{"id":"https://openalex.org/W2396923899","doi":null,"title":"Early pathogenic events in NSAID-induced gastrointestinal damage.","display_name":"Early pathogenic events in NSAID-induced gastrointestinal damage.","publication_year":1996,"publication_date":"1996-12-01","ids":{"openalex":"https://openalex.org/W2396923899","mag":"2396923899","pmid":"https://pubmed.ncbi.nlm.nih.gov/9032577"},"language":"en","primary_location":{"id":"pmid:9032577","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9032577","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Italian journal of gastroenterology","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5056626995","display_name":"Ingvar Bjarnason","orcid":"https://orcid.org/0000-0002-5520-492X","observed_orcids":["https://orcid.org/0000-0002-5520-492X"]},"institutions":[{"id":"https://openalex.org/I183935753","display_name":"King's College London","ror":"https://ror.org/0220mzb33","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I183935753"]},{"id":"https://openalex.org/I4210119896","display_name":"King's College School","ror":"https://ror.org/02bbqcn27","country_code":"GB","type":"education","lineage":["https://openalex.org/I4210119896"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"I Bjarnason","raw_affiliation_strings":["Department of Clinical Biochemistry, King's College School of Medicine and Dentistry, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Biochemistry, King's College School of Medicine and Dentistry, London, UK","institution_ids":["https://openalex.org/I183935753","https://openalex.org/I4210119896"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5006608189","display_name":"Jeremy S. Hayllar","orcid":"https://orcid.org/0000-0003-3065-7591","observed_orcids":["https://orcid.org/0000-0003-3065-7591"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J Hayllar","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.0686,"has_fulltext":false,"cited_by_count":19,"citation_normalized_percentile":{"value":0.7556105,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"28 Suppl 4","issue":null,"first_page":"19","last_page":"22"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10365","display_name":"Gastrointestinal motility and disorders","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/small-bowel-injury","display_name":"small bowel injury","score":0.5950000286102295},{"id":"https://openalex.org/keywords/mitochondrial-uncoupling","display_name":"mitochondrial uncoupling","score":0.906000018119812},{"id":"https://openalex.org/keywords/oxidative-phosphorylation","display_name":"oxidative phosphorylation","score":0.984000027179718},{"id":"https://openalex.org/keywords/cyclooxygenase-inhibition","display_name":"cyclooxygenase inhibition","score":0.9179999828338623},{"id":"https://openalex.org/keywords/flurbiprofen","display_name":"flurbiprofen","score":0.8309999704360962},{"id":"https://openalex.org/keywords/indomethacin","display_name":"indomethacin","score":0.828000009059906},{"id":"https://openalex.org/keywords/intestinal-permeability","display_name":"intestinal permeability","score":0.9070000052452087},{"id":"https://openalex.org/keywords/intestinal-inflammation","display_name":"intestinal inflammation","score":0.972000002861023},{"id":"https://openalex.org/keywords/prostanoids","display_name":"prostanoids","score":0.871999979019165},{"id":"https://openalex.org/keywords/bile-duct-ligation","display_name":"bile duct ligation","score":0.8220000267028809},{"id":"https://openalex.org/keywords/brush-border-enzymes","display_name":"brush border enzymes","score":0.8629999756813049}],"concepts":[{"id":"https://openalex.org/C2781000538","wikidata":"https://www.wikidata.org/wiki/Q419890","display_name":"Flurbiprofen","level":2,"score":0.8007787466049194},{"id":"https://openalex.org/C2779689624","wikidata":"https://www.wikidata.org/wiki/Q410251","display_name":"Cyclooxygenase","level":3,"score":0.7956122159957886},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.6393961906433105},{"id":"https://openalex.org/C2778266237","wikidata":"https://www.wikidata.org/wiki/Q962217","display_name":"Prostanoid","level":3,"score":0.5943744778633118},{"id":"https://openalex.org/C57600042","wikidata":"https://www.wikidata.org/wiki/Q227564","display_name":"Oxidative phosphorylation","level":2,"score":0.5374541878700256},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5004012584686279},{"id":"https://openalex.org/C2781071285","wikidata":"https://www.wikidata.org/wiki/Q17141320","display_name":"Intestinal permeability","level":2,"score":0.47422146797180176},{"id":"https://openalex.org/C26291073","wikidata":"https://www.wikidata.org/wiki/Q310484","display_name":"Ex vivo","level":3,"score":0.44349992275238037},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.4432280659675598},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.4345454275608063},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4325530230998993},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3352653980255127},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.25619012117385864},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.25210362672805786},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.20216631889343262},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.20157214999198914},{"id":"https://openalex.org/C2780664492","wikidata":"https://www.wikidata.org/wiki/Q209717","display_name":"Prostaglandin","level":2,"score":0.18397274613380432},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000894","descriptor_name":"Anti-Inflammatory Agents, Non-Steroidal","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D005767","descriptor_name":"Gastrointestinal Diseases","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D007408","descriptor_name":"Intestinal Absorption","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008854","descriptor_name":"Microscopy, Electron","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008871","descriptor_name":"Microvilli","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008930","descriptor_name":"Mitochondria, Liver","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D010085","descriptor_name":"Oxidative Phosphorylation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D016861","descriptor_name":"Cyclooxygenase Inhibitors","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:9032577","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9032577","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Italian journal of gastroenterology","raw_type":"Journal Article"},{"id":"mag:2396923899","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9032577","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1995937664","https://openalex.org/W2083519449","https://openalex.org/W1984590783","https://openalex.org/W2105766151","https://openalex.org/W2152351077","https://openalex.org/W2029992371","https://openalex.org/W2025053796","https://openalex.org/W2005549934","https://openalex.org/W2772755903","https://openalex.org/W2097086662"],"abstract_inverted_index":{"A":[0],"number":[1],"of":[2,10,16,28,31,62,111,115,121,201,215],"studies":[3,44,192],"show":[4,45,94],"that":[5,8,95,194],"the":[6,13,29,99,126,131,198,221],"idea":[7],"inhibition":[9,114,214],"cyclooxygenase":[11,116,137,216],"is":[12,20,102,133,217],"sole":[14],"mechanism":[15,30],"NSAID-induced":[17],"gastrointestinal":[18,100],"damage":[19,34,203],"no":[21,165],"longer":[22],"tenable.":[23],"We":[24],"re-examined":[25],"various":[26],"aspects":[27],"small":[32],"intestinal":[33,86,148,153,172,182,208],"due":[35],"to":[36,76,206,219,223],"NSAIDs":[37],"in":[38,48,89,142,145,181],"rat.":[39],"Subcellular":[40],"organelle":[41],"marker":[42,53],"enzyme":[43],"selective":[46],"alterations":[47],"mitochondrial":[49,63],"and":[50,108,113,123,144,150,163,170,187,210],"brush":[51],"border":[52],"enzymes.":[54],"Electron":[55],"microscopy":[56],"shows":[57],"changes":[58],"compatible":[59],"with":[60,178],"uncoupling":[61,112,195],"oxidative":[64,78],"phosphorylation.":[65],"In":[66],"vitro,":[67],"all":[68],"common":[69],"acidic-NSAIDs":[70],"(n":[71],"=":[72],"15)":[73],"were":[74,117],"found":[75],"uncouple":[77],"phosphorylation":[79],"at":[80],"concentrations":[81],"(microM)":[82],"easily":[83],"achievable":[84],"within":[85,98],"epithelium.":[87],"Experiments":[88],"bile":[90],"duct":[91],"ligated":[92],"animals":[93],"intact":[96],"indomethacin":[97],"lumen":[101],"required":[103],"for":[104],"uncoupling.":[105],"Relative":[106],"importance":[107],"pathophysiological":[109],"consequences":[110],"assessed":[118],"following":[119],"administration":[120],"R":[122,139],"S":[124,167],"flurbiprofen:":[125],"former":[127],"selectively":[128],"uncouples":[129],"whilst":[130],"latter":[132],"also":[134],"an":[135],"effective":[136],"inhibitor.":[138],"flurbiprofen":[140,168],"uncoupled":[141,169],"vitro":[143],"vivo,":[146],"increased":[147,171,207],"permeability":[149,173,209],"caused":[151],"mild":[152],"inflammation,":[154,211],"but":[155,175,212],"had":[156],"not":[157],"significant":[158,179],"effect":[159],"on":[160],"prostanoid":[161,183],"levels":[162],"produced":[164],"ulcers.":[166,189,224],"equally":[174],"was":[176],"associated":[177],"decreases":[180],"levels,":[184],"more":[185],"inflammation":[186,222],"numerous":[188],"Collectively":[190],"these":[191],"suggest":[193],"may":[196],"underlie":[197],"\"topical\"":[199],"phase":[200],"NSAID":[202],"which":[204],"leads":[205],"concomitant":[213],"essential":[218],"drive":[220]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}