{"id":"https://openalex.org/W2396926457","doi":null,"title":"Acquisition of bone mass in normal individuals and in patients with growth hormone deficiency.","display_name":"Acquisition of bone mass in normal individuals and in patients with growth hormone deficiency.","publication_year":2003,"publication_date":"2003-03-01","ids":{"openalex":"https://openalex.org/W2396926457","mag":"2396926457","pmid":"https://pubmed.ncbi.nlm.nih.gov/12729412"},"language":"en","primary_location":{"id":"pmid:12729412","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12729412","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of pediatric endocrinology & metabolism : JPEM","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5020016020","display_name":"Giampiero Igli Baroncelli","orcid":"https://orcid.org/0000-0001-8465-5087","observed_orcids":["https://orcid.org/0000-0001-8465-5087"]},"institutions":[{"id":"https://openalex.org/I108290504","display_name":"University of Pisa","ror":"https://ror.org/03ad39j10","country_code":"IT","type":"education","lineage":["https://openalex.org/I108290504"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Giampiero I Baroncelli","raw_affiliation_strings":["Endocrine Unit, Division of Pediatrics, Department of Reproductive Medicine and Pediatrics, University of Pisa, Pisa, Italy. g.baroncelli@clp.med.unipi.it","Endocrine Unit, Division of Pediatrics, Department of Reproductive Medicine and Pediatrics, University of Pisa, Pisa, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Endocrine Unit, Division of Pediatrics, Department of Reproductive Medicine and Pediatrics, University of Pisa, Pisa, Italy. g.baroncelli@clp.med.unipi.it","institution_ids":["https://openalex.org/I108290504"]},{"raw_affiliation_string":"Endocrine Unit, Division of Pediatrics, Department of Reproductive Medicine and Pediatrics, University of Pisa, Pisa, Italy","institution_ids":["https://openalex.org/I108290504"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058832061","display_name":"Silvano Bertelloni","orcid":"https://orcid.org/0000-0003-1264-3284","observed_orcids":["https://orcid.org/0000-0003-1264-3284"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Silvano Bertelloni","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031400416","display_name":"Federica Sodini","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Federica Sodini","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5051036940","display_name":"Giuseppe Saggese","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Giuseppe Saggese","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.4318,"has_fulltext":false,"cited_by_count":53,"citation_normalized_percentile":{"value":0.81871952,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":99},"biblio":{"volume":"16 Suppl 2","issue":null,"first_page":"327","last_page":"35"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10748","display_name":"Growth Hormone and Insulin-like Growth Factors","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10748","display_name":"Growth Hormone and Insulin-like Growth Factors","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10071","display_name":"Bone health and osteoporosis research","score":0.005400000140070915,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10960","display_name":"Hypothalamic control of reproductive hormones","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/growth-hormone-deficiency","display_name":"growth hormone deficiency","score":0.9940000176429749},{"id":"https://openalex.org/keywords/bone-mass-accrual","display_name":"bone accrual","score":0.871999979019165},{"id":"https://openalex.org/keywords/bone-turnover","display_name":"bone turnover","score":0.8650000095367432},{"id":"https://openalex.org/keywords/growth-hormone-replacement-therapy","display_name":"growth hormone replacement therapy","score":0.8669999837875366},{"id":"https://openalex.org/keywords/bone-mineral-density","display_name":"bone mineral density","score":0.8149999976158142},{"id":"https://openalex.org/keywords/lumbar-spine","display_name":"lumbar spine","score":0.9160000085830688},{"id":"https://openalex.org/keywords/fracture-risk","display_name":"fracture risk","score":0.8009999990463257},{"id":"https://openalex.org/keywords/peak-bone-mass","display_name":"peak bone mass","score":0.7689999938011169},{"id":"https://openalex.org/keywords/coming-of-age","display_name":"coming of age","score":0.8320000171661377},{"id":"https://openalex.org/keywords/children-and-adolescents","display_name":"children and adolescents","score":0.781000018119812}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.920721173286438},{"id":"https://openalex.org/C2778715236","wikidata":"https://www.wikidata.org/wiki/Q55622662","display_name":"Discontinuation","level":2,"score":0.7867926359176636},{"id":"https://openalex.org/C2780712178","wikidata":"https://www.wikidata.org/wiki/Q25326559","display_name":"Peak bone mass","level":4,"score":0.6995277404785156},{"id":"https://openalex.org/C170033053","wikidata":"https://www.wikidata.org/wiki/Q952019","display_name":"Bone remodeling","level":2,"score":0.6706624031066895},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6703672409057617},{"id":"https://openalex.org/C2993253760","wikidata":"https://www.wikidata.org/wiki/Q2304401","display_name":"Bone mass","level":3,"score":0.6189693808555603},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6183083653450012},{"id":"https://openalex.org/C2779952775","wikidata":"https://www.wikidata.org/wiki/Q369262","display_name":"Growth hormone deficiency","level":4,"score":0.5152928829193115},{"id":"https://openalex.org/C2777083390","wikidata":"https://www.wikidata.org/wiki/Q1367706","display_name":"Osteopenia","level":4,"score":0.5001084804534912},{"id":"https://openalex.org/C2776541429","wikidata":"https://www.wikidata.org/wiki/Q165328","display_name":"Osteoporosis","level":2,"score":0.4113050699234009},{"id":"https://openalex.org/C2984496839","wikidata":"https://www.wikidata.org/wiki/Q29956617","display_name":"Growth hormone","level":3,"score":0.35962700843811035},{"id":"https://openalex.org/C2776886416","wikidata":"https://www.wikidata.org/wiki/Q4941567","display_name":"Bone mineral","level":3,"score":0.27749669551849365},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.2688782513141632}],"mesh":[{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001827","descriptor_name":"Body Height","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001846","descriptor_name":"Bone Development","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008661","descriptor_name":"Metabolism, Inborn Errors","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D008661","descriptor_name":"Metabolism, Inborn Errors","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008661","descriptor_name":"Metabolism, Inborn Errors","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013006","descriptor_name":"Growth Hormone","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D019382","descriptor_name":"Human Growth Hormone","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":true},{"descriptor_ui":"D050723","descriptor_name":"Fractures, Bone","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmid:12729412","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12729412","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of pediatric endocrinology & metabolism : JPEM","raw_type":"Journal Article"},{"id":"pmh:oai:arpi.unipi.it:11568/77993","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11568/77993","pdf_url":null,"source":{"id":"https://openalex.org/S4377196265","display_name":"CINECA IRIS Institutial research information system (University of Pisa)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I108290504","host_organization_name":"University of Pisa","host_organization_lineage":["https://openalex.org/I108290504"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},{"id":"mag:2396926457","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12729412","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2282316160","https://openalex.org/W2087341274","https://openalex.org/W2034484159","https://openalex.org/W2047383846","https://openalex.org/W2019361743","https://openalex.org/W4415450670","https://openalex.org/W2426377784","https://openalex.org/W2789515908","https://openalex.org/W2057376984","https://openalex.org/W2038343917"],"abstract_inverted_index":{"Children":[0,67],"and":[1,13,27,33,68,166],"adolescents":[2,69],"with":[3,18,39,42,61,70,83,97],"growth":[4],"hormone":[5],"(GH)":[6],"deficiency":[7],"(GHD)":[8],"have":[9,44,54,72],"reduced":[10,55],"bone":[11,14,25,29,49,88,139,150,162,174],"turnover":[12,26],"mass":[15,30,89,140,151,163,175],"in":[16,81,95,158],"comparison":[17,82],"normal":[19,45],"individuals.":[20],"GH":[21,43,101,126,147,153],"replacement":[22],"therapy":[23],"stimulates":[24],"improves":[28],"during":[31,79,90,164,176],"childhood":[32,165],"adolescence.":[34],"At":[35],"final":[36,104,115],"height,":[37],"patients":[38,53,96],"GHD":[40,71,98,172],"treated":[41],"mean":[46],"values":[47],"of":[48,87,111,125,133,142,146,161,171],"mass,":[50],"but":[51,168],"some":[52],"lumbar":[56,112],"BMD":[57,113],"(Z":[58],"score":[59],"<1)":[60],"an":[62,155],"increased":[63],"susceptibility":[64],"to":[65,93,179],"fractures.":[66],"approximately":[73],"a":[74,134,143],"fourfold":[75],"decreased":[76],"fracture":[77],"frequency":[78],"treatment":[80,102,148],"controls.":[84],"The":[85],"changes":[86],"the":[91,131,159,169,177],"transition":[92],"adulthood":[94,180],"who":[99],"discontinued":[100],"after":[103,114,123],"height":[105,116],"are":[106],"not":[107],"defined.":[108],"An":[109],"increase":[110],"has":[117,154],"been":[118],"reported":[119],"until":[120],"2":[121],"years":[122],"discontinuation":[124],"treatment;":[127],"this":[128],"could":[129],"be":[130],"result":[132],"spontaneous":[135],"progression":[136],"towards":[137],"peak":[138],"or":[141],"persisting":[144],"effect":[145],"on":[149,173],"accumulation.":[152],"important":[156],"role":[157],"accrual":[160],"adolescence,":[167],"impact":[170],"transiton":[178],"is":[181],"unknown.":[182]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":8}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
