W2086051267","https://openalex.org/W2460116637","https://openalex.org/W152260535","https://openalex.org/W2042936404","https://openalex.org/W2765952315","https://openalex.org/W2009904690"],"abstract_inverted_index":{"Purpose:":[0],"Normal":[1],"aging":[2,25],"results":[3],"in":[4,7,22,38,64,115,117,122,145,164,166,181,233,259,272,278],"detectable":[5],"changes":[6,16,258],"the":[8,15,23,65,82,100,107,123,143,146,182,197,204,212,231,234,256,260,265,273,279],"brain":[9,77,95],"structure":[10],"and":[11,31,67,85,103,125,139,169,202,223],"function.":[12],"We":[13],"evaluated":[14],"of":[17,53,90,137,177,194,247,255,270,288],"regional":[18,253],"cerebral":[19,225,261],"glucose":[20,91,262],"metabolism":[21,92,271,281],"normal":[24],"process":[26,287],"with":[27,130,153,171,187,240,264,282,292],"FDG":[28,71,109],"PET.":[29],"Materials":[30],"Methods:":[32],"Brain":[33],"PET":[34],"images":[35],"were":[36,62,217],"obtained":[37],"44":[39],"healthy":[40],"volunteers":[41],"(age":[42],"range":[43],"20-69":[44],"'y';":[45],"M:F":[46],"=":[47],"29:15)":[48],"who":[49],"had":[50],"no":[51],"history":[52],"neuropsychiatric":[54],"disorders.":[55],"On":[56,196],"6":[57],"representative":[58],"transaxial":[59],"images,":[60],"ROIs":[61],"drawn":[63],"cortical":[66],"subcortical":[68],"areas.":[69],"Regional":[70],"uptake":[72,78,110],"was":[73,185,229,238],"normalized":[74,108],"using":[75],"whole":[76],"to":[79],"adjust":[80],"for":[81,87],"injection":[83],"dose":[84],"correct":[86],"nonspecific":[88],"declines":[89],"affecting":[93],"all":[94],"areas":[96],"equally.":[97],"Results:":[98],"In":[99],"prefrontal,":[101],"temporoparietal":[102,147],"primary":[104,126,198],"sensorimotor":[105,127],"cortex,":[106,200],"(NFU)":[111],"reached":[112],"a":[113,135,175,192,245,286],"peak":[114],"subjects":[116,165],"their":[118,167],"30s.":[119,156],"The":[120,157,179,276],"NFU":[121,144,180,205,232],"prefrontal":[124,274],"cortex":[128,148,237],"declined":[129,170],"age":[131,154,172,188,241,283],"after":[132,155,189,242],"30s":[133,168],"at":[134,174,191,244],"rate":[136,176,193,246],"3.15%/decade":[138],"1.93%/decade,":[140],"respectively.":[141],"However,":[142],"did":[149,207],"not":[150,208,218],"change":[151,209],"significantly":[152,210,219],"anterior":[158],"(prefrontal)":[159],"posterior":[160],"(temporoparietal)":[161],"gradient":[162],"peaked":[163],"thereafter":[173],"2.35%/decade.":[178],"caudate":[183],"nucleus":[184],"decreased":[186],"20s":[190,243],"2.39%/decade.":[195],"visual":[199],"putamen,":[201],"thalamus,":[203],"values":[206],"throughout":[211],"ages":[213],"covered.":[214],"These":[215,250],"patterns":[216],"different":[220],"between":[221],"right":[222],"left":[224,235],"hemispheres.":[226],"Of":[227],"interest":[228],"that":[230],"cerebellar":[236,280],"increased":[239],"2.86%/decade.":[248],"Conclusion:":[249],"data":[251],"demonstrate":[252],"variation":[254],"age-related":[257,268],"metabolism,":[263],"most":[266],"prominent":[267],"decline":[269],"cortex.":[275],"increase":[277],"might":[284],"reflect":[285],"neuronal":[289],"plasticity":[290],"associated":[291],"aging.":[293]},"counts_by_year":[],"updated_date":"2026-09-27T08:07:27.782135","created_date":"2016-06-24T00:00:00"}