{"id":"https://openalex.org/W2396895747","doi":null,"title":"Mechanisms of insulin resistance after kidney transplantation.","display_name":"Mechanisms of insulin resistance after kidney transplantation.","publication_year":1989,"publication_date":"1989-10-01","ids":{"openalex":"https://openalex.org/W2396895747","mag":"2396895747","pmid":"https://pubmed.ncbi.nlm.nih.gov/2678633"},"language":"en","primary_location":{"id":"pmid:2678633","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2678633","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transplantation","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5013030555","display_name":"Agneta Ekstrand","orcid":"https://orcid.org/0000-0001-9764-3966","observed_orcids":["https://orcid.org/0000-0001-9764-3966"]},"institutions":[{"id":"https://openalex.org/I2800394112","display_name":"Helsinki University Hospital","ror":"https://ror.org/02e8hzf44","country_code":"FI","type":"healthcare","lineage":["https://openalex.org/I2800394112","https://openalex.org/I4210166427"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"A Ekstrand","raw_affiliation_strings":["Fourth Department of Medicine, Helsinki University Hospital, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fourth Department of Medicine, Helsinki University Hospital, Finland","institution_ids":["https://openalex.org/I2800394112"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111546659","display_name":"J. Ahonen","orcid":"https://orcid.org/0000-0002-5523-2488","observed_orcids":["https://orcid.org/0000-0002-5523-2488"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J Ahonen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113775722","display_name":"C Gr\u00f6nhagen-Riska","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C Gr\u00f6nhagen-Riska","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5074771810","display_name":"Leif Groop","orcid":"https://orcid.org/0000-0002-0187-3263","observed_orcids":["https://orcid.org/0000-0002-0187-3263"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L Groop","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":4.6941,"has_fulltext":false,"cited_by_count":31,"citation_normalized_percentile":{"value":0.95480631,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":93},"biblio":{"volume":"48","issue":"4","first_page":"563","last_page":"8"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10373","display_name":"Renal Transplantation Outcomes and Treatments","score":0.35989999771118164,"subfield":{"id":"https://openalex.org/subfields/2747","display_name":"Transplantation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10373","display_name":"Renal Transplantation Outcomes and Treatments","score":0.35989999771118164,"subfield":{"id":"https://openalex.org/subfields/2747","display_name":"Transplantation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10027","display_name":"Diabetes, Cardiovascular Risks, and Lipoproteins","score":0.3163999915122986,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.10719999670982361,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"insulin resistance","score":0.9900000095367432},{"id":"https://openalex.org/keywords/kidney-transplantation","display_name":"kidney transplantation","score":0.9909999966621399},{"id":"https://openalex.org/keywords/corticosteroids","display_name":"corticosteroids","score":0.9129999876022339},{"id":"https://openalex.org/keywords/methylprednisolone","display_name":"methylprednisolone","score":0.9869999885559082},{"id":"https://openalex.org/keywords/glucose-utilization","display_name":"glucose utilization","score":0.6100000143051147},{"id":"https://openalex.org/keywords/glycogen-synthesis","display_name":"glycogen synthesis","score":0.7940000295639038},{"id":"https://openalex.org/keywords/nonoxidative-glucose-disposal","display_name":"nonoxidative glucose disposal","score":0.906000018119812},{"id":"https://openalex.org/keywords/thermogenesis","display_name":"thermogenesis","score":0.8080000281333923},{"id":"https://openalex.org/keywords/lean-body-mass","display_name":"lean body mass","score":0.7839999794960022},{"id":"https://openalex.org/keywords/hepatic-glucose-production","display_name":"hepatic glucose production","score":0.8330000042915344},{"id":"https://openalex.org/keywords/beta-cell-function","display_name":"beta-cell function","score":0.7850000262260437},{"id":"https://openalex.org/keywords/immunosuppression","display_name":"immunosuppression","score":0.7480000257492065},{"id":"https://openalex.org/keywords/energy-metabolism","display_name":"energy metabolism","score":0.7580000162124634}],"concepts":[{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.8570438027381897},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.845964789390564},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.6794963479042053},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.6419832706451416},{"id":"https://openalex.org/C17093226","wikidata":"https://www.wikidata.org/wiki/Q2734081","display_name":"Carbohydrate metabolism","level":2,"score":0.6106795072555542},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.5691304206848145},{"id":"https://openalex.org/C2777499176","wikidata":"https://www.wikidata.org/wiki/Q174936","display_name":"Glycogen","level":2,"score":0.5214706659317017},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.4743812680244446},{"id":"https://openalex.org/C2777866211","wikidata":"https://www.wikidata.org/wiki/Q5572349","display_name":"Glucose uptake","level":3,"score":0.4733543395996094},{"id":"https://openalex.org/C2778808658","wikidata":"https://www.wikidata.org/wiki/Q2975183","display_name":"Glucose clamp technique","level":5,"score":0.44175249338150024},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.38730892539024353},{"id":"https://openalex.org/C2780352109","wikidata":"https://www.wikidata.org/wiki/Q728309","display_name":"Pancreatic hormone","level":4,"score":0.35478490591049194},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3341628313064575},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.33360710740089417}],"mesh":[{"descriptor_ui":"D000305","descriptor_name":"Adrenal Cortex Hormones","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D001786","descriptor_name":"Blood Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001833","descriptor_name":"Body Temperature Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004734","descriptor_name":"Energy Metabolism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006003","descriptor_name":"Glycogen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007333","descriptor_name":"Insulin Resistance","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D007515","descriptor_name":"Islets of Langerhans","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016030","descriptor_name":"Kidney Transplantation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D050356","descriptor_name":"Lipid Metabolism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:2678633","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2678633","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transplantation","raw_type":"Journal Article"},{"id":"mag:2396895747","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2678633","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2076454593","https://openalex.org/W2040952922","https://openalex.org/W2043830941","https://openalex.org/W2062949388","https://openalex.org/W2085501859","https://openalex.org/W2411947146","https://openalex.org/W2105366458","https://openalex.org/W2137873612","https://openalex.org/W1992410164","https://openalex.org/W2562777758"],"abstract_inverted_index":{"In":[0,156,195],"order":[1],"to":[2,79,96,144,185,205],"study":[3],"the":[4,80,186,192,208,217],"effect":[5,82],"of":[6,63,83,111,151,159,171,188,211,219],"corticosteroids":[7],"on":[8],"energy":[9,22,146],"metabolism":[10],"in":[11,28,40,56,91,109,131,183,191,200,207,227],"immunosuppressed":[12],"patients":[13,31,76,202],"after":[14,149],"kidney":[15],"transplantation,":[16],"we":[17],"have":[18],"examined":[19],"glucose":[20,93,112,133,160,173,212],"utilization,":[21],"expenditure,":[23],"and":[24,39,44,61,142,161,177],"lean":[25,139],"body":[26,140],"mass":[27,141],"10":[29,41],"kidney-transplanted":[30,75,201],"receiving":[32],"steroids":[33],"(methylprednisolone":[34],"8.2":[35],"+/-":[36,116,120],"1.5":[37],"mg/day)":[38],"healthy":[42],"age-":[43],"weight-matched":[45],"control":[46,97],"subjects.":[47,98],"Glucose":[48],"utilization":[49],"was":[50,68,101,135,163,175,180],"measured":[51,69],"during":[52,70],"euglycemic":[53],"insulin":[54,178,189,198],"clamp":[55],"combination":[57],"with":[58,137],"indirect":[59],"calorimetry":[60],"infusion":[62,150],"[3H-3]-glucose,":[64],"while":[65],"beta-cell":[66],"function":[67],"a":[71,88,107],"hyperglycemic":[72],"clamp.":[73],"The":[74,129],"were":[77],"resistant":[78],"glucoregulatory":[81],"insulin,":[84,152],"as":[85,113,147],"demonstrated":[86],"by":[87,106,166],"25%":[89],"reduction":[90,130],"total":[92],"disposal":[94,134],"compared":[95],"This":[99],"defect":[100,108],"almost":[102],"completely":[103],"accounted":[104],"for":[105],"storage":[110],"glycogen":[114,225],"(3.3":[115],"0.5":[117,121],"vs.":[118],"5.0":[119],"mg/kg":[122],"LBM":[123],"min;":[124],"P":[125],"less":[126],"than":[127],"0.05).":[128],"nonoxidative":[132,209],"associated":[136],"reduced":[138],"incapacity":[143],"release":[145],"heat":[148],"i.e.":[153],"thermogenic":[154],"defect.":[155],"contrast,":[157],"oxidation":[158],"lipids":[162],"not":[164],"influenced":[165],"steroid":[167,221],"therapy.":[168],"Furthermore,":[169],"suppression":[170],"hepatic":[172],"production":[174],"normal,":[176],"secretion":[179],"normally":[181],"enhanced":[182],"relation":[184],"degree":[187],"resistance":[190,199],"steroid-treated":[193],"patients.":[194],"conclusion,":[196],"steroid-induced":[197],"is":[203],"due":[204],"alterations":[206],"pathway":[210],"metabolism.":[213],"These":[214],"findings":[215],"raise":[216],"question":[218],"whether":[220],"therapy":[222],"directly":[223],"influences":[224],"synthase":[226],"man.":[228]},"counts_by_year":[{"year":2017,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
