{"id":"https://openalex.org/W2396902545","doi":null,"title":"RAPID INDUCTION OF HETEROGENEOUS ICE NUCLEATION IN A BIOLOGICALLY COMPATIBLE COOLANT.","display_name":"RAPID INDUCTION OF HETEROGENEOUS ICE NUCLEATION IN A BIOLOGICALLY COMPATIBLE COOLANT.","publication_year":2011,"publication_date":"2011-01-01","ids":{"openalex":"https://openalex.org/W2396902545","mag":"2396902545","pmid":"https://pubmed.ncbi.nlm.nih.gov/25954121","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4420239"},"language":"en","primary_location":{"id":"pmid:25954121","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25954121","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of transport phenomena","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4420239","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5053812510","display_name":"Joshua W. Lampe","orcid":"https://orcid.org/0000-0001-6036-535X","observed_orcids":["https://orcid.org/0000-0001-6036-535X"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joshua Lampe","raw_affiliation_strings":["Center for Resuscitation Science, University of Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Resuscitation Science, University of Pennsylvania","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Diana Bull","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Diana Bull","raw_affiliation_strings":["Center for Resuscitation Science, University of Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Resuscitation Science, University of Pennsylvania","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5083278720","display_name":"Lance B. Becker","orcid":"https://orcid.org/0000-0001-7051-8778","observed_orcids":["https://orcid.org/0000-0001-7051-8778"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lance Becker","raw_affiliation_strings":["Center for Resuscitation Science, University of Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Resuscitation Science, University of Pennsylvania","institution_ids":["https://openalex.org/I79576946"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I79576946"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.37177693,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"12","issue":"3-4","first_page":"307","last_page":"317"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T14479","display_name":"Freezing and Crystallization Processes","score":0.5526999831199646,"subfield":{"id":"https://openalex.org/subfields/1506","display_name":"Filtration and Separation"},"field":{"id":"https://openalex.org/fields/15","display_name":"Chemical Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T14479","display_name":"Freezing and Crystallization Processes","score":0.5526999831199646,"subfield":{"id":"https://openalex.org/subfields/1506","display_name":"Filtration and Separation"},"field":{"id":"https://openalex.org/fields/15","display_name":"Chemical Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12202","display_name":"nanoparticles nucleation surface interactions","score":0.33980000019073486,"subfield":{"id":"https://openalex.org/subfields/1606","display_name":"Physical and Theoretical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11861","display_name":"Thermal Regulation in Medicine","score":0.05290000140666962,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/therapeutic-hypothermia","display_name":"therapeutic hypothermia","score":0.8859999775886536},{"id":"https://openalex.org/keywords/heterogeneous-ice-nucleation","display_name":"heterogeneous ice nucleation","score":0.9549999833106995},{"id":"https://openalex.org/keywords/heat-capacity","display_name":"heat capacity","score":0.6140000224113464},{"id":"https://openalex.org/keywords/cardiac-arrest","display_name":"cardiac arrest","score":0.6499999761581421},{"id":"https://openalex.org/keywords/stroke","display_name":"stroke","score":0.5429999828338623}],"concepts":[{"id":"https://openalex.org/C91914117","wikidata":"https://www.wikidata.org/wiki/Q1056832","display_name":"Coolant","level":2,"score":0.8484737277030945},{"id":"https://openalex.org/C2777390192","wikidata":"https://www.wikidata.org/wiki/Q1036696","display_name":"Hypothermia","level":2,"score":0.5942383408546448},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.502178430557251},{"id":"https://openalex.org/C2777397205","wikidata":"https://www.wikidata.org/wiki/Q275792","display_name":"Saline","level":2,"score":0.48018231987953186},{"id":"https://openalex.org/C94293008","wikidata":"https://www.wikidata.org/wiki/Q23925154","display_name":"Slurry","level":2,"score":0.43987518548965454},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.40068960189819336},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.3982866704463959},{"id":"https://openalex.org/C116915560","wikidata":"https://www.wikidata.org/wiki/Q83504","display_name":"Nuclear engineering","level":1,"score":0.35266345739364624},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.27955931425094604},{"id":"https://openalex.org/C78519656","wikidata":"https://www.wikidata.org/wiki/Q101333","display_name":"Mechanical engineering","level":1,"score":0.18652981519699097},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.10734188556671143},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.0933154821395874}],"mesh":[],"locations_count":4,"locations":[{"id":"pmid:25954121","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25954121","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of transport phenomena","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:3384207","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4420239","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4420239","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4420239","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Int J Transp Phenom","raw_type":"Text"},{"id":"mag:2396902545","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25954121","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:europepmc.org:3384207","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4420239","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[{"id":"https://openalex.org/G8777811324","display_name":"Optimizing heart and brain cooling during cardiac arrest","funder_award_id":"R01HL067630","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":22,"referenced_works":["https://openalex.org/W1560838288","https://openalex.org/W1964349082","https://openalex.org/W2013303926","https://openalex.org/W2018787568","https://openalex.org/W2031840724","https://openalex.org/W2048692124","https://openalex.org/W2059997000","https://openalex.org/W2062642814","https://openalex.org/W2078111650","https://openalex.org/W2104869294","https://openalex.org/W2109821965","https://openalex.org/W2110565948","https://openalex.org/W2111826116","https://openalex.org/W2113909339","https://openalex.org/W2114888710","https://openalex.org/W2136861362","https://openalex.org/W2137834530","https://openalex.org/W2144025192","https://openalex.org/W2150841313","https://openalex.org/W2166103891","https://openalex.org/W2342115977","https://openalex.org/W2916392902"],"related_works":["https://openalex.org/W2918484217","https://openalex.org/W2150841313","https://openalex.org/W2114888710","https://openalex.org/W4299359187","https://openalex.org/W2112517536","https://openalex.org/W1997104502","https://openalex.org/W2000126278","https://openalex.org/W2436932779","https://openalex.org/W2124696943","https://openalex.org/W4213012994"],"abstract_inverted_index":{"Hypothermia":[0],"is":[1,23,38,88,134,208],"gaining":[2],"recognition":[3],"as":[4,16],"an":[5,77,82,100],"important":[6],"medical":[7],"treatment.":[8],"To":[9,30],"treat":[10,31],"local":[11,28],"cases":[12],"of":[13,48,103,128,190],"injury":[14],"such":[15],"stroke,":[17],"or":[18,33,154],"certain":[19],"surgical":[20,151,157],"procedures,":[21],"there":[22,37],"a":[24,39,65,104,111,135,148,166,177,216],"need":[25,40,72],"to":[26,41,60,80,84,109,123,176],"induce":[27,43],"hypothermia.":[29,45],"shock":[32],"cardiac":[34],"arrest":[35],"survivors,":[36],"rapidly":[42],"global":[44],"Rapid":[46],"induction":[47],"hypothermia":[49,75],"has":[50,58,120,170],"been":[51,171],"achieved":[52,62],"in":[53,126,165],"animal":[54],"research,":[55],"but":[56],"it":[57],"yet":[59],"be":[61,124,144],"clinically":[63],"using":[64],"simple,":[66],"widely":[67],"practicable":[68],"method.":[69],"The":[70,132,159,203],"clinical":[71,130,222],"for":[73,224],"therapeutic":[74],"represents":[76,215],"engineering":[78],"opportunity":[79],"develop":[81],"easy":[83],"use":[85],"coolant":[86,94,118,133],"that":[87,119,142,169,193],"sterile,":[89,112],"biologically":[90,113],"compatible,":[91,114],"and":[92],"maximizes":[93],"heat":[95,116],"capacity.":[96],"Here":[97],"we":[98],"present":[99],"initial":[101],"characterization":[102],"prototype":[105],"platform":[106],"technology":[107],"designed":[108],"create":[110],"high":[115],"capacity":[117],"the":[121,180,185],"potential":[122],"used":[125],"all":[127],"these":[129],"applications.":[131],"specially":[136],"processed":[137],"micro-particulate":[138],"ice":[139,163,191,197,205],"saline":[140,167,181],"slurry,":[141],"can":[143],"easily":[145],"pumped":[146],"into":[147],"patient":[149],"through":[150],"tubing,":[152],"syringes,":[153],"minimally":[155],"invasive":[156],"instruments.":[158],"device":[160,186],"induces":[161],"heterogeneous":[162],"nucleation":[164],"stream":[168],"super-cooled":[172],"from":[173],"room":[174],"temperature":[175,178],"below":[179],"freezing":[182],"point.":[183],"Currently,":[184],"begins":[187],"continuous":[188],"production":[189],"slurry":[192],"contains":[194],"~30":[195],"%":[196],"by":[198],"mass":[199],"within":[200],"10":[201],"minutes.":[202],"nominal":[204],"particle":[206],"diameter":[207],"smaller":[209],"than":[210],"100":[211],"\u03bcm.":[212],"This":[213],"work":[214],"significant":[217],"first":[218],"step":[219],"toward":[220],"addressing":[221],"needs":[223],"rapid":[225],"human":[226],"cooling.":[227]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-06-24T00:00:00"}