{"id":"https://openalex.org/W2396830136","doi":null,"title":"Altered expression of natural killer cell inhibitory receptors (KIRs) on T cells in bronchoalveolar lavage fluid and peripheral blood of sarcoidosis patients.","display_name":"Altered expression of natural killer cell inhibitory receptors (KIRs) on T cells in bronchoalveolar lavage fluid and peripheral blood of sarcoidosis patients.","publication_year":2000,"publication_date":"2000-03-01","ids":{"openalex":"https://openalex.org/W2396830136","mag":"2396830136","pmid":"https://pubmed.ncbi.nlm.nih.gov/10746261"},"language":"en","primary_location":{"id":"pmid:10746261","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10746261","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG","raw_type":"Journal Article"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5114134256","display_name":"Masanari Mizuki","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Mizuki","raw_affiliation_strings":["Health Care Center, Oita Medical University, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Health Care Center, Oita Medical University, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008925868","display_name":"Anders Eklund","orcid":"https://orcid.org/0000-0002-2031-722X","observed_orcids":["https://orcid.org/0000-0002-2031-722X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Eklund","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5000843678","display_name":"Johan Gr\u00fcnewald","orcid":"https://orcid.org/0000-0003-0473-3984","observed_orcids":["https://orcid.org/0000-0003-0473-3984"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J Grunewald","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.0205,"has_fulltext":false,"cited_by_count":11,"citation_normalized_percentile":{"value":0.77891043,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"17","issue":"1","first_page":"54","last_page":"9"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11571","display_name":"Sarcoidosis and Beryllium Toxicity Research","score":0.49900001287460327,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11571","display_name":"Sarcoidosis and Beryllium Toxicity Research","score":0.49900001287460327,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11020","display_name":"Immune Cell Function and Interaction","score":0.4957999885082245,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11510","display_name":"Reproductive System and Pregnancy","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sarcoidosis","display_name":"sarcoidosis","score":0.8949999809265137},{"id":"https://openalex.org/keywords/cd8-t-cells","display_name":"CD8+ T cells","score":0.9760000109672546},{"id":"https://openalex.org/keywords/cd4-t-cells","display_name":"CD4+ T cells","score":0.8569999933242798},{"id":"https://openalex.org/keywords/bronchoalveolar-lavage","display_name":"bronchoalveolar lavage","score":0.890999972820282},{"id":"https://openalex.org/keywords/peripheral-blood-lymphocytes","display_name":"peripheral blood lymphocytes","score":0.8510000109672546},{"id":"https://openalex.org/keywords/cd94","display_name":"CD94","score":0.9409999847412109},{"id":"https://openalex.org/keywords/p70","display_name":"p70","score":0.7839999794960022},{"id":"https://openalex.org/keywords/p58","display_name":"p58","score":0.9959999918937683},{"id":"https://openalex.org/keywords/disease-activity","display_name":"disease activity","score":0.8069999814033508},{"id":"https://openalex.org/keywords/disease-stage","display_name":"disease stage","score":0.5220000147819519}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7652561664581299},{"id":"https://openalex.org/C2777961210","wikidata":"https://www.wikidata.org/wiki/Q927148","display_name":"Bronchoalveolar lavage","level":3,"score":0.7104024887084961},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.6887377500534058},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.6445906758308411},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.532258927822113},{"id":"https://openalex.org/C553184892","wikidata":"https://www.wikidata.org/wiki/Q1141429","display_name":"Flow cytometry","level":2,"score":0.48889580368995667},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.4638049602508545},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.42495235800743103},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.25713735818862915},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.13934361934661865}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001992","descriptor_name":"Bronchoalveolar Lavage Fluid","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007694","descriptor_name":"Killer Cells, Natural","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011971","descriptor_name":"Receptors, Immunologic","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D015496","descriptor_name":"CD4-Positive T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D016516","descriptor_name":"CD4-CD8 Ratio","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017565","descriptor_name":"Sarcoidosis, Pulmonary","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D017565","descriptor_name":"Sarcoidosis, Pulmonary","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D018414","descriptor_name":"CD8-Positive T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D054340","descriptor_name":"Receptors, KIR","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054344","descriptor_name":"Receptors, KIR2DL3","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:10746261","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10746261","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG","raw_type":"Journal Article"},{"id":"mag:2396830136","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10746261","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2108560097","https://openalex.org/W4313585066","https://openalex.org/W2003021383","https://openalex.org/W2283174507","https://openalex.org/W2155295885","https://openalex.org/W952711023","https://openalex.org/W4229363825","https://openalex.org/W2005186483","https://openalex.org/W4387970452","https://openalex.org/W2037274024"],"abstract_inverted_index":{"BACKGROUND":[0],"AND":[1],"AIM":[2],"OF":[3],"THE":[4],"WORK:":[5],"The":[6,226],"role":[7],"for":[8,119,126],"natural":[9],"killer":[10],"cell":[11,32,49],"inhibitory":[12],"receptors":[13],"(KIRs)":[14],"on":[15,26,57,90,233],"T":[16,27,31,48,58,101,235],"cells":[17,28,59,102,236,250],"is":[18],"not":[19,80],"fully":[20],"understood,":[21],"but":[22],"signalling":[23],"through":[24],"KIRs":[25,232],"may":[29],"inhibit":[30],"receptor":[33],"mediated":[34,50],"activation,":[35],"and":[36,83,92,97,106,123,136,199,213,254],"KIR":[37,55,88,112],"expression":[38,56,89,229],"has":[39],"been":[40,81],"suggested":[41],"to":[42,130,151,170,188,251],"be":[43,62,252],"one":[44],"mechanism":[45],"of":[46,63,103,134,230,244,260],"controlling":[47],"immune":[51],"responses.":[52],"An":[53],"aberrant":[54],"could":[60],"thus":[61],"importance":[64],"in":[65,144,195,205,214,237,240,257],"autoimmune":[66],"as":[67,69],"well":[68],"infectious":[70],"disorders.":[71],"Sarcoidosis":[72],"patients":[73,105,206,215,241],"have":[74,79],"several":[75],"immunological":[76],"impairments":[77],"that":[78,128],"clarified,":[82],"we":[84],"here":[85],"examined":[86],"the":[87,258,261],"CD4+":[91],"CD8+":[93,146,164,182,196,234],"peripheral":[94],"blood":[95],"(PBL)":[96],"bronchoalveolar":[98],"lavage":[99],"(BAL)":[100],"sarcoidosis":[104],"controls.":[107],"METHODS:":[108],"We":[109],"used":[110],"three":[111],"specific":[113],"monoclonal":[114],"antibodies,":[115],"namely":[116],"DX9":[117],"(specific":[118,125],"p70),":[120],"DX27":[121],"(p58)":[122],"DX22":[124],"CD94,":[127],"belongs":[129],"another":[131],"major":[132],"group":[133],"KIRs)":[135],"flow":[137],"cytometry.":[138],"RESULTS:":[139],"p70":[140],"was":[141,160,178],"expressed":[142,161,179,202],"lower":[143,204],"patient":[145],"PBL":[147,171,189],"(median":[148,167,185],"2.3%)":[149],"compared":[150,169,187],"controls":[152],"(6.3%)":[153],"(p":[154,173,191],"<":[155,174,192],"0.01).":[156,193],"In":[157],"patients,":[158],"p58":[159,200],"by":[162,180],"less":[163],"BAL":[165,183],"lymphocytes":[166,184],"1.2%)":[168],"(6.8%)":[172],"0.01)":[175],"while":[176],"CD94":[177,198],"more":[181],"14.5%)":[186],"(9.6%)":[190],"Moreover,":[194],"PBL,":[197],"were":[201],"significantly":[203,227],"with":[207,216,242],"an":[208,245],"active":[209,246],"vs.":[210,221],"inactive":[211],"disease,":[212,247],"chest":[217],"radiographic":[218],"stage":[219,222],"I":[220],"II,":[223],"respectively.":[224],"CONCLUSIONS:":[225],"altered":[228],"distinct":[231],"sarcoidosis,":[238],"especially":[239],"signs":[243],"indicate":[248],"these":[249],"dysregulated":[253],"implicate":[255],"them":[256],"pathogenesis":[259],"disease.":[262]},"counts_by_year":[{"year":2017,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
