{"id":"https://openalex.org/W2396974083","doi":"https://doi.org/10.1038/srep16940","title":"P2\u00d77 purinergic signaling in dilated cardiomyopathy induced by auto-immunity against muscarinic M2 receptors: autoantibody levels, heart functionality and cytokine expression","display_name":"P2\u00d77 purinergic signaling in dilated cardiomyopathy induced by auto-immunity against muscarinic M2 receptors: autoantibody levels, heart functionality and cytokine expression","publication_year":2015,"publication_date":"2015-11-23","ids":{"openalex":"https://openalex.org/W2396974083","doi":"https://doi.org/10.1038/srep16940","mag":"2396974083","pmid":"https://pubmed.ncbi.nlm.nih.gov/26592184","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4655336"},"language":"en","primary_location":{"id":"doi:10.1038/srep16940","doi":"https://doi.org/10.1038/srep16940","is_oa":true,"landing_page_url":"https://doi.org/10.1038/srep16940","pdf_url":"https://www.nature.com/articles/srep16940.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/srep16940.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5020697102","display_name":"Camila Guerra Martinez","orcid":"https://orcid.org/0000-0001-6116-9182","observed_orcids":["https://orcid.org/0000-0001-6116-9182","https://orcid.org/0000-0002-3136-2325"]},"institutions":[{"id":"https://openalex.org/I11385950","display_name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","ror":"https://ror.org/03swz6y49","country_code":"BR","type":"government","lineage":["https://openalex.org/I11385950","https://openalex.org/I4210151455"]},{"id":"https://openalex.org/I122140584","display_name":"Universidade Federal do Rio de Janeiro","ror":"https://ror.org/03490as77","country_code":"BR","type":"education","lineage":["https://openalex.org/I122140584"]},{"id":"https://openalex.org/I4387153105","display_name":"Instituto de Biof\u00edsica Carlos Chagas Filho","ror":"https://ror.org/051xsx468","country_code":"BR","type":"facility","lineage":["https://openalex.org/I122140584","https://openalex.org/I4387153105"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Camila Guerra Martinez","raw_affiliation_strings":["Instituto Nacional de Ci\u00eancia e Tecnologia para Pesquisa Translacional em Sa\u00fade e Ambiente na Regi\u00e3o Amaz\u00f4nica, Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico/MCT, Rio de Janeiro, Brasil","Instituto de Biof\u00edsica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, 21941-902, Brasil","Instituto de Biof\u00edsica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, 21941-902, RJ, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto Nacional de Ci\u00eancia e Tecnologia para Pesquisa Translacional em Sa\u00fade e Ambiente na Regi\u00e3o Amaz\u00f4nica, Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico/MCT, Rio de Janeiro, Brasil","institution_ids":["https://openalex.org/I11385950"]},{"raw_affiliation_string":"Instituto de Biof\u00edsica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, 21941-902, Brasil","institution_ids":["https://openalex.org/I122140584","https://openalex.org/I4387153105"]},{"raw_affiliation_string":"Instituto de Biof\u00edsica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, 21941-902, RJ, Brazil","institution_ids":["https://openalex.org/I122140584","https://openalex.org/I4387153105"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038899314","display_name":"Daniel Zamith\u2010Miranda","orcid":"https://orcid.org/0000-0001-7532-2432","observed_orcids":["https://orcid.org/0000-0001-7532-2432"]},"institutions":[{"id":"https://openalex.org/I122140584","display_name":"Universidade Federal do Rio de Janeiro","ror":"https://ror.org/03490as77","country_code":"BR","type":"education","lineage":["https://openalex.org/I122140584"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Daniel Zamith-Miranda","raw_affiliation_strings":["Instituto de Microbiologia Prof. Paulo de Goes, Universidade Federal do Rio de Janeiro, 21941-900 Rio de Janeiro, RJ, Brasil","Instituto de Microbiologia Prof. Paulo de Goes, Universidade Federal do Rio de Janeiro, Rio de Janeiro, 21941-900, RJ, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto de Microbiologia Prof. Paulo de Goes, Universidade Federal do Rio de Janeiro, 21941-900 Rio de Janeiro, RJ, Brasil","institution_ids":["https://openalex.org/I122140584"]},{"raw_affiliation_string":"Instituto de Microbiologia Prof. Paulo de Goes, Universidade Federal do Rio de Janeiro, Rio de Janeiro, 21941-900, RJ, Brazil","institution_ids":["https://openalex.org/I122140584"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027269934","display_name":"Marcia Gracindo da Silva","orcid":"https://orcid.org/0000-0003-4468-2827","observed_orcids":["https://orcid.org/0000-0003-4468-2827","https://orcid.org/0000-0002-8159-1572"]},"institutions":[{"id":"https://openalex.org/I11385950","display_name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","ror":"https://ror.org/03swz6y49","country_code":"BR","type":"government","lineage":["https://openalex.org/I11385950","https://openalex.org/I4210151455"]},{"id":"https://openalex.org/I122140584","display_name":"Universidade Federal do Rio de Janeiro","ror":"https://ror.org/03490as77","country_code":"BR","type":"education","lineage":["https://openalex.org/I122140584"]},{"id":"https://openalex.org/I4387153105","display_name":"Instituto de Biof\u00edsica Carlos Chagas Filho","ror":"https://ror.org/051xsx468","country_code":"BR","type":"facility","lineage":["https://openalex.org/I122140584","https://openalex.org/I4387153105"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Marcia Gracindo da Silva","raw_affiliation_strings":["Instituto Nacional de Ci\u00eancia e Tecnologia para Pesquisa Translacional em Sa\u00fade e Ambiente na Regi\u00e3o Amaz\u00f4nica, Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico/MCT, Rio de Janeiro, Brasil","Instituto de Biof\u00edsica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, 21941-902, Brasil","Instituto de Biof\u00edsica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, 21941-902, RJ, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto Nacional de Ci\u00eancia e Tecnologia para Pesquisa Translacional em Sa\u00fade e Ambiente na Regi\u00e3o Amaz\u00f4nica, Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico/MCT, Rio de Janeiro, Brasil","institution_ids":["https://openalex.org/I11385950"]},{"raw_affiliation_string":"Instituto de Biof\u00edsica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, 21941-902, Brasil","institution_ids":["https://openalex.org/I122140584","https://openalex.org/I4387153105"]},{"raw_affiliation_string":"Instituto de Biof\u00edsica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, 21941-902, RJ, Brazil","institution_ids":["https://openalex.org/I122140584","https://openalex.org/I4387153105"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109995699","display_name":"Karla Consort Ribeiro","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210153431","display_name":"Instituto Nacional da Propriedade Industrial","ror":"https://ror.org/04w1y7251","country_code":"BR","type":"government","lineage":["https://openalex.org/I2801200668","https://openalex.org/I2802647933","https://openalex.org/I4210153431"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Karla Consort Ribeiro","raw_affiliation_strings":["Instituto Nacional de Propriedade Industrial. Rua S\u00e3o Bento no 1, Rio de Janeiro, RJ, 20090-010, Brazil","Instituto Nacional de Propriedade Industrial. Rua S\u00e3o Bento no 1, Rio de Janeiro, 20090-010, RJ, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto Nacional de Propriedade Industrial. Rua S\u00e3o Bento no 1, Rio de Janeiro, RJ, 20090-010, Brazil","institution_ids":["https://openalex.org/I4210153431"]},{"raw_affiliation_string":"Instituto Nacional de Propriedade Industrial. Rua S\u00e3o Bento no 1, Rio de Janeiro, 20090-010, RJ, Brazil","institution_ids":["https://openalex.org/I4210153431"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110625643","display_name":"Iza\u00edra Tincani Brand\u00e3o","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Iza\u00edra Trincani Brand\u00e3o","raw_affiliation_strings":["Departamento de Bioqu\u00edmica e Imunologia, Faculdade de Medicina de Ribeir\u00e3o Preto, Universidade de S\u00e3o Paulo, Av. Bandeirantes 3900, Ribeir\u00e3o Preto, SP, Brasil","Departamento de Bioqu\u00edmica e Imunologia, Faculdade de Medicina de Ribeir\u00e3o Preto, Universidade de S\u00e3o Paulo, Av. Bandeirantes 3900, Ribeir\u00e3o Preto, SP, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Bioqu\u00edmica e Imunologia, Faculdade de Medicina de Ribeir\u00e3o Preto, Universidade de S\u00e3o Paulo, Av. Bandeirantes 3900, Ribeir\u00e3o Preto, SP, Brasil","institution_ids":["https://openalex.org/I17974374"]},{"raw_affiliation_string":"Departamento de Bioqu\u00edmica e Imunologia, Faculdade de Medicina de Ribeir\u00e3o Preto, Universidade de S\u00e3o Paulo, Av. Bandeirantes 3900, Ribeir\u00e3o Preto, SP, Brazil","institution_ids":["https://openalex.org/I17974374"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088246304","display_name":"C\u00e9lio Lopes Silva","orcid":"https://orcid.org/0000-0002-0043-4568","observed_orcids":["https://orcid.org/0000-0002-0043-4568"]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Celio Lopes Silva","raw_affiliation_strings":["Departamento de Bioqu\u00edmica e Imunologia, Faculdade de Medicina de Ribeir\u00e3o Preto, Universidade de S\u00e3o Paulo, Av. Bandeirantes 3900, Ribeir\u00e3o Preto, SP, Brasil","Departamento de Bioqu\u00edmica e Imunologia, Faculdade de Medicina de Ribeir\u00e3o Preto, Universidade de S\u00e3o Paulo, Av. Bandeirantes 3900, Ribeir\u00e3o Preto, SP, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Bioqu\u00edmica e Imunologia, Faculdade de Medicina de Ribeir\u00e3o Preto, Universidade de S\u00e3o Paulo, Av. Bandeirantes 3900, Ribeir\u00e3o Preto, SP, Brasil","institution_ids":["https://openalex.org/I17974374"]},{"raw_affiliation_string":"Departamento de Bioqu\u00edmica e Imunologia, Faculdade de Medicina de Ribeir\u00e3o Preto, Universidade de S\u00e3o Paulo, Av. Bandeirantes 3900, Ribeir\u00e3o Preto, SP, Brazil","institution_ids":["https://openalex.org/I17974374"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035358800","display_name":"Bruno Louren\u00e7o Diaz","orcid":"https://orcid.org/0000-0001-8393-3823","observed_orcids":["https://orcid.org/0000-0001-8393-3823"]},"institutions":[{"id":"https://openalex.org/I122140584","display_name":"Universidade Federal do Rio de Janeiro","ror":"https://ror.org/03490as77","country_code":"BR","type":"education","lineage":["https://openalex.org/I122140584"]},{"id":"https://openalex.org/I4387153105","display_name":"Instituto de Biof\u00edsica Carlos Chagas Filho","ror":"https://ror.org/051xsx468","country_code":"BR","type":"facility","lineage":["https://openalex.org/I122140584","https://openalex.org/I4387153105"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Bruno Louren\u00e7o Diaz","raw_affiliation_strings":["Instituto de Biof\u00edsica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, 21941-902, Brasil","Instituto de Biof\u00edsica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, 21941-902, RJ, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto de Biof\u00edsica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, 21941-902, Brasil","institution_ids":["https://openalex.org/I122140584","https://openalex.org/I4387153105"]},{"raw_affiliation_string":"Instituto de Biof\u00edsica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, 21941-902, RJ, Brazil","institution_ids":["https://openalex.org/I122140584","https://openalex.org/I4387153105"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029817299","display_name":"Maria Bellio","orcid":"https://orcid.org/0000-0002-3360-2740","observed_orcids":["https://orcid.org/0000-0002-3360-2740"]},"institutions":[{"id":"https://openalex.org/I122140584","display_name":"Universidade Federal do Rio de Janeiro","ror":"https://ror.org/03490as77","country_code":"BR","type":"education","lineage":["https://openalex.org/I122140584"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Maria Bellio","raw_affiliation_strings":["Instituto de Microbiologia Prof. Paulo de Goes, Universidade Federal do Rio de Janeiro, 21941-900 Rio de Janeiro, RJ, Brasil","Instituto de Microbiologia Prof. Paulo de Goes, Universidade Federal do Rio de Janeiro, Rio de Janeiro, 21941-900, RJ, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto de Microbiologia Prof. Paulo de Goes, Universidade Federal do Rio de Janeiro, 21941-900 Rio de Janeiro, RJ, Brasil","institution_ids":["https://openalex.org/I122140584"]},{"raw_affiliation_string":"Instituto de Microbiologia Prof. Paulo de Goes, Universidade Federal do Rio de Janeiro, Rio de Janeiro, 21941-900, RJ, Brazil","institution_ids":["https://openalex.org/I122140584"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027668084","display_name":"Pedro Muanis Persechini","orcid":"https://orcid.org/0000-0002-3278-1951","observed_orcids":["https://orcid.org/0000-0002-3278-1951"]},"institutions":[{"id":"https://openalex.org/I11385950","display_name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","ror":"https://ror.org/03swz6y49","country_code":"BR","type":"government","lineage":["https://openalex.org/I11385950","https://openalex.org/I4210151455"]},{"id":"https://openalex.org/I122140584","display_name":"Universidade Federal do Rio de Janeiro","ror":"https://ror.org/03490as77","country_code":"BR","type":"education","lineage":["https://openalex.org/I122140584"]},{"id":"https://openalex.org/I4387153105","display_name":"Instituto de Biof\u00edsica Carlos Chagas Filho","ror":"https://ror.org/051xsx468","country_code":"BR","type":"facility","lineage":["https://openalex.org/I122140584","https://openalex.org/I4387153105"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Pedro Muanis Persechini","raw_affiliation_strings":["Instituto Nacional de Ci\u00eancia e Tecnologia para Pesquisa Translacional em Sa\u00fade e Ambiente na Regi\u00e3o Amaz\u00f4nica, Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico/MCT, Rio de Janeiro, Brasil","Instituto de Biof\u00edsica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, 21941-902, Brasil","Instituto de Biof\u00edsica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, 21941-902, RJ, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto Nacional de Ci\u00eancia e Tecnologia para Pesquisa Translacional em Sa\u00fade e Ambiente na Regi\u00e3o Amaz\u00f4nica, Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico/MCT, Rio de Janeiro, Brasil","institution_ids":["https://openalex.org/I11385950"]},{"raw_affiliation_string":"Instituto de Biof\u00edsica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, 21941-902, Brasil","institution_ids":["https://openalex.org/I122140584","https://openalex.org/I4387153105"]},{"raw_affiliation_string":"Instituto de Biof\u00edsica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, 21941-902, RJ, Brazil","institution_ids":["https://openalex.org/I122140584","https://openalex.org/I4387153105"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5030477433","display_name":"Eleonora Kurtenbach","orcid":"https://orcid.org/0000-0002-2141-518X","observed_orcids":["https://orcid.org/0000-0002-2141-518X"]},"institutions":[{"id":"https://openalex.org/I11385950","display_name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","ror":"https://ror.org/03swz6y49","country_code":"BR","type":"government","lineage":["https://openalex.org/I11385950","https://openalex.org/I4210151455"]},{"id":"https://openalex.org/I122140584","display_name":"Universidade Federal do Rio de Janeiro","ror":"https://ror.org/03490as77","country_code":"BR","type":"education","lineage":["https://openalex.org/I122140584"]},{"id":"https://openalex.org/I4387153105","display_name":"Instituto de Biof\u00edsica Carlos Chagas Filho","ror":"https://ror.org/051xsx468","country_code":"BR","type":"facility","lineage":["https://openalex.org/I122140584","https://openalex.org/I4387153105"]}],"countries":["BR"],"is_corresponding":true,"raw_author_name":"Eleonora Kurtenbach","raw_affiliation_strings":["Instituto Nacional de Ci\u00eancia e Tecnologia para Pesquisa Translacional em Sa\u00fade e Ambiente na Regi\u00e3o Amaz\u00f4nica, Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico/MCT, Rio de Janeiro, Brasil","Instituto de Biof\u00edsica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, 21941-902, Brasil","Instituto Nacional de Ci\u00eancia e Tecnologia para Pesquisa Translacional em Sa\u00fade e Ambiente na Regi\u00e3o Amaz\u00f4nica, Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico/MCT, Rio de Janeiro, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto Nacional de Ci\u00eancia e Tecnologia para Pesquisa Translacional em Sa\u00fade e Ambiente na Regi\u00e3o Amaz\u00f4nica, Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico/MCT, Rio de Janeiro, Brasil","institution_ids":["https://openalex.org/I11385950"]},{"raw_affiliation_string":"Instituto de Biof\u00edsica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, 21941-902, Brasil","institution_ids":["https://openalex.org/I122140584","https://openalex.org/I4387153105"]},{"raw_affiliation_string":"Instituto Nacional de Ci\u00eancia e Tecnologia para Pesquisa Translacional em Sa\u00fade e Ambiente na Regi\u00e3o Amaz\u00f4nica, Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico/MCT, Rio de Janeiro, Brazil","institution_ids":["https://openalex.org/I11385950"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5030477433"],"corresponding_institution_ids":["https://openalex.org/I11385950","https://openalex.org/I122140584","https://openalex.org/I4387153105"],"apc_list":{"value":2690,"currency":"USD","value_usd":2690},"apc_paid":{"value":2690,"currency":"USD","value_usd":2690},"fwci":1.8452,"has_fulltext":true,"cited_by_count":24,"citation_normalized_percentile":{"value":0.83631754,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"5","issue":"1","first_page":"16940","last_page":"16940"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11112","display_name":"Viral Infections and Immunology Research","score":0.45750001072883606,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11112","display_name":"Viral Infections and Immunology Research","score":0.45750001072883606,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11193","display_name":"Adenosine and Purinergic Signaling","score":0.3977000117301941,"subfield":{"id":"https://openalex.org/subfields/1314","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11962","display_name":"Cardiac Fibrosis and Remodeling","score":0.02329999953508377,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/p2x7-receptor","display_name":"P2X7 receptor","score":0.8840000033378601},{"id":"https://openalex.org/keywords/dilated-cardiomyopathy","display_name":"dilated cardiomyopathy","score":0.9110000133514404},{"id":"https://openalex.org/keywords/m2-muscarinic-receptor","display_name":"M2 muscarinic receptor","score":0.8700000047683716},{"id":"https://openalex.org/keywords/autoantibodies","display_name":"autoantibodies","score":0.9229999780654907},{"id":"https://openalex.org/keywords/autoimmunity","display_name":"autoimmunity","score":0.8309999704360962},{"id":"https://openalex.org/keywords/p2x7-knockout-mice","display_name":"P2X7 knockout mice","score":0.8289999961853027},{"id":"https://openalex.org/keywords/regulatory-t-cells","display_name":"regulatory T cells","score":0.7910000085830688},{"id":"https://openalex.org/keywords/foxp3","display_name":"Foxp3","score":0.8569999933242798},{"id":"https://openalex.org/keywords/cytokines","display_name":"cytokines","score":0.7379999756813049},{"id":"https://openalex.org/keywords/il-17","display_name":"IL-17","score":0.9129999876022339},{"id":"https://openalex.org/keywords/interferon-gamma","display_name":"interferon-gamma","score":0.800000011920929},{"id":"https://openalex.org/keywords/interleukin-1beta","display_name":"IL-1\u03b2","score":0.8410000205039978},{"id":"https://openalex.org/keywords/cardiac-function","display_name":"cardiac function","score":0.4729999899864197},{"id":"https://openalex.org/keywords/exercise-tolerance","display_name":"exercise tolerance","score":0.6990000009536743},{"id":"https://openalex.org/keywords/myocarditis","display_name":"myocarditis","score":0.3540000021457672}],"concepts":[{"id":"https://openalex.org/C163764329","wikidata":"https://www.wikidata.org/wiki/Q785022","display_name":"Autoantibody","level":3,"score":0.6855879426002502},{"id":"https://openalex.org/C2776383484","wikidata":"https://www.wikidata.org/wiki/Q283656","display_name":"Dilated cardiomyopathy","level":3,"score":0.6310238242149353},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5831539630889893},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5673292279243469},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5244084596633911},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.507677435874939},{"id":"https://openalex.org/C2778921608","wikidata":"https://www.wikidata.org/wiki/Q2002035","display_name":"Ventricle","level":2,"score":0.4944305419921875},{"id":"https://openalex.org/C126042315","wikidata":"https://www.wikidata.org/wiki/Q18033763","display_name":"SOCS3","level":4,"score":0.46095848083496094},{"id":"https://openalex.org/C2779727006","wikidata":"https://www.wikidata.org/wiki/Q426188","display_name":"FOXP3","level":3,"score":0.45897215604782104},{"id":"https://openalex.org/C33789571","wikidata":"https://www.wikidata.org/wiki/Q410959","display_name":"Muscarinic acetylcholine receptor","level":3,"score":0.44406867027282715},{"id":"https://openalex.org/C2780931953","wikidata":"https://www.wikidata.org/wiki/Q9371","display_name":"Spleen","level":2,"score":0.44065776467323303},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4370518624782562},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.42082923650741577},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4111912250518799},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.387279748916626},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.3463074564933777},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.28859591484069824},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.0},{"id":"https://openalex.org/C179185449","wikidata":"https://www.wikidata.org/wiki/Q219699","display_name":"Suppressor","level":3,"score":0.0},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001323","descriptor_name":"Autoantibodies","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D001324","descriptor_name":"Autoantigens","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001324","descriptor_name":"Autoantigens","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D002311","descriptor_name":"Cardiomyopathy, Dilated","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D002311","descriptor_name":"Cardiomyopathy, Dilated","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D002311","descriptor_name":"Cardiomyopathy, Dilated","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006339","descriptor_name":"Heart Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007114","descriptor_name":"Immunization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007371","descriptor_name":"Interferon-gamma","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D007371","descriptor_name":"Interferon-gamma","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009206","descriptor_name":"Myocardium","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D009206","descriptor_name":"Myocardium","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D010805","descriptor_name":"Physical Conditioning, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010957","descriptor_name":"Plasmids","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D013154","descriptor_name":"Spleen","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D013154","descriptor_name":"Spleen","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020257","descriptor_name":"Ventricular Remodeling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020381","descriptor_name":"Interleukin-17","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D020381","descriptor_name":"Interleukin-17","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D043585","descriptor_name":"Receptor, Muscarinic M2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D043585","descriptor_name":"Receptor, Muscarinic M2","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D050378","descriptor_name":"T-Lymphocytes, Regulatory","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D050378","descriptor_name":"T-Lymphocytes, Regulatory","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051858","descriptor_name":"Forkhead Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051858","descriptor_name":"Forkhead Transcription Factors","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D053583","descriptor_name":"Interleukin-1beta","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D053583","descriptor_name":"Interleukin-1beta","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D053645","descriptor_name":"Interleukin-2 Receptor alpha Subunit","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D053645","descriptor_name":"Interleukin-2 Receptor alpha Subunit","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D058486","descriptor_name":"Receptors, Purinergic P2X7","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D058486","descriptor_name":"Receptors, Purinergic P2X7","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1038/srep16940","doi":"https://doi.org/10.1038/srep16940","is_oa":true,"landing_page_url":"https://doi.org/10.1038/srep16940","pdf_url":"https://www.nature.com/articles/srep16940.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},{"id":"pmid:26592184","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26592184","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific reports","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4655336","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4655336/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sci Rep","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1038/srep16940","doi":"https://doi.org/10.1038/srep16940","is_oa":true,"landing_page_url":"https://doi.org/10.1038/srep16940","pdf_url":"https://www.nature.com/articles/srep16940.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320322025","display_name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","ror":"https://ror.org/03swz6y49"},{"id":"https://openalex.org/F4320322749","display_name":"Funda\u00e7\u00e3o Carlos Chagas Filho de Amparo \u00e0 Pesquisa do Estado do Rio de Janeiro","ror":"https://ror.org/03kk0s825"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2396974083.pdf","grobid_xml":"https://content.openalex.org/works/W2396974083.grobid-xml"},"referenced_works_count":60,"referenced_works":["https://openalex.org/W7020484","https://openalex.org/W565312498","https://openalex.org/W1489915299","https://openalex.org/W1515978161","https://openalex.org/W1917138271","https://openalex.org/W1967961046","https://openalex.org/W1968343481","https://openalex.org/W1973524804","https://openalex.org/W1980910300","https://openalex.org/W1982138730","https://openalex.org/W1986332119","https://openalex.org/W1995478042","https://openalex.org/W1997105547","https://openalex.org/W2001051250","https://openalex.org/W2002407541","https://openalex.org/W2007065684","https://openalex.org/W2008868638","https://openalex.org/W2011882192","https://openalex.org/W2016812523","https://openalex.org/W2020373191","https://openalex.org/W2028479654","https://openalex.org/W2029566138","https://openalex.org/W2035396878","https://openalex.org/W2040977790","https://openalex.org/W2042114176","https://openalex.org/W2047070823","https://openalex.org/W2050516476","https://openalex.org/W2053302471","https://openalex.org/W2054780499","https://openalex.org/W2064282763","https://openalex.org/W2066828989","https://openalex.org/W2067850904","https://openalex.org/W2075994380","https://openalex.org/W2076063279","https://openalex.org/W2083467607","https://openalex.org/W2084371269","https://openalex.org/W2084559018","https://openalex.org/W2086539844","https://openalex.org/W2089503694","https://openalex.org/W2093076255","https://openalex.org/W2097811455","https://openalex.org/W2098531238","https://openalex.org/W2100709073","https://openalex.org/W2101420246","https://openalex.org/W2104040734","https://openalex.org/W2107548301","https://openalex.org/W2108723776","https://openalex.org/W2111457187","https://openalex.org/W2117047064","https://openalex.org/W2120259955","https://openalex.org/W2130153302","https://openalex.org/W2131833124","https://openalex.org/W2135198293","https://openalex.org/W2142925715","https://openalex.org/W2145190952","https://openalex.org/W2146861064","https://openalex.org/W2148075660","https://openalex.org/W2159400334","https://openalex.org/W2170665860","https://openalex.org/W2170688253"],"related_works":["https://openalex.org/W1537117234","https://openalex.org/W2107548301","https://openalex.org/W2018003299","https://openalex.org/W1979302468","https://openalex.org/W2098853737","https://openalex.org/W1976213628","https://openalex.org/W1966779129","https://openalex.org/W2024366795","https://openalex.org/W1579813993","https://openalex.org/W2007750772"],"abstract_inverted_index":{"Autoantibodies":[0],"against":[1],"the":[2,14,34,124,137,154,187,194],"M2":[3],"receptors":[4,17],"(M2AChR)":[5],"have":[6],"been":[7],"associated":[8],"with":[9,67],"Dilated":[10],"Cardiomyopathy":[11],"(DCM).":[12],"In":[13],"heart,":[15,155],"P2\u00d77":[16,179],"influence":[18],"electrical":[19],"conduction,":[20],"coronary":[21],"circulation":[22],"and":[23,33,39,50,88,95,150,164,166,182,185,191],"response":[24],"to":[25,60,107,111,174],"ischemia.":[26],"They":[27],"can":[28],"also":[29],"trigger":[30],"pro-inflammatory":[31],"responses":[32],"development":[35],"of":[36,100,126,162,169,178,189,196],"neurological,":[37],"cardiac":[38],"renal":[40],"disorders.":[41],"Here,":[42],"P2\u00d77(-/-)":[43,79,89,117,157],"mice":[44,74,80,106,118,143],"displayed":[45,119],"an":[46,82,112,145],"increased":[47],"heart":[48,115],"rate":[49],"ST":[51],"segment":[52],"depression,":[53],"but":[54],"similar":[55],"exercise":[56,97],"performance":[57],"when":[58],"compared":[59],"wild":[61],"type":[62],"(WT)":[63],"animals.":[64],"After":[65],"immunization":[66],"plasmid":[68],"containing":[69],"M2AChR":[70,103,140],"cDNA":[71],"sequence,":[72],"WT":[73,87,104,141],"produced":[75,159],"anti-M2AChR":[76],"antibodies,":[77],"while":[78,156],"showed":[81,90,144],"attenuated":[83],"production.":[84],"Despite":[85],"this,":[86],"left":[91],"ventricle":[92],"cavity":[93],"enlargement":[94],"decreased":[96],"tolerance.":[98],"Transfer":[99],"serum":[101],"from":[102],"immunized":[105,142],"n\u00e4ive":[108],"recipients":[109],"led":[110],"alteration":[113],"in":[114,123,147,153,180,193],"shape.":[116],"a":[120],"significant":[121],"increase":[122,146],"frequency":[125],"spleen":[127],"regulatory":[128],"T":[129],"cells":[130],"population,":[131],"which":[132],"is":[133],"mainly":[134],"composed":[135],"by":[136],"FoxP3(+)CD25(-)":[138],"subset.":[139],"IL-1\u03b2,":[148],"IFN\u03b3":[149,192],"IL-17":[151,165,190],"levels":[152],"group":[158],"lower":[160],"amounts":[161,168],"IL-1\u03b2":[163],"higher":[167],"IFN\u03b3.":[170],"These":[171],"results":[172],"pointed":[173],"previously":[175],"unnoticed":[176],"roles":[177],"cardiovascular":[181],"immune":[183],"systems,":[184],"underscored":[186],"participation":[188],"progress":[195],"autoimmune":[197],"DCM.":[198]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":5}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}