{"id":"https://openalex.org/W2396972038","doi":null,"title":"[Progress in inverse metabolic engineering].","display_name":"[Progress in inverse metabolic engineering].","publication_year":2014,"publication_date":"2014-08-01","ids":{"openalex":"https://openalex.org/W2396972038","mag":"2396972038","pmid":"https://pubmed.ncbi.nlm.nih.gov/25423745"},"language":"zh","primary_location":{"id":"pmid:25423745","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25423745","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sheng wu gong cheng xue bao = Chinese journal of biotechnology","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5057631131","display_name":"Guiying Li","orcid":"https://orcid.org/0000-0002-6777-4786","observed_orcids":["https://orcid.org/0000-0002-6777-4786","https://orcid.org/0000-0003-0299-1349"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Guiying Li","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087936668","display_name":"Xinbo Zhang","orcid":"https://orcid.org/0000-0002-5806-159X","observed_orcids":["https://orcid.org/0000-0002-5806-159X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xinbo Zhang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100362837","display_name":"Zhiwen Wang","orcid":"https://orcid.org/0000-0001-8938-3631","observed_orcids":["https://orcid.org/0000-0001-8938-3631","https://orcid.org/0009-0009-0127-7849"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zhiwen Wang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088309746","display_name":"Ying Shi","orcid":"https://orcid.org/0000-0003-4671-4896","observed_orcids":["https://orcid.org/0000-0003-4671-4896"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ying Shi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100428795","display_name":"Tao Chen","orcid":"https://orcid.org/0000-0001-9588-1821","observed_orcids":["https://orcid.org/0000-0001-9588-1821"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tao Chen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5100775467","display_name":"Xueming Zhao","orcid":"https://orcid.org/0000-0001-6110-2690","observed_orcids":["https://orcid.org/0000-0001-6110-2690"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xueming Zhao","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.22118773,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"30","issue":"8","first_page":"1151","last_page":"63"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10497","display_name":"Fungal and yeast genetics research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/inverse-metabolic-engineering","display_name":"inverse metabolic engineering","score":1.0},{"id":"https://openalex.org/keywords/genotype-phenotype-correlation","display_name":"genotype-phenotype correlation","score":0.8019999861717224},{"id":"https://openalex.org/keywords/strain-improvement","display_name":"strain improvement","score":0.6489999890327454},{"id":"https://openalex.org/keywords/industrial-microorganisms","display_name":"industrial microorganisms","score":0.7269999980926514},{"id":"https://openalex.org/keywords/substrate-utilization","display_name":"substrate utilization","score":0.8420000076293945},{"id":"https://openalex.org/keywords/comparative-genomics","display_name":"comparative genomics","score":0.6460000276565552},{"id":"https://openalex.org/keywords/next-generation-sequencing","display_name":"next-generation sequencing","score":0.7279999852180481},{"id":"https://openalex.org/keywords/genetic-modification","display_name":"genetic modification","score":0.5630000233650208}],"concepts":[{"id":"https://openalex.org/C6350086","wikidata":"https://www.wikidata.org/wiki/Q6822347","display_name":"Metabolic engineering","level":3,"score":0.6528924703598022},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5464070439338684},{"id":"https://openalex.org/C191908910","wikidata":"https://www.wikidata.org/wiki/Q862838","display_name":"Synthetic biology","level":2,"score":0.49610647559165955},{"id":"https://openalex.org/C63479239","wikidata":"https://www.wikidata.org/wiki/Q7353546","display_name":"Robustness (evolution)","level":3,"score":0.45019838213920593},{"id":"https://openalex.org/C145290725","wikidata":"https://www.wikidata.org/wiki/Q5533489","display_name":"Genome engineering","level":5,"score":0.44730234146118164},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.4438480734825134},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.432074636220932},{"id":"https://openalex.org/C24432333","wikidata":"https://www.wikidata.org/wiki/Q2068526","display_name":"Whole genome sequencing","level":4,"score":0.42710500955581665},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4172329902648926},{"id":"https://openalex.org/C183696295","wikidata":"https://www.wikidata.org/wiki/Q2487696","display_name":"Biochemical engineering","level":1,"score":0.3647667467594147},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.3334788680076599},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3224905729293823},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.22613993287086487},{"id":"https://openalex.org/C144501496","wikidata":"https://www.wikidata.org/wiki/Q5533489","display_name":"Genome editing","level":4,"score":0.16672280430793762},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.16486793756484985}],"mesh":[{"descriptor_ui":"D007218","descriptor_name":"Industrial Microbiology","qualifier_ui":"Q000639","qualifier_name":"trends","is_major_topic":true},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060847","descriptor_name":"Metabolic Engineering","qualifier_ui":"Q000639","qualifier_name":"trends","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:25423745","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25423745","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sheng wu gong cheng xue bao = Chinese journal of biotechnology","raw_type":"Journal Article"},{"id":"mag:2396972038","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25423745","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":47,"referenced_works":["https://openalex.org/W1690124835","https://openalex.org/W1973748500","https://openalex.org/W1978434225","https://openalex.org/W1987363227","https://openalex.org/W1988692388","https://openalex.org/W1989148233","https://openalex.org/W1989316655","https://openalex.org/W1993447713","https://openalex.org/W2000004958","https://openalex.org/W2000315438","https://openalex.org/W2001061405","https://openalex.org/W2005063728","https://openalex.org/W2008681679","https://openalex.org/W2010451964","https://openalex.org/W2010566861","https://openalex.org/W2015088216","https://openalex.org/W2036988150","https://openalex.org/W2037060512","https://openalex.org/W2039522748","https://openalex.org/W2042299646","https://openalex.org/W2047842052","https://openalex.org/W2052550543","https://openalex.org/W2053558244","https://openalex.org/W2061680337","https://openalex.org/W2066885996","https://openalex.org/W2067296707","https://openalex.org/W2068003115","https://openalex.org/W2074910098","https://openalex.org/W2080040554","https://openalex.org/W2093487685","https://openalex.org/W2104669330","https://openalex.org/W2115960756","https://openalex.org/W2118526609","https://openalex.org/W2122462612","https://openalex.org/W2123378400","https://openalex.org/W2127297472","https://openalex.org/W2129576083","https://openalex.org/W2129726349","https://openalex.org/W2130769450","https://openalex.org/W2135829725","https://openalex.org/W2136832197","https://openalex.org/W2142586675","https://openalex.org/W2148590972","https://openalex.org/W2150936918","https://openalex.org/W2153238155","https://openalex.org/W2161392139","https://openalex.org/W2273625928"],"related_works":["https://openalex.org/W2005063728","https://openalex.org/W2375450111","https://openalex.org/W6903180193","https://openalex.org/W2008842117","https://openalex.org/W3028585460","https://openalex.org/W2000315438","https://openalex.org/W3045507148","https://openalex.org/W1994918916","https://openalex.org/W2415494263","https://openalex.org/W25789786"],"abstract_inverted_index":{"In":[0],"the":[1,96,125],"last":[2],"few":[3],"years,":[4],"high-throughput":[5],"(or":[6],"'next-generation')":[7],"sequencing":[8],"technologies":[9],"have":[10],"delivered":[11],"a":[12,88],"step":[13],"change":[14],"in":[15,44,112],"our":[16],"ability":[17],"to":[18,31,46],"sequence":[19],"genomes,":[20],"whether":[21],"human":[22],"or":[23,37,60],"bacterial.":[24],"Further":[25],"comparative":[26],"genome":[27],"analysis":[28],"enables":[29],"us":[30],"reveal":[32],"detailed":[33],"knowledge":[34],"of":[35,39,50,98,104,115,122,130,139],"genetics":[36],"physiology":[38],"industrial":[40,99],"important":[41],"strains":[42],"obtained":[43],"laboratory,":[45],"analyze":[47],"genotype-phenotype":[48,123],"correlations":[49],"mutants":[51],"with":[52,117],"improved":[53],"performance.":[54],"Based":[55],"on":[56,120],"identified":[57],"key":[58],"mutations":[59],"mutation":[61],"combinations,":[62],"Inverse":[63],"Metabolic":[64],"Engineering":[65],"(IME)":[66],"can":[67],"be":[68],"performed":[69],"by":[70],"using":[71],"accurate":[72],"genetic":[73],"modification":[74],"system.":[75],"Recently,":[76],"IME":[77,140],"has":[78,86],"been":[79],"successfully":[80],"used":[81],"for":[82,136],"strain":[83],"improvement":[84],"and":[85,101,124,128,134],"become":[87],"research":[89,113],"hotspot,":[90],"including":[91],"improving":[92],"substrate":[93],"utilization,":[94],"engineering":[95],"robustness":[97],"microbes":[100],"enhancing":[102],"production":[103],"bio-based":[105],"products.":[106],"Here,":[107],"we":[108],"describe":[109],"recent":[110],"advances":[111,127],"methods":[114],"IME,":[116],"an":[118],"emphasis":[119],"characterization":[121],"latest":[126],"application":[129],"IME.":[131],"Possible":[132],"directions":[133],"challenges":[135],"further":[137],"development":[138],"are":[141],"also":[142],"discussed.":[143]},"counts_by_year":[],"updated_date":"2026-11-02T09:45:03.842371","created_date":"2016-06-24T00:00:00"}
