{"id":"https://openalex.org/W2396835341","doi":null,"title":"Physiological aspects of thyroglobulin immunity. 3. Studies of localization of antibodies in vascular tissue and abnormal plasma thyroxine binding in the guinea pig.","display_name":"Physiological aspects of thyroglobulin immunity. 3. Studies of localization of antibodies in vascular tissue and abnormal plasma thyroxine binding in the guinea pig.","publication_year":1965,"publication_date":"1965-12-01","ids":{"openalex":"https://openalex.org/W2396835341","mag":"2396835341","pmid":"https://pubmed.ncbi.nlm.nih.gov/4158725"},"language":"en","primary_location":{"id":"pmid:4158725","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/4158725","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of laboratory and clinical medicine","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5007254402","display_name":"B. N. Premachandra","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"B N Premachandra","raw_affiliation_strings":["From the Department of Psychology, Washington University St. Louis, Mo., USA","From the Veterans Administration Hospital, Jefferson Barracks, St. Louis, Mo., USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Psychology, Washington University St. Louis, Mo., USA","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"From the Veterans Administration Hospital, Jefferson Barracks, St. Louis, Mo., USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035637367","display_name":"Aline W. Berns","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A W Berns","raw_affiliation_strings":["From the Department of Psychology, Washington University St. Louis, Mo., USA","From the Veterans Administration Hospital, Jefferson Barracks, St. Louis, Mo., USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Psychology, Washington University St. Louis, Mo., USA","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"From the Veterans Administration Hospital, Jefferson Barracks, St. Louis, Mo., USA","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5044519211","display_name":"Blumenthal Ht","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"H T Blumenthal","raw_affiliation_strings":["From the Department of Psychology, Washington University St. Louis, Mo., USA","From the Veterans Administration Hospital, Jefferson Barracks, St. Louis, Mo., USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Psychology, Washington University St. Louis, Mo., USA","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"From the Veterans Administration Hospital, Jefferson Barracks, St. Louis, Mo., USA","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I204465549"],"apc_list":null,"apc_paid":null,"fwci":0.5852,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.68462883,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"66","issue":"6","first_page":"893","last_page":"905"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10293","display_name":"Thyroid Disorders and Treatments","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10293","display_name":"Thyroid Disorders and Treatments","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10329","display_name":"Thyroid Cancer Diagnosis and Treatment","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12421","display_name":"Adrenal Hormones and Disorders","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/anti-thyroglobulin-antibodies","display_name":"thyroglobulin antibodies","score":0.9290000200271606},{"id":"https://openalex.org/keywords/thyroxine-binding","display_name":"thyroxine binding","score":0.7850000262260437},{"id":"https://openalex.org/keywords/thyroid-follicular-epithelium","display_name":"thyroid follicular epithelium","score":0.7350000143051147},{"id":"https://openalex.org/keywords/thyroiditis","display_name":"thyroiditis","score":0.7319999933242798},{"id":"https://openalex.org/keywords/guinea-pig","display_name":"guinea pig","score":0.734000027179718}],"concepts":[{"id":"https://openalex.org/C2778835679","wikidata":"https://www.wikidata.org/wiki/Q412228","display_name":"Thyroglobulin","level":3,"score":0.865425705909729},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7595986127853394},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7441502809524536},{"id":"https://openalex.org/C526584372","wikidata":"https://www.wikidata.org/wiki/Q16399","display_name":"Thyroid","level":2,"score":0.7314929962158203},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.567470371723175},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.561510443687439},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5094879269599915},{"id":"https://openalex.org/C539932907","wikidata":"https://www.wikidata.org/wiki/Q1103","display_name":"Iodine","level":2,"score":0.5075058341026306},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2636886537075043},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.18997737765312195},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000273","descriptor_name":"Adipose Tissue","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001323","descriptor_name":"Autoantibodies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005455","descriptor_name":"Fluorescent Antibody Technique","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006168","descriptor_name":"Guinea Pigs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008856","descriptor_name":"Microscopy, Fluorescence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009132","descriptor_name":"Muscles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013954","descriptor_name":"Thyroglobulin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013960","descriptor_name":"Thyroid Function Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013974","descriptor_name":"Thyroxine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:4158725","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/4158725","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of laboratory and clinical medicine","raw_type":"Journal Article"},{"id":"mag:2396835341","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/4158725","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8999999761581421,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":29,"referenced_works":["https://openalex.org/W1476286421","https://openalex.org/W1970798295","https://openalex.org/W1978708466","https://openalex.org/W2008677555","https://openalex.org/W2015934957","https://openalex.org/W2024824874","https://openalex.org/W2041094538","https://openalex.org/W2041353896","https://openalex.org/W2042247673","https://openalex.org/W2046080522","https://openalex.org/W2052225826","https://openalex.org/W2057733647","https://openalex.org/W2085455709","https://openalex.org/W2085725955","https://openalex.org/W2088550479","https://openalex.org/W2104048504","https://openalex.org/W2106556874","https://openalex.org/W2115430692","https://openalex.org/W2117873789","https://openalex.org/W2161793121","https://openalex.org/W2162529628","https://openalex.org/W2272495043","https://openalex.org/W2323027060","https://openalex.org/W2327374710","https://openalex.org/W2402949110","https://openalex.org/W2419178665","https://openalex.org/W2464984902","https://openalex.org/W4313375013","https://openalex.org/W4313375078"],"related_works":["https://openalex.org/W2046080522","https://openalex.org/W2015934957","https://openalex.org/W2162529628","https://openalex.org/W1974066896","https://openalex.org/W2094797555","https://openalex.org/W2332223725","https://openalex.org/W1963805769","https://openalex.org/W2399682955","https://openalex.org/W2062977910","https://openalex.org/W2316356321"],"abstract_inverted_index":{"Abstract":[0],"Immunofluorescent":[2],"and":[3,16,43,53,73,134,141,147],"thyroxine":[4,29,36,44,69,188,204,234],"I":[5],"131":[6],"kinetic":[8],"studies":[9,152],"were":[10,48,55],"carried":[11],"out":[12,217],"in":[13,57,71,82,95,104,108,130,142,156,163,171,178,241,249],"untreated,":[14],"adjuvant-treated,":[15],"actively":[17,179],"thyroglobulin-immunized":[18],"animals.":[19,75,84,166,174],"Twelve":[20],"weeks":[21],"after":[22],"the":[23,28,102,109,115,131,139,143,157,164,172,193,219],"first":[24],"injection":[25],"of":[26,35,68,117,127,138,145,160,187,196,218,233,244],"thyroglobulin,":[27],"distribution":[30],"space":[31],"(TDS),":[32],"fractional":[33],"turnover":[34,67],"(t12),":[37],"extrathyroidal":[38,96],"organic":[39,97],"iodine":[40,98,106],"pool":[41],"(EOI),":[42],"degradation":[45,77],"rate":[46,78],"(TDR)":[47],"determined.":[49],"Relatively":[50],"greater":[51,81],"TDS":[52],"EOI":[54],"noted":[56],"immunized":[58,83,110,165,180],"animals":[59,111],"but":[60],"with":[61,120,183],"a":[62,197],"very":[63],"much":[64],"reduced":[65],"peripheral":[66,198],"than":[70],"untreated":[72],"adjuvant-treated":[74,173],"Thyroxine":[76],"was":[79,90,112,169],"also":[80],"It":[85,227],"is":[86,228],"suggested":[87,230],"that":[88,231],"this":[89],"related":[91],"to":[92,211,214,254],"an":[93],"increase":[94,103],"pool.":[99],"We":[100],"believe":[101],"protein-bound":[105],"(PBI)":[107],"caused":[113],"by":[114,190,235],"association":[116],"thyroid":[118,140,225],"hormone":[119],"antithyroglobulin":[121,236],"antibody.":[122],"Fluorescent":[123],"microscopy":[124],"demonstrated":[125],"localization":[126],"fluorescent-labeled":[128],"thyroglobulin":[129,255],"blood":[132,158],"vessel":[133],"follicular":[135],"epithelial":[136],"cells":[137],"vessels":[144,159],"muscle":[146],"adipose":[148],"tissue.":[149],"Furthermore,":[150],"fluorescence":[151,168],"revealed":[153],"thyroglobulin-binding":[154],"coagula":[155],"muscular":[161],"tissue":[162],"No":[167],"observed":[170],"The":[175],"present":[176],"investigations":[177],"animals,":[181],"along":[182],"our":[184],"previous":[185],"observations":[186],"binding":[189,232],"antithyroglobulin,":[191],"suggest":[192],"possible":[194],"existence":[195],"immune":[199],"block":[200],"which":[201],"prevents":[202],"antibody-bound":[203],"from":[205],"exerting":[206],"its":[207,212],"full":[208],"effects":[209],"due":[210],"inability":[213],"diffuse":[215],"freely":[216],"vascular":[220],"compartment,":[221],"thereby":[222],"affecting":[223],"other":[224,242,250],"parameters.":[226],"further":[229],"may":[237],"affect":[238],"hormonal":[239],"kinetics":[240],"types":[243],"thyroiditis,":[245],"as":[246,248],"well":[247],"circumstances":[251],"where":[252],"antibody":[253],"can":[256],"be":[257],"detected.":[258]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
