{"id":"https://openalex.org/W2396909254","doi":null,"title":"[Circadian and seasonal changes of the inducer:suppressor ratio (OKT4+:OKT8+) in venous blood of healthy adults].","display_name":"[Circadian and seasonal changes of the inducer:suppressor ratio (OKT4+:OKT8+) in venous blood of healthy adults].","publication_year":1986,"publication_date":"1986-01-01","ids":{"openalex":"https://openalex.org/W2396909254","mag":"2396909254","pmid":"https://pubmed.ncbi.nlm.nih.gov/2871910"},"language":"fr","primary_location":{"id":"pmid:2871910","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2871910","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Comptes rendus de l'Academie des sciences. Serie III, Sciences de la vie","raw_type":"English Abstract"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5038849276","display_name":"Chantal Canon","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C Canon","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078259466","display_name":"Fran\u00e7is L\u00e9vi","orcid":"https://orcid.org/0000-0003-1364-7463","observed_orcids":["https://orcid.org/0000-0003-1364-7463"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"F Levi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030176148","display_name":"Yvan Touitou","orcid":"https://orcid.org/0000-0002-5990-0244","observed_orcids":["https://orcid.org/0000-0002-5990-0244"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Y Touitou","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080720067","display_name":"Jose\u0301 Sulon","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J Sulon","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055270101","display_name":"Emilie Demey-Ponsart","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E Demey-Ponsart","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113813656","display_name":"Alain Reinberg","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Reinberg","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5080259363","display_name":"Georges Math\u00e9","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G Math\u00e9","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.7047,"has_fulltext":false,"cited_by_count":10,"citation_normalized_percentile":{"value":0.63003503,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"302","issue":"14","first_page":"519","last_page":"24"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10342","display_name":"Circadian rhythm and melatonin","score":0.9648000001907349,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10342","display_name":"Circadian rhythm and melatonin","score":0.9648000001907349,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10529","display_name":"Stress Responses and Cortisol","score":0.022099999710917473,"subfield":{"id":"https://openalex.org/subfields/2802","display_name":"Behavioral Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.005100000184029341,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/okt4-okt8-ratio","display_name":"OKT4/OKT8 ratio","score":0.8429999947547913},{"id":"https://openalex.org/keywords/circadian-rhythm","display_name":"circadian rhythm","score":0.9160000085830688},{"id":"https://openalex.org/keywords/seasonal-variation","display_name":"seasonal variation","score":0.9980000257492065},{"id":"https://openalex.org/keywords/plasma-cortisol","display_name":"plasma cortisol","score":0.8619999885559082},{"id":"https://openalex.org/keywords/free-cortisol","display_name":"free cortisol","score":0.9459999799728394},{"id":"https://openalex.org/keywords/peripheral-blood-lymphocytes","display_name":"peripheral blood lymphocytes","score":0.7289999723434448},{"id":"https://openalex.org/keywords/t-cell-subsets","display_name":"T cell subsets","score":0.7149999737739563},{"id":"https://openalex.org/keywords/healthy-young-men","display_name":"healthy young men","score":0.621999979019165}],"concepts":[{"id":"https://openalex.org/C121446783","wikidata":"https://www.wikidata.org/wiki/Q208353","display_name":"Circadian rhythm","level":2,"score":0.8864589333534241},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5996126532554626},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5964735150337219},{"id":"https://openalex.org/C43044207","wikidata":"https://www.wikidata.org/wiki/Q618363","display_name":"Venous blood","level":2,"score":0.46624794602394104},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.44047537446022034},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3823736310005188},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3525508642196655},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.10207030177116394},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.09119760990142822}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002940","descriptor_name":"Circadian Rhythm","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006377","descriptor_name":"T-Lymphocytes, Helper-Inducer","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006854","descriptor_name":"Hydrocortisone","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D007958","descriptor_name":"Leukocyte Count","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012621","descriptor_name":"Seasons","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D050378","descriptor_name":"T-Lymphocytes, Regulatory","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:2871910","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2871910","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Comptes rendus de l'Academie des sciences. Serie III, Sciences de la vie","raw_type":"English Abstract"},{"id":"mag:2396909254","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2871910","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9476000070571899}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2412724059","https://openalex.org/W276807243","https://openalex.org/W1964130172","https://openalex.org/W163195939","https://openalex.org/W1977047809","https://openalex.org/W2462875048","https://openalex.org/W1545062236","https://openalex.org/W1945215925","https://openalex.org/W2327067203","https://openalex.org/W7097852297"],"abstract_inverted_index":{"Circadian":[0],"and":[1,32,52,63,69,100,124,137,147,163,185],"seasonal":[2,186],"variations":[3,187],"in":[4,13,40,122,128,145,151,157,168],"the":[5,56,135,169,196],"T":[6,8,203,205],"helper:":[7,204],"suppressor-cytotoxic":[9,206],"ratio":[10,171],"were":[11,23,50],"investigated":[12],"peripheral":[14],"blood":[15],"from":[16],"five":[17],"healthy":[18],"young":[19],"men.":[20],"Mononuclear":[21],"cells":[22],"isolated":[24],"on":[25],"Ficoll-Paque":[26],"gradient,":[27],"then":[28],"incubated":[29],"with":[30],"OKT4":[31],"OKT8":[33],"monoclonal":[34],"antibodies.":[35],"Plasma":[36],"cortisol":[37,66,95,103],"was":[38,78,140,155],"determined":[39],"four":[41],"of":[42,58,64,134,180,198],"these":[43],"seven":[44],"time":[45],"series.":[46],"Large":[47],"interindividual":[48],"differences":[49],"documented":[51],"statistically":[53,118],"validated":[54],"for":[55,86,110],"24-hr.-means":[57],"total":[59,68,87,93],"lymphocytes,":[60],"OKT4+:OKT8+":[61,111,170],"ratio,":[62],"plasma":[65,94,102,181],"(both":[67],"free).":[70],"For":[71],"a":[72,75,117],"pooled":[73],"data,":[74],"circadian":[76,120,166,184],"rhythm":[77,121,167],"demonstrated":[79],"by":[80],"cosinor":[81],"(p":[82],"less":[83],"than":[84],"0.001)":[85],"lymphocytes":[88],"(acrophase":[89,96,104],"at":[90,97,105,142,148],"1.00":[91],"hr.),":[92],"10.30":[98],"hrs.)":[99],"free":[101],"9.50":[106],"hrs.),":[107],"but":[108,126],"not":[109,127,173],"ratio.":[112,207],"This":[113],"index":[114],"however":[115],"exhibited":[116],"significant":[119],"April":[123,146,162],"August,":[125],"November.":[129,164],"Its":[130,153],"double-amplitude":[131],"exceeded":[132],"80%":[133],"24-hour-mean":[136],"its":[138],"acrophase":[139],"localized":[141],"6.40":[143],"hrs.":[144,150],"22.30":[149],"August.":[152],"24-hr-mean":[154],"higher":[156],"August":[158],"as":[159,202],"compared":[160],"to":[161,175,178,189],"The":[165],"did":[172],"seem":[174],"be":[176,190],"related":[177],"that":[179],"cortisol.":[182],"Both":[183],"need":[188],"taken":[191],"into":[192],"account":[193],"when":[194],"investigating":[195],"regulations":[197],"immune":[199],"variables":[200],"such":[201]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}