{"id":"https://openalex.org/W2396837434","doi":"https://doi.org/10.1177/135965350501000609","title":"Prostratin and Bortezomib are Novel Inducers of Latent Kaposi'S Sarcoma-Associated Herpesvirus","display_name":"Prostratin and Bortezomib are Novel Inducers of Latent Kaposi'S Sarcoma-Associated Herpesvirus","publication_year":2005,"publication_date":"2005-08-01","ids":{"openalex":"https://openalex.org/W2396837434","doi":"https://doi.org/10.1177/135965350501000609","mag":"2396837434","pmid":"https://pubmed.ncbi.nlm.nih.gov/16218174"},"language":"en","primary_location":{"id":"doi:10.1177/135965350501000609","doi":"https://doi.org/10.1177/135965350501000609","is_oa":false,"landing_page_url":"https://doi.org/10.1177/135965350501000609","pdf_url":null,"source":{"id":"https://openalex.org/S137629795","display_name":"Antiviral Therapy","issn_l":"1359-6535","issn":["1359-6535","2040-2058"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antiviral Therapy","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5005467486","display_name":"Helen J. Brown","orcid":"https://orcid.org/0000-0002-1095-5148","observed_orcids":["https://orcid.org/0000-0002-1095-5148"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Helen J Brown","raw_affiliation_strings":["Department of Microbiology, Immunology and Molecular Genetics, UCLA, Los Angeles, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, Immunology and Molecular Genetics, UCLA, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039693749","display_name":"William H. McBride","orcid":"https://orcid.org/0000-0001-5008-3180","observed_orcids":["https://orcid.org/0000-0001-5008-3180"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William H McBride","raw_affiliation_strings":["Department of Radiation Oncology, Roy E. Coats Research Laboratories, UCLA, Los Angeles, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, Roy E. Coats Research Laboratories, UCLA, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072471885","display_name":"Jerome A. Zack","orcid":"https://orcid.org/0000-0001-5486-8495","observed_orcids":["https://orcid.org/0000-0001-5486-8495"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jerome A Zack","raw_affiliation_strings":["David Geffen School of Medicine, UCLA, Los Angeles, CA, USA","Department of Microbiology, Immunology and Molecular Genetics, UCLA, Los Angeles, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"David Geffen School of Medicine, UCLA, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"Department of Microbiology, Immunology and Molecular Genetics, UCLA, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5029398617","display_name":"Ren Sun","orcid":"https://orcid.org/0000-0002-8628-7019","observed_orcids":["https://orcid.org/0000-0002-8628-7019"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ren Sun","raw_affiliation_strings":["Department of Medical and Molecular Pharmacology, Los Angeles, CA, USA","David Geffen School of Medicine, UCLA, Los Angeles, CA, USA","Department of Microbiology, Immunology and Molecular Genetics, UCLA, Los Angeles, CA, USA","Department of Radiation Oncology, Roy E. Coats Research Laboratories, UCLA, Los Angeles, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical and Molecular Pharmacology, Los Angeles, CA, USA","institution_ids":[]},{"raw_affiliation_string":"David Geffen School of Medicine, UCLA, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"Department of Microbiology, Immunology and Molecular Genetics, UCLA, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"Department of Radiation Oncology, Roy E. Coats Research Laboratories, UCLA, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I161318765"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I161318765"],"apc_list":{"value":2800,"currency":"USD","value_usd":2800},"apc_paid":null,"fwci":1.5544,"has_fulltext":false,"cited_by_count":42,"citation_normalized_percentile":{"value":0.83023698,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"10","issue":"6","first_page":"745","last_page":"751"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10685","display_name":"Viral-associated cancers and disorders","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10685","display_name":"Viral-associated cancers and disorders","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10625","display_name":"Herpesvirus Infections and Treatments","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10981","display_name":"Cytomegalovirus and herpesvirus research","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/kaposi-s-sarcoma-associated-herpesvirus","display_name":"Kaposi's sarcoma-associated herpesvirus","score":0.9929999709129333},{"id":"https://openalex.org/keywords/prostratin","display_name":"prostratin","score":0.8349999785423279},{"id":"https://openalex.org/keywords/bortezomib","display_name":"bortezomib","score":0.9990000128746033},{"id":"https://openalex.org/keywords/lytic-gene-expression","display_name":"lytic gene expression","score":0.7360000014305115},{"id":"https://openalex.org/keywords/viral-reactivation","display_name":"viral reactivation","score":0.8600000143051147},{"id":"https://openalex.org/keywords/latent-infection","display_name":"latent infection","score":0.8140000104904175},{"id":"https://openalex.org/keywords/phorbol-ester","display_name":"phorbol ester","score":0.9390000104904175},{"id":"https://openalex.org/keywords/proteasome-inhibitors","display_name":"proteasome inhibitors","score":0.9290000200271606},{"id":"https://openalex.org/keywords/therapeutic-agents","display_name":"therapeutic agents","score":0.44200000166893005}],"concepts":[{"id":"https://openalex.org/C182615771","wikidata":"https://www.wikidata.org/wiki/Q1369386","display_name":"Lytic cycle","level":3,"score":0.8909227848052979},{"id":"https://openalex.org/C2777478702","wikidata":"https://www.wikidata.org/wiki/Q419319","display_name":"Bortezomib","level":3,"score":0.7668352723121643},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6053181886672974},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5505226254463196},{"id":"https://openalex.org/C2780797929","wikidata":"https://www.wikidata.org/wiki/Q983850","display_name":"Kaposi's sarcoma-associated herpesvirus","level":5,"score":0.5118007063865662},{"id":"https://openalex.org/C2778367456","wikidata":"https://www.wikidata.org/wiki/Q7251235","display_name":"Proteasome inhibitor","level":3,"score":0.4597355127334595},{"id":"https://openalex.org/C2779594685","wikidata":"https://www.wikidata.org/wiki/Q3832899","display_name":"Primary effusion lymphoma","level":3,"score":0.44007304310798645},{"id":"https://openalex.org/C2779338263","wikidata":"https://www.wikidata.org/wiki/Q208414","display_name":"Lymphoma","level":2,"score":0.42329227924346924},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.42225009202957153},{"id":"https://openalex.org/C2778852064","wikidata":"https://www.wikidata.org/wiki/Q4115619","display_name":"Virus latency","level":4,"score":0.41323086619377136},{"id":"https://openalex.org/C27740335","wikidata":"https://www.wikidata.org/wiki/Q14878333","display_name":"Proteasome","level":2,"score":0.4099435806274414},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.34977930784225464},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.3397142291069031},{"id":"https://openalex.org/C2776409557","wikidata":"https://www.wikidata.org/wiki/Q149348","display_name":"Herpesviridae","level":4,"score":0.33149394392967224},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.28862255811691284},{"id":"https://openalex.org/C2776364478","wikidata":"https://www.wikidata.org/wiki/Q467635","display_name":"Multiple myeloma","level":2,"score":0.25050896406173706},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.21695154905319214},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.1976574957370758},{"id":"https://openalex.org/C140704245","wikidata":"https://www.wikidata.org/wiki/Q3933202","display_name":"Viral replication","level":3,"score":0.15436801314353943},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1102861762046814},{"id":"https://openalex.org/C2780727368","wikidata":"https://www.wikidata.org/wiki/Q1928978","display_name":"Viral disease","level":3,"score":0.10718926787376404}],"mesh":[{"descriptor_ui":"D000069286","descriptor_name":"Bortezomib","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001897","descriptor_name":"Boronic Acids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010703","descriptor_name":"Phorbol Esters","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D011480","descriptor_name":"Protease Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D011719","descriptor_name":"Pyrazines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D014764","descriptor_name":"Viral Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014764","descriptor_name":"Viral Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014775","descriptor_name":"Virus Activation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D015534","descriptor_name":"Trans-Activators","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015534","descriptor_name":"Trans-Activators","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015967","descriptor_name":"Gene Expression Regulation, Viral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017735","descriptor_name":"Virus Latency","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017874","descriptor_name":"Immediate-Early Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017874","descriptor_name":"Immediate-Early Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019288","descriptor_name":"Herpesvirus 8, Human","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D019288","descriptor_name":"Herpesvirus 8, Human","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1177/135965350501000609","doi":"https://doi.org/10.1177/135965350501000609","is_oa":false,"landing_page_url":"https://doi.org/10.1177/135965350501000609","pdf_url":null,"source":{"id":"https://openalex.org/S137629795","display_name":"Antiviral Therapy","issn_l":"1359-6535","issn":["1359-6535","2040-2058"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antiviral Therapy","raw_type":"journal-article"},{"id":"pmid:16218174","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16218174","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antiviral therapy","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":37,"referenced_works":["https://openalex.org/W1548623075","https://openalex.org/W1981899340","https://openalex.org/W1982316892","https://openalex.org/W1992258294","https://openalex.org/W1992978957","https://openalex.org/W2000238187","https://openalex.org/W2006264155","https://openalex.org/W2027230991","https://openalex.org/W2032438721","https://openalex.org/W2038130483","https://openalex.org/W2061789335","https://openalex.org/W2076603205","https://openalex.org/W2078057624","https://openalex.org/W2086420850","https://openalex.org/W2096520038","https://openalex.org/W2097329956","https://openalex.org/W2097718228","https://openalex.org/W2098190927","https://openalex.org/W2104107907","https://openalex.org/W2108233169","https://openalex.org/W2113694619","https://openalex.org/W2116403673","https://openalex.org/W2117184453","https://openalex.org/W2119734571","https://openalex.org/W2120542113","https://openalex.org/W2129503336","https://openalex.org/W2130651313","https://openalex.org/W2145455317","https://openalex.org/W2150459227","https://openalex.org/W2151478533","https://openalex.org/W2170799547","https://openalex.org/W2187388644","https://openalex.org/W2330374913","https://openalex.org/W2335735158","https://openalex.org/W2336241188","https://openalex.org/W2410723119","https://openalex.org/W2970213870"],"related_works":["https://openalex.org/W2137616052","https://openalex.org/W2991710795","https://openalex.org/W2883295815","https://openalex.org/W1965522181","https://openalex.org/W2889670243","https://openalex.org/W1978853479","https://openalex.org/W3110918979","https://openalex.org/W7095099246","https://openalex.org/W2044962700","https://openalex.org/W7019300352"],"abstract_inverted_index":{"Kaposi's":[0],"sarcoma-associated":[1],"herpesvirus":[2],"(KSHV)":[3],"establishes":[4],"latent":[5,13],"infections":[6],"in":[7,38,70,88],"lymphocytes":[8],"and":[9,12,32,52,60,84,91,97],"endothelial":[10],"cells,":[11],"infection":[14],"is":[15],"closely":[16],"linked":[17],"to":[18,74],"tumorigenesis.":[19],"As":[20],"few":[21],"viral":[22],"markers":[23],"are":[24],"expressed":[25],"during":[26],"latency,":[27],"compounds":[28],"that":[29,46],"can":[30],"safely":[31],"efficiently":[33],"increase":[34],"lytic":[35,76],"gene":[36,63,77],"expression":[37,64,78],"vivo":[39],"have":[40,44],"been":[41],"sought.":[42],"We":[43],"found":[45],"the":[47,53],"non-tumour-promoting":[48],"phorbol":[49],"ester":[50],"prostratin":[51,96],"proteasome":[54],"inhibitor":[55],"bortezomib":[56,98],"induce":[57,75],"immediate-early,":[58],"early":[59],"late":[61],"KSHV":[62,89],"from":[65],"two":[66],"lymphoma":[67],"cell":[68],"lines":[69],"vitro.":[71],"Their":[72],"ability":[73],"supports":[79],"a":[80],"role":[81],"for":[82,102],"phorbol-ester":[83],"proteasome-regulated":[85],"signalling":[86],"pathways":[87],"reactivation":[90],"prompts":[92],"further":[93],"investigation":[94],"of":[95],"as":[99],"therapeutic":[100],"agents":[101],"KSHV-associated":[103],"malignancies.":[104]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}