{"id":"https://openalex.org/W2396891335","doi":null,"title":"The effect of prolonged ethanol administration on central alpha 2-adrenoceptors sensitivity.","display_name":"The effect of prolonged ethanol administration on central alpha 2-adrenoceptors sensitivity.","publication_year":1989,"publication_date":"1989-05-01","ids":{"openalex":"https://openalex.org/W2396891335","mag":"2396891335","pmid":"https://pubmed.ncbi.nlm.nih.gov/2559397"},"language":"en","primary_location":{"id":"pmid:2559397","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2559397","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Polish journal of pharmacology and pharmacy","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5083476200","display_name":"Andrzej Szmigielski","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Szmigielski","raw_affiliation_strings":["Department of Pharmacodynamics, Medical Academy, L\u00f3d\u017a, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacodynamics, Medical Academy, L\u00f3d\u017a, Poland","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082411306","display_name":"H Szmigielska","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H Szmigielska","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5004270105","display_name":"Irena Wejman","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"I Wejman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.1258,"has_fulltext":false,"cited_by_count":15,"citation_normalized_percentile":{"value":0.28105384,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"41","issue":"3","first_page":"263","last_page":"72"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.6068999767303467,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.6068999767303467,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.2612000107765198,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11207","display_name":"Alcohol Consumption and Health Effects","score":0.07779999822378159,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ethanol","display_name":"ethanol","score":0.8899999856948853},{"id":"https://openalex.org/keywords/alpha2-adrenergic-receptors","display_name":"alpha2-adrenoceptors","score":0.9319999814033508},{"id":"https://openalex.org/keywords/clonidine","display_name":"clonidine","score":0.800000011920929},{"id":"https://openalex.org/keywords/receptor-subsensitivity","display_name":"receptor subsensitivity","score":0.7519999742507935},{"id":"https://openalex.org/keywords/nucleus-accumbens","display_name":"nucleus accumbens","score":0.9049999713897705},{"id":"https://openalex.org/keywords/hippocampus","display_name":"hippocampus","score":0.996999979019165},{"id":"https://openalex.org/keywords/hypothalamus","display_name":"hypothalamus","score":0.9700000286102295},{"id":"https://openalex.org/keywords/alcohol-tolerance","display_name":"alcohol tolerance","score":0.3179999887943268}],"concepts":[{"id":"https://openalex.org/C2778399450","wikidata":"https://www.wikidata.org/wiki/Q412221","display_name":"Clonidine","level":2,"score":0.8419990539550781},{"id":"https://openalex.org/C197341189","wikidata":"https://www.wikidata.org/wiki/Q863533","display_name":"Postsynaptic potential","level":3,"score":0.8082672357559204},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.64143967628479},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.638944149017334},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.6330523490905762},{"id":"https://openalex.org/C64943373","wikidata":"https://www.wikidata.org/wiki/Q2651003","display_name":"Alpha (finance)","level":4,"score":0.6138358116149902},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5277729034423828},{"id":"https://openalex.org/C2777003273","wikidata":"https://www.wikidata.org/wiki/Q164386","display_name":"Hypothalamus","level":2,"score":0.509456217288971},{"id":"https://openalex.org/C2776552330","wikidata":"https://www.wikidata.org/wiki/Q1476178","display_name":"Nucleus accumbens","level":3,"score":0.4560551345348358},{"id":"https://openalex.org/C13348194","wikidata":"https://www.wikidata.org/wiki/Q288084","display_name":"Alpha-2 adrenergic receptor","level":3,"score":0.43797045946121216},{"id":"https://openalex.org/C2780161600","wikidata":"https://www.wikidata.org/wiki/Q153","display_name":"Ethanol","level":2,"score":0.43655237555503845},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2368737757205963},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.22549685835838318},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.21038693189620972},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.05782172083854675},{"id":"https://openalex.org/C2775944032","wikidata":"https://www.wikidata.org/wiki/Q22907659","display_name":"Patient satisfaction","level":2,"score":0.0},{"id":"https://openalex.org/C159110408","wikidata":"https://www.wikidata.org/wiki/Q121176","display_name":"Nursing","level":1,"score":0.0},{"id":"https://openalex.org/C49453240","wikidata":"https://www.wikidata.org/wiki/Q1592163","display_name":"Construct validity","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000431","descriptor_name":"Ethanol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000628","descriptor_name":"Aminophylline","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001933","descriptor_name":"Brain Stem","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001933","descriptor_name":"Brain Stem","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003000","descriptor_name":"Clonidine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007031","descriptor_name":"Hypothalamus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D007031","descriptor_name":"Hypothalamus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011919","descriptor_name":"Rats, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011942","descriptor_name":"Receptors, Adrenergic, alpha","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D015016","descriptor_name":"Yohimbine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:2559397","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2559397","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Polish journal of pharmacology and pharmacy","raw_type":"Journal Article"},{"id":"mag:2396891335","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2559397","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1971984968","https://openalex.org/W2160664059","https://openalex.org/W2014124129","https://openalex.org/W2102410077","https://openalex.org/W1967201412","https://openalex.org/W2048275569","https://openalex.org/W2075693464","https://openalex.org/W2103006613","https://openalex.org/W1975084714","https://openalex.org/W7036728063"],"abstract_inverted_index":{"The":[0],"response":[1,145],"of":[2,6,19,21,27,57,64,92,95,105,123,130,142,146,153],"an":[3,17,32],"endogenous":[4],"inhibitor":[5,37,76,149],"protein":[7],"kinases":[8],"(type":[9],"II":[10,36,75,148],"inhibitor)":[11],"to":[12,150],"clonidine":[13,28,65,96,154],"was":[14,159],"used":[15],"as":[16,162],"index":[18],"sensitivity":[20],"central":[22],"alpha":[23,54,59,107,132],"2-adrenoceptors.":[24,55],"Low":[25],"doses":[26,63,94,152],"(20-50":[29],"micrograms/kg)":[30],"induced":[31,125],"increase":[33],"in":[34,39,45,69,73,97,134,155,163],"type":[35,74,147],"activity":[38],"the":[40,46,90,99,116,135,144,160],"nucleus":[41],"accumbens,":[42],"hippocampus":[43],"and":[44,48],"anterior":[47,136],"posterior":[49],"hypothalamus":[50],"by":[51,61],"stimulating":[52],"presynaptic":[53],"Stimulation":[56],"postsynaptic":[58,106,131],"2-adrenoceptors":[60,108,133],"high":[62,93,151],"0.5-1.0":[66],"mg/kg":[67],"resulted":[68],"a":[70,126],"dose-dependent":[71],"decrease":[72],"activity.":[77],"Prolonged":[78],"treatment":[79],"with":[80],"ethanol":[81,118,124],"(5":[82],"g/kg/day":[83],"po":[84],"for":[85,110],"21":[86],"days)":[87],"greatly":[88],"reduced":[89],"action":[91],"all":[98],"examined":[100],"brain":[101,157],"areas,":[102],"suggesting":[103],"subsensitivity":[104,129],"lasting":[109,128],"at":[111],"least":[112],"48":[113],"h":[114,139],"after":[115,140],"last":[117],"administration.":[119],"A":[120],"single":[121],"dose":[122],"short":[127],"hypothalamus.":[137],"12":[138],"administration":[141],"alcohol":[143],"this":[156],"area":[158],"same":[161],"untreated":[164],"rats.":[165]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2020,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
