{"id":"https://openalex.org/W2396933770","doi":null,"title":"Population dynamics of lymphocyte subsets in the central nervous system of rats with different susceptibility to coronavirus-induced demyelinating encephalitis.","display_name":"Population dynamics of lymphocyte subsets in the central nervous system of rats with different susceptibility to coronavirus-induced demyelinating encephalitis.","publication_year":1991,"publication_date":"1991-11-01","ids":{"openalex":"https://openalex.org/W2396933770","mag":"2396933770","pmid":"https://pubmed.ncbi.nlm.nih.gov/1663079","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1384652"},"language":"en","primary_location":{"id":"pmid:1663079","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1663079","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunology","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC1384652/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5076590630","display_name":"R\u00fcdiger D\u00f6rries","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I25974101","display_name":"University of W\u00fcrzburg","ror":"https://ror.org/00fbnyb24","country_code":"DE","type":"education","lineage":["https://openalex.org/I25974101"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"R D\u00f6rries","raw_affiliation_strings":["Institut f\u00fcr Virologie und Immunobiologie, Universit\u00e4t W\u00fcrzburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut f\u00fcr Virologie und Immunobiologie, Universit\u00e4t W\u00fcrzburg, Germany","institution_ids":["https://openalex.org/I25974101"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111551178","display_name":"S. Schwender","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S Schwender","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037009330","display_name":"Horst Imrich","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H Imrich","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5063154936","display_name":"Harry Harms","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H Harms","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.443,"has_fulltext":false,"cited_by_count":35,"citation_normalized_percentile":{"value":0.91370901,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":93},"biblio":{"volume":"74","issue":"3","first_page":"539","last_page":"45"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":0.5429999828338623,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":0.5429999828338623,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13201","display_name":"Infectious Encephalopathies and Encephalitis","score":0.05530000105500221,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.054999999701976776,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/demyelinating-encephalitis","display_name":"demyelinating encephalitis","score":0.9210000038146973},{"id":"https://openalex.org/keywords/coronavirus","display_name":"coronavirus","score":0.42500001192092896},{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":0.6869999766349792},{"id":"https://openalex.org/keywords/cd8-t-cells","display_name":"CD8+ T cells","score":0.875},{"id":"https://openalex.org/keywords/b-cells","display_name":"B cells","score":0.675000011920929},{"id":"https://openalex.org/keywords/immunoglobulin-containing-cells","display_name":"immunoglobulin-containing cells","score":0.6690000295639038},{"id":"https://openalex.org/keywords/lymphocytic-infiltration","display_name":"lymphocyte infiltration","score":0.6740000247955322},{"id":"https://openalex.org/keywords/strain-susceptibility","display_name":"strain susceptibility","score":0.6330000162124634},{"id":"https://openalex.org/keywords/lewis-rats","display_name":"Lewis rats","score":0.9129999876022339},{"id":"https://openalex.org/keywords/brown-norway-rats","display_name":"Brown Norway rats","score":1.0},{"id":"https://openalex.org/keywords/viral-dissemination","display_name":"viral dissemination","score":0.5090000033378601}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6375139951705933},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.597531259059906},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.5387879610061646},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.5369529724121094},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.530124843120575},{"id":"https://openalex.org/C83455156","wikidata":"https://www.wikidata.org/wiki/Q199615","display_name":"Encephalitis","level":3,"score":0.49360191822052},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.4836769998073578},{"id":"https://openalex.org/C2777761686","wikidata":"https://www.wikidata.org/wiki/Q715347","display_name":"Lymphocyte","level":2,"score":0.46805188059806824},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.4607499837875366},{"id":"https://openalex.org/C153400128","wikidata":"https://www.wikidata.org/wiki/Q3150731","display_name":"Infiltration (HVAC)","level":2,"score":0.43230515718460083},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.42807531356811523},{"id":"https://openalex.org/C2778531937","wikidata":"https://www.wikidata.org/wiki/Q1186703","display_name":"Demyelinating disease","level":3,"score":0.4263843595981598},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.422377347946167},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.397293359041214},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.19958117604255676},{"id":"https://openalex.org/C2780640218","wikidata":"https://www.wikidata.org/wiki/Q8277","display_name":"Multiple sclerosis","level":2,"score":0.18687528371810913},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.06199461221694946},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0},{"id":"https://openalex.org/C97355855","wikidata":"https://www.wikidata.org/wiki/Q11473","display_name":"Thermodynamics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002490","descriptor_name":"Central Nervous System","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D003333","descriptor_name":"Coronaviridae Infections","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D003711","descriptor_name":"Demyelinating Diseases","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D004198","descriptor_name":"Disease Susceptibility","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004660","descriptor_name":"Encephalitis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D007091","descriptor_name":"Image Processing, Computer-Assisted","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011914","descriptor_name":"Rats, Inbred BN","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011919","descriptor_name":"Rats, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015704","descriptor_name":"CD4 Antigens","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D016131","descriptor_name":"Lymphocyte Subsets","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D016827","descriptor_name":"CD8 Antigens","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmid:1663079","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1663079","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:1384652","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC1384652/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunology","raw_type":"Text"},{"id":"mag:2396933770","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1663079","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:1384652","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC1384652/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunology","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9476000070571899}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":23,"referenced_works":["https://openalex.org/W1498231868","https://openalex.org/W1514436302","https://openalex.org/W1928696491","https://openalex.org/W1968637585","https://openalex.org/W1970877332","https://openalex.org/W1974967271","https://openalex.org/W1988565751","https://openalex.org/W1992203744","https://openalex.org/W2001358864","https://openalex.org/W2009520704","https://openalex.org/W2018664427","https://openalex.org/W2050220074","https://openalex.org/W2057284222","https://openalex.org/W2073423268","https://openalex.org/W2094413071","https://openalex.org/W2104735980","https://openalex.org/W2136600979","https://openalex.org/W2140892076","https://openalex.org/W2151567849","https://openalex.org/W2171009645","https://openalex.org/W2172466148","https://openalex.org/W2404426619","https://openalex.org/W2436626125"],"related_works":["https://openalex.org/W2068995496","https://openalex.org/W2105498506","https://openalex.org/W2404426619","https://openalex.org/W2089905390","https://openalex.org/W2409903202","https://openalex.org/W1972227837","https://openalex.org/W4206602755","https://openalex.org/W2033718952","https://openalex.org/W2108080472","https://openalex.org/W2118021730"],"abstract_inverted_index":{"The":[0,45],"inflammatory":[1,49],"response":[2],"in":[3,32,108,120,123,132,175,182,197,216,232,247],"the":[4,26,48,59,69,82,124,127,133,155,171,183,217,224],"central":[5],"nervous":[6],"system":[7],"(CNS)":[8],"of":[9,28,40,47,101,129,135,157,173,192,200,219,227,250],"rats":[10,202],"with":[11,64,97],"differing":[12],"susceptibility":[13],"to":[14,111,150,188],"demyelinating":[15],"encephalitis":[16],"induced":[17],"by":[18,37,53,239],"coronavirus":[19],"MHV4":[20],"was":[21,51,95,116,160],"characterized.":[22],"Topographical":[23],"maps":[24],"showing":[25],"arrangement":[27],"infiltrating":[29,102],"lymphocyte":[30,158],"subsets":[31],"virus-infected":[33,112,136,145,248],"tissue":[34],"were":[35,79,147,179,195,230,245],"developed":[36],"digital-image":[38],"processing":[39],"immunohistologically":[41],"stained":[42],"CNS":[43,125,218],"sections.":[44],"kinetics":[46],"process":[50],"evaluated":[52],"flow-cytometry":[54],"on":[55],"lymphocytes":[56,229],"isolated":[57],"from":[58,92],"CNS.":[60],"Cumulative":[61],"data":[62],"obtained":[63],"these":[65],"two":[66],"techniques":[67],"demonstrated":[68],"following":[70],"features.":[71],"In":[72,138],"susceptible":[73,220],"Lewis":[74],"(LE)":[75],"rats,":[76,144,236],"viral":[77],"antigens":[78],"disseminated":[80],"throughout":[81],"CNS,":[83],"including":[84],"spinal":[85],"cord.":[86],"Onset":[87],"as":[88,90,162,164,237],"well":[89],"recovery":[91],"neurological":[93],"disease":[94],"associated":[96],"a":[98,117],"steep":[99],"rise":[100],"CD8+":[103,184],"T":[104],"cells,":[105],"which":[106],"localized":[107],"close":[109],"contact":[110],"cells.":[113],"Accompanying":[114],"convalescence":[115],"slight":[118],"increase":[119],"B(OX33+)":[121,228],"cells":[122,131,146,244],"and":[126,154,207,234],"accumulation":[128],"immunoglobulin-containing":[130,242],"centre":[134],"areas.":[137],"clinically":[139],"resistant":[140],"Brown":[141],"Norway":[142],"(BN)":[143],"mainly":[148],"restricted":[149],"small":[151],"periventricular":[152],"foci":[153],"extent":[156],"infiltration":[159,209],"never":[161],"high":[163],"that":[165],"found":[166],"at":[167],"any":[168],"time":[169],"during":[170],"course":[172],"infection":[174],"LE":[176,189,221,235],"rats.":[177,190,222,252],"There":[178],"striking":[180],"differences":[181],"T-cell":[185],"population":[186,225],"compared":[187],"Cells":[191],"this":[193],"phenotype":[194],"identified":[196],"virus-affected":[198],"areas":[199,249],"BN":[201,233,251],"only":[203],"early":[204],"after":[205],"infection,":[206],"their":[208],"profile":[210],"revealed":[211],"much":[212],"lower":[213],"quantities":[214],"than":[215],"Although":[223],"dynamics":[226],"comparable":[231],"determined":[238],"flow-cytometry,":[240],"less":[241],"B":[243],"detected":[246]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2016,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}